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Number of items: 231.


Abban, Cynthia Y. and Meneses, Patricio I. and Hatakeyama, Shinji (2010) Usage of heparan sulfate, integrins, and FAK in HPV16 infection. Virology, 403 (1). pp. 1-16.

Abdel Samad, Omar and Liu, Yang and Yang, Fu-Chia and Kramer, Ina and Arber, Silvia and Ma, Qiufu (2010) Characterization of two Runx1-dependent nociceptor differentiation programs necessary for inflammatory versus neuropathic pain. Molecular Pain, 6. p. 45. ISSN 1744-8069

Abdubeck, Polat and Chen, Connie and Feuerhelm, Julie and Grant, Joanna and Bakolitsa, Constantina and Klock, Heath and Knuth, Mark and Mcmullan, Daniel and Okach, Linda and Puckett, Christina and Lesley, Scott and Stolz, Barbara (2010) GNF ID 100605: Crystal structure of BT_3984, the first representative of the SusD/RagB family of nutrient binding. Acta F.

Abdubeck, Polat and Chen, Connie and Feuerhelm, Julie and Grant, Joanna and Klock, Heath and Knuth, Mark and Nigoghossian, Edward and Okach, Linda and Puckett, Christina and Wooten, Tiffany and Zhou, Jiadong and Lesley, Scott and Stolz, Barbara and Xu, Qingping (2010) GNF ID 100603: Crystal structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes. Acta F.

Abdubek, Polat and Chen, Connie and Chiu, Michelle and Feuerhelm, Julie and Grant, Joanna and Klock, Heath and Knuth, Mark and Nigoghossian, Edward and Okach, Linda and Puckett, Christina and Lesley, Scott and Stolz, Barbara (2010) GNF ID 100504: The crystal structure of Neisseria gonorrhoea NGO1391 defines a novel set of bacterial proteins that are similar to the N-terminal domain of human Sufu (Suppresor of Fused). Protein Science or Journal of Bacteriology.

Abdulla, Salim and Amuri, Baraka and Kabanywanyi, Abdunoor M and Ubben, David and Reynolds, Christine and Pascoe, Steve and Fitoussi, Serge and Yeh, Ching-Ming and Nuortti, Marja and Sechaud, Romain and Kaiser, Guenther and Lefevre, Gilbert (2010) Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects. Malaria journal, 9. p. 253. ISSN 1475-2875

Adams, Christopher and Hu, Chii-Whei and Jeng, Arco and Karki, Rajeshri and Ksander, Gary and Lasala, Daniel and Leung-Chu, Jennifer and Liang, Guiqing and Liu, Qian and Meredith, Erik and Rao, Chang and Rigel, Dean and Springer, Clayton and Zhang, Chun and Shi, Jie and Smith, Sherri (2010) The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-Beta-hydroxylase. Bioorganic and Medicinal Chemistry Letters, 20 (15). pp. 4324-4327.

Apfel, Ulf_Peter and Rudolph, Manfred and Apfel, Christina and Robl, Christian and Langenegger, Daniel and Hoyer, Daniel and Jaun, Bernhard and Seebach, Dieter and Weigand, Wolfgang (2010) Reaction of Fe3(CO)12 with Octreotide – Chemical, Electrochemical and Biological Investigations. Dalton Transactions, 39 (12). p. 3065. ISSN 1477-92261477-9234

Argikar, Upendra and Gomez, Javier and Ung, Din and Parkman, Henry and Nagar, Swati (2010) Identification of novel metoclopramide metabolites in humans: in vitro and in vivo studies. Drug Metabolism and Disposition.

Arias, H and Gu, R and Feuerbach, Dominik and Wei, D (2010) Different Interaction between the Agonist JN403 and the Competitive Antagonist Methyllycaconitine with the Human α7 Nicotinic Acetylcholine Receptor. Biochemistry.

Arias, HR and Feuerbach, Dominik and Targowska-Duda, KM and Jozwiak, Krysztof (2010) Catharanthine alkaloids are noncompetitive antagonists of muscle-type nicotinic acetylcholine receptors. Neurochemistry international.

Arias, HR and Feuerbach, Dominik and Targowska-Duda, KM and Russell, M and Jozwiak, K (2010) Interaction of Selective Serotonin Reuptake Inhibitors with Neuronal Nicotinic Acetylcholine Receptors. Biochemistry.

Arias, Hugo and Rosenberg, Avraham and Targowska-Dudac, Katarzyna and Feuerbach, Dominik and Jozwiak, Krzysztof and Moaddel, Ruin and Wainer, Irving (2010) Comparative Interaction between tricyclic antidepressants and mecamylamine with the human α4β2 nicotinic acetylcholine receptor. The International Journal of Biochemistry.

Artman Iii, Gerald and Solovay, Catherine and Adams, Christopher and Diaz, Brian and Dimitroff, Martin and Ehara, Takeru and Gu, Danlin and Ma, Fupeng and Liu, Donglei and Miller, Bridget Ranae and Pick, Teresa and Poon, Daniel and Ryckman, David and Siesel, David and Stillwell, Brady and Swiftney, Tyson and Van Dyck, Jonathan and Ji, Nan (2010) One-pot synthesis of 2-aminobenzimidazoles using 2-chloro-1,3-dimethylimidazolinium chloride (DMC). Tetrahedron Letters, 51 (40). pp. 5319-5321. ISSN 0040-4039

Avlasevich, Svetlana and Bryce, Steven and De Boeck, Marlies and Elhajouji, Azeddine and Van Goethem, Freddy and Lynch, Anthony and Nicolette, John and Shi, Jing and Dertinger, Stephen (2010) Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future. Mutagenesis, 26 (1). pp. 147-152.

Azzaoui, Kamal and Hamon, Jacques and Whitebread, Steven and Urban, Laszlo (2010) Bayesian modeling for Predicting Promiscuity and Selectivity of Molecules based on Safety Pharmacology Profiling Data. In: Adverse Side Effect Prediction in Preclinical Drug Discovery. Wiley.


Baffert, Fabienne and Blasco, Francesca and Brueggen, Josef and Chene, Patrick and De Pover, Alain and Drueckes, Peter and Erdmann, Dirk and Furet, Pascal and Gerspacher, Marc and Hofmann, Francesco and Lang, Marc and Ledieu, David and Nolan, Lynda and Pissot Soldermann, Carole and Regnier, Catherine and Ruetz, Stephan and Tavares, Gisele and Trappe, Joerg and Vangrevelinghe, Eric and Wartmann, Markus and Wyder, Lorenza and Radimerski, Thomas (2010) Potent and selective inhibition of JAK2 by the quinoxaline NVP-BSK805. Molecular Cancer Therapeutics, 9 (7). pp. 1945-1955. ISSN 1535-7163

Balibar, Carl and Shen, Xiaoyu and Mcguire, Dorothy and Yu, Donghui and Mckenney, David and Tao, Jianshi (2010) CwrA, a gene that specifically responds to cell wall damage in Staphylococcus aureus. Microbiology, 156 (Pt 5). pp. 1372-1383.

Beattie, David and Beer, David and Bentley, David and Bradley, Michelle and Bruce, Ian and Charlton, Steven and Cuenoud, Bernard and Ernst, Roland and Fairhurst, Robin and Faller, Bernard and Farr, David Colin and Keller, Thomas and Fozard, John R. and Fullerton, Joe and Garman, Sheila and Hatto, Julia and Hayden, Claire and He, Handan and Howes, Colin and Janus, Diana and Jiang, Zhengjin and Loeuillet-Ritzler, Frederique and Moser, Heinz and Reilly, John and Steward, Alan and Sykes, David and Tedaldi, Lauren and Trifilieff, Alexandre and Tweed, Morris and Watson, Simon and Wissler, Elke and Wyss, Daniel and Baur, Francois and Charman, Christine (2010) The Identification of Indacaterol as an Ultra-Long-Acting Inhaled Beta-2-Adrenoceptor Agonist. Journal of Medicinal Chemistry, 53. pp. 3675-3684.

Beattie, David and Bradley, Michelle and Brearley, Andrew and Charlton, Steven and Cuenoud, Bernard and Fairhurst, Robin and Gedeck, Peter and Gosling, Martin and Janus, Diana and Jones, Darryl and Lewis, Christine and Mccarthy, Clive and Oakman, Helen and Stringer, Rowan and Taylor, Roger and Tuffnell, Andrew (2010) A Physical Properties Based Approach for the Exploration of a 4-Hydroxybenzothiazolone Series of Beta2-Adrenoceptor Agonists as Inhaled Long-Acting Bronchodilators. Bioorganic and Medicinal Chemistry Letters, 20 (17). pp. 5302-5307.

Beattie, David and Brearley, Andrew and Brown, Zarin and Charlton, Steven and Cox, Brian and Fairhurst, Robin and Fozard, John R. and Gedeck, Peter and Kirkham, Paul and Meja, Koremu and Nanson, Lana and Neef, James and Oakman, Helen and Taylor, Roger and Turner, Robert and West, Ryan and Woodward, Hannah (2010) Synthesis and Evaluation of Two Series of 4'-Aza-Carbocyclic Nucleosides as Adenosine A2A Receptor Agonists. Bioorganic and Medicinal Chemistry Letters, 20 (3). pp. 1219-1224. ISSN 0960-894X

Bell, Oliver and Schwaiger, Michaela and Oakeley, Edward James and Lienert, Florian and Beisel, Christian and Stadler, Michael B and Schübeler, Dirk (2010) Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing. Nature Structural & Molecular Biology, 17 (7). pp. 894-900. ISSN 1545-9985

Bergsdorf, Christian and Ottl, Johannes (2010) Affinity-based screening techniques: Their impact and benefit to increase the number of high quality leads. Expert Opinion on Drug Discovery, 5 (11). pp. 1095-1107. ISSN 1746-045X

Bhoumik, Priyasma and Hughes, Austin L (2010) Reassortment of ancient neuraminidase and recent hemagglutinin in pandemic (H1N1) 2009 virus. Emerging infectious diseases, 16 (11). pp. 1748-1750. ISSN 1080-6059

Blumer, Jeffrey and Rodriguez, Adib and Sánchez, Pablo J and Sallas, William and Kaiser, Guenther and Hamed, Kamal (2010) Single-dose pharmacokinetics of famciclovir in infants and population pharmacokinetic analysis in infants and children. Antimicrobial agents and chemotherapy, 54 (5). pp. 2032-2041. ISSN 1098-6596

