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Items where Year is 2010

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Number of items: 231.


Abban, Cynthia Y., Meneses, Patricio I. and Hatakeyama, Shinji (2010) Usage of heparan sulfate, integrins, and FAK in HPV16 infection. Virology, 403 (1). pp. 1-16.

Abdel Samad, Omar, Liu, Yang, Yang, Fu-Chia, Kramer, Ina, Arber, Silvia and Ma, Qiufu (2010) Characterization of two Runx1-dependent nociceptor differentiation programs necessary for inflammatory versus neuropathic pain. Molecular Pain, 6. p. 45. ISSN 1744-8069

Abdubeck, Polat, Chen, Connie, Feuerhelm, Julie, Grant, Joanna, Bakolitsa, Constantina, Klock, Heath, Knuth, Mark, Mcmullan, Daniel, Okach, Linda, Puckett, Christina, Lesley, Scott and Stolz, Barbara (2010) GNF ID 100605: Crystal structure of BT_3984, the first representative of the SusD/RagB family of nutrient binding. Acta F.

Abdubeck, Polat, Chen, Connie, Feuerhelm, Julie, Grant, Joanna, Klock, Heath, Knuth, Mark, Nigoghossian, Edward, Okach, Linda, Puckett, Christina, Wooten, Tiffany, Zhou, Jiadong, Lesley, Scott, Stolz, Barbara and Xu, Qingping (2010) GNF ID 100603: Crystal structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes. Acta F.

Abdubek, Polat, Chen, Connie, Chiu, Michelle, Feuerhelm, Julie, Grant, Joanna, Klock, Heath, Knuth, Mark, Nigoghossian, Edward, Okach, Linda, Puckett, Christina, Lesley, Scott and Stolz, Barbara (2010) GNF ID 100504: The crystal structure of Neisseria gonorrhoea NGO1391 defines a novel set of bacterial proteins that are similar to the N-terminal domain of human Sufu (Suppresor of Fused). Protein Science or Journal of Bacteriology.

Abdulla, Salim, Amuri, Baraka, Kabanywanyi, Abdunoor M, Ubben, David, Reynolds, Christine, Pascoe, Steve, Fitoussi, Serge, Yeh, Ching-Ming, Nuortti, Marja, Sechaud, Romain, Kaiser, Guenther and Lefevre, Gilbert (2010) Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects. Malaria journal, 9. p. 253. ISSN 1475-2875

Adams, Christopher, Hu, Chii-Whei, Jeng, Arco, Karki, Rajeshri, Ksander, Gary, Lasala, Daniel, Leung-Chu, Jennifer, Liang, Guiqing, Liu, Qian, Meredith, Erik, Rao, Chang, Rigel, Dean, Springer, Clayton, Zhang, Chun, Shi, Jie and Smith, Sherri (2010) The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-Beta-hydroxylase. Bioorganic and Medicinal Chemistry Letters, 20 (15). pp. 4324-4327.

Apfel, Ulf_Peter, Rudolph, Manfred, Apfel, Christina, Robl, Christian, Langenegger, Daniel, Hoyer, Daniel, Jaun, Bernhard, Seebach, Dieter and Weigand, Wolfgang (2010) Reaction of Fe3(CO)12 with Octreotide – Chemical, Electrochemical and Biological Investigations. Dalton Transactions, 39 (12). p. 3065. ISSN 1477-92261477-9234

Argikar, Upendra, Gomez, Javier, Ung, Din, Parkman, Henry and Nagar, Swati (2010) Identification of novel metoclopramide metabolites in humans: in vitro and in vivo studies. Drug Metabolism and Disposition.

Arias, H, Gu, R, Feuerbach, Dominik and Wei, D (2010) Different Interaction between the Agonist JN403 and the Competitive Antagonist Methyllycaconitine with the Human α7 Nicotinic Acetylcholine Receptor. Biochemistry.

Arias, HR, Feuerbach, Dominik, Targowska-Duda, KM and Jozwiak, Krysztof (2010) Catharanthine alkaloids are noncompetitive antagonists of muscle-type nicotinic acetylcholine receptors. Neurochemistry international.

Arias, HR, Feuerbach, Dominik, Targowska-Duda, KM, Russell, M and Jozwiak, K (2010) Interaction of Selective Serotonin Reuptake Inhibitors with Neuronal Nicotinic Acetylcholine Receptors. Biochemistry.

Arias, Hugo, Rosenberg, Avraham, Targowska-Dudac, Katarzyna, Feuerbach, Dominik, Jozwiak, Krzysztof, Moaddel, Ruin and Wainer, Irving (2010) Comparative Interaction between tricyclic antidepressants and mecamylamine with the human α4β2 nicotinic acetylcholine receptor. The International Journal of Biochemistry.

Artman Iii, Gerald, Solovay, Catherine, Adams, Christopher, Diaz, Brian, Dimitroff, Martin, Ehara, Takeru, Gu, Danlin, Ma, Fupeng, Liu, Donglei, Miller, Bridget Ranae, Pick, Teresa, Poon, Daniel, Ryckman, David, Siesel, David, Stillwell, Brady, Swiftney, Tyson, Van Dyck, Jonathan and Ji, Nan (2010) One-pot synthesis of 2-aminobenzimidazoles using 2-chloro-1,3-dimethylimidazolinium chloride (DMC). Tetrahedron Letters, 51 (40). pp. 5319-5321. ISSN 0040-4039

Avlasevich, Svetlana, Bryce, Steven, De Boeck, Marlies, Elhajouji, Azeddine, Van Goethem, Freddy, Lynch, Anthony, Nicolette, John, Shi, Jing and Dertinger, Stephen (2010) Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future. Mutagenesis, 26 (1). pp. 147-152.

Azzaoui, Kamal, Hamon, Jacques, Whitebread, Steven and Urban, Laszlo (2010) Bayesian modeling for Predicting Promiscuity and Selectivity of Molecules based on Safety Pharmacology Profiling Data. In: Adverse Side Effect Prediction in Preclinical Drug Discovery. Wiley.


Baffert, Fabienne, Blasco, Francesca, Brueggen, Josef, Chene, Patrick, De Pover, Alain, Drueckes, Peter, Erdmann, Dirk, Furet, Pascal, Gerspacher, Marc, Hofmann, Francesco, Lang, Marc, Ledieu, David, Nolan, Lynda, Pissot Soldermann, Carole, Regnier, Catherine, Ruetz, Stephan, Tavares, Gisele, Trappe, Joerg, Vangrevelinghe, Eric, Wartmann, Markus, Wyder, Lorenza and Radimerski, Thomas (2010) Potent and selective inhibition of JAK2 by the quinoxaline NVP-BSK805. Molecular Cancer Therapeutics, 9 (7). pp. 1945-1955. ISSN 1535-7163

Balibar, Carl, Shen, Xiaoyu, Mcguire, Dorothy, Yu, Donghui, Mckenney, David and Tao, Jianshi (2010) CwrA, a gene that specifically responds to cell wall damage in Staphylococcus aureus. Microbiology, 156 (Pt 5). pp. 1372-1383.

Beattie, David, Beer, David, Bentley, David, Bradley, Michelle, Bruce, Ian, Charlton, Steven, Cuenoud, Bernard, Ernst, Roland, Fairhurst, Robin, Faller, Bernard, Farr, David Colin, Keller, Thomas, Fozard, John R., Fullerton, Joe, Garman, Sheila, Hatto, Julia, Hayden, Claire, He, Handan, Howes, Colin, Janus, Diana, Jiang, Zhengjin, Loeuillet-Ritzler, Frederique, Moser, Heinz, Reilly, John, Steward, Alan, Sykes, David, Tedaldi, Lauren, Trifilieff, Alexandre, Tweed, Morris, Watson, Simon, Wissler, Elke, Wyss, Daniel, Baur, Francois and Charman, Christine (2010) The Identification of Indacaterol as an Ultra-Long-Acting Inhaled Beta-2-Adrenoceptor Agonist. Journal of Medicinal Chemistry, 53. pp. 3675-3684.

Beattie, David, Bradley, Michelle, Brearley, Andrew, Charlton, Steven, Cuenoud, Bernard, Fairhurst, Robin, Gedeck, Peter, Gosling, Martin, Janus, Diana, Jones, Darryl, Lewis, Christine, Mccarthy, Clive, Oakman, Helen, Stringer, Rowan, Taylor, Roger and Tuffnell, Andrew (2010) A Physical Properties Based Approach for the Exploration of a 4-Hydroxybenzothiazolone Series of Beta2-Adrenoceptor Agonists as Inhaled Long-Acting Bronchodilators. Bioorganic and Medicinal Chemistry Letters, 20 (17). pp. 5302-5307.

