Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Items where Year is 2018

Up a level
Export as [feed] RSS
Group by: Creators | Item Type | No Grouping
Jump to: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | R | S | T | U | V | W | X | Y | Z
Number of items: 341.


Abend, Andreas and Heimbach, Tycho and Cohen, Michael and Kesisoglou, Filippos and Pepin, Xavier and Suarez, Sandra (2018) DISSOLUTION AND TRANSLATIONAL MODELING STRATEGIES ENABLING PATIENT-CENTRIC PRODUCT DEVELOPMENT M-CERSI WORKSHOP SUMMARY REPORT. American Association of Pharmaceutical Scientists Journal.

Abrams, Tinya and Connor, Anu and Fanton, Christie and Cohen, Steven and Huber, Thomas and Miller, Kathy and Hong, E. Erica and Niu, Xiaohong and Kline, Janine and Ison-Dugenny, Marjorie and Harris, Sarah and Walker, Dana and Krauser, Klaus and Galimi, Francesco and Wang, Zhen and Ghoddusi, Majid and Mansfield, Keith and Lee-Hoeflich, Si Tuen and Holash, Jocelyn and Pryer, Nancy and Kluwe, William and Ettenberg, Seth and Sellers, William and Lees, Emma and Kwon, Paul and Abraham, Judy and Schleyer, Siew (2018) Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors. Clinical Cancer Research, 24 (17). pp. 4297-4308. ISSN 15573265

Adams, Christopher and Anderson, Karen and Artman Iii, Gerald and Cepeda, Rosemarie and Bizec, Jean-Claude and Elliott, Jason and Fassbender, Elizabeth and Ghosh, Malay and Hanks, Shawn and Hardegger, Leo and Hosagrahara, Vinayak and Jaffee, Bruce and Jendza, Keith and Ji, Nan and Johnson, Leland and Liu, Donglei and Liu, Fang and Long, Debby and Ma, Fupeng and Mainolfi, Nello and Meredith, Erik and Miranda, Karl and Peng, Penny and Poor, Stephen and Powers, James and Qiu, Yubin and Rao, Chang and Shen, Siyuan and Sivak, Jeremy and Solovay, Catherine and Tarsa, Peter and Woolfenden, Amber and Zhang, Chun and Zhang, Yiqin (2018) The discovery of N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (acrizanib), a VEGFR-2 inhibitor specifically designed for topical ocular delivery, as a therapy for neovascular age- related macular degeneration. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Adriana, Sánchez-Danés and Jean-Christophe , Larsimont and Mélanie, Liagre and Eva , Muñoz and Audrey, Brisebarre and Christine, Dubois and Josep, Tabernero and Cédric , Blanpain (2018) A slow cycling Lgr5 tumor cell population mediates resistance to Smoothened inhibitor in Basal Cell Carcinoma. Nature. ISSN 1476-4687

Akbar, Mohammad and Ahn, Mee and Bashaw, Dennis and Blithe, Diana and Berry-Bibee, Erin and Davis, Daniel and Day, Ruth and Edelman, Alison and Hochel, Joachim and Huang, Shiew-Mei and Jamshidi, Roxanne and Kim, Myong-Jin and Kim, Na Hyung and Lee, LaiMing and Li, Li and Purohit, Vivek and Turpin, Jim and Scott, Pamela and Shon, Jihong and Soule, Lisa and Strauss, David and Sun, Haiying and Tassinari, Melissa and Tepper, Naomi and Willett, Gerald and Zhang, Lei and Zhang, Nan and Zhao, Ping and Yu, Chongwoo (2018) FDA Public Meeting Report on “Drug Interactions with Hormonal Contraceptives: Public Health and Drug Development Implication”. Journal of Clinial Pharmacology.

Albiol, Laia and Cilla, Myriam and Pflanz, David and Kramer, Ina and Kneissel, Michaela and Duda, Georg N. and Willie, Bettina M. and Checa, Sara (2018) Sost deficiency leads to reduced mechanical strains at the tibia midshaft in strain-matched in vivo loading experiments in mice. Journal of the Royal Society Interface.

Alexander, Schuhmacher and Oliver, Gassmann and Nigel, McCracken and Hinder, Markus (2018) Open innovation and external sources of innovation. An opportunity to fuel the R&D pipeline and enhance decision making? Journal of Translational Medicine, 16 (1). ISSN 14795876

Andersson, Martin and Lipshutz, Bruce and Gallou, Fabrice (2018) Nanoparticle structure in TPGS-750M surfactant based organic synthesis modeled by COSMO-RS. European journal of organic chemistry, 24. pp. 6778-6786.

