Lehmann, Hansjoerg and La Vecchia, Luigi (2010) Scale-up of Organic Reactions in a Pharmaceutical Kilo-Lab Using a Commercial Microwave Reactor. Organic Process Research & Development, 14 (3). pp. 650-656.

Abstract

A range of pharmaceutically relevant reactions were investigated for scale-up in a kilo-lab environment using a commercial batch microwave reactor. Typical scale-up issues are discussed, taking into account the specific limitations of microwave heating in large scale experiments. Examples for scale-up from 15 mL to 1 L are presented and demonstrate that the synthesis of compounds on greater than 100 g scale is feasible in one batch. Reaction times are significantly reduced and the productivity of our scale-up laboratory is enhanced. Production rates of 0.5 – 1 kg per day have been achieved using microwave technology. The article concludes with a brief discussion of advantages and disadvantages of this type of batch microwave reactor.

Item Type:	Article
Keywords:	microwave assisted organic synthesis, scale-up, organic reactions
Date Deposited:	13 Oct 2015 13:16
Last Modified:	13 Oct 2015 13:16
URI:	https://oak.novartis.com/id/eprint/1816