Borawski, Jason and Gaither, Larry (2010) The evolution of RNAi technologies in the drug discovery business. European Pharmaceutical Review, 5. pp. 35-39. ISSN 1360-8606

Borrmann, Steffen and Sallas, William and Machevo, Sonia and González, Raquel and Björkman, Anders and Mårtensson, Andreas and Hamel, Mary and Juma, Elizabeth and Peshu, Judy and Ogutu, Bernhards and Djimdé, Abdoulaye and D'Alessandro, Umberto and Marrast, Anne Claire and Lefevre, Gilbert and Kern, Steven (2010) The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria. Tropical medicine & international health : TM & IH, 15 (4). pp. 434-441. ISSN 1365-3156

Brosig, Michaela and Ferralli, Jacqueline and Gelman, Laurent and Chiquet, Matthias and Chiquet-Ehrismann, Ruth (2010) Interfering with the connection between the nucleus and the cytoskeleton affects nuclear rotation, mechanotransduction and myogenesis. The International Journal of Biochemistry & Cell Biology, 42 (10). pp. 1717-1728. ISSN 1878-5875

Brown, Ann and Bickford, Shari and Hatsis, Panagiotis and Amin, Jakal and Bell, Leslie and Harriman, Shawn (2010) High-Throughput Analysis of In-Vitro Cytochrome P450 Inhibition Samples Using Mass Spectrometry Coupled with an Integrated Liquid Chromatography and Autosampler System. Rapid Communications in Mass Spectrometry, 24 (8). pp. 1207-1210. ISSN 1097-0231

Browne, BC and Crown, J and Venkatesan, N and Duffy, MJ and Clynes, M and Slamon, D and O'Donovan, N and Jeay, Sebastien (2010) Inhibition of IGF1R activity enhances response to trastuzumab in HER-2 positive breast cancer cells. Annals of Oncology.

Busskamp, Volker and Duebel, Jens and Balya, David and Fradot, Mathias and Viney, Tim James and Siegert, Sandra and Groner, Anna C and Cabuy, Erik and Forster, Valérie and Seeliger, Mathias and Biel, Martin and Humphries, Peter and Paques, Michel and Mohand-Said, Saddek and Trono, Didier and Deisseroth, Karl and Sahel, José A and Picaud, Serge and Roska, Botond (2010) Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa. Science (New York, N.Y.), 329 (5990). pp. 413-417. ISSN 1095-9203


Camara, Joana and Jarai, Gabor (2010) Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha. Fibrogenesis & Tissue Repair, 3 (1). p. 2. ISSN 1755-1536

Cao, Xueying and Lee, Yan and Holmqvist, Mats and lin, Yingxin and Ni, Yucheng and Mikhailov, Dmitri and Zhang, Haiyan and Hogan, Christopher and Zhou, Liping and Lu, Qiang and Digan, Mary and Urban, Laszlo and Erdemli, Gul (2010) Cardiac ion channel safety profiling on the IonWorks Quattro™ Automated Patch Clamp System. Assay and drug development technologies.

Cao, Xueying and Lee, Yan and Holmqvist, Mats and lin, Yingxin and Ni, Yucheng and Mikhailov, Dmitri and Zhang, Haiyan and Hogan, Christopher and Zhou, Liping and Lu, Qiang and Digan, Mary and Urban, Laszlo and Erdemli, Gul (2010) Cardiac ion channel safety profiling on the IonWorks Quattro™ Automated Patch Clamp System. Assay and drug development technologies.

Castillo, Victor and Theodoropoulou, Marily and Stalla, Johanna and Gallelli, Maria Florencia and Cabrera-Blatter, Maria Fernanda and Haedo, Mariana R and Labeur, Marta and Schmid, Herbert and Stalla, Günter K and Arzt, Eduardo (2010) Effect of SOM230 (pasireotide) on corticotropic cells: action in dogs with Cushing's disease. Neuroendrocrinology, 94 (2). pp. 124-136. ISSN 0028-3835

Cescato, Renzo and Loesch, Kimberly A and Waser, Beatrice and Mäcke, Helmut R and Rivier, Jean E and Reubi, Jean Claude and Schonbrunn, Agnes and Imark, Esther (2010) AGONIST BIASED SIGNALING AT THE SST2A RECEPTOR: THE PAN-SOMATOSTATIN ANALOGS KE108 AND SOM230 ACTIVATE AND ANTAGONIZE DISTINCT SIGNALING PATHWAYS. Molecular Endocrinology, 24 (1). pp. 240-249. ISSN 0888-8809

Chablais, F. and Jazwinska, A. (2010) IGF signaling between blastema and wound epidermis is required for fin regeneration. Development, 137 (6). pp. 871-879. ISSN 0950-1991

Chene, Patrick and Hau, Jean-Christophe and Blechschmidt, Anke and Fontana, Patrizia and Bohn, Jacqueline and Zimmermann, Catherine and De Pover, Alain and Erdmann, Dirk (2010) Study of the selectivity of insulin-like growth factor-1 receptor (IGF1R) inhibitors. The open enzyme Inhibition Journal, 3 (1). pp. 27-37. ISSN 1874-9402

Chetty, Rajkumar and Ozer, Josef and Lanevschi, Anne and Schuppe-Koistinen, Ina and McHale, Duncan and Pears, John and Vonderscher, Jacky and Sistare, Frank and Dieterle, Frank (2010) A systematic approach to preclinical and clinical safety biomarker qualification incorporating Bradford Hill’s principles of causality association. Clinical Pharmacology & Therapeutics, 88 (2). pp. 260-262. ISSN 0009-9236

Cheung, Atwood and Jain, Rishi (2010) Accelerating the discovery of new drug targets with chemical proteomics. IDrugs, 13 (12). pp. 862-868. ISSN 1369-7056

Cho, Young and Borland, Maria and Brain, Christopher and Chen, Christine and Cheng, Hong and Chopra, Rajiv and Chung, Kristy and Groarke, James and He, Guo and Hou, Ying and Kovats, Steven and Shen, Junqing and Trakshel, Gary and Voegtle, Markus and Xu, Mei and Xu, Ming and Sung, Moo (2010) 4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6. Journal of Medicinal Chemistry, 53 (22). pp. 7938-7957. ISSN 0022-2623

Cho, Young and Whitehead, Lewis and Li, Jianke and Chen, Christine and Shultz, Michael and Jiang, Lei and Voegtle, Markus and Francotte, Eric and Richert, Paul and Wagner, Beatrix and Traebert, Martin and lu, qiang and Cao, Xueying and Dumotier, Berengere and Fejzo, Jasna and Rajan, Srinivasan and Wang, Ping and Yan-Neale, Yan and Shao, Wenlin and Atadja, Peter (2010) Conformational Refinement of Hydroxamate-Based Histone Deacetylase Inhibitors and Exploration of 3-Piperidin-3-yl-indole Analogues of Dacinostat (LAQ824). Journal of Medicinal Chemistry, 53 (7). pp. 2952-2963. ISSN 0022-2623

Choi Kong, Kok and Butcher, Adrian and McWilliams, Phillip and Wess, Jurgen and Hamdan, Fadi F and Werry, Tim and Rosethorne, Liz and Charlton, Steven and Cragg, Hannah A and Smart, Alison D and Tobin, Andrew (2010) M3-muscarinic receptor mediates insulin release via receptor-phosphorylation dependent activation of protein kinase D1. Proceedings of the National Academy of Sciences, 107 (49). pp. 21181-21186. ISSN 0027-8424

Clarkson, Paul and Cheng, Hongwei and West, Robert and Gao, Doris and Wang, Y.Z. and Nielsen, Torsten and Abraham, Judith (2010) Therapeutic antibodies targeting CSF1 impede macrophage recruitment in a xenograft model of tenosynovial giant cell tumor. Sarcoma, 2010 (Octobe).

Coomaraswamy, Janaky and Kilger, Ellen and Wölfing, Heidrun and Schäfer, Claudia and Kaeser, Stephan and Wegenast-Braun, Bettina and Hefendehl, Jasmin K and Wolburg, Hartwig and Mazella, Matthew and Ghiso, Jorge and Goedert, Michel and Akiyama, Haruhiko and Garcia-Sierra, Francisco and Wolfer, David and Mathews, Paul M and Jucker, Mathias (2010) Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Proceedings of the National Academy of Science USA, 107 (17). pp. 7969-7974.

Craig, Ian and Essex, Jonathan W. and Spiegel, Katrin (2010) Ensemble Docking into Multiple Crystallographically Derived Protein Structures: An Evaluation Based on the Statistical Analysis of Enrichments. Journal of Chemical Information and Modeling, 50 (4). pp. 511-524. ISSN 1549-9596


Danahay, Henry and Gosling, Martin and Paisley, Derek (2010) Regulation of airway mucosal hydration. Expert Review of Clinical Pharmacology, 3 (3). pp. 361-369. ISSN 1751-2433

Dey, Julien H and Bianchi, Fabrizio and Voshol, Johannes and Bonenfant, Debora and Oakeley, Edward J and Hynes, Nancy E and Imark, Esther (2010) Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis. Cancer Research, 70 (10). pp. 4151-4162. ISSN 0008-5472

Dey, Julien Hervé and Imark, Esther (2010) Investigating the contribution of FGF receptors in breast tumorigenesis using models of mammary cancer. Inauguraldissertation (Thesis).

Doghman, Mabrouka and Wakil, Abeer EL and Cardinaud, Bruno and Thomas, Emilie and Wang, Jinling and Zhao, Wei and Figueiredo, Bonald C and Zambetti, Gerard P and Lalli, Enzo and Imark, Esther (2010) Regulation of IGF - mTOR signalling by miRNA in childhood adrenocortical tumors. Cancer Research, 70 (11). pp. 4666-4675. ISSN 0008-5472

Domanski, Luke and Sun, Changming and Hassan, Raquibul and Vallotton, Pascal and Wang, Dadong (2010) Linear feature detection on GPUs. International Conference on Digital Image Computing: Techniques and Applications (DICTA), Sydney, Australia, 1–3 December 2010.

