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AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation

Holbro, Niklaus and Grunditz, Asa and Wiegert, J Simon and Oertner, Thomas (2010) AMPA receptors gate spine Ca2+ transients and spike-timing-dependent potentiation. Proceedings of the National Academy of Sciences of the United States of America, 107 (36). pp. 15975-15980. ISSN 1091-6490

Abstract

Spike timing-dependent long-term potentiation (t-LTP) is the embodiment of Donald Hebb's postulated rule for associative memory formation. Pre- and postsynaptic action potentials need to be precisely correlated in time to induce this form of synaptic plasticity. NMDA receptors have been proposed to detect correlated activity and to trigger synaptic plasticity. However, the slow kinetic of NMDA receptor currents is at odds with the millisecond precision of coincidence detection. Here we show that AMPA receptors are responsible for the extremely narrow time window for t-LTP induction. Furthermore, we visualized synergistic interactions between AMPA and NMDA receptors and back-propagating action potentials on the level of individual spines. Supralinear calcium signals were observed for spike timings that induced t-LTP and were most pronounced in spines well isolated from the dendrite. We conclude that AMPA receptors gate the induction of associative synaptic plasticity by regulating the temporal precision of coincidence detection.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: coincidence detection; dendritic spines; caged glutamate; STDP; two-photon imaging
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Date Deposited: 27 Sep 2010 23:45
Last Modified: 01 Feb 2013 00:48
URI: https://oak.novartis.com/id/eprint/3751

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