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One-Pot Reductive Amination and Suzuki-Miyaura Cross-Coupling of Formyl Aryl and Heteroaryl MIDA Boronates in Array Format

Grob, Jonathan and Nunez, Jill and Dechantsreiter, Michael and Hamann, Lawrence (2011) One-Pot Reductive Amination and Suzuki-Miyaura Cross-Coupling of Formyl Aryl and Heteroaryl MIDA Boronates in Array Format. The Journal of organic chemistry, 76 (12). pp. 4930-4940. ISSN 0022-3263

Abstract

Formyl-substituted aryl and heteroaryl MIDA boronates were prepared by a DMSO-free method and used in the first reported one-pot reductive amination–Suzuki-Miyaura cross-coupling sequence. This sequence was then carried out in parallel array format, using microwave assisted in-situ release cross-coupling of MIDA boronates to generate a library with diversity along three axes, affording rapid and convenient access to an array of drug like molecules.

Item Type: Article
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/4616

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