Antonova-Koch, Yevgeniya and Meister, Stephan and Abraham, Matthew and Ottilie, Sabine and Vanaerschot, Manu and Rodriguez, Juan Carlos Jado and Calla, Jaeson and Plouffe, David and Luth, Madeline and Zhong, Yang and Chen, Kaisheng and Owen, Edward and Lukens, Amanda and Sakata-Kata, Tomoyo and Maher, Steven and Chaumeau, Victor and Serrano, Fernando Neria and Eribez, Korina and Taggard, Cullin McClean and Roullier, Melanie and Siegel, Dionicio and Nosten, Francois and Kyle, Dennis and Gamo, Francisco-Javier and Zhou, Yingyao and Llinas, Manuel and Fidock, David and Wirth, Dyann and Burrows, Jeremy and Campo, Brice and Winzeler, Elizabeth (2018) Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science, 362 (6419). ISSN 10959203

Appleton, Brent and Benton, Bret and De Vicente Fidalgo, Javier and Drumm Iii, Joseph and Feng, Brian and Geng, Mei and Lu, Yipin and Mamo, Mulugeta and Moreau, Bob and Mergo, Wosenu and Skepper, Colin and Steffek, Micah and Takeoka, Ken and Uehara, Kyoko and Wang, Lisha and Wei, Jun-Rong and Xie, Lili and Xu, Wenjian and Zhang, Qiong and Li, Cindy and Hu, Cheng (2018) Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity. Journal of Medicinal Chemistry, 61 (8). pp. 3325-3349. ISSN 15204804

Appleton, Brent and Blechschmidt, Anke and Balibar, Carl and Benton, Bret and De Vicente Fidalgo, Javier and Drumm Iii, Joseph and Feng, Brian and Geng, Mei and Lingel, Andreas and Lu, Yipin and Mamo, Mulugeta and Mergo, Wosenu and Moreau, Bob and Polyakov, Valery and Skepper, Colin and Smith, Thomas and Takeoka, Ken and Uehara, Kyoko and Wang, Lisha and Wei, Jun-Rong and Weiss, Andrew and Xie, Lili and Xu, Wenjian and Zhang, Qiong and Li, Cindy (2018) Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria. Journal of Medicinal Chemistry, 61 (8). pp. 3309-3324. ISSN 15204804

Argikar, Aneesh and Argikar, Upendra (2018) Mesentery: An ADME perspective on a 'new' organ. Drug metabolism reviews. pp. 1-8. ISSN 1097-9883

Argikar, Upendra (2018) Saccharolactone: the history, the myth, and the practice. Current drug metabolism, 19. pp. 304-309. ISSN 1875-5453

Arias, H R and Feuerbach, Dominik and Ortells, M (2018) Bupropion inhibits human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites. Neurotransmitter.

Arias, HR and Feuerbach, Dominik and Schmidt, Bernd and Heydenreich, Matthias and Paz, Christian and Ortells, MO (2018) Drimane sesquiterpenoids purified from Drimys winteri inhibit the human α4β2 nicotinic acetylcholine receptor by noncompetitive mechanisms. Journal of natural products. ISSN 1520-6025; 0163-3864

Arias, HR and Vázquez-Gómez, E and Hernández-Abrego, A and Gallino, S and Feuerbach, Dominik and Ortells, MO and Elgoyhen, AB and García-Colunga, J (2018) Tricyclic antidepressants inhibit hippocampal α7*and α9α10 nicotinic acetylcholine receptors by different mechanisms. The international journal of biochemistry & cell biology.

Auberson, Yves and Briard, Emmanuelle and Rudolph, Bettina and Kaupmann, Klemens and Smith, Paul and Oberhauser, Berndt (2018) PET Imaging of T Cells: Target Identification and Feasibility Assessment. ChemMedChem. ISSN 18607187

Auld, Douglas S. and Narahari, Janaki and Ho, Pei-i and Casalena, Dominick and Nguyen, Vy and Cirbaite, Evelina and Hughes, Doug and Daly, John and Webb, Brian (2018) Characterization and Use of TurboLuc Luciferase as a Reporter for High-Throughput Assays. Biochemistry. ISSN 0006-2960

Avery, Danielle A and Kane, Elisa and Nguyen, Tina and Lau, Anthony and Nguyen, Akira and Payne, Kathryn and Lenthall, Ellen and Wei, Shi and Brigden, henry and French , Elise and Bier, Julia and Hermes, Jana R and Zahra, David and Sewell, William and Boztug, Kaan and Meyts, Isabelle and Choo, Sharon and Hsu, Peter and Wong, Melanie and Berglund, Lucinda and Gray, Paul and O'Sullivan, Michael and Cole, Therese and Holland, Steven M and Ma, Cindy S and Burkhart, Christoph and Corcoran, Lynn M and Phan, Tri G and Brink, Robert and Uzel, Gulbu and Deenick, Elissa K and Tanguye, Stuart G (2018) Pathogenic germline activating mutations in PIK3CD compromise B-cell development and function, underlying humoral defects in human primary immunodeficiency. Journal of Experimental Medicine.

Avery, Danielle A and Kane, Elisa and Nguyen, Tina and Lau, Anthony and Nguyen, Akira and Payne, Kathryn and Lenthall, Ellen and Wei, Shi and Brigden, henry and French , Elise and Bier, Julia and Hermes, Jana R and Zahra, David and Sewell, William and Boztug, Kaan and Meyts, Isabelle and Choo, Sharon and Hsu, Peter and Wong, Melanie and Berglund, Lucinda and Gray, Paul and O'Sullivan, Michael and Cole, Therese and Holland, Steven M and Ma, Cindy S and Burkhart, Christoph and Corcoran, Lynn M and Phan, Tri G and Brink, Robert and Uzel, Gulbu and Deenick, Elissa K and Tanguye, Stuart G (2018) Pathogenic germline activating mutations in PIK3CD intrinsically compromise B-cell development and function, underlying humoral defects in human primary immunodeficiency. Journal of Experimental Medicine.