Doucet, Julie and Avrameas, Alexandre (2010) A novel method for quantitative measurement of a therapeutic monoclonal antibody in the presence of its target protein using enzymatic digestion. Journal of Pharmaceutical and Biomedical Analysis, 52 (4). pp. 565-570. ISSN 0731-7085

Duthaler, Rudolf and Fischer, Reto and Katopodis, Andreas and Marterer, Wolfgang and Streiff, Markus and Thoma, Gebhard and Ernst, Beat and Kinzy, Willy and Oehrlein, Reinhold (2010) In vivo Neutralization of naturally occuring Antibodies against Linear alpha(1,3)-Galactosidic Carbohydrate Epitopes by Multivalent Antigen Presentation: A Solution for the first Hurdle of Pig-to-Human Xenotransplantation. Chimia: International Journal for Chemistry, 64 (1/2). pp. 23-28. ISSN 0009-4293

Düvel, Katrin and Yecies, Jessica L. and Raman, Pichai and Menon, Suchithra and Lipovsky, Alex I. and Souza, Amanda L. and Triantafellow, Ellen and Ma, Qicheng and Gorski, Regina and Cleaver, Stephen and Mackeigan, Jeff and Finan, Peter and Clish, Clary B. and Murphy, Leon and Manning, Brendan D. (2010) Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Molecular Cell, 39 (2). pp. 171-183. ISSN 1097-2765


Elhajouji, Azeddine (2010) Mitomycin C, 5-fluoruracil, colchicine and etoposide tested in the in vitro mammalian cell micronucleus test (MNvit) in the human lymphoblastoid cell line TK6 at Novartis in support of OECD draft Test Guideline 487. Mutation Research - Genetic Toxicology and Environmental Mutagenesis.

Elhajouji, Azeddine and Cammerer, Zoryana and Lukamowicz, Magdalena and Kirsch-Volders, Micheline (2010) Potential thresholds for genotoxic effects by micronucleus scoring. Mutagenesis, 26 (1). pp. 199-204. ISSN 1464-3804

Ennulat, Daniela and Walker, Dana and Clemo, Frances and Magidslav, Michal and Ledieu, David and Graham, Mark and Botts, Suzanne and Boone, Laura (2010) Effects of Hepatic Drug Metabolizing Enzyme Induction on Clinical Pathology Parameters in Animals and Man. Toxicologic Pathology.

Ertl, Peter (2010) Molecular Structure Input on the Web. Journal of Cheminformatics, 2. p. 1. ISSN 1758-2946


Fayard, Elisabeth and Moncayo, Gerald and Hemmings, Brian Arthur and Hollaender, Georg A (2010) Phosphatidylinositol 3-Kinase Signaling in Thymocytes: the Need for Stringent Control. Science Signaling, 3 (135). re5-re5. ISSN 1937-9145

Fendt, Markus and Buchi, Melanie and Buerki, Hugo and Imobersteg, Stefan and Ricoux, Berangere and Suply, Thomas and Sailer, Andreas (2010) Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response. Behavioral Brain Research. ISSN 0166-4328

Fendt, Markus and Imobersteg, Stefan and Buerki, Hugo and Mcallister, Kevin and Sailer, Andreas (2010) Intra-amygdala injections of neuropeptide S block fear-potentiated startle. Neuroscience Letters, 474 (3). pp. 154-157. ISSN 0304-3940

Fiorina, Paolo and Jurewicz, Mollie and Vergani, Andrea and Vergelli, Alessandra and Carvello, Michele and D'Addio, Francesca and Godwin, Jonathan and Law, Kenneth and Wu, Erxi and Tian, Ze and Thoma, Gebhard and Kovarik, Jiri and La Rosa, Stefano and Capella, Carlo and Rodig, Scott and Zerwes, Hans-Guenter and Sayegh, Mohammed and Abdi, Reza (2010) Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via PD-L1. The Journal of Immunology, 186 (3). pp. 121-131. ISSN 0022-1767

Fritz, Nicholas F. and Cronican, Andreas and Pham, Tam and Fogg, Allison and Lefterov, Iliya and Koldamova, Radosveta (2010) LXR agonist treatment ameliorates amyloid pathology and memory deficits caused by high fat diet in APP23 mice. The Journal of Neuroscience, 30 (20). pp. 6862-6872.

Furet, Pascal and Gerspacher, Marc and Pissot Soldermann, Carole (2010) Design of Two New Chemotypes for Inhibiting the Janus Kinase 2 by Scaffold Morphing. Bioorganic & Medicinal Chemistry Letters, 20 (6). pp. 1858-1860. ISSN 0960-894X


Gamber, Gabriel and Meredith, Erik and Zhu, Qingming and Yan, Wanlin and Rao, Chang and Capparelli, Michael and Burgis, Robin and Enyedy, Istvan and Zhang, Ji and Soldermann, Nicolas and Beattie, Kimberley and Rozhitskaya, Olga and Koch, Keith and Pagratis, Nikos and Hosagrahara, Vinayak and Vega, Richard and McKinsey, Timothy and Monovich, Lauren (2010) Preliminary Studies of 3,5-Diarylazoles as Novel and Selective Inhibitors of Protein Kinase D. Bioorganic and Medicinal Chemistry Letters, 21 (5). pp. 1447-1451. ISSN 0960-894X

Gao, Zhenhai and Garcia-Echeverria, Carlos and Jensen, Michael Rugaard (2010) Hsp90 inhibitors: Clinical development and future opportunities in oncology therapy. Current Opinion in Drug Discovery and Development, 13 (2). pp. 193-202. ISSN 1367-6733

Gariboldi, Marzia B. and Ravizza, Raffaella and Monti, Elena (2010) The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells. Biochemical Pharmacology, 80 (4). pp. 455-462. ISSN 00062952

Gedeck, Peter and Kramer, Christian and Ertl, Peter (2010) Computational Analysis of Structure-Activity Relationships. In: Progress in Medicinal Chemistry. Elsevier.

Gerspacher, Marc and Altmann, Eva and Beerli, Rene and Buhl, Thomas and Endres, Ralf and Gamse, Rainer and Kameni Tcheudji, Jacques and Kneissel, Michaela and Krawinkler, Karl Heinz and Missbach, Martin and Schmidt, Alfred and Seuwen, Klaus and Weiler, Sven and Widler, Leo (2010) Penta-Substituted Benzimidazoles as Potent Antagonists of the Calcium Sensing Receptor (CaSR-Antagonists). Bioorganic & Medicinal Chemistry Letters.

Gerspacher, Marc and Furet, Pascal and Pissot Soldermann, Carole and Gaul, Christoph and Holzer, Philipp and Vangrevelinghe, Eric and Lang, Marc and Buhl, Thomas and Aichholz, Reiner and Blasco, Francesca and Endres, Ralf and Erdmann, Dirk and Radimerski, Thomas and Regnier, Catherine and Chene, Patrick and Hofmann, Francesco and Trappe, Joerg and Drueckes, Peter and Baffert, Fabienne and De Pover, Alain (2010) 2-Amino-aryl-7-aryl-benzoxazoles as Potent, Selective and Orally Available JAK2 Inhibitors. Bioorganic & Medicinal Chemistry Letters, 20 (5). pp. 1724-1727. ISSN 0960-894X

Glass, David and Roubenoff, Ronenn (2010) Recent advances in the biology and therapy of muscle wasting. Annals of the New York Academy of Sciences, 1211. pp. 25-36. ISSN 0077-8923

Goette, Marjo and Hofmann, Gabriele and Gallani, Anne-Isabelle and Glickman, Fraser and Wishart, William L. and Gabriel, Daniela (2010) An imaging assay to analyze primary neurons for cellular neurotoxicity. Journal of Neuroscience Methods, 192 (1). pp. 7-16.

Gommermann, Nina and Buehlmayer, Peter and Von Matt, Anette and Breitenstein, Werner and Masuya, Keiichi and Pirard, Bernard and Furet, Pascal and Jacob, Sandra and Weckbecker, Gisbert (2010) New Pyrazolo[1,5a]pyrimidines as Orally Active Inhibitors of Lck. Bioorganic & Medicinal Chemistry Letters, 20 (12). pp. 3628-3631. ISSN 0960-894X

Gong, Ting and Hartmann, Nicole and Kohane, Isaac S. and Brinkmann, Volker and Staedtler, Frank and Letzkus, Martin and Szustakowski, Joseph (2010) Optimal deconvolution of transciptional profiling data using quadratic proagramming with application to complex clinical blood samples. RECOMB2011-Journal of Computational Biology.

Gossert, Alvar and Hiller, Sebastian and Fernandez, Cesar (2010) Automated projection spectroscopy (APSY) for efficient structural characterization of protein-ligand interactions. Journal of the American Chemical Society. ISSN 0002-7863

Grausenburger, Reinhard and Bilic, Ivan and Boucheron, Nicole and Zupkovitz, Gordin and El-Housseiny, Lamia and Tschismarov, Roland and Zhang, Yu and Rembold, Martina and Gaisberger, Martin and Hartl, Arnulf and Epstein, Michelle M and Matthias, Patrick and Seiser, Christian and Ellmeier, Wilfried (2010) Conditional Deletion of Histone Deacetylase 1 in T Cells Leads to Enhanced Airway Inflammation and Increased Th2 Cytokine Production. The Journal of Immunology (Baltimore, Md. : 1950), 185 (6). pp. 3489-3497. ISSN 1550-6606

Guetg, Nicole and Aziz, Said Abdel and Holbro, Niklaus and Turecek, Rostislav and Rose, Tobias and Seddik, Riad and Gassmann, Martin and Moes, Suzette and Jenoe, Paul and Oertner, Thomas and Casanova, Emilio and Bettler, Bernhard (2010) NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1. Proceedings of the National Academy of Sciences of the United States of America, 107 (31). pp. 13924-13929. ISSN 1091-6490


Halilovic, Ensar and She, Qing-Bai and Ye, Qing Ye and Pagliarini, Raymond and Sellers, William and Solit, David and Rosen, Neal (2010) PIK3CA mutation uncouples tumor growth and Cyclin D1 regulation from MEK/ERK and mutant KRAS signaling. Cancer Research, 70 (17). pp. 6804-6814. ISSN 0008-5472

Hanessian, Stephen and Shao, Zhihui and Betschart, Claudia and Rondeau, Jean-Michel and Neumann, Ulf and Tintelnot-Blomley, Marina (2010) Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors. Bioorganic and Medicinal Chemistry Letters, 20 (6). pp. 1924-1927. ISSN 0960-894X