Beattie, David, Brearley, Andrew, Brown, Zarin, Charlton, Steven, Cox, Brian, Fairhurst, Robin, Fozard, John R., Gedeck, Peter, Kirkham, Paul, Meja, Koremu, Nanson, Lana, Neef, James, Oakman, Helen, Taylor, Roger, Turner, Robert, West, Ryan and Woodward, Hannah (2010) Synthesis and Evaluation of Two Series of 4'-Aza-Carbocyclic Nucleosides as Adenosine A2A Receptor Agonists. Bioorganic and Medicinal Chemistry Letters, 20 (3). pp. 1219-1224. ISSN 0960-894X

Bell, Oliver, Schwaiger, Michaela, Oakeley, Edward James, Lienert, Florian, Beisel, Christian, Stadler, Michael B and Schübeler, Dirk (2010) Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing. Nature Structural & Molecular Biology, 17 (7). pp. 894-900. ISSN 1545-9985

Bergsdorf, Christian and Ottl, Johannes (2010) Affinity-based screening techniques: Their impact and benefit to increase the number of high quality leads. Expert Opinion on Drug Discovery, 5 (11). pp. 1095-1107. ISSN 1746-045X

Bhoumik, Priyasma and Hughes, Austin L (2010) Reassortment of ancient neuraminidase and recent hemagglutinin in pandemic (H1N1) 2009 virus. Emerging infectious diseases, 16 (11). pp. 1748-1750. ISSN 1080-6059

Blumer, Jeffrey, Rodriguez, Adib, Sánchez, Pablo J, Sallas, William, Kaiser, Guenther and Hamed, Kamal (2010) Single-dose pharmacokinetics of famciclovir in infants and population pharmacokinetic analysis in infants and children. Antimicrobial agents and chemotherapy, 54 (5). pp. 2032-2041. ISSN 1098-6596

Borawski, Jason and Gaither, Larry (2010) The evolution of RNAi technologies in the drug discovery business. European Pharmaceutical Review, 5. pp. 35-39. ISSN 1360-8606

Borrmann, Steffen, Sallas, William, Machevo, Sonia, González, Raquel, Björkman, Anders, Mårtensson, Andreas, Hamel, Mary, Juma, Elizabeth, Peshu, Judy, Ogutu, Bernhards, Djimdé, Abdoulaye, D'Alessandro, Umberto, Marrast, Anne Claire, Lefevre, Gilbert and Kern, Steven (2010) The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria. Tropical medicine & international health : TM & IH, 15 (4). pp. 434-441. ISSN 1365-3156

Brosig, Michaela, Ferralli, Jacqueline, Gelman, Laurent, Chiquet, Matthias and Chiquet-Ehrismann, Ruth (2010) Interfering with the connection between the nucleus and the cytoskeleton affects nuclear rotation, mechanotransduction and myogenesis. The International Journal of Biochemistry & Cell Biology, 42 (10). pp. 1717-1728. ISSN 1878-5875

Brown, Ann, Bickford, Shari, Hatsis, Panagiotis, Amin, Jakal, Bell, Leslie and Harriman, Shawn (2010) High-Throughput Analysis of In-Vitro Cytochrome P450 Inhibition Samples Using Mass Spectrometry Coupled with an Integrated Liquid Chromatography and Autosampler System. Rapid Communications in Mass Spectrometry, 24 (8). pp. 1207-1210. ISSN 1097-0231

Browne, BC, Crown, J, Venkatesan, N, Duffy, MJ, Clynes, M, Slamon, D, O'Donovan, N and Jeay, Sebastien (2010) Inhibition of IGF1R activity enhances response to trastuzumab in HER-2 positive breast cancer cells. Annals of Oncology.

Busskamp, Volker, Duebel, Jens, Balya, David, Fradot, Mathias, Viney, Tim James, Siegert, Sandra, Groner, Anna C, Cabuy, Erik, Forster, Valérie, Seeliger, Mathias, Biel, Martin, Humphries, Peter, Paques, Michel, Mohand-Said, Saddek, Trono, Didier, Deisseroth, Karl, Sahel, José A, Picaud, Serge and Roska, Botond (2010) Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa. Science (New York, N.Y.), 329 (5990). pp. 413-417. ISSN 1095-9203


Camara, Joana and Jarai, Gabor (2010) Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha. Fibrogenesis & Tissue Repair, 3 (1). p. 2. ISSN 1755-1536

Cao, Xueying, Lee, Yan, Holmqvist, Mats, lin, Yingxin, Ni, Yucheng, Mikhailov, Dmitri, Zhang, Haiyan, Hogan, Christopher, Zhou, Liping, Lu, Qiang, Digan, Mary, Urban, Laszlo and Erdemli, Gul (2010) Cardiac ion channel safety profiling on the IonWorks Quattro™ Automated Patch Clamp System. Assay and drug development technologies.

Cao, Xueying, Lee, Yan, Holmqvist, Mats, lin, Yingxin, Ni, Yucheng, Mikhailov, Dmitri, Zhang, Haiyan, Hogan, Christopher, Zhou, Liping, Lu, Qiang, Digan, Mary, Urban, Laszlo and Erdemli, Gul (2010) Cardiac ion channel safety profiling on the IonWorks Quattro™ Automated Patch Clamp System. Assay and drug development technologies.

Castillo, Victor, Theodoropoulou, Marily, Stalla, Johanna, Gallelli, Maria Florencia, Cabrera-Blatter, Maria Fernanda, Haedo, Mariana R, Labeur, Marta, Schmid, Herbert, Stalla, Günter K and Arzt, Eduardo (2010) Effect of SOM230 (pasireotide) on corticotropic cells: action in dogs with Cushing's disease. Neuroendrocrinology, 94 (2). pp. 124-136. ISSN 0028-3835

Cescato, Renzo, Loesch, Kimberly A, Waser, Beatrice, Mäcke, Helmut R, Rivier, Jean E, Reubi, Jean Claude, Schonbrunn, Agnes and Imark, Esther (2010) AGONIST BIASED SIGNALING AT THE SST2A RECEPTOR: THE PAN-SOMATOSTATIN ANALOGS KE108 AND SOM230 ACTIVATE AND ANTAGONIZE DISTINCT SIGNALING PATHWAYS. Molecular Endocrinology, 24 (1). pp. 240-249. ISSN 0888-8809

Chablais, F. and Jazwinska, A. (2010) IGF signaling between blastema and wound epidermis is required for fin regeneration. Development, 137 (6). pp. 871-879. ISSN 0950-1991

Chene, Patrick, Hau, Jean-Christophe, Blechschmidt, Anke, Fontana, Patrizia, Bohn, Jacqueline, Zimmermann, Catherine, De Pover, Alain and Erdmann, Dirk (2010) Study of the selectivity of insulin-like growth factor-1 receptor (IGF1R) inhibitors. The open enzyme Inhibition Journal, 3 (1). pp. 27-37. ISSN 1874-9402

Chetty, Rajkumar, Ozer, Josef, Lanevschi, Anne, Schuppe-Koistinen, Ina, McHale, Duncan, Pears, John, Vonderscher, Jacky, Sistare, Frank and Dieterle, Frank (2010) A systematic approach to preclinical and clinical safety biomarker qualification incorporating Bradford Hill’s principles of causality association. Clinical Pharmacology & Therapeutics, 88 (2). pp. 260-262. ISSN 0009-9236

Cheung, Atwood and Jain, Rishi (2010) Accelerating the discovery of new drug targets with chemical proteomics. IDrugs, 13 (12). pp. 862-868. ISSN 1369-7056

Cho, Young, Borland, Maria, Brain, Christopher, Chen, Christine, Cheng, Hong, Chopra, Rajiv, Chung, Kristy, Groarke, James, He, Guo, Hou, Ying, Kovats, Steven, Shen, Junqing, Trakshel, Gary, Voegtle, Markus, Xu, Mei, Xu, Ming and Sung, Moo (2010) 4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6. Journal of Medicinal Chemistry, 53 (22). pp. 7938-7957. ISSN 0022-2623

Cho, Young, Whitehead, Lewis, Li, Jianke, Chen, Christine, Shultz, Michael, Jiang, Lei, Voegtle, Markus, Francotte, Eric, Richert, Paul, Wagner, Beatrix, Traebert, Martin, lu, qiang, Cao, Xueying, Dumotier, Berengere, Fejzo, Jasna, Rajan, Srinivasan, Wang, Ping, Yan-Neale, Yan, Shao, Wenlin and Atadja, Peter (2010) Conformational Refinement of Hydroxamate-Based Histone Deacetylase Inhibitors and Exploration of 3-Piperidin-3-yl-indole Analogues of Dacinostat (LAQ824). Journal of Medicinal Chemistry, 53 (7). pp. 2952-2963. ISSN 0022-2623

Choi Kong, Kok, Butcher, Adrian, McWilliams, Phillip, Wess, Jurgen, Hamdan, Fadi F, Werry, Tim, Rosethorne, Liz, Charlton, Steven, Cragg, Hannah A, Smart, Alison D and Tobin, Andrew (2010) M3-muscarinic receptor mediates insulin release via receptor-phosphorylation dependent activation of protein kinase D1. Proceedings of the National Academy of Sciences, 107 (49). pp. 21181-21186. ISSN 0027-8424

Clarkson, Paul, Cheng, Hongwei, West, Robert, Gao, Doris, Wang, Y.Z., Nielsen, Torsten and Abraham, Judith (2010) Therapeutic antibodies targeting CSF1 impede macrophage recruitment in a xenograft model of tenosynovial giant cell tumor. Sarcoma, 2010 (Octobe).

Coomaraswamy, Janaky, Kilger, Ellen, Wölfing, Heidrun, Schäfer, Claudia, Kaeser, Stephan, Wegenast-Braun, Bettina, Hefendehl, Jasmin K, Wolburg, Hartwig, Mazella, Matthew, Ghiso, Jorge, Goedert, Michel, Akiyama, Haruhiko, Garcia-Sierra, Francisco, Wolfer, David, Mathews, Paul M and Jucker, Mathias (2010) Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Proceedings of the National Academy of Science USA, 107 (17). pp. 7969-7974.

Craig, Ian, Essex, Jonathan W. and Spiegel, Katrin (2010) Ensemble Docking into Multiple Crystallographically Derived Protein Structures: An Evaluation Based on the Statistical Analysis of Enrichments. Journal of Chemical Information and Modeling, 50 (4). pp. 511-524. ISSN 1549-9596


Danahay, Henry, Gosling, Martin and Paisley, Derek (2010) Regulation of airway mucosal hydration. Expert Review of Clinical Pharmacology, 3 (3). pp. 361-369. ISSN 1751-2433

Dey, Julien H, Bianchi, Fabrizio, Voshol, Johannes, Bonenfant, Debora, Oakeley, Edward J, Hynes, Nancy E and Imark, Esther (2010) Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis. Cancer Research, 70 (10). pp. 4151-4162. ISSN 0008-5472

Dey, Julien Hervé and Imark, Esther (2010) Investigating the contribution of FGF receptors in breast tumorigenesis using models of mammary cancer. Inauguraldissertation (Thesis).