Awale, Mahendra and Sirockin, Finton and Stiefl, Nikolaus and Reymond, Jean-Louis (2018) Drug Analogs from Fragment Based Long Short-Term Memory Generative Neural Networks. ChemRXiv.


Badal Tejedor, Maria and Pazesh, Samaneh and Nordgren, Niklas and Rutland, Mark and Schuleit, Michael and Alderborn, Göran and Millqvist Fureby, Anna (2018) Milling induced amorphisation and recrystallisation of α-lactose monohydrate. International journal of pharmaceutics, 537. pp. 140-147. ISSN 1873-3476; 0378-5173

Badaoui, Magd and Kells, Adam and Molteni, Carla and Dickson, Callum and Hornak, Viktor and Rosta, Edina (2018) Calculating kinetic rates and membrane permeability from biased simulation. The Journal of Physical Chemistry B. ISSN 1520-61061520-5207

Bardet, Maureen and Unterreiner, Adeline and Malinverni, Claire and Lafossas, Frederique and Vedrine, Corinne and Boesch, Danielle and Kolb, Yeter and Kaiser, Daniel and Glueck, Anton and Schneider, Martin Alexander and Katopodis, Andreas and Renatus, Martin and Simic, Oliver and Schlapbach, Achim and Quancard, Jean and Regnier, Catherine and Bold, Guido and Pissot Soldermann, Carole and Carballido, Jose and Kovarik, Jiri and Calzascia, Thomas and Bornancin, Frederic (2018) The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition. Immunology and cell biology.

Barkley, Deborah and Han, Sang Uk and Koga, Tadanori and Rudick, Jonathan G. (2018) Peptide–dendron hybrids that adopt sequence-encoded β-sheet conformations. Polymer Chemistry. ISSN 1759-9954

Barrow, Alexander/D and Edeling, Melissa/A and Trifonov, Vladimir and Luo, Jingqin and Goyal, Piyush and Bohl, Benjamin and Bando, Jennifer and Kim, Albert and Andahazy, Mary and Melocchi, Laura and Bugatti, Mattia and Vermi, Wiliam and Fremont, Daved and Cox, Sarah and Cella, Marina and Schmedt, Christian and Colonna, Marco (2018) Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor. Cell, 172 (3). 534-548.e19. ISSN 10974172

Beach, Aaron and Wassmann, Paul and Lorenz, Thorsten (2018) Analytical strategies for developability assessment of therapeutic proteins. American Pharmaceutical Review, 21 (4). ISSN 10998012

Beato, Stefania and Kourentas, Alexandros and Vertzoni, Maria and Barmpatsalou, Vicky and Butler, James and Holm, Rene and Rosenberg, Joerg and Tannergren, Christer and Symillides, Mira and Reppas, Christos (2018) The use of BioGIT system to assess the impact of dose and formulation on early exposure to low solubility drugs after oral administration. The AAPS journal, 20 (71). pp. 1-12. ISSN 10-1208

Beckmann, Nicolau and Giorgetti, Elisa and Neuhaus, Anna and Zurbruegg, Stefan and Accart Gris, Nathalie and Smith, Paul and Perdoux, Julien and Perrot, Ludovic and Nash, Mark and Desrayaud, Sandrine and Wipfli, Peter and Frieauff, Wilfried and Shimshek, Derya (2018) Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945. Acta neuropathologica communications.. ISSN 2051-5960

Beckwith, Rohan (2018) Reactive carbon species tamed for synthesis. Nature, 554 (7690). pp. 36-38. ISSN 14764687

Becquet, Mike and Laborde, Laurent and Texier, Celine and Sterker, Dario and Gschwind, Hans-Peter and Pfaar, Ulrike and Wartmann, Markus and O'Reilly, Terence and Mcsheehy, Paul M.J. (2018) Continuous low-dose infusion of patupilone increases the therapeutic index in mouse and rat tumour models. Anti-Cancer Drugs, 29 (7). pp. 691-701. ISSN 14735741

Beninson, Jennifer A and Lofgren, Jennifer L and Lester, Patrick A and Hileman, Madeline M and Berkowitz, Daniel J and Myers, Daniel D (2018) Analgesic Efficacy and Hematologic Effects of Robenacoxib in Mice. Journal of the American Association for Laboratory Animal Science : JAALAS, 57 (3). pp. 258-267. ISSN 1559-6109

Bennet, Bindu M. and Regan, Karen S. and Romeike, Annette and Schafer, Kenneth and Thibodeau, Michael and Thomas, Heath and Colman, Karyn and Fikes, James and Francke, Sabine and Geoly, Frank and Keirstead, Natalie and Schorsch, Frederic and Vahle, John (2018) The Pathology Community’s Interpretation of Settiagounder’s Proposals on GLP Process as Applied to Pathology Peer Review. Journal of Regulatory Science, 6 (1). v-xi.