Hardaker, Liz and Freeman, Mark and Dale, Nicole and Bahra, Parmjit and Raza, Farheen and Banner, Kathy and Poll, Chris (2010) Exposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung. British Journal of Pharmacology, 160 (8). pp. 1985-1996. ISSN 0007-1188

Hassan, Asm Quamrul and Sharma, Sreenath and Warmuth, Markus (2010) Allosteric inhibition of BCR-ABL. Cell Cycle, 9 (18). pp. 3710-3714. ISSN 1538-4101

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He, Yanli and Zhang, Jiahua and Zheng, Jin'e and Du, Wen and Liu, Wei and Li, Xiaoqing and Chen, Xiangjun and Xiao, Hong and Yang, Lin and Huang, Shiang and Jeay, Sebastien (2010) The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, suppresses survival and resistance to chemotherapy in acute myeloid leukemia cells. Oncology Research, 19 (1). pp. 35-43. ISSN 0965-0407

Hintermann, Samuel and Hurth, Konstanze and Nozulak, Joachim and Tintelnot-Blomley, Marina and Aichholz, Reiner and Blanz, Joachim and Kaupmann, Klemens and Mosbacher, Johannes (2010) Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor. Bioorganic and Medicinal Chemistry Letters. ISSN 1464-3405

Hoegenauer, Klemens and Hinterding, Klaus and Nussbaumer, Peter (2010) S1P receptor mediated activity of FTY720 phosphate mimics. Bioorganic & Medicinal Chemistry Letters, 20 (5). pp. 1485-1487. ISSN 0960-894X

Hoffmann, D and Adler, M and Clement, M and Vaidya, V and Rached, E and Mulrane, L and Gallagher,, WM and Callanan, JJ and Gautier, JC and Matheis, K and Staedtler, Frank and Dieterle, Frank and Walijew, A and Hewitt, P and Ellinger-Ziegelbauer, H and Bonventre, JV and Dekant, W and Mally, A (2010) Performance of Novel Kidney Biomarkers in Preclinical Toxicity Studies. Toxicological Sciences, 116 (1). pp. 8-22.

Holbro, Niklaus and Grunditz, Asa and Wiegert, J Simon and Oertner, Thomas (2010) AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proceedings of the National Academy of Sciences of the United States of America, 107 (36). pp. 15975-15980. ISSN 1091-6490

Holmes, Alan and Soon, Elaine and Southwood, Mark and Machado, Rajiv and Barker, Lucy and Treacy, Carmen and Nicklin, Paul and Walker, Christoph and Budd, David and Pepke-Zaba, Joanna and Morrell, Nicholas (2010) ELEVATED LEVELS OF INFLAMMATORY CYTOKINES ARE STRONG PREDICTORS OF SURVIVAL IN IDIOPATHIC AND FAMILIAL PULMONARY ARTERIAL HYPERTENSION. Circulation, 122 (9). pp. 920-927.

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Honer, Michael and Ebenhan, Thomas and Allegrini, Peter Roland and Ametamey, Simon M and Becquet, Mike and Cannet, Catherine and Lane, Heidi and O'Reilly, Terence and Schubiger, Pius A and Sticker-Jantscheff, Melanie and Stumm, Michael and Mcsheehy, Paul M.J. and Imark, Esther (2010) Anti-Angiogenic/Vascular Effects of the mTOR Inhibitor Everolimus Are Not Detectable by FDG/FLT-PET. Translational oncology, 3 (4). pp. 264-275. ISSN 1936-5233

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Hugo R. Arias, HR and Ruo-Xu Gu, R and Feuerbach, Dominik and Dong-Qing Wei, W (2010) Different Interaction between the Agonist JN403 and the Competitive Antagonist Methyllycaconitine with the Human α7 Nicotinic Acetylcholine Receptor. Biochemistry.

Hynes, Nancy and Dey, Julien H (2010) Potential for Targeting the Fibroblast Growth Factor Receptors in Breast Cancer. Cancer Research, 70 (13). pp. 5199-5202. ISSN 1538-7445


Iannacone, Matteo and Moseman, E. Ashley and Tonti, Elena and Bosurgi, Lidia and Junt, Tobias and Whelan, Sean P. and Guidotti, Luca and von Andrian, Ulrich H. and Henrickson, S.E. (2010) Lymph Node Subcapsular Sinus Macrophages Confer Resistance to CNS Invasion Upon Peripheral Infection With a Neurotropic Virus. Nature, 465 (7301). pp. 1079-1083. ISSN 0028-0836

Ibebunjo, Chikwendu and Eash, John and Li, Christine and Ma, Qicheng and Glass, David (2010) Testosterone-induce changes in muscle mass and signaling in sedentary and voluntary-running mice. American Journal of Physiology Endocrinology and Metabolism, 300 (2). E327-E340. ISSN 0193-1849


Jaeger-Lansky, Agnes and Cejka, Daniel and Ying, Liu and Presser, Matthias and Höflmayer, Doris and Fuereder, Thorsten and Köhrer, Stefan and Wacheck, Volker and Imark, Esther (2010) Effects of vatalanib on tumor growth can be potentiated by mTOR blockade in vivo. Cancer Biology & Therapy, 9 (11). pp. 919-927. ISSN 1538-4047

Jahnke, Wolfgang and Grotzfeld, Robert and Pelle, Xavier and Strauss, Andre and Fendrich, Gabriele and Jacob, Sandra and Cotesta, Simona and Fabbro, Doriano and Furet, Pascal and Mestan, Juergen and Marzinzik, Andreas (2010) Binding or bending: Distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay. Journal of the American Chemical Society, 130 (20). pp. 7043-7048.

Jahnke, Wolfgang and Henry, Christelle (2010) An in vitro assay to measure targeted drug delivery to bone mineral. ChemMedChem, 5 (5). pp. 770-776. ISSN 1860-7179

Jahnke, Wolfgang and Rondeau, Jean-Michel and Cotesta, Simona and Marzinzik, Andreas and Pelle, Xavier and Geiser, Martin and Strauss, Andre and Goette, Marjo and Bitsch, Francis and Hemmig, Rene and Henry, Christelle and Lehmann, Sylvie and Glickman, Fraser and Roddy, Thomas and Stout, Steven and Green, Jonathan (2010) Allosteric non-bisphosphonate inhibitors of farnesyl pyrophosphate synthase identified by fragment-based discovery. Nature Chemical Biology, 6 (6). pp. 660-666. ISSN 1552-4450

Ji, Nan and Meredith, Erik and Liu, Donglei and Adams, Christopher and Artman Iii, Gerald and Jendza, Keith and Ma, Fupeng and Mainolfi, Nello and Powers, James and Zhang, Chun (2010) Syntheses of 1-substituted-3-aminopyrazoles. Tetrahedron Letters, 51 (52). pp. 6799-6801. ISSN 0040-4039

Jiang, Zhengjin and Reilly, John and Everatt, Brian and Briard, Emmanuelle (2010) A rapid vesicle electrokinetic chromatography method for the assessment of Non-Specific Binding of potential PET ligands in-vitro. Journal of Pharmaceutical and Biomedical Analysis., 54 (4). pp. 722-729. ISSN 0731-7085

Johnson, Keith and Oakeley, Edward James and Staedtler, Frank (2010) Will Pharma buy the $1,000 Genome? BioIT World, 9 (5). p. 70.

Jones, Rachel and Davison, Robert and Tuan Tran, Anh and Galen, M Carmen and Smith, Nichola (2010) Iodine catalyzed one pot acetalation-esterification reaction for the preparation of orthogonal protected glycosides. Carbohydrate Research, 345 (13). pp. 1842-1845. ISSN 0008-6215

Juillard, Audrey and Falgayrac, Guillaume and Cortet, Bernard and Vieillard, Marie-Hélène and Azaroual, Nathalie and Hornez, Jean-Christophe and Penel, Guillaume and Gasser, Juerg Andreas (2010) Molecular interactions between zoledronic acid and bone: an in vitro Raman microspectroscopic study. Bone, 25. ISSN 8756-3282


Keating, Joanna and Haber, Michelle and Zawel, Leigh and Ziegler, David (2010) A small molecule IAP inhibitor sensitises medulloblastoma cells to radiation therapy and cytotoxic chemotherapy in vitro and in vivo. Molecular cancer Therapeutics.

Kettle, Rachel and Simmons, Jenniferh and Schindler, Francis and Jones, Peter and Dicker, Tina and Dubois, Gerald and Giddings, June and Van Heeke, Gino and Jones, Carol (2010) Regulation of Neuregulin 1b1-Induced MUC5AC and MUC5B Expression in Human Airway Epithelium. American Journal of Respiratory Cell Molecular Biology, 42 (4). pp. 472-481. ISSN 1044-1549

Kirsch-Volders, Micheline and Elhajouji, Azeddine and Decordier, Ilse and Plas, Gina and Aardema, Marilyn J. and Fenech, Michael (2010) IN VITRO GENOTOXICITY TESTING USING THE MICRONUCLEUS ASSAY IN CELL LINES, HUMAN LYMPHOCYTES AND 3D HUMAN SKIN MODELS. Mutagenesis, 26 (1). pp. 177-184. ISSN 0267-8357

Kitamura, Takanori and Fujishita, Teruaki and Loetscher, Pius and Revesz, Laszlo and Hashida, Hiroki and Kizaka-Kondoh, Shinae and Aoki, Masahiro and Taketo, Makoto M (2010) Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proceedings of the National Academy of Sciences of America, 107 (29). pp. 13063-13068. ISSN 0027-8424

Kohler, Reto and Schmitz, Debora and Cornils, Hauke and Hemmings, Brian Arthur and Hergovich, Alexander (2010) Differential NDR/LATS Interactions with the Human MOB Family Reveal a Negative Role for Human MOB2 in the Regulation of Human NDR Kinases. Molecular and Cellular Biology, 30 (18). pp. 4507-4520. ISSN 1098-5549

Koller, Manuel and Lingenhoehl, Kurt and Schmutz, Markus and Vranesic, Ivan-Toma and Kallen, Joerg and Auberson, Yves and Carcache, David and Mattes, Henri and Ofner, Silvio and Orain, David and Urwyler, Stephan (2010) Quinazolinedione sulfonamides: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity. Bioorganic and medicinal chemistry letters, 21 (11). pp. 3358-3361. ISSN 0960-894X