Doghman, Mabrouka, Wakil, Abeer EL, Cardinaud, Bruno, Thomas, Emilie, Wang, Jinling, Zhao, Wei, Figueiredo, Bonald C, Zambetti, Gerard P, Lalli, Enzo and Imark, Esther (2010) Regulation of IGF - mTOR signalling by miRNA in childhood adrenocortical tumors. Cancer Research, 70 (11). pp. 4666-4675. ISSN 0008-5472

Domanski, Luke, Sun, Changming, Hassan, Raquibul, Vallotton, Pascal and Wang, Dadong (2010) Linear feature detection on GPUs. International Conference on Digital Image Computing: Techniques and Applications (DICTA), Sydney, Australia, 1–3 December 2010.

Doucet, Julie and Avrameas, Alexandre (2010) A novel method for quantitative measurement of a therapeutic monoclonal antibody in the presence of its target protein using enzymatic digestion. Journal of Pharmaceutical and Biomedical Analysis, 52 (4). pp. 565-570. ISSN 0731-7085

Duthaler, Rudolf, Fischer, Reto, Katopodis, Andreas, Marterer, Wolfgang, Streiff, Markus, Thoma, Gebhard, Ernst, Beat, Kinzy, Willy and Oehrlein, Reinhold (2010) In vivo Neutralization of naturally occuring Antibodies against Linear alpha(1,3)-Galactosidic Carbohydrate Epitopes by Multivalent Antigen Presentation: A Solution for the first Hurdle of Pig-to-Human Xenotransplantation. Chimia: International Journal for Chemistry, 64 (1/2). pp. 23-28. ISSN 0009-4293

Düvel, Katrin, Yecies, Jessica L., Raman, Pichai, Menon, Suchithra, Lipovsky, Alex I., Souza, Amanda L., Triantafellow, Ellen, Ma, Qicheng, Gorski, Regina, Cleaver, Stephen, Mackeigan, Jeff, Finan, Peter, Clish, Clary B., Murphy, Leon and Manning, Brendan D. (2010) Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Molecular Cell, 39 (2). pp. 171-183. ISSN 1097-2765


Elhajouji, Azeddine (2010) Mitomycin C, 5-fluoruracil, colchicine and etoposide tested in the in vitro mammalian cell micronucleus test (MNvit) in the human lymphoblastoid cell line TK6 at Novartis in support of OECD draft Test Guideline 487. Mutation Research - Genetic Toxicology and Environmental Mutagenesis.

Elhajouji, Azeddine, Cammerer, Zoryana, Lukamowicz, Magdalena and Kirsch-Volders, Micheline (2010) Potential thresholds for genotoxic effects by micronucleus scoring. Mutagenesis, 26 (1). pp. 199-204. ISSN 1464-3804

Ennulat, Daniela, Walker, Dana, Clemo, Frances, Magidslav, Michal, Ledieu, David, Graham, Mark, Botts, Suzanne and Boone, Laura (2010) Effects of Hepatic Drug Metabolizing Enzyme Induction on Clinical Pathology Parameters in Animals and Man. Toxicologic Pathology.

Ertl, Peter (2010) Molecular Structure Input on the Web. Journal of Cheminformatics, 2. p. 1. ISSN 1758-2946


Fayard, Elisabeth, Moncayo, Gerald, Hemmings, Brian Arthur and Hollaender, Georg A (2010) Phosphatidylinositol 3-Kinase Signaling in Thymocytes: the Need for Stringent Control. Science Signaling, 3 (135). re5-re5. ISSN 1937-9145

Fendt, Markus, Buchi, Melanie, Buerki, Hugo, Imobersteg, Stefan, Ricoux, Berangere, Suply, Thomas and Sailer, Andreas (2010) Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response. Behavioral Brain Research. ISSN 0166-4328

Fendt, Markus, Imobersteg, Stefan, Buerki, Hugo, Mcallister, Kevin and Sailer, Andreas (2010) Intra-amygdala injections of neuropeptide S block fear-potentiated startle. Neuroscience Letters, 474 (3). pp. 154-157. ISSN 0304-3940

Fiorina, Paolo, Jurewicz, Mollie, Vergani, Andrea, Vergelli, Alessandra, Carvello, Michele, D'Addio, Francesca, Godwin, Jonathan, Law, Kenneth, Wu, Erxi, Tian, Ze, Thoma, Gebhard, Kovarik, Jiri, La Rosa, Stefano, Capella, Carlo, Rodig, Scott, Zerwes, Hans-Guenter, Sayegh, Mohammed and Abdi, Reza (2010) Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via PD-L1. The Journal of Immunology, 186 (3). pp. 121-131. ISSN 0022-1767

Fritz, Nicholas F., Cronican, Andreas, Pham, Tam, Fogg, Allison, Lefterov, Iliya and Koldamova, Radosveta (2010) LXR agonist treatment ameliorates amyloid pathology and memory deficits caused by high fat diet in APP23 mice. The Journal of Neuroscience, 30 (20). pp. 6862-6872.

Furet, Pascal, Gerspacher, Marc and Pissot Soldermann, Carole (2010) Design of Two New Chemotypes for Inhibiting the Janus Kinase 2 by Scaffold Morphing. Bioorganic & Medicinal Chemistry Letters, 20 (6). pp. 1858-1860. ISSN 0960-894X


Gamber, Gabriel, Meredith, Erik, Zhu, Qingming, Yan, Wanlin, Rao, Chang, Capparelli, Michael, Burgis, Robin, Enyedy, Istvan, Zhang, Ji, Soldermann, Nicolas, Beattie, Kimberley, Rozhitskaya, Olga, Koch, Keith, Pagratis, Nikos, Hosagrahara, Vinayak, Vega, Richard, McKinsey, Timothy and Monovich, Lauren (2010) Preliminary Studies of 3,5-Diarylazoles as Novel and Selective Inhibitors of Protein Kinase D. Bioorganic and Medicinal Chemistry Letters, 21 (5). pp. 1447-1451. ISSN 0960-894X

Gao, Zhenhai, Garcia-Echeverria, Carlos and Jensen, Michael Rugaard (2010) Hsp90 inhibitors: Clinical development and future opportunities in oncology therapy. Current Opinion in Drug Discovery and Development, 13 (2). pp. 193-202. ISSN 1367-6733

Gariboldi, Marzia B., Ravizza, Raffaella and Monti, Elena (2010) The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells. Biochemical Pharmacology, 80 (4). pp. 455-462. ISSN 00062952

Gedeck, Peter, Kramer, Christian and Ertl, Peter (2010) Computational Analysis of Structure-Activity Relationships. In: Progress in Medicinal Chemistry. Elsevier.

Gerspacher, Marc, Altmann, Eva, Beerli, Rene, Buhl, Thomas, Endres, Ralf, Gamse, Rainer, Kameni Tcheudji, Jacques, Kneissel, Michaela, Krawinkler, Karl Heinz, Missbach, Martin, Schmidt, Alfred, Seuwen, Klaus, Weiler, Sven and Widler, Leo (2010) Penta-Substituted Benzimidazoles as Potent Antagonists of the Calcium Sensing Receptor (CaSR-Antagonists). Bioorganic & Medicinal Chemistry Letters.

Gerspacher, Marc, Furet, Pascal, Pissot Soldermann, Carole, Gaul, Christoph, Holzer, Philipp, Vangrevelinghe, Eric, Lang, Marc, Buhl, Thomas, Aichholz, Reiner, Blasco, Francesca, Endres, Ralf, Erdmann, Dirk, Radimerski, Thomas, Regnier, Catherine, Chene, Patrick, Hofmann, Francesco, Trappe, Joerg, Drueckes, Peter, Baffert, Fabienne and De Pover, Alain (2010) 2-Amino-aryl-7-aryl-benzoxazoles as Potent, Selective and Orally Available JAK2 Inhibitors. Bioorganic & Medicinal Chemistry Letters, 20 (5). pp. 1724-1727. ISSN 0960-894X

Glass, David and Roubenoff, Ronenn (2010) Recent advances in the biology and therapy of muscle wasting. Annals of the New York Academy of Sciences, 1211. pp. 25-36. ISSN 0077-8923

Goette, Marjo, Hofmann, Gabriele, Gallani, Anne-Isabelle, Glickman, Fraser, Wishart, William L. and Gabriel, Daniela (2010) An imaging assay to analyze primary neurons for cellular neurotoxicity. Journal of Neuroscience Methods, 192 (1). pp. 7-16.

Gommermann, Nina, Buehlmayer, Peter, Von Matt, Anette, Breitenstein, Werner, Masuya, Keiichi, Pirard, Bernard, Furet, Pascal, Jacob, Sandra and Weckbecker, Gisbert (2010) New Pyrazolo[1,5a]pyrimidines as Orally Active Inhibitors of Lck. Bioorganic & Medicinal Chemistry Letters, 20 (12). pp. 3628-3631. ISSN 0960-894X

Gong, Ting, Hartmann, Nicole, Kohane, Isaac S., Brinkmann, Volker, Staedtler, Frank, Letzkus, Martin and Szustakowski, Joseph (2010) Optimal deconvolution of transciptional profiling data using quadratic proagramming with application to complex clinical blood samples. RECOMB2011-Journal of Computational Biology.