Benton, Bret and de Vicente, Javier and Drumm, Joseph and Feng, Brian and Geng, Mei and Li, Cindy and Moreau, Bob and Rath, Christopher and Shen, Xiaoyu and Skepper, Colin and Steffek, Micah and Takeoka, Kenneth and Wang, Lisha and Wei, Jun-Rong and Xu, Wenjian and Zhang, Qiong (2018) Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics. ACS Infectious Diseases, 4 (3). pp. 391-402. ISSN 23738227

Bergsdorf, Christian and Kallen, Joerg and Galimberti, Ivan and Cobos-Correa, Amanda and Kaufmann, Markus and Roma, Guglielmo and Elhajouji, Azeddine and Uteng, Marianne and Hunziker, Juerg and Arnaud, Bertrand and Guibourdenche, Christel and Stiefl, Nikolaus and Roethlisberger, Patrik and Polyakov, Valery and Von Matt, Peter and Martus, Hans-Joerg and Izaac, Aude and Leder, Lukas and Holzinger, Sandra and Haenni, Simon and Freuler, Felix and Brichet, Murielle and Bernhard, Mario and Lerchner, Andreas (2018) X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan–McDermid Syndrome. ChemMedChem, 13 (18). pp. 1997-2007. ISSN 18607187

Bitter, Hans and Orlando, Elena and Marco, Ruella and Jun, Xu and David, Barrett and Joseph, Fraietta and Tyler , Reich and David , Ambrose and Michael, Klichinsky and Olga, Shestova and Prachi, Patel and Irina, Kulikovskaya and Farzana, Nazimuddin and Vijay, Bhoj and Shannon, Maude and Bruce, Levine and Christopher, Nobles and Frederic, Bushman and Regina, Young and John, Scholler and Saar, Gill and Carl, June and Stephan, Grupp and Joseph, Melenhorst and Simon, Lacey (2018) Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nature Medicine, 24 (10). pp. 1499-1503. ISSN 1546170X

Blais, Johanne and Lopez, Sara and Li, Cindy and Ruzin, Alexey and Ranjikar, Srijan and Dean, Charles and Leeds, Jennifer and Casarez, Anthony and Simmons, Bob and Reck, Folkert (2018) In Vitro Activity of LYS228, a Novel Monobactam Antibiotic, against Multidrug-resistant Enterobacteriaceae. Antimicrobial agents and chemotherapy. ISSN 1098-6596

Blais, Johanne and Lopez, Sara and Li, Cindy and Ruzin, Alexey and Ranjikar, Srijan and Dean, Charles and Leeds, Jennifer and Casarez, Anthony and Simmons, Bob and Reck, Folkert (2018) In vitro activity of LYS228, a novel monobactam antibiotic, against multidrug-resistant enterobacteriaceae. Antimicrobial Agents and Chemotherapy, 62 (10). pp. 1-10. ISSN 10986596

Blasko, Andrei and Tam, Yat Kong and Haidar Ahmad, Imad A. and Sajeevi, Gunasekera and Irina, Oshchepkova and Alexey, Galin and Andrey, Vazhentsev and Vadim, Tashlitsky and David, Adams (2018) A Four-Dimensional (4D) Stability Indicating Analytical Method Optimization and Potency Assay Prediction Using MS and UV Peak Tracking. Journal of Applied Pharmacy, 10 (1). pp. 1-11. ISSN 1920-4159

Blasko, Andrei and Tam, Yat Kong and Kadrichu, Nani and Ahmad, Imad A. Haidar (2018) Amikacin analysis and aerosol particle size distribution (aPSD) determination using charged aerosol detector (CAD). Atlas of Science, - (April ). pp. 1-3.

Blatter, Markus and Sellier, Chantal and Cerro-Herreros, Estefanía and Allain, Frédéric H.T. and Llamusi, Beatriz and Charlet-Berguerand, Nicolas (2018) RbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences. Nature Communications, 9 (1). ISSN 20411723

Boehme, Philip and Hansen, Arne and Roubenoff, Ronenn and Scheeren, Joseph and Herrmann, Maximilian and Mondritzki, Thomas and Ehlers, Jan and Truebel, Hubert (2018) How soon will digital endpoints become a cornerstone for future drug development? Drug Discovery Today. ISSN 18785832

Bonhoeffer, Bastian and Kwade, Arno and Juhnke, Michael (2018) Alternative manufacturing concepts for solid oral dosage forms from drug nanosuspensions using fluid dispensing and forced drying technology. Journal of pharmaceutical sciences, 107 (3). pp. 909-921. ISSN 00223549

Bot, Corina T. and Juhasz, Krisztina and Häusermann, Fabian and Liudmila , Polonchuk and Traebert, Martin and Stölzle-Feix2, Sonja (2018) Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes. Journal of pharmacological and toxicological methods. ISSN 10568719

Bourgoint, Clelia and Rispal , Delphine and Berti, Marina and Filipuzzi, Ireos and Helliwell, Stephen and Prouteau, Manuel and Loewith, Robbie (2018) The Target of Rapamycin Complex 2-dependent phosphorylation of Pan1 by Akl1 controls endocytosis dynamics. Journal of Biological Chemistry, 293 (31). ISSN 0021-92581083-351X

