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Discontinued drugs in 2008: anti-infectives

Ryder, Neil (2010) Discontinued drugs in 2008: anti-infectives. Expert Opinion on Investigational Drugs, 19 (1). pp. 1-21. ISSN 1354-3784


Of the many drugs dropped from development in 2008, 27 were under development for therapy or prophylaxis of infectious diseases. The majority of these were for diseases of viral etiology (fifteen agents), while nine were antibacterials and the remaining three were directed against fungal and protozoan pathogens. The antiviral agents were primarily against HIV and hepatitis C virus, together with agents against hepatitis B virus and West Nile Virus. The antibacterial agents were mostly from known classes (carbapenems, fluroquinolones, oxazolidinones) but also included several novel compounds and approaches. With regard to drug type, nineteen were small-molecule therapeutics, seven were biologics comprising five vaccines and two antibodies, and one was a high molecular weight polymer. Each of these agents is briefly reviewed and the reasons for failure are discussed.

Item Type: Article
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Additional Information: Author can archive post-print (ie final draft post-refereeing); 12 month embargo for STM Journals; on a non-profit server
Keywords: anti-infectives; bacterial infection; discontinued drugs; fungal infection; HCV; HIV; HPV; malaria; vaccine; West Nile virus
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Date Deposited: 13 Oct 2015 13:16
Last Modified: 13 Oct 2015 13:16


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