Gossert, Alvar, Hiller, Sebastian and Fernandez, Cesar (2010) Automated projection spectroscopy (APSY) for efficient structural characterization of protein-ligand interactions. Journal of the American Chemical Society. ISSN 0002-7863

Grausenburger, Reinhard, Bilic, Ivan, Boucheron, Nicole, Zupkovitz, Gordin, El-Housseiny, Lamia, Tschismarov, Roland, Zhang, Yu, Rembold, Martina, Gaisberger, Martin, Hartl, Arnulf, Epstein, Michelle M, Matthias, Patrick, Seiser, Christian and Ellmeier, Wilfried (2010) Conditional Deletion of Histone Deacetylase 1 in T Cells Leads to Enhanced Airway Inflammation and Increased Th2 Cytokine Production. The Journal of Immunology (Baltimore, Md. : 1950), 185 (6). pp. 3489-3497. ISSN 1550-6606

Guetg, Nicole, Aziz, Said Abdel, Holbro, Niklaus, Turecek, Rostislav, Rose, Tobias, Seddik, Riad, Gassmann, Martin, Moes, Suzette, Jenoe, Paul, Oertner, Thomas, Casanova, Emilio and Bettler, Bernhard (2010) NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1. Proceedings of the National Academy of Sciences of the United States of America, 107 (31). pp. 13924-13929. ISSN 1091-6490


Halilovic, Ensar, She, Qing-Bai, Ye, Qing Ye, Pagliarini, Raymond, Sellers, William, Solit, David and Rosen, Neal (2010) PIK3CA mutation uncouples tumor growth and Cyclin D1 regulation from MEK/ERK and mutant KRAS signaling. Cancer Research, 70 (17). pp. 6804-6814. ISSN 0008-5472

Hanessian, Stephen, Shao, Zhihui, Betschart, Claudia, Rondeau, Jean-Michel, Neumann, Ulf and Tintelnot-Blomley, Marina (2010) Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors. Bioorganic and Medicinal Chemistry Letters, 20 (6). pp. 1924-1927. ISSN 0960-894X

Hardaker, Liz, Freeman, Mark, Dale, Nicole, Bahra, Parmjit, Raza, Farheen, Banner, Kathy and Poll, Chris (2010) Exposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung. British Journal of Pharmacology, 160 (8). pp. 1985-1996. ISSN 0007-1188

Hassan, Asm Quamrul, Sharma, Sreenath and Warmuth, Markus (2010) Allosteric inhibition of BCR-ABL. Cell Cycle, 9 (18). pp. 3710-3714. ISSN 1538-4101

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He, Yanli, Zhang, Jiahua, Zheng, Jin'e, Du, Wen, Liu, Wei, Li, Xiaoqing, Chen, Xiangjun, Xiao, Hong, Yang, Lin, Huang, Shiang and Jeay, Sebastien (2010) The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, suppresses survival and resistance to chemotherapy in acute myeloid leukemia cells. Oncology Research, 19 (1). pp. 35-43. ISSN 0965-0407

Hintermann, Samuel, Hurth, Konstanze, Nozulak, Joachim, Tintelnot-Blomley, Marina, Aichholz, Reiner, Blanz, Joachim, Kaupmann, Klemens and Mosbacher, Johannes (2010) Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor. Bioorganic and Medicinal Chemistry Letters. ISSN 1464-3405

Hoegenauer, Klemens, Hinterding, Klaus and Nussbaumer, Peter (2010) S1P receptor mediated activity of FTY720 phosphate mimics. Bioorganic & Medicinal Chemistry Letters, 20 (5). pp. 1485-1487. ISSN 0960-894X

Hoffmann, D, Adler, M, Clement, M, Vaidya, V, Rached, E, Mulrane, L, Gallagher,, WM, Callanan, JJ, Gautier, JC, Matheis, K, Staedtler, Frank, Dieterle, Frank, Walijew, A, Hewitt, P, Ellinger-Ziegelbauer, H, Bonventre, JV, Dekant, W and Mally, A (2010) Performance of Novel Kidney Biomarkers in Preclinical Toxicity Studies. Toxicological Sciences, 116 (1). pp. 8-22.

Holbro, Niklaus, Grunditz, Asa, Wiegert, J Simon and Oertner, Thomas (2010) AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proceedings of the National Academy of Sciences of the United States of America, 107 (36). pp. 15975-15980. ISSN 1091-6490

Holmes, Alan, Soon, Elaine, Southwood, Mark, Machado, Rajiv, Barker, Lucy, Treacy, Carmen, Nicklin, Paul, Walker, Christoph, Budd, David, Pepke-Zaba, Joanna and Morrell, Nicholas (2010) ELEVATED LEVELS OF INFLAMMATORY CYTOKINES ARE STRONG PREDICTORS OF SURVIVAL IN IDIOPATHIC AND FAMILIAL PULMONARY ARTERIAL HYPERTENSION. Circulation, 122 (9). pp. 920-927.

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Hynes, Nancy and Dey, Julien H (2010) Potential for Targeting the Fibroblast Growth Factor Receptors in Breast Cancer. Cancer Research, 70 (13). pp. 5199-5202. ISSN 1538-7445


Iannacone, Matteo, Moseman, E. Ashley, Tonti, Elena, Bosurgi, Lidia, Junt, Tobias, Whelan, Sean P., Guidotti, Luca, von Andrian, Ulrich H. and Henrickson, S.E. (2010) Lymph Node Subcapsular Sinus Macrophages Confer Resistance to CNS Invasion Upon Peripheral Infection With a Neurotropic Virus. Nature, 465 (7301). pp. 1079-1083. ISSN 0028-0836

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Jaeger-Lansky, Agnes, Cejka, Daniel, Ying, Liu, Presser, Matthias, Höflmayer, Doris, Fuereder, Thorsten, Köhrer, Stefan, Wacheck, Volker and Imark, Esther (2010) Effects of vatalanib on tumor growth can be potentiated by mTOR blockade in vivo. Cancer Biology & Therapy, 9 (11). pp. 919-927. ISSN 1538-4047

Jahnke, Wolfgang, Grotzfeld, Robert, Pelle, Xavier, Strauss, Andre, Fendrich, Gabriele, Jacob, Sandra, Cotesta, Simona, Fabbro, Doriano, Furet, Pascal, Mestan, Juergen and Marzinzik, Andreas (2010) Binding or bending: Distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay. Journal of the American Chemical Society, 130 (20). pp. 7043-7048.

Jahnke, Wolfgang and Henry, Christelle (2010) An in vitro assay to measure targeted drug delivery to bone mineral. ChemMedChem, 5 (5). pp. 770-776. ISSN 1860-7179

Jahnke, Wolfgang, Rondeau, Jean-Michel, Cotesta, Simona, Marzinzik, Andreas, Pelle, Xavier, Geiser, Martin, Strauss, Andre, Goette, Marjo, Bitsch, Francis, Hemmig, Rene, Henry, Christelle, Lehmann, Sylvie, Glickman, Fraser, Roddy, Thomas, Stout, Steven and Green, Jonathan (2010) Allosteric non-bisphosphonate inhibitors of farnesyl pyrophosphate synthase identified by fragment-based discovery. Nature Chemical Biology, 6 (6). pp. 660-666. ISSN 1552-4450

Ji, Nan, Meredith, Erik, Liu, Donglei, Adams, Christopher, Artman Iii, Gerald, Jendza, Keith, Ma, Fupeng, Mainolfi, Nello, Powers, James and Zhang, Chun (2010) Syntheses of 1-substituted-3-aminopyrazoles. Tetrahedron Letters, 51 (52). pp. 6799-6801. ISSN 0040-4039

Jiang, Zhengjin, Reilly, John, Everatt, Brian and Briard, Emmanuelle (2010) A rapid vesicle electrokinetic chromatography method for the assessment of Non-Specific Binding of potential PET ligands in-vitro. Journal of Pharmaceutical and Biomedical Analysis., 54 (4). pp. 722-729. ISSN 0731-7085

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Juillard, Audrey, Falgayrac, Guillaume, Cortet, Bernard, Vieillard, Marie-Hélène, Azaroual, Nathalie, Hornez, Jean-Christophe, Penel, Guillaume and Gasser, Juerg Andreas (2010) Molecular interactions between zoledronic acid and bone: an in vitro Raman microspectroscopic study. Bone, 25. ISSN 8756-3282


Keating, Joanna, Haber, Michelle, Zawel, Leigh and Ziegler, David (2010) A small molecule IAP inhibitor sensitises medulloblastoma cells to radiation therapy and cytotoxic chemotherapy in vitro and in vivo. Molecular cancer Therapeutics.