Brocklehurst, Cara and Hartwieg, Constanze and Palmieri, Marco and Rufle, Dominik and Gallou, Fabrice (2018) Microtiter Plate (MTP) Reaction Screening and Optimization of Surfactant Chemistry: Examples of Suzuki-Miyaura and Buchwald-Hartwig Cross-Couplings in Water. Organic Process Research & Development. ISSN 1083-61601520-586X


Calabretta, Sara and Vogel, Gillian and Yu, Zhenbao and Choquet, Karine and Darbelli, Lama and Nicholson, Thomas and Kleinman, Claudia and Richard, Stephane (2018) Loss of PRMT5 promotes PDGFRa degradation during oligodendrocyte differentiation and myelination. Developmental cell, 46 (4). pp. 426-440. ISSN 15345807

Calvani, R and Bejuit, R and Roller-Wirnsberger, R and Barnebei, R and Vellas, B and Tosato, M and Jonsson , P and Grodzicki, T and Landi, F and Del Signore , S and Rodrigues-Manas, L and Skalska, A and Schols, A and Ryznarova , I and Msihid , J and Sinclair, A and Pahor, M and Maggio, M and Topinkova, E and Cruz-Jentoft, A and Roubenoff, Ronenn and Dantoine, T and Di Bari, M and Freiberger, E and Cesari, M and Marzetti, E and Sieber, C and Strandberg, T and Cherubini, A (2018) The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants. Experimental Gerontology, 113. pp. 48-57. ISSN 18736815

Capparelli, Claudia and Purwin , Timothy J. and Heilman , Shea and Chervoneva, Inna and McCue, Peter and Davies, Michael A. and Gershenwald, Jeffrey and Aplin, Andrew E. (2018) Stromal neuregulin-1 modulates the response to MEK inhibitors in WT BRAF/WT NRAS (WT/WT) melanomas. Molecular Cancer Therapeutics, 17 (1). ISSN 15388514

Carcache, David and Vulpetti, Anna and Kallen, Joerg and Mattes, Henri and Orain, David and Stringer, Rowan and Vangrevelinghe, Eric and Wolf, Romain and Kaupmann, Klemens and Ottl, Johannes and Dawson King, Janet and Cooke, Nigel Graham and Hoegenauer, Klemens and Billich, Andreas and Wagner, Juergen and Guntermann, Christine and Hintermann, Samuel (2018) Optimizing a weakly binding fragment into a potent RORγt inverse agonist with efficacy in an in vivo inflammation model. Journal of medicinal chemistry.

Cardoso, Ana-Luisa and Fernandes, Adelaide and Aguilar-Pimentel, Juan Antonio and Hrabě de Angelis, Martin and Ribeiro Guedes, , Joana and Brito, Maria Alexandra and Ortolano, Saida and Pani, Giovambattista and Athanasopoulou, Sophia and Gonos, Efstathios S. and Schosserer, Markus and Grillari, Johannes and Peterson, Pärt and Guvenc Tuna, Bilge and Dogan, Soner and van Os, Ronald and Meyer, Angelika and Trendelenburg, Anne-Ulrike (2018) Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Research Reviews, 47. pp. 214-277. ISSN 18729649

Cardoso, Ana-Luisa and Fernandes, Adelaide and Aguilar-Pimentel, Juan Antonio and Hrabě de Angelis, Martin and Ribeiro Guedes, , Joana and Brito, Maria Alexandra and Ortolano, Saida and Pani, Giovambattista and Athanasopoulou, Sophia and Gonos, Efstathios S. and Schosserer, Markus and Grillari, Johannes and Peterson, Pärt and Guvenc Tuna, Bilge and Dogan, Soner and van Os, Ronald and Meyer, Angelika and Trendelenburg, Anne-Ulrike (2018) Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Research Reviews, 47. pp. 214-277. ISSN 18729649

Cardoso, Ana-Luisa and Fernandes, Adelaide and Aguilar-Pimentel, Juan Antonio and Hrabě de Angelis, Martin and Ribeiro Guedes, , Joana and Brito, Maria Alexandra and Ortolano, Saida and Pani, Giovambattista and Athanasopoulou, Sophia and Gonos, Efstathios S. and Schosserer, Markus and Grillari, Johannes and Peterson, Pärt and Guvenc Tuna, Bilge and Dogan, Soner and van Os, Ronald and Meyer, Angelika and Trendelenburg, Anne-Ulrike (2018) Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Research Reviews, 47. pp. 214-277. ISSN 18729649

Clarke, Brian and Cruz Jr, Joseph and Wilson, Liz and Hupper, Nicole and Wang, Yuan and Patora-Komisarska, Krystyna and Oberhauser, Berndt and Concannon, John and Glass, David and Trendelenburg, Anne-Ulrike and Zhang, Yunyu (2018) Protein kinase A activation inhibits DUX4 gene expression in facioscapulohumeral muscular dystrophy patient myotubes. Journal of Biological Chemistry. ISSN 0021-92581083-351X

Clayton, Gemma and Schachter, Asher and Magnusson, Baldur and Li, Yue and Colin, Laurence (2018) How often do safety signals occur by chance in first-in-human trials? Clinical and translational science, 11 (5). pp. 471-476. ISSN 1752-8062; 1752-8054


De Pascale, Gianfranco and Uehara, Tsuyoshi (2018) Target identification of cystobactamid and albicidin. ACS infectious diseases.