Koller, Manuel and Urwyler, S (2010) Novel NMDA Receptor Antagonists: A Review of Compounds Patented since 2006. Expert Opinion On Therapeutic Patents, 20 (12). pp. 1683-1702. ISSN 1354-3776

Kometani, Motohiko and Nonomura, Kazuhiko and Tomoo, Takashi and Niwa, Satoru (2010) Hurdles in the drug discovery of cathepsin K inhibitors (Review). Current Topics of Medicinal Chemistry, 10 (7). pp. 733-744. ISSN 1568-0266

Kovarik, John M and Stitah, Sylvie and Slade, Alan and Vitaliti, Alessandra and Straube, Frank and Grenet, Olivier and Winter, Serge and Sfikas, Nikolaos and Seiberling, Michael (2010) Sotrastaurin and cyclosporine drug interaction study in healthy subjects. Biopharmaceutics & Drug Disposition, 31 (5-6). pp. 331-339. ISSN 1099-081X

Kovarik, John M and Stitah, Sylvie and Slade, Alan and Vitaliti, Alessandra and Straube, Frank and Grenet, Olivier and Winter, Serge and Sfikas, Nikolaos and Seiberling, Michael (2010) Sotrastaurin and tacrolimus coadministration: effects on pharmacokinetics and biomarker responses. Journal of Clinical Pharmacology, 50 (11). pp. 1260-1266. ISSN 1552-4604

Kovarik, John M. and Slade, Alan (2010) Overview of sotrastaurin clinical pharmacokinetics. Therapeutic Drug Monitoring, 32 (5). pp. 540-543. ISSN 1536-3694

Kramer, Christian and Gedeck, Peter (2010) Leave-cluster-out crossvalidation is appropriate for Scoring Functions derived on diverse protein datasets. Journal of Chemical Information and Modeling, 50 (11). pp. 1961-1969. ISSN 1549-960X

Krol, Jacek and Loedige, Inga and Filipowicz, Witold (2010) The widespread regulation of microRNA biogenesis, function and decay. Nature Reviews. Genetics, 11 (9). pp. 597-610. ISSN 1471-0064

Kuhen, Kelli and Gilligan, James and Gagaring, Kerstin Mae and Borboa, Rachel and Francek, Carolyn and Zhong, Chen and Dagostino, Eleanor and Justin, Stockmyer and Yu, Wang and Brinker, Achim and Engels, Ingo and Taylor, Jennifer and Chatterjee, Arnab and Glynne, Richard and Kuhen, Kelli and Greg, Crowther and Stolz, Barbara (2010) GNF ID 100602: Identification of inhibitors for putative malaria drug targets amongst novel antimalarial compounds. Molecular and Biochemical Parasitology.

Kumar, Ashutosch and Heise, Henrike and Blommers, Marcel J.J. and Krastel, Philipp and Schmitt, Esther and Petersen, Frank and Mandelkow, Eva-Maria and Carlomagno, Teresa and Griesinger, Christian and Baldus, Marc (2010) Interaction of epothilone B (patupilone) with microtubules as detected by two-domesional Solid-state NMR. Angewandte Chemie International Edition, 49 (41). pp. 7504-7507. ISSN 1433-7851

Kumar Dev, Kumlesh and Bouhelal, Rochdi and Barske, Carmen and Guerini, Danilo and Gasparini, Fabrizio and Mir, Anis Khusro and Orain, David and Osinde, Maribel and Picard, Anne and Dubois, Celine and Tasdelen, Engin and Haessig, Samuel and Mattes, Henri (2010) Design and Synthesis of Selective and Potent Orally Active S1P5 Agonists. ChemMedChem, 5 (10). pp. 1693-1696. ISSN 1860-7179


Landrum, Gregory and Palmer, Andrew (2010) A Postgresql cartridge for similarity searching. RDKit: open source cheminformatics.

Landrum, Gregory and Palmer, Andrew and Davies, John and Berthold, Michael (2010) RDKit nodes for knime. Knime community website.

Langdon, Sarah and Ertl, Peter and Brown, Nathan (2010) Bioisosteric Replacement and Scaffold Hopping in Lead Generation and Optimization. Molecular Informatics, 29 (5). pp. 366-385.

Leder, Lukas and Stark, Wilhelm and Freuler, Felix and Marsh, May and Meyerhofer, Marco and Stettler, Thomas and Mayr, Lorenz and Britanova, Olga V and Strukova, Lydia A and Chudakov, Dmitriy M and Souslova, Ekaterina A (2010) The Structure of Ca2+ Sensor Case16 Reveals the Mechanism of Reaction to Low Ca2+ Concentrations. Sensors, 10 (9). pp. 8143-8160. ISSN 1424-8220

Lee, Lac and Granda, Brian and Dean, Karl and Tao, Jianshi and Liu, Eugene and Zhang, Rui and Peukert, Stefan and Wattanasin, Sompong and Xie, Xiaoling and Ryder, Neil and Tommasi, Ruben and Deng, Gejing (2010) Biophysical investigation of the mode of inhibition of tetramic acids, the allosteric inhibitors of undecaprenyl pyrophosphate synthase. Biochemistry, 49 (25). pp. 5366-5376. ISSN 1520-4995

Lehmann, Hansjoerg and La Vecchia, Luigi (2010) Scale-up of Organic Reactions in a Pharmaceutical Kilo-Lab Using a Commercial Microwave Reactor. Organic Process Research & Development, 14 (3). pp. 650-656.

Lewis, Richard (2010) Computer-Aided Drug Design 2007-2009. Specialist Periodical Reports Chemical Modelling :Applications and Theory, 7. pp. 213-233.

Limpert, Allison S. and Carter, Bruce D and Ritson, Margaret (2010) Axonal Neuregulin 1 type III activates NF-kB in schwann cells during myelin formation. Journal Biology Chemistry, 285 (22). pp. 16614-16622. ISSN 0021-9258

Lin, Chi-Iou and Lorch, Jochen and Whang, Edward E and Jiang, Xiaofeng and Price, Brendan D and He, Frank and Du, Jinyan and Carothers, Adelaide M and Nose, Vania and Moore, Francis D Jr and Ruan, Daniel T and Imark, Esther (2010) Autophagy induction with RAD001 improves chemosensitivity and radiosensitivity in papillary thyroid cancer. Molecular Cancer Research, 8 (9). pp. 1217-1226. ISSN 1541-7786

Lin, Xuena and Skolnik, Suzanne and Chen, Xiao-Hui and Wang, Jianling (2010) Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative tools and strategies using Caco-2 model. Drug Metabolism and Deposition, 39 (2). pp. 265-274. ISSN 0090-9556

Lohmann, Felix and Loureiro, Joseph and Su, Hui and Fang, Qing and Lei, Hong and Lewis, Tanya and Yang, Yi and Labow, Mark and Li, En and Taiping, Chen and Kadam, Shilpa (2010) KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation. Stem Cells, 28 (2). pp. 201-212. ISSN 1066-5099

Loibl, Andreas (2010) The Influence of Epistemological Beliefs on Training Outcomes A Correlation Analysis of Training Variables in a Workplace Setting. University of Freiburg, Germany, - (-).


Ma, Hong and Togawa, Akashi and Soda, Keita and Zhang, Junhui and Lee, Sik and Ma, Ming and Yu, Zhiheng and Ardito, Thomas and Czyzyk, Jan and Diggs, Lonnette and Joly, Dominique and Hatakeyama, Shinji and Kawahara, Eiji and Holzman, Lawrence B. and Guan, Jun Lin and Ishibe, Shuta (2010) Loss of focal adhesion kinase activation in podocytes protects mice from proteinuria and foot process effacement. Journal of the American Society of Nephrolgy, 21 (7). pp. 1145-1156.

Malinverni, Claire and Unterreiner, Adeline and Staal, Jens and Demeyer, Annelies and Galaup, Marion and Luyten, Marcel and Beyaert, Rudi and Bornancin, Frederic (2010) Cleavage by MALT1 induces cytosolic release of A20. Biochem Biophys Res Commun, 400 (4). pp. 543-547. ISSN 0006-291X

Manley, Paul W. and Stiefl, Nikolaus and Jacob, Sandra and Kaufman, Susan and Mestan, Juergen and Wiesmann, Marion and Gallagher, Neil and Woodman, Richard (2010) Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib. Bioorganic Medicinal Chemistry, 18 (19). pp. 6977-6986. ISSN 0968-0896

Marrer, Estelle and Dieterle, Frank (2010) Impact of biomarker development on drug safety assessment. Toxicology and Applied Pharmacology, 243 (2). pp. 167-179. ISSN 0041-008X

Martin, Laetitia and Marzinzik, Andreas and Ley, Steven V. and Baxendale, Ian R. (2010) Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow reactor. Organic Letters. ISSN 1523-7052

Martus, Hans-Joerg and Hayashi, Makoto and Dearfield, Kerry and Kasper, Peter and Lovell, David and Thybaud, Veronique (2010) Compilation and Use of Genetic Toxicity Historical Control Data. Mutation Research, 723 (2). pp. 87-90. ISSN 0027-5107

Massey, A. J. and Schoepfer, Joseph and Brough, P. A. and Brueggen, Josef and Chene, Patrick and Drysdale, M. J. and Pfaar, Ulrike and Radimerski, Thomas and Ruetz, Stephan and Schweitzer, Alain and Wood, M and Garcia-Echeverria, Carlos and Jensen, Michael Rugaard (2010) Preclinical anti-tumor activity of the orally available Hsp90 inhibitor NVP-BEP800. Molecular cancer therapeutics, 9 (4). pp. 906-919.

Masuya, Keiichi and Teno, Naoki (2010) Small molecules for bone diseases. Expert Opinion on Therapeutic Patents, 20 (4). pp. 563-582. ISSN 1354-3776

Mattes, Henri and Carcache, David and Kalkman, Hans O. and Koller, Manuel (2010) AMPA Antagonists: From bench to bedside. Journal of Medicinal Chemistry.

