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Large-scale benchmark of Endeavour using MetaCore maps

Tranchevent, Léon-Charles and Schuierer, Sven and Dengler, Uwe and Moreau, Yves (2010) Large-scale benchmark of Endeavour using MetaCore maps. Bioinformatics, 26 (15). pp. 1922-1923. ISSN 1367-4803

Abstract

1. Endeavour is a tool that detects the most promising genes within large lists of candidates with respect to a biological process of interest and by combining several genomic data sources.
2. We have benchmarked Endeavour using 454 pathway maps and 833 disease marker sets from MetaCoreTM of GeneGo, Inc containing a total of 10,053 and 12,699 genes respectively. We obtain an AUC of 0.97 for pathway and of 0.77 for disease gene sets.
3. The results indicate that Endeavour can be used to efficiently prioritize candidate genes for pathways and diseases.

Item Type: Article
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Date Deposited: 13 Oct 2015 13:16
Last Modified: 13 Oct 2015 13:16
URI: https://oak.novartis.com/id/eprint/1846

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