Dean, Charles and Barkan, Dave and Bermingham, Alun and Blais, Johanne and Casey, Fergal and Casarez, Anthony and Colvin, Richard and Fuller, John and Jones, Adriana and Li, Cindy and Lopez, Sara and Metzger Iv, Louis and Mostafavi, Mina and Prathapam, Ramadevi and Rasper, Dita and Reck, Folkert and Ruzin, Alexey and Shaul, Jacob and Shen, Xiaoyu and Simmons, Robert and Skewes-Cox, Peter and Takeoka, Ken and Tamrakar, Pramila and Uehara, Tsuyoshi and Wei, Jun-Rong (2018) The monobactam LYS228: mode of action and mechanisms decreasing in vitro susceptibility of Escherichia coli and Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 62 (10). ISSN 1098-6596

Deurinck, Mark and Schindler, Stefanie and Zeiter, Stephan and Desbaillets, Isabelle and Gyger, Marcel and Bugnon, Philippe and Heimann, Maike and Ferrand, Gisele and Wyss, Stefanie (2018) Report from the 2017 Annual SGV Meeting. Laboratory Animals, 52 (2). pp. 211-213. ISSN 0023-67721758-1117

Dickson, Callum and Hornak, Viktor and Bednarczyk, Dallas and Duca, Jose (2018) Using membrane partitioning simulations to predict permeability of forty-nine drug-like molecules. Journal of Chemical Information and Modeling. ISSN 1549-95961549-960X

Dincer, Zuhal and Piccicuto, Virginie and Junker Walker, Ursula and Mahl, Joerg Andreas and McKeag, Sean (2018) Spontaneous and Drug-induced Arteritis/Polyarteritis in the Göttingen Minipig—Review. Toxicologic Pathology, 46 (2). pp. 121-130. ISSN 15331601

Donovan, Katherine and Fischer, Eric (2018) CRL4CRBN Mediated Degradation of SALL4 Links Thalidomide Syndrome to Duane Radial Ray Syndrome. ELife., 7. ISSN 2050-084X

Dumouchel, Jennifer and Chemuturi, Nagendra and Milton, Mark and Camenisch, Gian P. and Chastain, Jim and Walles, Markus and Sasseville, Vito and Gunduz, Mithat and Iyer, Ganesh and Argikar, Upendra (2018) Models and approaches describing metabolism, transport, and toxicity of drugs administered by the ocular route. Drug metabolism and disposition, 46. pp. 1670-1683. ISSN 1521-009X

Dutta, Priyanka and Dargahi, Leila and O'Connell, Kara and Bolina, Ashini and Ozkan, Sefika and Sailer, Andreas and Dev, Kumlesh (2018) A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease. Neuroscience Letters, 673. pp. 12-18. ISSN 18727972

Dégardin, Klara and Guillemain, Aurélie and Klespe, Philippe and Hindelang, Florine and Zurbach, Raphaël and Roggo, Yves (2018) Packaging analysis of counterfeit medicines. Forensic Science International, 291. pp. 144-157. ISSN 03790738

de Jong, Arthur P H and Roggero, Carlos M and Ho, Meng-Ru and Wong, Man Yan and Brautigam, Chad A and Rizo, Josep and Kaeser, Pascal S (2018) RIM CB Domains Target Presynaptic Active Zone Functions to PIP-Containing Membranes. Neuron, 98 (2). 335-349.e7. ISSN 1097-4199


Ehara, Takeru and Adams, Christopher and Bevan Jr, Doug and Ji, Nan and Meredith, Erik and Belanger, David and Powers, James and Kato, Mitsunori and Solovay, Catherine and Liu, Donglei and Capparelli, Michael and Bolduc, Philippe and Grob, Jonathan and Daniels, Matthew and Ferrara, Luciana and Yang, Louis and Towler, Christopher and Li, Byron and Stacy, Rebecca and Prasanna, Ganesh and Mogi, Muneto (2018) The discovery of (S)-1-(6-(3-((4-(1-(cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid, an sGC activator specifically designed for topical ocular delivery as a therapy for glaucoma. Journal of medicinal chemistry. ISSN DOI: 10.1021/acs.jmedchem.8b00007

Erlanson, Daniel A and de Esch, Iwan JP and Jahnke, Wolfgang and Johnson, Christopher N and Mortenson, Paul N (2018) Fragment-to-Lead Medicinal Chemistry Publications in 2016. Journal of Medicinal Chemistry, 61 (5). pp. 1774-1784. ISSN 15204804


Faller, Bernard and Berben, Philippe and Bauer-Brandl, Annette and Flaten, Goril Eide and Jacobsen, Christin and Brouwers, Joachim and Augustijins, Patrick (2018) Drug permeability profiling using cell-free permeation tools: Overview and applications. European Journal of Pharmaceutical Sciences, 119. pp. 219-233. ISSN 18790720

