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Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response

Fendt, Markus and Buchi, Melanie and Buerki, Hugo and Imobersteg, Stefan and Ricoux, Berangere and Suply, Thomas and Sailer, Andreas (2010) Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response. Behavioral Brain Research. ISSN 0166-4328

Abstract

The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype. These results support an important role of neuropeptide S in regulating locomotor activity.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Acoustic startle response; anxiety; circadian rhythm; freezing; prepulse inhibition
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/3749

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