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Reaction of Fe3(CO)12 with Octreotide – Chemical, Electrochemical and Biological Investigations

Apfel, Ulf_Peter and Rudolph, Manfred and Apfel, Christina and Robl, Christian and Langenegger, Daniel and Hoyer, Daniel and Jaun, Bernhard and Seebach, Dieter and Weigand, Wolfgang (2010) Reaction of Fe3(CO)12 with Octreotide – Chemical, Electrochemical and Biological Investigations. Dalton Transactions, 39 (12). p. 3065. ISSN 1477-92261477-9234

Official URL: http://10.1039/B921299J

Abstract

In search for peptidic [FeFe] hydrogenase mimics the cyclic disulfide sandostatin® (octreotide) was allowed to react with Fe3(CO)12. An Fe2(CO)6 complex was isolated and characterized spectroscopically and by elemental and thermochemical analysis. The complex catalyzes the electrochemical reduction of H+ to H2. It is suggested by radioligand binding assays that the complex retains ca. 10% of the binding affinity for the GCPRs hsstr1-5 of somatostatin.

Item Type: Article
Keywords: somatostatin, octreotide
Date Deposited: 24 Mar 2016 00:45
Last Modified: 24 Mar 2016 00:45
URI: https://oak.novartis.com/id/eprint/1150

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