Ferretti, Stephane Raymond and Holzer, Philipp and Fuchs, Jeannette and Chapeau, Emilie and Wartmann, Markus and Sterker, Dario and Romanet, Vincent and Kerr, Grainne and Durand, Eric and Gaulis, Swann and Kallen, Joerg and Furet, Pascal and Cortes-Cros, Marta and Guerreiro, Nelson and Halilovic, Ensar and Jullion, Astrid and Kuriakose, Emil and Wiesmann, Marion and Jensen, Michael Rugaard and Hofmann, Francesco and Sellers, William and Jeay, Sebastien and Murakami, Masato and Wuerthner, Jens (2018) Dose and schedules determines distinct molecular mechanism underlying the efficacy of the p53-MDM2 inhibitor NVP-HDM201. Cancer research. ISSN 1538-7445; 0008-5472

Fodor, Michelle and Price, Edmund and Wang, Ping and Lu, Henry and Argintaru, Andreea and Chen, Zhuoliang and Glick, Meir and Hao, Huaixiang and Kato, Mitsunori and Koenig, Robert and Jonathan, LaRochelle and Liu, Gang and Mcneill, Eric and Majumdar, Dyuti and Nishiguchi, Gisele and Perez, Lawrence and Paris, Greg and Quinn, Christopher and Ramsey, Timothy and Sendzik, Martin and Shultz, Michael and Williams, Sarah and Stams, Travis and Stephen, Blacklow and Acker, Michael and Lamarche, Matthew (2018) Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chemical Biology.


Galli, Giorgio and Dirk, Schuebeler (2018) Job description for Post-doc position. Distributed to academic collaborator.

Gallou, Fabrice (2018) Copper-Catalyzed Oxidative Cleavage of Electron-Rich Olefins in Wa-ter at Room Temperature. Organic letters, 20 (17). pp. 5094-5097.

Gallou, Fabrice (2018) Forewords of Symposium in Print issue on Process Chemistry for Bioorganic and Medicinal Chemistry. Bioorganic and medicinal chemistry.

Gallou, Fabrice (2018) Inspiring process innovation via a breakthrough green manufacturing metric: iGAL. Green chemistry, 20. pp. 2206-2211.

Gallou, Fabrice (2018) Journal highlight for the article: π-Allylpalladium Species in Micelles of FI-750-M for Sustainable and General Suzuki-Miyaura Couplings of Unactivated Quinoline Systems in Water. ChemCatChem., 10 (19). pp. 4229-4233.

Gallou, Fabrice (2018) PQS-Enabled Visible-Light Photoredox Ir Catalysis in Water at Room Temperature. Green chemistry, 20 (Green ). pp. 1233-1237.

Gallou, Fabrice and Handa, Sachin (2018) π-Allyl Palladium Species in Micelles of FI-750-M for Sustainable and General Suzuki-Miyaura Couplings of Quinoline Systems in Water. ChemCatChem, 10 (19). pp. 4229-4233.

Gallou, Fabrice and Handa, Sachin (2018) Micelle-Enabled Clean Sulfonylation of Polyfluoroarenes in Water Under Mild Conditions. Green chemistry. ISSN 1463-9270; 1463-9262

Gallou, Fabrice and Lipshutz, Bruce (2018) B-Alkyl sp3-sp2 Suzuki-Miyaura Couplings Under Mild Aqueous Micellar Conditions. Organic letters, 20 (10). pp. 2902-2905. ISSN 1523-7052; 1523-7060

Gallou, Fabrice and Walde, Peter (2018) Aqueous soft dispersed interface-rich systems that promote and guide chemical reactions. Nature reviews chemistry, 2. pp. 306-327.

Gallou, Fabrice and lipshutz, Bruce (2018) Sustainable, Copper-Free HandaPhos-ppm Palladium Technology for Sonogashira Couplings in Water Under Mild Conditions. Organic letters, 20. pp. 542-545. ISSN 1523-7052; 1523-7060

Gallou, Fabrice and lipshutz, Bruce (2018) Transition Metal Synergy in Fe Nanoparticles Doped with ppm Levels of (Pd + Ni). A New Catalyst for Nitro Group Reductions under Environmentally Responsible Conditions. Green chemistry, 20. pp. 130-135. ISSN 1463-9270; 1463-9262

Galyan, Keith and Reilly, John (2018) Green Chemistry Approaches for the Purification of Pharmaceuticals. Current Opinion in Green and Sustainable Chemistry.

Gampe, Christian and White, Amy and Siva, Swetha and Zecri, Frederic and Diener, John (2018) 3′-Modification stabilizes mRNA and increases translation in cells. Bioorganic and Medicinal Chemistry Letters. ISSN 1464-3405

Garito, Tania (2018) PhD Thesis of Tania Garito, MD: THE METABOLIC IMPLICATIONS OF CHANGES IN BODY COMPOSITION. Thesis, University of Milan.

Gauthier, Anne and Fisch, Andreas and Seuwen, Klaus and Baumgarten, Birgit and Ruffner, Heinz and Aebi, Alexandra and Rausch, Martin and Bartneck, Matthias and Weiskirchen, Ralf and Tacke, Franck and Storm, Gert and Lammers, Twan and Ludwig, Marie-Gabrielle (2018) Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials.