McPherson, Jamie and Rivero, Guadalupe and Baptist, Myma and Llorente, Javier and Al-Sabah, Suleiman and Krasel, Cornelius and Dewey, William L and Bailey, Chris P and Rosethorne, Liz and Charlton, Steven and Henderson, Graeme and Kelly, Eamonn (2010) μ-Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization. Molecular Pharmacology, 78 (4). pp. 756-766. ISSN 0026-895X

Meredith, Erik and Ardayfio, Ophelia and Beattie, Kimberley and Dobler, Markus and Enyedy, Istvan and Gaul, Christoph and Hosagrahara, Vinayak and Jewell, Charles and Koch, Keith and Lee, Wendy and Lehmann, Hansjoerg and McKinsey, Timothy and Miranda, Karl and Pagratis, Nikos and Pancost, Margaret and Patnaik, Anup and Plato, Craig and Qian, Ming and Rajaraman, Vasumathy and Rao, Chang and Rozhitskaya, Olga and Ruppen, Thomas and Shi, Jie and Siska, Sarah and Springer, Clayton and Van Eis, Maurice and Vega, Richard and Von Matt, Anette and Yang, Lihua and Yoon, Taeyoung and Zhang, Ji and Zhu, Na and Monovich, Lauren (2010) Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors. Journal of Medicinal Chemistry, 53 (15). pp. 5400-5421. ISSN 0022-2623

Meredith, Erik and Burgis, Robin and Beattie, Kimberley and Capparelli, Michael and Dipietro, Lucian and Gamber, Gabriel and Hosagrahara, Vinayak and Jewell, Charles and Lee, Wendy and Miranda, Karl and Rao, Chang and Rozhitskaya, Olga and Soldermann, Nicolas and Van Eis, Maurice and Vega, Richard and Yan, Wanlin and Zhu, Qingming and Monovich, Lauren and Chapo, Joseph and Hood, David and Koch, Keith and Lemon, Douglas and McKinsey, Timothy and Pagratis, Nikos and Phan, Dillon and Plato, Craig and Springer, Clayton and Enyedy, Istvan (2010) Identification of Potent and Selective Aminobipyridyl Inhibitors of Protein Kinase D. Journal of Medicinal Chemistry, 53 (15). pp. 5422-5438. ISSN 1520-4804

Micoli, Francesca and Rondini, Simona and Pisoni, Ivan and Proietti, Daniela and Berti, Francesco and Costantino, Paolo and Rappuoli, Rino and Szu, Shousun and Saul, Allan and Martin, Laura (2010) Vi-CRM197 as a new conjugate vaccine against Salmonella Typhi. Vaccine, 29 (4). pp. 712-720. ISSN 0264-410X

Miller, Keith and Dunsmore, Colin and Leeds, Jennifer and Patching, Simon and Sachdeva, Meena and Blake, Katy and Stubbings, William and Simmons, Katie and Henderson, Peter and De Los Angeles, Joseph and Fishwick, Colin and Chopra, Ian (2010) Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ). Journal of Antimicrobial Chemotherapy, 65 (12). pp. 2566-2573. ISSN 1460-2091

Miller, Todd W and Hennessy, Bryan T and Gonzalez-Angulo, Ana M and Fox, Emily M and Mills, Gordon B and Ghazoui, Zara and Dowsett, Mitch and Higham, Catherine and Garcia-Echeverria, Carlos and Shyr, Yu and Arteaga, Carlos L (2010) Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone-dependence in estrogen receptor-positive breast cancer cells. Journal of clinical investigation, 120 (7). pp. 2406-2413. ISSN 0021-9738

Milletti, Francesca and Vulpetti, Anna (2010) Tautomer Preference in PDB Complexes and its Impact on Structure-Based Drug Discovery. Journal of Chemical Information and Modeling, 50 (6). pp. 1062-1074.

Minoux, Maryline and Rijli, Filippo M (2010) Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development. Development, 137 (16). pp. 2605-2621. ISSN 1477-9129

Mittal, Ashwani and Bhatnagar, Shephali and Trifilieff, Estelle and Wauters, Sandrine and li, hong and makonchuk, denys and Glass, David and kumar, ashok (2010) TWEAK/Fn14 Regulates Denervation-Induced Skeletal Muscle Atrophy through an “Inside-Out” Signaling Pathway. J Cell Biol, 188 (6). pp. 833-849. ISSN 10.1083/jcb.200909117

Moeker, Nina and Dean, Charles and Tao, Jianshi (2010) Pseudomonas aeruginosa increases formation of multidrug tolerant persister cells in response to quorum sensing signaling molecules. Journal of Bacteriology, 192 (7). pp. 1946-1955. ISSN 0021-9193

Moggs, Jonathan (2010) IMI MARCAR consortium - publishable summary - Year 1 progress report. MARCAR & IMI websites.

Moggs, Jonathan (2010) Toxicogenomics : Epigenomics & Impact for Drug Safety Sciences. Bio-IT World on-line journal.

Mouton, Véronique and Toussaint, Louise and Vertommen, Didier and Gueuning, Marie-Agnès and Maisin, Liliane and Havaux, Xavier and Sanchez-Canedo, Cossette and Bertrand, Luc and Dequiedt, Franck and Hemmings, Brian Arthur and Hue, Louis and Rider, Mark H (2010) Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3). The Biochemical Journal, 431 (2). pp. 267-275. ISSN 1470-8728


Nelson, Aaron and Dhimolea, Eugen and Reichert, Janice (2010) Development trends for human monoclonal antibody therapeutics. Nature Reviews Drug Discovery, 9 (10). pp. 767-774. ISSN 1474-1776

Niwa, Satoru and urtz, nicole and Baumruker, Thomas and Billich, Andreas and Bornancin, Frederic (2010) Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1–/– mice. Lipids in Health and Disease, 9 (1). p. 1. ISSN 1476-511X


Ohnmacht, Stephan A. and Culshaw, Andrew and Greaney, Michael F. (2010) Direct Arylations of 2H-Indazoles On Water. Organic Letters, 12 (2). pp. 224-226. ISSN 1523-7052

Ortega, Adam James (2010) LOCAL APPLICATION OF THE BISPHOSPHONATE ZOLEDRONATE TO PROVIDE MAXIMUM ANCHORAGE FOR EXTRACTION SPACE CLOSURE IN RATS. Thesis in partial fulfillment of the requirements for the degree of Master in Science. Baylor College of Dentistry, Texas A&M Health Science Center.

Ozgur, Sevim and Chekulaeva, Marina and Stoecklin, Georg (2010) Human Pat1b Connects Deadenylation with mRNA Decapping and Controls the Assembly of Processing Bodies. Molecular and Cellular Biology, 30 (17). pp. 4308-4323. ISSN 1098-5549


Pace, Virgilio and Wieczorek, Grazyna and Pace, M and Weber, Klaus and Perentes, Elias (2010) Spontaneous Metastatic Angiosarcoma of the Tongue in a Wistar Rat: Morphological and Immunohistochemical Characterisation. Toxicologic Pathology, 38 (3). pp. 472-475.

Pan, Shifeng and Wu, Xu and Jiang, Jiqing and Gao, Wenqi and Wan, Yongqin and Cheng, Dai and Han, Dong and Englund, Nathan and Wang, Yan and Peukert, Stefan and Miller-Moslin, Karen and Williams, Juliet and Yuan, Jing and Guo, Ribo and Vattay, Anthony and Jiang, Yun and Tsao, Jeffrey and Buonamici, Silvia and Sun, Fangxian and Pferdekamper, AnneMarie and Dodd, Stephanie and Tuntland, Tove and Maniara, Wieslawa and Kelleher Iii, Joseph and Warmuth, Markus and Dorsch, Marion (2010) Discovery of NVP-LDE225, a potent and selective biphenyl-3-carboxamide smoothened antagonist. ACS Medicinal Chemistry Letters, 1 (3). pp. 130-134. ISSN 1948-5875

Pearlstein, Robert and Hu, Qi-Ying and Zhou, Jing and Yowe, David and Levell, Julian (2010) NEW HYPOTHESES ABOUT THE STRUCTURE-FUNCTION OF PCSK9, PART 1: ANALYSIS OF THE EGF-A DOCKING SITE USING WATERMAP. PROTEINS: Structure, Function, and Bioinformatics.

Pennarun, Bodvael and Kleibeuker, Jan H and Oenema, Tjitske and Stegehuis, Janet H and de Vries, Elisabeth G E and de Jong, Steven (2010) Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL. Analytical Cellular Pathology (Amsterdam), 33 (5-6). pp. 229-244. ISSN 2210-7185

Pieczyk, Markus and Cuttat-Theurillat, Rachel and Nitsche, Eric and Huesken, Dieter (2010) Establishment of an automated process based on FastLane technology for screening of chemically modified siRNAs. QIAGEN News. e1.

Pissot Soldermann, Carole and Gerspacher, Marc and Gaul, Christoph and Holzer, Philipp and Radimerski, Thomas and Regnier, Catherine and Baffert, Fabienne and Drueckes, Peter and Tavares, Gisele and Furet, Pascal and Vangrevelinghe, Eric and Blasco, Francesca and Ottaviani, Giorgio and Ossola, Flavio and Scesa, Julien and Reetz, Janitha (2010) Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors. Bioorganic and Medicinal Chemistry Letters, 20 (8). pp. 2609-2613. ISSN 0960-894X

Plaza-Menacho, Iván and Morandi, Andrea and Mologni, Luca and Piet, Boender and Gambacorti-Passerini, Carlo and Magee, Anthony I. and Hofstra, Robert M. W. and Knowles, Phillip and McDonald, Neil Q. and Hatakeyama, Shinji and Isacke, Clare M. (2010) Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. Journal of Biological Chemistry, 286 (19). pp. 17272-17302. ISSN 0021-9258

Podda, Audino and Saul, Allan and Rashimi, Arora and Bhutta, Zulfiqar and Sinha, Anju and Gaind, Rajni and Singhal, Tanu and Saha, Samir and Brooks, Abdullah and Martin, Laura and Amdekar, Yeshwant and Chitkara, Amar Jeet and Shieh, Mae and Kapur, AMbujam Nair and Chugh, Tulsi Das (2010) Conjugate vaccines for enteric fever: proceedings of a meeting organized in New Delhi, India in 2009. Journal of Infection in Developing Countries, 4 (6). pp. 404-411. ISSN 1972-2680

Poulin, Benoit and Butcher, Adrian and McWilliams, Phillip and Bourgognon, Julie-Myrtille and Pawlak, Robert and Bottrill, Andrew and Mistry, Sharad and Wess, Jurgen and Rosethorne, Liz and Charlton, Steven and Tobin, Andrew (2010) The M3-muscarinic receptor regulates memory and learning in a receptor phosphorylation/arrestin-dependent manner. Proceedings of the National Academy of Sciences, 107 (20). pp. 9440-9445. ISSN 0027-8424

Premkumar, Daniel R and Jane, Esther P and Pollack, Ian F and Imark, Esther (2010) Coadministration of NVP-AEW541 and Dasatinib induces mitochondrial-mediated apoptosis through Bax activation in Malignant Human Glioma Cell Lines. International Journal of Oncology, 37 (3). pp. 633-643. ISSN 1019-6439

Press, Neil and Fozard, John R. (2010) Progress Towards Novel Adenosine Receptor Therapeutics Gleaned From The Recent Patent Literature. Expert Opinion On Therapeutic Patents, 20 (8). pp. 987-1005.

perez, Laurent-Herve and Butler, Matt and Creasey, Tammy and Dzink-Fox, Joann and Gounarides, John and Petit, Stephanie and Ropenga, Anna and Ryder, Neil and smith, kathryn and Smith, Philip and Parkinson, Scott (2010) Direct Bacterial Killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations. PLoS ONE, 5 (6). e10915.