Kettle, Rachel, Simmons, Jenniferh, Schindler, Francis, Jones, Peter, Dicker, Tina, Dubois, Gerald, Giddings, June, Van Heeke, Gino and Jones, Carol (2010) Regulation of Neuregulin 1b1-Induced MUC5AC and MUC5B Expression in Human Airway Epithelium. American Journal of Respiratory Cell Molecular Biology, 42 (4). pp. 472-481. ISSN 1044-1549

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Kitamura, Takanori, Fujishita, Teruaki, Loetscher, Pius, Revesz, Laszlo, Hashida, Hiroki, Kizaka-Kondoh, Shinae, Aoki, Masahiro and Taketo, Makoto M (2010) Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proceedings of the National Academy of Sciences of America, 107 (29). pp. 13063-13068. ISSN 0027-8424

Kohler, Reto, Schmitz, Debora, Cornils, Hauke, Hemmings, Brian Arthur and Hergovich, Alexander (2010) Differential NDR/LATS Interactions with the Human MOB Family Reveal a Negative Role for Human MOB2 in the Regulation of Human NDR Kinases. Molecular and Cellular Biology, 30 (18). pp. 4507-4520. ISSN 1098-5549

Koller, Manuel, Lingenhoehl, Kurt, Schmutz, Markus, Vranesic, Ivan-Toma, Kallen, Joerg, Auberson, Yves, Carcache, David, Mattes, Henri, Ofner, Silvio, Orain, David and Urwyler, Stephan (2010) Quinazolinedione sulfonamides: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity. Bioorganic and medicinal chemistry letters, 21 (11). pp. 3358-3361. ISSN 0960-894X

Koller, Manuel and Urwyler, S (2010) Novel NMDA Receptor Antagonists: A Review of Compounds Patented since 2006. Expert Opinion On Therapeutic Patents, 20 (12). pp. 1683-1702. ISSN 1354-3776

Kometani, Motohiko, Nonomura, Kazuhiko, Tomoo, Takashi and Niwa, Satoru (2010) Hurdles in the drug discovery of cathepsin K inhibitors (Review). Current Topics of Medicinal Chemistry, 10 (7). pp. 733-744. ISSN 1568-0266

Kovarik, John M, Stitah, Sylvie, Slade, Alan, Vitaliti, Alessandra, Straube, Frank, Grenet, Olivier, Winter, Serge, Sfikas, Nikolaos and Seiberling, Michael (2010) Sotrastaurin and cyclosporine drug interaction study in healthy subjects. Biopharmaceutics & Drug Disposition, 31 (5-6). pp. 331-339. ISSN 1099-081X

Kovarik, John M, Stitah, Sylvie, Slade, Alan, Vitaliti, Alessandra, Straube, Frank, Grenet, Olivier, Winter, Serge, Sfikas, Nikolaos and Seiberling, Michael (2010) Sotrastaurin and tacrolimus coadministration: effects on pharmacokinetics and biomarker responses. Journal of Clinical Pharmacology, 50 (11). pp. 1260-1266. ISSN 1552-4604

Kovarik, John M. and Slade, Alan (2010) Overview of sotrastaurin clinical pharmacokinetics. Therapeutic Drug Monitoring, 32 (5). pp. 540-543. ISSN 1536-3694

Kramer, Christian and Gedeck, Peter (2010) Leave-cluster-out crossvalidation is appropriate for Scoring Functions derived on diverse protein datasets. Journal of Chemical Information and Modeling, 50 (11). pp. 1961-1969. ISSN 1549-960X

Krol, Jacek, Loedige, Inga and Filipowicz, Witold (2010) The widespread regulation of microRNA biogenesis, function and decay. Nature Reviews. Genetics, 11 (9). pp. 597-610. ISSN 1471-0064

Kuhen, Kelli, Gilligan, James, Gagaring, Kerstin Mae, Borboa, Rachel, Francek, Carolyn, Zhong, Chen, Dagostino, Eleanor, Justin, Stockmyer, Yu, Wang, Brinker, Achim, Engels, Ingo, Taylor, Jennifer, Chatterjee, Arnab, Glynne, Richard, Kuhen, Kelli, Greg, Crowther and Stolz, Barbara (2010) GNF ID 100602: Identification of inhibitors for putative malaria drug targets amongst novel antimalarial compounds. Molecular and Biochemical Parasitology.

Kumar, Ashutosch, Heise, Henrike, Blommers, Marcel J.J., Krastel, Philipp, Schmitt, Esther, Petersen, Frank, Mandelkow, Eva-Maria, Carlomagno, Teresa, Griesinger, Christian and Baldus, Marc (2010) Interaction of epothilone B (patupilone) with microtubules as detected by two-domesional Solid-state NMR. Angewandte Chemie International Edition, 49 (41). pp. 7504-7507. ISSN 1433-7851

Kumar Dev, Kumlesh, Bouhelal, Rochdi, Barske, Carmen, Guerini, Danilo, Gasparini, Fabrizio, Mir, Anis Khusro, Orain, David, Osinde, Maribel, Picard, Anne, Dubois, Celine, Tasdelen, Engin, Haessig, Samuel and Mattes, Henri (2010) Design and Synthesis of Selective and Potent Orally Active S1P5 Agonists. ChemMedChem, 5 (10). pp. 1693-1696. ISSN 1860-7179


Landrum, Gregory and Palmer, Andrew (2010) A Postgresql cartridge for similarity searching. RDKit: open source cheminformatics.

Landrum, Gregory, Palmer, Andrew, Davies, John and Berthold, Michael (2010) RDKit nodes for knime. Knime community website.

Langdon, Sarah, Ertl, Peter and Brown, Nathan (2010) Bioisosteric Replacement and Scaffold Hopping in Lead Generation and Optimization. Molecular Informatics, 29 (5). pp. 366-385.

Leder, Lukas, Stark, Wilhelm, Freuler, Felix, Marsh, May, Meyerhofer, Marco, Stettler, Thomas, Mayr, Lorenz, Britanova, Olga V, Strukova, Lydia A, Chudakov, Dmitriy M and Souslova, Ekaterina A (2010) The Structure of Ca2+ Sensor Case16 Reveals the Mechanism of Reaction to Low Ca2+ Concentrations. Sensors, 10 (9). pp. 8143-8160. ISSN 1424-8220

Lee, Lac, Granda, Brian, Dean, Karl, Tao, Jianshi, Liu, Eugene, Zhang, Rui, Peukert, Stefan, Wattanasin, Sompong, Xie, Xiaoling, Ryder, Neil, Tommasi, Ruben and Deng, Gejing (2010) Biophysical investigation of the mode of inhibition of tetramic acids, the allosteric inhibitors of undecaprenyl pyrophosphate synthase. Biochemistry, 49 (25). pp. 5366-5376. ISSN 1520-4995

Lehmann, Hansjoerg and La Vecchia, Luigi (2010) Scale-up of Organic Reactions in a Pharmaceutical Kilo-Lab Using a Commercial Microwave Reactor. Organic Process Research & Development, 14 (3). pp. 650-656.

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Lin, Chi-Iou, Lorch, Jochen, Whang, Edward E, Jiang, Xiaofeng, Price, Brendan D, He, Frank, Du, Jinyan, Carothers, Adelaide M, Nose, Vania, Moore, Francis D Jr, Ruan, Daniel T and Imark, Esther (2010) Autophagy induction with RAD001 improves chemosensitivity and radiosensitivity in papillary thyroid cancer. Molecular Cancer Research, 8 (9). pp. 1217-1226. ISSN 1541-7786

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Lohmann, Felix, Loureiro, Joseph, Su, Hui, Fang, Qing, Lei, Hong, Lewis, Tanya, Yang, Yi, Labow, Mark, Li, En, Taiping, Chen and Kadam, Shilpa (2010) KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation. Stem Cells, 28 (2). pp. 201-212. ISSN 1066-5099

Loibl, Andreas (2010) The Influence of Epistemological Beliefs on Training Outcomes A Correlation Analysis of Training Variables in a Workplace Setting. University of Freiburg, Germany, - (-).


Ma, Hong, Togawa, Akashi, Soda, Keita, Zhang, Junhui, Lee, Sik, Ma, Ming, Yu, Zhiheng, Ardito, Thomas, Czyzyk, Jan, Diggs, Lonnette, Joly, Dominique, Hatakeyama, Shinji, Kawahara, Eiji, Holzman, Lawrence B., Guan, Jun Lin and Ishibe, Shuta (2010) Loss of focal adhesion kinase activation in podocytes protects mice from proteinuria and foot process effacement. Journal of the American Society of Nephrolgy, 21 (7). pp. 1145-1156.

Malinverni, Claire, Unterreiner, Adeline, Staal, Jens, Demeyer, Annelies, Galaup, Marion, Luyten, Marcel, Beyaert, Rudi and Bornancin, Frederic (2010) Cleavage by MALT1 induces cytosolic release of A20. Biochem Biophys Res Commun, 400 (4). pp. 543-547. ISSN 0006-291X

Manley, Paul W., Stiefl, Nikolaus, Jacob, Sandra, Kaufman, Susan, Mestan, Juergen, Wiesmann, Marion, Gallagher, Neil and Woodman, Richard (2010) Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib. Bioorganic Medicinal Chemistry, 18 (19). pp. 6977-6986. ISSN 0968-0896

Marrer, Estelle and Dieterle, Frank (2010) Impact of biomarker development on drug safety assessment. Toxicology and Applied Pharmacology, 243 (2). pp. 167-179. ISSN 0041-008X

Martin, Laetitia, Marzinzik, Andreas, Ley, Steven V. and Baxendale, Ian R. (2010) Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow reactor. Organic Letters. ISSN 1523-7052

Martus, Hans-Joerg, Hayashi, Makoto, Dearfield, Kerry, Kasper, Peter, Lovell, David and Thybaud, Veronique (2010) Compilation and Use of Genetic Toxicity Historical Control Data. Mutation Research, 723 (2). pp. 87-90. ISSN 0027-5107

Massey, A. J., Schoepfer, Joseph, Brough, P. A., Brueggen, Josef, Chene, Patrick, Drysdale, M. J., Pfaar, Ulrike, Radimerski, Thomas, Ruetz, Stephan, Schweitzer, Alain, Wood, M, Garcia-Echeverria, Carlos and Jensen, Michael Rugaard (2010) Preclinical anti-tumor activity of the orally available Hsp90 inhibitor NVP-BEP800. Molecular cancer therapeutics, 9 (4). pp. 906-919.

