Masuya, Keiichi and Teno, Naoki (2010) Small molecules for bone diseases. Expert Opinion on Therapeutic Patents, 20 (4). pp. 563-582. ISSN 1354-3776

Abstract

Drug discovery for bone diseases has made progress in the last years, and also the research area has dynamically shifted from historical targets (Bisphosphonate, PTH and Calcitonin) to newly confirmed targets or targets re-visited which were biologically validated in the past. Cathepsin K inhibitor would be very closed to lanch into the market, however there are lots of progress and new findings in other relevant targets, which we discuss in this paper.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/20302...
Additional Information:	author can archive post-print (ie final draft post-refereeing); Restrictions: 12 month embargo for STM, Behavioural Science and Public Health Journals 18 month embargo for SSH journals
Keywords:	Bone disease, Bisphosphonate, cathepsin K, v3 antagonists, MMP, Prostaglandin EP4 receptor, Vacuolar H+-ATPase, Secreted Frizzled-related protein
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/20302...
Date Deposited:	13 Oct 2015 13:16
Last Modified:	13 Oct 2015 13:16
URI:	https://oak.novartis.com/id/eprint/1992