Rangwala, Shamina and Wang, Xiaomei and Lindsley, Loren and Zhang, Yunyu and Calvo, Jennifer and Turner, Gordon and Beaulieu, Valerie and Gao, Jiaping and Markovits, Judit (2010) Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity. Journal of Biological Chemistry.

Raymond, Marianne and Van, Vu Quang and Rubio, Manuel and Welzenbach, Karl and Sarfati, Marika (2010) Targeting SIRP-a protects from type 2 -driven allergic airway inflammation. European Journal of Immunology, 12 (40). pp. 3510-3518. ISSN 0014-2980

Reilly, John and Etheridge, Donnya and Porter, David and Springer, Clayton and Fairhurst, Robin and Everatt, Brian and Jiang, Zhengjin and Aldcroft, Clive and Wright, Penny and Clemens, Ian and Cox, Brian and Press, Neil and Watson, Simon (2010) Studies in Drug Albumin binding using HSA and RSA affinity methods. Journal of Liquid Chromatography and Related Technologies, 34 (4). pp. 317-327. ISSN 1082-6076

Rigel, Dean and Fu, Fumin and Beil, Michael and Hu, Chii-Whei and Liang, Guiqing and Jeng, Arco (2010) Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11{beta}-hydroxylase inhibitor metyrapone. Journal of Pharmacology and Experimental Therapeutics, 334 (1). pp. 232-243. ISSN 0022-3565

Rosenquist, Thomas and Einolf, Heidi and Dickman, Kathleen and Wang, Lai and Smith, Amanda and Grollman, Arthur (2010) Cytochrome P450 1A2 is responsible for detoxifying aristolochic acid in the mouse. Drug Metabolism and Disposition, 38 (5). pp. 761-768. ISSN 0090-9556

Roth, Daniel Robert and Perentes, Elias (2010) Ectopic thyroid tissue in the periaortic area, cardiac cavity and aortic valve in a Beagle dog – a case report. Experimental and Toxicologic Pathology.

Ryder, Neil (2010) Discontinued drugs in 2008: anti-infectives. Expert Opinion on Investigational Drugs, 19 (1). pp. 1-21. ISSN 1354-3784


Schirle, Markus (2010) J. Reinders and A. Sickmann: "Proteomics. Methods and Protocols" (Methods in Molecular Biology). Analytical and Bioanalytical Chemistry, 396 (7). pp. 2367-2368. ISSN 1618-2642

Schmid, Herbert (2010) Pasireotide (SOM230) as a potential treatment for endocrine and non-endocrine tumors. Current Drug Therapy, 5 (4). pp. 301-311. ISSN 1574-8855

Schoenenberger, Philipp and Zhang Schärer, Yan-Ping and Oertner, Thomas (2010) Channelrhodopsin as a tool to study synaptic transmission and plasticity. Experimental Physiology. ISSN 1469-445X

Schroer, Kirsten and Kittelmann, Matthias and Luetz, Stephan (2010) Recombinant human cytochrome P450 monooxygenases for drug metabolite synthesis. Biotechnology & Bioengineering.

Shimshek, Derya and Mueller, Matthias and Wiessner, Christoph and Schweizer, Tatjana and Van Der Putten, P. Herman (2010) The HSP70 molecular chaperone is not beneficial in a mouse model of α-synucleinopathy. Public Library of Science one, 5 (4). e10014. ISSN 1932-6203

Sinkkonen, Lasse and Hugenschmidt, Tabea and Filipowicz, Witold and Svoboda, Petr (2010) Dicer Is Associated with Ribosomal DNA Chromatin in Mammalian Cells. PloS One, 5 (8). e12175-e12175. ISSN 1932-6203

Spanka, Carsten and Glatthar, Ralf and Desrayaud, Sandrine and Fendt, Markus and Orain, David and Troxler, Thomas J. and Vranesic, Ivan-Toma (2010) Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity. Bioorganic & Medicinal Chemistry Letters, 20 (1). pp. 184-188. ISSN 0960-894X

Spencer, John and Baltus, Christine and Patel, Hiren and Press, Neil and Callear, Samantha K. and Male, Louise and Coles, Simon (2010) Microwave Mediated Synthesis of an Arylboronate Library. Journal of combinatorial chemistry, 13 (1). pp. 24-31. ISSN 1520-4766

Straub, Christopher (2010) Targeting IAPs as an Approach to Anti-cancer Therapy. Current Topics in Medicinal Chemistry, 11 (3). pp. 291-316. ISSN 1568-0266

Sunkara, Gangadhar and Yeh, Ching-Ming and Ligueros-Saylan, Monica and Kawashita, Hiroto and Koseki, Nozomu and Fukui, Yoshihiro (2010) ASSESSMENT OF ETHNIC DIFFERENCES IN THE PHARMACOKINETICS OF VALSARTAN. Journal of Bioequivalence and Bioavailability, 2 (6). pp. 120-124. ISSN 0975-0851


Taguchi, Fumiko and Kodera, Yasuo and Yanagihara, Kazuyoshi and Tamura, Tomohide and Koizumi, Fumiaki and Imark, Esther (2010) Efficacy of RAD001 (everolimus) in peritoneal dissemination of gastric cancer. Investigational New Drugs, 29 (6). pp. 1198-1205. ISSN 0167-6997

Takeda, Shuko and Sato, Naoyuki and Uchio-Yamada, Kozue and Sawada, Kyoko and Kunieda, Takanori and Takeuchi, Daisuke and Kurinami, Hitomi and Shinohara, Mitsuru and Rakugi, Hiromi and Morishita, Ryuichi and Staufenbiel, Matthias (2010) Diabetes Accelerated Memory Dysfunction via Cerebrovascular Inflammation and Aβ Deposition in Alzheimer Mouse Model with Diabetes. Proceedings of the National Academy of Sciences of the United States of America, 107 (15). pp. 7036-7041. ISSN 0027-8424

Tang, Xiao Yan and Takekoshi, Susumu and Itoh, Johbu and Shoji, Sunao and Umemura, Shinobu and Terachi, Toshiro and Osamura, Robert Yoshiyuki and Imark, Esther (2010) Somatostatin analogue inhibits mobility of prostate carcinoma cells and SSTR2a is a prognostic and therapeutic biomarker for prostate carcinoma. International Journal of Oncology, 37 (5). pp. 1077-1083. ISSN 1019-6439

Teno, Naoki and Masuya, Keiichi (2010) Orally Bioavailable Cathepsin K inhibitors with Pyrrolopyrimidine Scaffold. Current Topics in Medicinal Chemistry, 10 (7). pp. 752-766. ISSN 1568-0266

Thamm, Douglas H. and Huelsmeyer, Michael K. and Mitzey, Ann M. and Qurollo, Barbara and Rose, Barbara J. and Kurzman, Ilene D. (2010) RT-PCR-based tyrosine kinase display profiling of canine melanoma: IGF-1 receptor as a potential therapeutic target. Melanoma Research, 20 (1). pp. 35-42. ISSN 0960-8931

Thaçi, Diamant and Kaufmann, Roland and Bieber, Thomas and Hanfland, Julia and Hauffe, Suzanne and Koehne-Voss, Stephan and Waldmeier, Felix (2010) Percutaneous absorption of pimecrolimus is not increased in patients with moderate to severe atopic dermatitis when pimecrolimus cream 1% is applied under occlusion. Dermatology (Basel, Switzerland), 221 (4). pp. 342-351. ISSN 1421-9832

Thaçi, Diamant and Kaufmann, Roland and Bieber, Thomas and Hanfland, Julia and Hauffe, Suzanne and Koehne-Voss, Stephan and Waldmeier, Felix (2010) Percutaneous absorption of pimecrolimus is not increased in patients with moderate to severe atopic dermatitis when pimecrolimus cream 1% is applied under occlusion. Dermatology (Basel, Switzerland), 221 (4). pp. 342-351. ISSN 1421-9832

Tranchevent, Léon-Charles and Schuierer, Sven and Dengler, Uwe and Moreau, Yves (2010) Large-scale benchmark of Endeavour using MetaCore maps. Bioinformatics, 26 (15). pp. 1922-1923. ISSN 1367-4803

Troxler, Thomas J. and Hurth, Konstanze and Schuh, Karl Heinrich and Schoeffter, Philippe and Langenegger, Daniel and Enz, Albert and Hoyer, Daniel (2010) Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 20 (5). pp. 1728-1734. ISSN 0960-894X

Tsukamoto, Z and Yamanaka, R and Inagaki, K and Ritson, Margaret and Yamashita, M and Otani, H and Takeda, M and Suzuki, J and Ogura, T and Iwasaki, Y and Makino, H (2010) Effects of bone morphogenetic protein (BMP) on adrenocorticotropin production by pituitary corticotrope cells: involvement of up-regulation of BMP receptor signaling by somatostatin analogs. Endicronology, 151 (3). pp. 1129-1141. ISSN 0013-7227


Van, VQ and Raymond, M and Baba, N and Wakahara, K and Martinez-Torres, AC and Santos, AS and Sarfati, M (2010) Targeting SIRP-α protects from type 2-driven allergic airway inflammation. Eur J Immunol..

