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GNF ID 100605: Crystal structure of BT_3984, the first representative of the SusD/RagB family of nutrient binding

Abdubeck, Polat and Chen, Connie and Feuerhelm, Julie and Grant, Joanna and Bakolitsa, Constantina and Klock, Heath and Knuth, Mark and Mcmullan, Daniel and Okach, Linda and Puckett, Christina and Lesley, Scott and Stolz, Barbara (2010) GNF ID 100605: Crystal structure of BT_3984, the first representative of the SusD/RagB family of nutrient binding. Acta F.

Abstract

The crystal structure of Bacteroides thetaiotaomicron protein BT_3984 was solved to a resolution
of 1.7 Å by multiple-wavelength anomalous dispersion (MAD) using the semi-automated, highthroughput
pipeline of the Joint Center for Structural Genomics (JCSG), as part of the NIGMS
Protein Structure Initiative (PSI). BT_3984 is the first structure to be determined from the extensive
SusD family of polysaccharide binding proteins, which define a new paradigm for glycan utilization
in dominant members of the human gut microbiota. Structural analysis of BT_3984 reveals an Nterminal
region containing several tetratricopeptide repeats (TPR), while the signature C-terminal
region is less structured and contains extensive loop regions. Sequence and structure analysis of
BT_3984 suggests binding interfaces for other proteins from the polysaccharide utilization
complex

Item Type: Article
Additional Information: grant requirement B. Stolz is NOT an author -- NVS contact person for GNF manuscript approval. This manuscript shall NOT be copied to the OAK internet.
Keywords: Structural Genomics, starch utilization system, gut microbiome, metagenomics
Date Deposited: 13 Oct 2015 13:16
Last Modified: 13 Oct 2015 13:16
URI: https://oak.novartis.com/id/eprint/3112

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