Masuya, Keiichi and Teno, Naoki (2010) Small molecules for bone diseases. Expert Opinion on Therapeutic Patents, 20 (4). pp. 563-582. ISSN 1354-3776

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McPherson, Jamie, Rivero, Guadalupe, Baptist, Myma, Llorente, Javier, Al-Sabah, Suleiman, Krasel, Cornelius, Dewey, William L, Bailey, Chris P, Rosethorne, Liz, Charlton, Steven, Henderson, Graeme and Kelly, Eamonn (2010) μ-Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization. Molecular Pharmacology, 78 (4). pp. 756-766. ISSN 0026-895X

Meredith, Erik, Ardayfio, Ophelia, Beattie, Kimberley, Dobler, Markus, Enyedy, Istvan, Gaul, Christoph, Hosagrahara, Vinayak, Jewell, Charles, Koch, Keith, Lee, Wendy, Lehmann, Hansjoerg, McKinsey, Timothy, Miranda, Karl, Pagratis, Nikos, Pancost, Margaret, Patnaik, Anup, Plato, Craig, Qian, Ming, Rajaraman, Vasumathy, Rao, Chang, Rozhitskaya, Olga, Ruppen, Thomas, Shi, Jie, Siska, Sarah, Springer, Clayton, Van Eis, Maurice, Vega, Richard, Von Matt, Anette, Yang, Lihua, Yoon, Taeyoung, Zhang, Ji, Zhu, Na and Monovich, Lauren (2010) Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors. Journal of Medicinal Chemistry, 53 (15). pp. 5400-5421. ISSN 0022-2623

Meredith, Erik, Burgis, Robin, Beattie, Kimberley, Capparelli, Michael, Dipietro, Lucian, Gamber, Gabriel, Hosagrahara, Vinayak, Jewell, Charles, Lee, Wendy, Miranda, Karl, Rao, Chang, Rozhitskaya, Olga, Soldermann, Nicolas, Van Eis, Maurice, Vega, Richard, Yan, Wanlin, Zhu, Qingming, Monovich, Lauren, Chapo, Joseph, Hood, David, Koch, Keith, Lemon, Douglas, McKinsey, Timothy, Pagratis, Nikos, Phan, Dillon, Plato, Craig, Springer, Clayton and Enyedy, Istvan (2010) Identification of Potent and Selective Aminobipyridyl Inhibitors of Protein Kinase D. Journal of Medicinal Chemistry, 53 (15). pp. 5422-5438. ISSN 1520-4804

Micoli, Francesca, Rondini, Simona, Pisoni, Ivan, Proietti, Daniela, Berti, Francesco, Costantino, Paolo, Rappuoli, Rino, Szu, Shousun, Saul, Allan and Martin, Laura (2010) Vi-CRM197 as a new conjugate vaccine against Salmonella Typhi. Vaccine, 29 (4). pp. 712-720. ISSN 0264-410X

Miller, Keith, Dunsmore, Colin, Leeds, Jennifer, Patching, Simon, Sachdeva, Meena, Blake, Katy, Stubbings, William, Simmons, Katie, Henderson, Peter, De Los Angeles, Joseph, Fishwick, Colin and Chopra, Ian (2010) Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ). Journal of Antimicrobial Chemotherapy, 65 (12). pp. 2566-2573. ISSN 1460-2091

Miller, Todd W, Hennessy, Bryan T, Gonzalez-Angulo, Ana M, Fox, Emily M, Mills, Gordon B, Ghazoui, Zara, Dowsett, Mitch, Higham, Catherine, Garcia-Echeverria, Carlos, Shyr, Yu and Arteaga, Carlos L (2010) Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone-dependence in estrogen receptor-positive breast cancer cells. Journal of clinical investigation, 120 (7). pp. 2406-2413. ISSN 0021-9738

Milletti, Francesca and Vulpetti, Anna (2010) Tautomer Preference in PDB Complexes and its Impact on Structure-Based Drug Discovery. Journal of Chemical Information and Modeling, 50 (6). pp. 1062-1074.

Minoux, Maryline and Rijli, Filippo M (2010) Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development. Development, 137 (16). pp. 2605-2621. ISSN 1477-9129

Mittal, Ashwani, Bhatnagar, Shephali, Trifilieff, Estelle, Wauters, Sandrine, li, hong, makonchuk, denys, Glass, David and kumar, ashok (2010) TWEAK/Fn14 Regulates Denervation-Induced Skeletal Muscle Atrophy through an “Inside-Out” Signaling Pathway. J Cell Biol, 188 (6). pp. 833-849. ISSN 10.1083/jcb.200909117

Moeker, Nina, Dean, Charles and Tao, Jianshi (2010) Pseudomonas aeruginosa increases formation of multidrug tolerant persister cells in response to quorum sensing signaling molecules. Journal of Bacteriology, 192 (7). pp. 1946-1955. ISSN 0021-9193

Moggs, Jonathan (2010) IMI MARCAR consortium - publishable summary - Year 1 progress report. MARCAR & IMI websites.

Moggs, Jonathan (2010) Toxicogenomics : Epigenomics & Impact for Drug Safety Sciences. Bio-IT World on-line journal.

Mouton, Véronique, Toussaint, Louise, Vertommen, Didier, Gueuning, Marie-Agnès, Maisin, Liliane, Havaux, Xavier, Sanchez-Canedo, Cossette, Bertrand, Luc, Dequiedt, Franck, Hemmings, Brian Arthur, Hue, Louis and Rider, Mark H (2010) Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3). The Biochemical Journal, 431 (2). pp. 267-275. ISSN 1470-8728


Nelson, Aaron, Dhimolea, Eugen and Reichert, Janice (2010) Development trends for human monoclonal antibody therapeutics. Nature Reviews Drug Discovery, 9 (10). pp. 767-774. ISSN 1474-1776

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Ohnmacht, Stephan A., Culshaw, Andrew and Greaney, Michael F. (2010) Direct Arylations of 2H-Indazoles On Water. Organic Letters, 12 (2). pp. 224-226. ISSN 1523-7052

Ortega, Adam James (2010) LOCAL APPLICATION OF THE BISPHOSPHONATE ZOLEDRONATE TO PROVIDE MAXIMUM ANCHORAGE FOR EXTRACTION SPACE CLOSURE IN RATS. Thesis in partial fulfillment of the requirements for the degree of Master in Science. Baylor College of Dentistry, Texas A&M Health Science Center.

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Pearlstein, Robert, Hu, Qi-Ying, Zhou, Jing, Yowe, David and Levell, Julian (2010) NEW HYPOTHESES ABOUT THE STRUCTURE-FUNCTION OF PCSK9, PART 1: ANALYSIS OF THE EGF-A DOCKING SITE USING WATERMAP. PROTEINS: Structure, Function, and Bioinformatics.

Pennarun, Bodvael, Kleibeuker, Jan H, Oenema, Tjitske, Stegehuis, Janet H, de Vries, Elisabeth G E and de Jong, Steven (2010) Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL. Analytical Cellular Pathology (Amsterdam), 33 (5-6). pp. 229-244. ISSN 2210-7185

Pieczyk, Markus, Cuttat-Theurillat, Rachel, Nitsche, Eric and Huesken, Dieter (2010) Establishment of an automated process based on FastLane technology for screening of chemically modified siRNAs. QIAGEN News. e1.

Pissot Soldermann, Carole, Gerspacher, Marc, Gaul, Christoph, Holzer, Philipp, Radimerski, Thomas, Regnier, Catherine, Baffert, Fabienne, Drueckes, Peter, Tavares, Gisele, Furet, Pascal, Vangrevelinghe, Eric, Blasco, Francesca, Ottaviani, Giorgio, Ossola, Flavio, Scesa, Julien and Reetz, Janitha (2010) Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors. Bioorganic and Medicinal Chemistry Letters, 20 (8). pp. 2609-2613. ISSN 0960-894X

Plaza-Menacho, Iván, Morandi, Andrea, Mologni, Luca, Piet, Boender, Gambacorti-Passerini, Carlo, Magee, Anthony I., Hofstra, Robert M. W., Knowles, Phillip, McDonald, Neil Q., Hatakeyama, Shinji and Isacke, Clare M. (2010) Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. Journal of Biological Chemistry, 286 (19). pp. 17272-17302. ISSN 0021-9258

Podda, Audino, Saul, Allan, Rashimi, Arora, Bhutta, Zulfiqar, Sinha, Anju, Gaind, Rajni, Singhal, Tanu, Saha, Samir, Brooks, Abdullah, Martin, Laura, Amdekar, Yeshwant, Chitkara, Amar Jeet, Shieh, Mae, Kapur, AMbujam Nair and Chugh, Tulsi Das (2010) Conjugate vaccines for enteric fever: proceedings of a meeting organized in New Delhi, India in 2009. Journal of Infection in Developing Countries, 4 (6). pp. 404-411. ISSN 1972-2680

Poulin, Benoit, Butcher, Adrian, McWilliams, Phillip, Bourgognon, Julie-Myrtille, Pawlak, Robert, Bottrill, Andrew, Mistry, Sharad, Wess, Jurgen, Rosethorne, Liz, Charlton, Steven and Tobin, Andrew (2010) The M3-muscarinic receptor regulates memory and learning in a receptor phosphorylation/arrestin-dependent manner. Proceedings of the National Academy of Sciences, 107 (20). pp. 9440-9445. ISSN 0027-8424

Premkumar, Daniel R, Jane, Esther P, Pollack, Ian F and Imark, Esther (2010) Coadministration of NVP-AEW541 and Dasatinib induces mitochondrial-mediated apoptosis through Bax activation in Malignant Human Glioma Cell Lines. International Journal of Oncology, 37 (3). pp. 633-643. ISSN 1019-6439

Press, Neil and Fozard, John R. (2010) Progress Towards Novel Adenosine Receptor Therapeutics Gleaned From The Recent Patent Literature. Expert Opinion On Therapeutic Patents, 20 (8). pp. 987-1005.

perez, Laurent-Herve, Butler, Matt, Creasey, Tammy, Dzink-Fox, Joann, Gounarides, John, Petit, Stephanie, Ropenga, Anna, Ryder, Neil, smith, kathryn, Smith, Philip and Parkinson, Scott (2010) Direct Bacterial Killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations. PLoS ONE, 5 (6). e10915.