Varin, Thibault and Gubler, Hanspeter and Parker, Christian and Zhang, Ji and Raman, Pichai and Ertl, Peter and Schuffenhauer, Ansgar (2010) Compound Set Enrichment: A novel approach to analysis of primary HTS data. Journal of Chemical Information and Modeling. ISSN 1549-960X

Velcicky, Juraj and Pflieger, Daniel (2010) Synthesis of 3-chloro-4-fluoro-7,8-dihydro-6H-isoquinolin-5-one and its derivatives. Synlett. pp. 1397-1401. ISSN 1437-2096

Vitari, Alberto (2010) Career development opportunity at Novartis. Career development opportunity at Novartis.

Vulpetti, Anna and Landrum, Gregory (2010) Source codes for methods implemented in RDKit. RDKit project / Journal of Fluorine Chemistry (see also OAK=1376), 131 (5). pp. 570-577.

Vulpetti, Anna and Landrum, Gregory and Ruedisser, Simon and Erbel, Paulus and Dalvit, Claudio (2010) 19F NMR Chemical Shift Prediction with Fluorine Fingerprint Descriptor. Journal of Fluorine Chemistry, 131 (5). pp. 570-577.

Vulpetti, Anna and Milletti, Francesca (2010) Predicting Polypharmacology by Binding Site Similarity: from Kinases to the Protein Universe. Journal of Chemical Information and Modeling, 50 (8). pp. 1418-1431. ISSN 1549-960X

Vulpetti, Anna and Schiering, Nikolaus and Dalvit, Claudio (2010) Combined Use of Computational Chemistry, NMR Screening and X-Ray Crystallography for Identification and Characterization of Fluorophilic Protein Environments. Proteins, 78 (16). pp. 3281-3291. ISSN 1097-0134


Waldmeier, Felix and Bruin, Gerard J and Glaenzel, Ulrike and Hazell, Katharine and Sechaud, Romain and Warrington, Steve and Porter, John B (2010) Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state. Drug metabolism and disposition: the biological fate of chemicals, 38 (5). pp. 808-816. ISSN 1521-009X

Waldmeier, Felix and Bruin, Gerardus and Glaenzel, Ulrike and Hazell, Katharine Mary and Sechaud, Romain and Warrington, Steve and Porter, John B (2010) Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state. Drug metabolism and disposition: the biological fate of chemicals, 38 (5). pp. 808-816. ISSN 1521-009X

Waldmeier, Felix and Bruin, Gerardus and Glaenzel, Ulrike and Hazell, Katharine Mary and Sechaud, Romain and Warrington, Steve and Porter, John B (2010) Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state. Drug metabolism and disposition: the biological fate of chemicals, 38 (5). pp. 808-816. ISSN 1521-009X

Wang, Dadong and Lagerstrom, Ryan and Sun, Changming and Bishof, Leanne and Vallotton, Pascal and Goette, Marjo (2010) HCA-Vision: Automated Neurite Outgrowth Analysis. Journal of Biomolecular Screening, 15 (9). pp. 1165-1170. ISSN 1087-0571

Wang, Tao and Lapadula, Daniel and Jacobson-Kram, David and Pilaro, Anne and Jacobs, Abigail and Brown, Paul and Lipscomb, John and McGuinn, David (2010) New and Revised ICH Guidelines: Insight and Challenges. Toxicological Sciences, 118 (2). pp. 356-367. ISSN 1096-6080

Wang, Youjun and Deng, Xiaoxiang and Mancarella, Salvatore and Hendron, Eunan and Eguchi, Satoru and Soboloff, Jonathan and Tang, Xiang D. and Gill, Donald L. (2010) The Calcium store-sensor, STIM1, reciprocally controls Orai1 and Cav1.2 channels. Science, 330 (6000). pp. 105-109. ISSN 0036-8075

Waters, Nigel and Lombardo, Franco (2010) Use of the Øie-Tozer Model in Understanding Mechanisms and Determinants of Drug Distribution. Drug Metabolism and Disposition, 38 (7). pp. 1159-1165.

Watson, Catherine and Weissbach, Nicole and Kjems, Lise and Ayalasomayajula, Surya and Zhang, Yiming and Chang, Ih and Navab, Mohamad and Hama, Susan and Hough, Greg and Reddy, Srinivasa and Soffer, Daniel and Rader, Daniel and Fogelman, Alan and Schecter, Alison (2010) Treatment of Patients with Cardiovascular Disease with L-4F, an Apo-A1 mimetic, Did Not Improve Select Biomarkers of HDL Function. Journal of Lipid Research, 52 (2). pp. 361-373. ISSN 0022-2275

Webb, Randy and Schiering, Nikolaus and Sedrani, Richard and Maibaum, Juergen Klaus (2010) Direct Renin Inhibitors as A New Therapy for Hypertension. Journal of Medicinal Chemistry.

Weisberg, Ellen and Roesel, Johannes and Furet, Pascal and Bold, Guido and Imbach, Patricia and Floersheimer, Andreas and Jiang, Jingrui and Manley, Paul W. and Ray, Arghya and Griffin, James D (2010) Anti-Leukemic Effects of Novel First and Second generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes & Cancer, 1 (10). pp. 1021-1032. ISSN 1947-6019

Widler, Leo and Altmann, Eva and Beerli, Rene and Breitenstein, Werner and Bouhelal, Rochdi and Buhl, Thomas and Gamse, Rainer and Gerspacher, Marc and Halleux, Christine and John, Markus and Lehmann, Hansjoerg and Kalb, Oskar and Kneissel, Michaela and Missbach, Martin and Mueller, Irene and Reidemeister, Sibylle and Taillardat, Agnes and Tommasi, Ruben and Weiler, Sven and Wolf, Romain and Seuwen, Klaus and Renaud, Johanne (2010) 1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists. Journal of Medicinal Chemistry, 53 (5). pp. 2250-2263. ISSN 0022-2623

Wiechert, Martin T and Judkewitz, Benjamin and Riecke, Hermann and Friedrich, Rainer W (2010) Mechanisms of pattern decorrelation by recurrent neuronal circuits. Nature Neuroscience, 13 (8). pp. 1003-1010. ISSN 1546-1726

Wirth, Thomas and Audiger, Logan and Robinson, Richard and Elmore, Simon C. (2010) Ritter Reactions in Flow. CHEMSUSCHEM, 2010 (20). pp. 3099-3103. ISSN 1864-5631

Wirth, Thomas and Elmore, Simon, C. and Brandt, Johan, C. and Robinson, Richard (2010) Safe and Efficient Ritter Reactions in Flow. SYNLETT, 20 (10). pp. 3099-3103. ISSN 0936-5214

Wolf, Samuel and Lorenz, Jana and Mössner, Joachim and Wiedmann, Marcus (2010) Treatment of biliary tract cancer with NVP-AEW541: Mechanisms of action and resistance. World Journal of Gastroenterology, 16 (2). pp. 156-166. ISSN 1007-9327

Woodward, Hannah and Smith, Nichola and Gallagher, Timothy (2010) Exo-Glycals: Versatile Intermediates in the Synthesis of 1,1-Disubstituted C Glycosides. Synlett (6). pp. 869-872. ISSN 0936-5214


Xu, Lingfei and Zhang, Yunyu and Cohen, Steven and Dipetrillo, Keith (2010) TrkB Agonist Antibody Dose-Dependently Raises Blood Pressure in Mice with Diet-Induced Obesity. American Journal of Hypertension.

Xu, Qingping and Abdubeck, Polat and Chen, Connie and Chiu, Michelle and Feuerhelm, Julie and Grant, Joanna and Klock, Heath and Knuth, Mark and Okach, Linda and Nigoghossian, Edward and Puckett, Christina and Wooten, Tiffany and Lesley, Scott and Stolz, Barbara (2010) GNF ID 100606: Crystal structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, F66. pp. 1-11. ISSN 1744-3091

Xu, Qingping and Abdubeck, Polat and Chen, Connie and Feuerhelm, Julie and Grant, Joanna and Klock, Heath and Knuth, Mark and Nigoghossian, Edward and Okach, Linda and Puckett, Christina and Wooten, Tiffany and Zhou, Jiadong and Lesley, Scott and Stolz, Barbara (2010) GNF ID 100604: Crystal structure of a membrane attack complex/perforin (MACPF) family protein from a human gut symbiont Bacteroides thetaiotaomicron. Acta F.


Yan, Wei and Goette, Marjo and Hofmann, Gabriele and Zaror, Isabel and Sim, Bang Janet (2010) High-level Soluble Expression, Purification and Characterization of Active Human Midkine from Escherichia coli. Protein Expression and Purification, 70 (2). pp. 270-276. ISSN 1046-5928

Yang, Xiuwei H. and Flores, Ludmila M. and Li, Qinglin and Zhou, Pengcheng and Xu, Fenghui and Krop, Ian E. and Hemler, Martin E. (2010) Disruption Of Laminin-Integrin-CD151-FAK Axis Sensitizes Breast Cancer Cells To ErbB2 Antagonists. Cancer Research, 70 (6). pp. 2256-2263.


Zanin, Esther and Pacquelet, Anne and Scheckel, Claudia and Ciosk, Rafal and Gotta, Monica (2010) LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline. Journal of Cell Science, 123 (Pt 16). pp. 2717-2724. ISSN 1477-9137

Zhou, Fei and Chang, Zai and Zhang, Luqing and Hong, Young-Kwon and Shen, Bin and Wang, Bo and Zhang, Fan and Lu, Guangming and Tvorogov, Denis and Alitalo, Kari and Hemmings, Brian Arthur and Yang, Zhongzhou and He, Yulong (2010) Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development. The American Journal of Pathology. ISSN 0002-9440

Zhu, Wenbin and Wang, Lan and Palmateer, Julie M and Libal, Nicole L and Hurn, Patricia D and Herson, Paco S and Murphy, Stephanie J and Imark, Esther (2010) Isoflurane Preconditioning Neuroprotection In Experimental Focal Stroke Is Androgen-Dependent In Male Mice. Neuroscience, 169 (2). pp. 758-769. ISSN 0306-4522

Zollinger, Markus and Gschwind, Hans-Peter and Jin, Yi and Sayer, Claudia and Zecri, Frederic and Hartmann, Stefan (2010) Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways. Drug Metabolism and Disposition. ISSN 1521-009X

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