Fendt, Markus and Buchi, Melanie and Buerki, Hugo and Imobersteg, Stefan and Ricoux, Berangere and Suply, Thomas and Sailer, Andreas (2010) Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response. Behavioral Brain Research. ISSN 0166-4328

Abstract

The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype. These results support an important role of neuropeptide S in regulating locomotor activity.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez http://www.wiley.com/bw/journal.asp?ref=...
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Acoustic startle response; anxiety; circadian rhythm; freezing; prepulse inhibition
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez http://www.wiley.com/bw/journal.asp?ref=...
Date Deposited:	13 Oct 2015 13:15
Last Modified:	13 Oct 2015 13:15
URI:	https://oak.novartis.com/id/eprint/3749