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Future perspectives of venoms for drug discovery

Stöcklin, Reto and Vorherr, Thomas (2011) Future perspectives of venoms for drug discovery. PharManufacturing.


Venoms have been regarded as an interesting source for screening difficult-to-address pharmaceutical targets like ion channels, transmembrane or circulating proteins for quite some time. Moreover, recent developments open up new opportunities to better exploit well-structured toxins - so called “mini-proteins” that we also like to refer to as “picologics” - in a more general way for lead discovery and drug development. In particular, progress in throughput and the first results from the next generation of genome/transcriptome analyses and systems biology investigations widen the scope of an integrated understanding of global transcriptional activity in venom glands. As a result, natural products from venoms are thought to represent a sustainable source of molecules for addressing a wider range of targets, and thus enable a more systematic approach to the identification of new peptide therapeutic candidates.

Item Type: Article
Additional Information: Review
Keywords: venom libraries, peptides, drug dsicovery
Date Deposited: 13 Oct 2015 13:14
Last Modified: 13 Oct 2015 13:15