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Quinazolinedione sulfonamides: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity

Koller, Manuel and Lingenhoehl, Kurt and Schmutz, Markus and Vranesic, Ivan-Toma and Kallen, Joerg and Auberson, Yves and Carcache, David and Mattes, Henri and Ofner, Silvio and Orain, David and Urwyler, Stephan (2010) Quinazolinedione sulfonamides: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity. Bioorganic and medicinal chemistry letters, 21 (11). pp. 3358-3361. ISSN 0960-894X

Abstract

Quinazoline-2,4-diones with a sulfonamide group attached to the N(3) ring atom constitute a novel class of competitive AMPA receptor antagonists. One of the synthesized compounds, 28, shows nanomolar receptor affinity, whereas other examples of the series display oral anticonvulsant activity in animal models.

Item Type: Article
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Keywords: AMPA receptor antagonist Glutamate receptor Anticonvulsive agents Quinazoline-2,4-dione sulfonamides
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/3794

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