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The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria.

Borrmann, Steffen and Sallas, William and Machevo, Sonia and González, Raquel and Björkman, Anders and Mårtensson, Andreas and Hamel, Mary and Juma, Elizabeth and Peshu, Judy and Ogutu, Bernhards and Djimdé, Abdoulaye and D'Alessandro, Umberto and Marrast, Anne Claire and Lefevre, Gilbert and Kern, Steven (2010) The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria. Tropical medicine & international health : TM & IH, 15 (4). pp. 434-441. ISSN 1365-3156

Abstract

Artemether-lumefantrine (AL) is first-line treatment for uncomplicated malaria in many African countries. Concomitant food consumption may affect absorption of lumefantrine but data in the most important target population, i.e. children, are lacking. Therefore, we evaluated the effect of food intake on oral lumefantrine bioavailability in African children with malaria.

Item Type: Article
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Date Deposited: 28 Jan 2012 00:45
Last Modified: 01 Feb 2013 00:47
URI: https://oak.novartis.com/id/eprint/5090

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