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Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects.

Abdulla, Salim and Amuri, Baraka and Kabanywanyi, Abdunoor M and Ubben, David and Reynolds, Christine and Pascoe, Steve and Fitoussi, Serge and Yeh, Ching-Ming and Nuortti, Marja and Sechaud, Romain and Kaiser, Guenther and Lefevre, Gilbert (2010) Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects. Malaria journal, 9. p. 253. ISSN 1475-2875

Abstract

Efforts to ease administration and enhance acceptability of the oral anti-malarial artemether-lumefantrine (A-L) crushed tablet to infants and children triggered the development of a novel dispersible tablet of A-L. During early development of this new formulation, two studies were performed in healthy subjects, one to evaluate the palatability of three flavours of A-L, and a second one to compare the bioavailability of active principles between the dispersible tablet and the tablet (administered crushed and intact).

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF may be used
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Date Deposited: 18 May 2011 23:45
Last Modified: 01 Feb 2013 00:47
URI: https://oak.novartis.com/id/eprint/5089

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