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Design of Two New Chemotypes for Inhibiting the Janus Kinase 2 by Scaffold Morphing

Furet, Pascal and Gerspacher, Marc and Pissot Soldermann, Carole (2010) Design of Two New Chemotypes for Inhibiting the Janus Kinase 2 by Scaffold Morphing. Bioorganic & Medicinal Chemistry Letters, 20 (6). pp. 1858-1860. ISSN 0960-894X

Abstract

JAK2 is a target of high interest in chronic myeloproliferative disorders drug research. Starting from a screening hit, two new JAK2 inhibitor chemotypes were designed by scaffold morphing. The prototype compounds of these new series showed nanomolar inhibition of the kinase.

Item Type: Article
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Additional Information: Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Scaffold morphing; Kinase inhibitor design
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Date Deposited: 13 Oct 2015 13:16
Last Modified: 13 Oct 2015 13:16
URI: https://oak.novartis.com/id/eprint/2154

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