Rangwala, Shamina, Wang, Xiaomei, Lindsley, Loren, Zhang, Yunyu, Calvo, Jennifer, Turner, Gordon, Beaulieu, Valerie, Gao, Jiaping and Markovits, Judit (2010) Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity. Journal of Biological Chemistry.

Raymond, Marianne, Van, Vu Quang, Rubio, Manuel, Welzenbach, Karl and Sarfati, Marika (2010) Targeting SIRP-a protects from type 2 -driven allergic airway inflammation. European Journal of Immunology, 12 (40). pp. 3510-3518. ISSN 0014-2980

Reilly, John, Etheridge, Donnya, Porter, David, Springer, Clayton, Fairhurst, Robin, Everatt, Brian, Jiang, Zhengjin, Aldcroft, Clive, Wright, Penny, Clemens, Ian, Cox, Brian, Press, Neil and Watson, Simon (2010) Studies in Drug Albumin binding using HSA and RSA affinity methods. Journal of Liquid Chromatography and Related Technologies, 34 (4). pp. 317-327. ISSN 1082-6076

Rigel, Dean, Fu, Fumin, Beil, Michael, Hu, Chii-Whei, Liang, Guiqing and Jeng, Arco (2010) Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11{beta}-hydroxylase inhibitor metyrapone. Journal of Pharmacology and Experimental Therapeutics, 334 (1). pp. 232-243. ISSN 0022-3565

Rosenquist, Thomas, Einolf, Heidi, Dickman, Kathleen, Wang, Lai, Smith, Amanda and Grollman, Arthur (2010) Cytochrome P450 1A2 is responsible for detoxifying aristolochic acid in the mouse. Drug Metabolism and Disposition, 38 (5). pp. 761-768. ISSN 0090-9556

Roth, Daniel Robert and Perentes, Elias (2010) Ectopic thyroid tissue in the periaortic area, cardiac cavity and aortic valve in a Beagle dog – a case report. Experimental and Toxicologic Pathology.

Ryder, Neil (2010) Discontinued drugs in 2008: anti-infectives. Expert Opinion on Investigational Drugs, 19 (1). pp. 1-21. ISSN 1354-3784


Schirle, Markus (2010) J. Reinders and A. Sickmann: "Proteomics. Methods and Protocols" (Methods in Molecular Biology). Analytical and Bioanalytical Chemistry, 396 (7). pp. 2367-2368. ISSN 1618-2642

Schmid, Herbert (2010) Pasireotide (SOM230) as a potential treatment for endocrine and non-endocrine tumors. Current Drug Therapy, 5 (4). pp. 301-311. ISSN 1574-8855

Schoenenberger, Philipp, Zhang Schärer, Yan-Ping and Oertner, Thomas (2010) Channelrhodopsin as a tool to study synaptic transmission and plasticity. Experimental Physiology. ISSN 1469-445X

Schroer, Kirsten, Kittelmann, Matthias and Luetz, Stephan (2010) Recombinant human cytochrome P450 monooxygenases for drug metabolite synthesis. Biotechnology & Bioengineering.

Shimshek, Derya, Mueller, Matthias, Wiessner, Christoph, Schweizer, Tatjana and Van Der Putten, P. Herman (2010) The HSP70 molecular chaperone is not beneficial in a mouse model of α-synucleinopathy. Public Library of Science one, 5 (4). e10014. ISSN 1932-6203

Sinkkonen, Lasse, Hugenschmidt, Tabea, Filipowicz, Witold and Svoboda, Petr (2010) Dicer Is Associated with Ribosomal DNA Chromatin in Mammalian Cells. PloS One, 5 (8). e12175-e12175. ISSN 1932-6203

Spanka, Carsten, Glatthar, Ralf, Desrayaud, Sandrine, Fendt, Markus, Orain, David, Troxler, Thomas J. and Vranesic, Ivan-Toma (2010) Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity. Bioorganic & Medicinal Chemistry Letters, 20 (1). pp. 184-188. ISSN 0960-894X

Spencer, John, Baltus, Christine, Patel, Hiren, Press, Neil, Callear, Samantha K., Male, Louise and Coles, Simon (2010) Microwave Mediated Synthesis of an Arylboronate Library. Journal of combinatorial chemistry, 13 (1). pp. 24-31. ISSN 1520-4766

Straub, Christopher (2010) Targeting IAPs as an Approach to Anti-cancer Therapy. Current Topics in Medicinal Chemistry, 11 (3). pp. 291-316. ISSN 1568-0266

Sunkara, Gangadhar, Yeh, Ching-Ming, Ligueros-Saylan, Monica, Kawashita, Hiroto, Koseki, Nozomu and Fukui, Yoshihiro (2010) ASSESSMENT OF ETHNIC DIFFERENCES IN THE PHARMACOKINETICS OF VALSARTAN. Journal of Bioequivalence and Bioavailability, 2 (6). pp. 120-124. ISSN 0975-0851


Taguchi, Fumiko, Kodera, Yasuo, Yanagihara, Kazuyoshi, Tamura, Tomohide, Koizumi, Fumiaki and Imark, Esther (2010) Efficacy of RAD001 (everolimus) in peritoneal dissemination of gastric cancer. Investigational New Drugs, 29 (6). pp. 1198-1205. ISSN 0167-6997

Takeda, Shuko, Sato, Naoyuki, Uchio-Yamada, Kozue, Sawada, Kyoko, Kunieda, Takanori, Takeuchi, Daisuke, Kurinami, Hitomi, Shinohara, Mitsuru, Rakugi, Hiromi, Morishita, Ryuichi and Staufenbiel, Matthias (2010) Diabetes Accelerated Memory Dysfunction via Cerebrovascular Inflammation and Aβ Deposition in Alzheimer Mouse Model with Diabetes. Proceedings of the National Academy of Sciences of the United States of America, 107 (15). pp. 7036-7041. ISSN 0027-8424

Tang, Xiao Yan, Takekoshi, Susumu, Itoh, Johbu, Shoji, Sunao, Umemura, Shinobu, Terachi, Toshiro, Osamura, Robert Yoshiyuki and Imark, Esther (2010) Somatostatin analogue inhibits mobility of prostate carcinoma cells and SSTR2a is a prognostic and therapeutic biomarker for prostate carcinoma. International Journal of Oncology, 37 (5). pp. 1077-1083. ISSN 1019-6439

Teno, Naoki and Masuya, Keiichi (2010) Orally Bioavailable Cathepsin K inhibitors with Pyrrolopyrimidine Scaffold. Current Topics in Medicinal Chemistry, 10 (7). pp. 752-766. ISSN 1568-0266

Thamm, Douglas H., Huelsmeyer, Michael K., Mitzey, Ann M., Qurollo, Barbara, Rose, Barbara J. and Kurzman, Ilene D. (2010) RT-PCR-based tyrosine kinase display profiling of canine melanoma: IGF-1 receptor as a potential therapeutic target. Melanoma Research, 20 (1). pp. 35-42. ISSN 0960-8931

Thaçi, Diamant, Kaufmann, Roland, Bieber, Thomas, Hanfland, Julia, Hauffe, Suzanne, Koehne-Voss, Stephan and Waldmeier, Felix (2010) Percutaneous absorption of pimecrolimus is not increased in patients with moderate to severe atopic dermatitis when pimecrolimus cream 1% is applied under occlusion. Dermatology (Basel, Switzerland), 221 (4). pp. 342-351. ISSN 1421-9832

Thaçi, Diamant, Kaufmann, Roland, Bieber, Thomas, Hanfland, Julia, Hauffe, Suzanne, Koehne-Voss, Stephan and Waldmeier, Felix (2010) Percutaneous absorption of pimecrolimus is not increased in patients with moderate to severe atopic dermatitis when pimecrolimus cream 1% is applied under occlusion. Dermatology (Basel, Switzerland), 221 (4). pp. 342-351. ISSN 1421-9832

Tranchevent, Léon-Charles, Schuierer, Sven, Dengler, Uwe and Moreau, Yves (2010) Large-scale benchmark of Endeavour using MetaCore maps. Bioinformatics, 26 (15). pp. 1922-1923. ISSN 1367-4803

Troxler, Thomas J., Hurth, Konstanze, Schuh, Karl Heinrich, Schoeffter, Philippe, Langenegger, Daniel, Enz, Albert and Hoyer, Daniel (2010) Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 20 (5). pp. 1728-1734. ISSN 0960-894X

Tsukamoto, Z, Yamanaka, R, Inagaki, K, Ritson, Margaret, Yamashita, M, Otani, H, Takeda, M, Suzuki, J, Ogura, T, Iwasaki, Y and Makino, H (2010) Effects of bone morphogenetic protein (BMP) on adrenocorticotropin production by pituitary corticotrope cells: involvement of up-regulation of BMP receptor signaling by somatostatin analogs. Endicronology, 151 (3). pp. 1129-1141. ISSN 0013-7227


Van, VQ, Raymond, M, Baba, N, Wakahara, K, Martinez-Torres, AC, Santos, AS and Sarfati, M (2010) Targeting SIRP-α protects from type 2-driven allergic airway inflammation. Eur J Immunol..

Varin, Thibault, Gubler, Hanspeter, Parker, Christian, Zhang, Ji, Raman, Pichai, Ertl, Peter and Schuffenhauer, Ansgar (2010) Compound Set Enrichment: A novel approach to analysis of primary HTS data. Journal of Chemical Information and Modeling. ISSN 1549-960X

Velcicky, Juraj and Pflieger, Daniel (2010) Synthesis of 3-chloro-4-fluoro-7,8-dihydro-6H-isoquinolin-5-one and its derivatives. Synlett. pp. 1397-1401. ISSN 1437-2096

Vitari, Alberto (2010) Career development opportunity at Novartis. Career development opportunity at Novartis.

