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Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow reactor

Martin, Laetitia and Marzinzik, Andreas and Ley, Steven V. and Baxendale, Ian R. (2010) Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow reactor. Organic Letters. ISSN 1523-7052

Abstract

A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride precursors has been developed and used to prepare quinoxalines in a multistep sequence without isolation of the potentially explosive diazoketone. The protocol showcases an efficient in-line purification using supported scavengers with time-saving and safety benefits and in particular a reduction in the operator's exposure to carcinogenic phenylenediamines

Item Type: Article
Additional Information: archiving not formally supported by this publisher
Keywords: diazoketone; quinoxaline; flow chemistry
Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/3936

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