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New Pyrazolo[1,5a]pyrimidines as Orally Active Inhibitors of Lck

Gommermann, Nina, Buehlmayer, Peter, Von Matt, Anette, Breitenstein, Werner, Masuya, Keiichi, Pirard, Bernard, Furet, Pascal, Jacob, Sandra and Weckbecker, Gisbert (2010) New Pyrazolo[1,5a]pyrimidines as Orally Active Inhibitors of Lck. Bioorganic & Medicinal Chemistry Letters, 20 (12). pp. 3628-3631. ISSN 0960-894X


A novel series of pyrazolo[1,5a]pyrimidines was optimized to target lymphocyte-specific kinase (Lck). An efficient synthetic route was developed and SAR studies towards activity and selectivity are described, leading to Lck inhibitors with enzymatic, cellular and in vivo potency.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: lymphocyte-specific kinase; (Lck)
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Date Deposited: 13 Oct 2015 13:16
Last Modified: 13 Oct 2015 13:16


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