Vulpetti, Anna and Landrum, Gregory (2010) Source codes for methods implemented in RDKit. RDKit project / Journal of Fluorine Chemistry (see also OAK=1376), 131 (5). pp. 570-577.

Vulpetti, Anna, Landrum, Gregory, Ruedisser, Simon, Erbel, Paulus and Dalvit, Claudio (2010) 19F NMR Chemical Shift Prediction with Fluorine Fingerprint Descriptor. Journal of Fluorine Chemistry, 131 (5). pp. 570-577.

Vulpetti, Anna and Milletti, Francesca (2010) Predicting Polypharmacology by Binding Site Similarity: from Kinases to the Protein Universe. Journal of Chemical Information and Modeling, 50 (8). pp. 1418-1431. ISSN 1549-960X

Vulpetti, Anna, Schiering, Nikolaus and Dalvit, Claudio (2010) Combined Use of Computational Chemistry, NMR Screening and X-Ray Crystallography for Identification and Characterization of Fluorophilic Protein Environments. Proteins, 78 (16). pp. 3281-3291. ISSN 1097-0134


Waldmeier, Felix, Bruin, Gerard J, Glaenzel, Ulrike, Hazell, Katharine, Sechaud, Romain, Warrington, Steve and Porter, John B (2010) Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state. Drug metabolism and disposition: the biological fate of chemicals, 38 (5). pp. 808-816. ISSN 1521-009X

Waldmeier, Felix, Bruin, Gerardus, Glaenzel, Ulrike, Hazell, Katharine Mary, Sechaud, Romain, Warrington, Steve and Porter, John B (2010) Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state. Drug metabolism and disposition: the biological fate of chemicals, 38 (5). pp. 808-816. ISSN 1521-009X

Waldmeier, Felix, Bruin, Gerardus, Glaenzel, Ulrike, Hazell, Katharine Mary, Sechaud, Romain, Warrington, Steve and Porter, John B (2010) Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state. Drug metabolism and disposition: the biological fate of chemicals, 38 (5). pp. 808-816. ISSN 1521-009X

Wang, Dadong, Lagerstrom, Ryan, Sun, Changming, Bishof, Leanne, Vallotton, Pascal and Goette, Marjo (2010) HCA-Vision: Automated Neurite Outgrowth Analysis. Journal of Biomolecular Screening, 15 (9). pp. 1165-1170. ISSN 1087-0571

Wang, Tao, Lapadula, Daniel, Jacobson-Kram, David, Pilaro, Anne, Jacobs, Abigail, Brown, Paul, Lipscomb, John and McGuinn, David (2010) New and Revised ICH Guidelines: Insight and Challenges. Toxicological Sciences, 118 (2). pp. 356-367. ISSN 1096-6080

Wang, Youjun, Deng, Xiaoxiang, Mancarella, Salvatore, Hendron, Eunan, Eguchi, Satoru, Soboloff, Jonathan, Tang, Xiang D. and Gill, Donald L. (2010) The Calcium store-sensor, STIM1, reciprocally controls Orai1 and Cav1.2 channels. Science, 330 (6000). pp. 105-109. ISSN 0036-8075

Waters, Nigel and Lombardo, Franco (2010) Use of the Øie-Tozer Model in Understanding Mechanisms and Determinants of Drug Distribution. Drug Metabolism and Disposition, 38 (7). pp. 1159-1165.

Watson, Catherine, Weissbach, Nicole, Kjems, Lise, Ayalasomayajula, Surya, Zhang, Yiming, Chang, Ih, Navab, Mohamad, Hama, Susan, Hough, Greg, Reddy, Srinivasa, Soffer, Daniel, Rader, Daniel, Fogelman, Alan and Schecter, Alison (2010) Treatment of Patients with Cardiovascular Disease with L-4F, an Apo-A1 mimetic, Did Not Improve Select Biomarkers of HDL Function. Journal of Lipid Research, 52 (2). pp. 361-373. ISSN 0022-2275

Webb, Randy, Schiering, Nikolaus, Sedrani, Richard and Maibaum, Juergen Klaus (2010) Direct Renin Inhibitors as A New Therapy for Hypertension. Journal of Medicinal Chemistry.

Weisberg, Ellen, Roesel, Johannes, Furet, Pascal, Bold, Guido, Imbach, Patricia, Floersheimer, Andreas, Jiang, Jingrui, Manley, Paul W., Ray, Arghya and Griffin, James D (2010) Anti-Leukemic Effects of Novel First and Second generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes & Cancer, 1 (10). pp. 1021-1032. ISSN 1947-6019

Widler, Leo, Altmann, Eva, Beerli, Rene, Breitenstein, Werner, Bouhelal, Rochdi, Buhl, Thomas, Gamse, Rainer, Gerspacher, Marc, Halleux, Christine, John, Markus, Lehmann, Hansjoerg, Kalb, Oskar, Kneissel, Michaela, Missbach, Martin, Mueller, Irene, Reidemeister, Sibylle, Taillardat, Agnes, Tommasi, Ruben, Weiler, Sven, Wolf, Romain, Seuwen, Klaus and Renaud, Johanne (2010) 1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists. Journal of Medicinal Chemistry, 53 (5). pp. 2250-2263. ISSN 0022-2623

Wiechert, Martin T, Judkewitz, Benjamin, Riecke, Hermann and Friedrich, Rainer W (2010) Mechanisms of pattern decorrelation by recurrent neuronal circuits. Nature Neuroscience, 13 (8). pp. 1003-1010. ISSN 1546-1726

Wirth, Thomas, Audiger, Logan, Robinson, Richard and Elmore, Simon C. (2010) Ritter Reactions in Flow. CHEMSUSCHEM, 2010 (20). pp. 3099-3103. ISSN 1864-5631

Wirth, Thomas, Elmore, Simon, C., Brandt, Johan, C. and Robinson, Richard (2010) Safe and Efficient Ritter Reactions in Flow. SYNLETT, 20 (10). pp. 3099-3103. ISSN 0936-5214

Wolf, Samuel, Lorenz, Jana, Mössner, Joachim and Wiedmann, Marcus (2010) Treatment of biliary tract cancer with NVP-AEW541: Mechanisms of action and resistance. World Journal of Gastroenterology, 16 (2). pp. 156-166. ISSN 1007-9327

Woodward, Hannah, Smith, Nichola and Gallagher, Timothy (2010) Exo-Glycals: Versatile Intermediates in the Synthesis of 1,1-Disubstituted C Glycosides. Synlett (6). pp. 869-872. ISSN 0936-5214


Xu, Lingfei, Zhang, Yunyu, Cohen, Steven and Dipetrillo, Keith (2010) TrkB Agonist Antibody Dose-Dependently Raises Blood Pressure in Mice with Diet-Induced Obesity. American Journal of Hypertension.

Xu, Qingping, Abdubeck, Polat, Chen, Connie, Chiu, Michelle, Feuerhelm, Julie, Grant, Joanna, Klock, Heath, Knuth, Mark, Okach, Linda, Nigoghossian, Edward, Puckett, Christina, Wooten, Tiffany, Lesley, Scott and Stolz, Barbara (2010) GNF ID 100606: Crystal structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, F66. pp. 1-11. ISSN 1744-3091

Xu, Qingping, Abdubeck, Polat, Chen, Connie, Feuerhelm, Julie, Grant, Joanna, Klock, Heath, Knuth, Mark, Nigoghossian, Edward, Okach, Linda, Puckett, Christina, Wooten, Tiffany, Zhou, Jiadong, Lesley, Scott and Stolz, Barbara (2010) GNF ID 100604: Crystal structure of a membrane attack complex/perforin (MACPF) family protein from a human gut symbiont Bacteroides thetaiotaomicron. Acta F.


Yan, Wei, Goette, Marjo, Hofmann, Gabriele, Zaror, Isabel and Sim, Bang Janet (2010) High-level Soluble Expression, Purification and Characterization of Active Human Midkine from Escherichia coli. Protein Expression and Purification, 70 (2). pp. 270-276. ISSN 1046-5928

Yang, Xiuwei H., Flores, Ludmila M., Li, Qinglin, Zhou, Pengcheng, Xu, Fenghui, Krop, Ian E. and Hemler, Martin E. (2010) Disruption Of Laminin-Integrin-CD151-FAK Axis Sensitizes Breast Cancer Cells To ErbB2 Antagonists. Cancer Research, 70 (6). pp. 2256-2263.


Zanin, Esther, Pacquelet, Anne, Scheckel, Claudia, Ciosk, Rafal and Gotta, Monica (2010) LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline. Journal of Cell Science, 123 (Pt 16). pp. 2717-2724. ISSN 1477-9137

Zhou, Fei, Chang, Zai, Zhang, Luqing, Hong, Young-Kwon, Shen, Bin, Wang, Bo, Zhang, Fan, Lu, Guangming, Tvorogov, Denis, Alitalo, Kari, Hemmings, Brian Arthur, Yang, Zhongzhou and He, Yulong (2010) Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development. The American Journal of Pathology. ISSN 0002-9440

Zhu, Wenbin, Wang, Lan, Palmateer, Julie M, Libal, Nicole L, Hurn, Patricia D, Herson, Paco S, Murphy, Stephanie J and Imark, Esther (2010) Isoflurane Preconditioning Neuroprotection In Experimental Focal Stroke Is Androgen-Dependent In Male Mice. Neuroscience, 169 (2). pp. 758-769. ISSN 0306-4522

Zollinger, Markus, Gschwind, Hans-Peter, Jin, Yi, Sayer, Claudia, Zecri, Frederic and Hartmann, Stefan (2010) Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways. Drug Metabolism and Disposition. ISSN 1521-009X

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