Gauthier, Anne and Fisch, Andreas and Seuwen, Klaus and Baumgarten, Birgit and Ruffner, Heinz and Aebi, Alexandra and Rausch, Martin and Bartneck, Matthias and Weiskirchen, Ralf and Tacke, Frank and Storm, Gert and Lammers, Twan and Ludwig, Marie-Gabrielle (2018) Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials.

Geneste , Olivier and Clapéron, Audrey and Colland, Frédéric and Kraus-Berthier, Laurence and Le Toumelin-Braizat, Gaëtane and Studeny, Aurélie and Guasconi, Ghislaine and Bruno, Alain and Chanrion, Maia and Lysiak-Auvity, Gaelle and Girard, Anne-Marie and Schneider, Emilie and Gravé, Fabienne and Casara, Patrick and Le Diguarher, Thierry and Starck, Jérome-Benoit and Henlin, Jean-Michel and Murray, James and Davidson, James and Chen, Ijen and Whitehead, Neil and Graham, Christopher and Matassova, Natalia and Dokurno, Pawel and Pedder, Christopher and Hubbard, Roderick and Wood, Mike and Morris, Erick and Wang, Youzhen and Qiu, Shumei and Amiot, Martine and Maïga, Sophie and Le Gouill, Steven and Vogler, Meike and Cohen, Gerry M and Dyer, Martin JS and Rocchetti, Franscesca and Hickman, John A. (2018) S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget, 9 (28). pp. 20075-20088. ISSN 19492553

Glaenzel, Ulrike and Jin, Yi and Nufer, Robert and Li, Wenkui and Schroer, Kirsten and Adam, Sylvie and van Marle, Sjoerd Peter and Legangneux, Eric and Borell, Hubert and James, Alexander David and Meissner, Axel and Camenisch, Gian P. and Gardin, Anne (2018) Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism. Drug metabolism and disposition, 46 (7). pp. 1001-1013. ISSN 1521-009X

Glowienke, Susanne (2018) Potential impurities in drug substances: Compound-specific toxicology limits for 20 synthetic reagents and by-products, and a class-specific toxicology limit for alkyl bromides. Regulatory Toxicology and Pharmacology, 94. pp. 172-182. ISSN 10960295

Glowienke, Susanne and Glogovac, Milica (2018) Making reliable negative predictions of human skin sensitisation using an in silico fragmentation approach. Regulatory toxicology and pharmacology.

Gordillo-Sala, Marta and Auberson, Yves and Adell, Albert (2018) Signaling pathways responsible for the rapid anti-depressant effects of a GluN2A-preferring NMDA receptor antagonist. Translational psychiatry. ISSN 2158-3188

Gounarides, John and Cook, Frank (2018) Sample Preparation and LC-MS methods for the measurement of NAD, NADP, NADPH. NADH and NMN. no journal, none (none). ISSN none

Groot Kormelink, Paul and Bouhelal, Rochdi and Corminboeuf , Olivier and Kenakin , Terry and Durroux , Thierry and Pin , Jean-Philippe and Roux, Thomas and Bdioui, Sara and Trinquet, Eric and Pierre, Pierre and Scholler , Pauline and Degorce, Francois (2018) Sharing meaningful and relevant assay data – the experts' opinion. CisBio Expert Opinion.

Growcott, Ellena and Bamba, Douty and Galarneau, Jean-Rene and Leonard, Vincent and Schul, Wouter and Stein, Daniel and Osborne, Colin (2018) The Effect of P38 MAP Kinase Inhibition in a Mouse Model of Influenza. Journal of Medical Microbiology. ISSN 0022-26151473-5644

Grunseich, Christopher and Miller, Ram and Swan, Therese and Glass, David and El Mouelhi, Mohamed and Fornaro, Mara and Petricoul, Olivier and Vostiar, Igor and Roubenoff, Ronenn and Meriggioli, Matthew and Kokkinis, Angela and Guber, Robert D. and Budron, Maher S. and Vissing, John and Soraru, Gianni and Mozaffar, Tahseen and Ludolph, Albert and Kissel, John T and Fischbeck, Kenneth H. (2018) A placebo-controlled study to evaluate the safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy. Lancet Neurology.

Guo, Chenying and Qu, Paul and Rangaswamy, Nalini and Leehy, Barrett and Xiang, Chuanxi and Rice, Dennis and Prasanna, Ganesh (2018) A murine glaucoma model induced by rapid in vivo photopolymerization of hyaluronic acid glycidyl methacrylate. PLoS ONE, 13 (6). N/A-N/A. ISSN 19326203


Haidar Ahmad, Imad and Blasko, Andrei (2018) Two Dimensional Liquid Chromatography (2DLC) in pharmaceutical analysis. Applications beyond increasing peak capacity. Chromatographia, 81. pp. 401-418. ISSN 0009-5893

Haiser, Henry and Oakeley, Edward James and Porter, Jeffrey and Rudolph, Sabine and Ke, Xiaobo and Young, Rachel (2018) Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life. Nature Microbiology. ISSN 20585276

Hallam, Dean and Hilgen2, Gerrit and Dorgau, Birthe and Yu, Min and Zhu, Lili and Bojic, Sanja and Hewitt, Philip and Schmitt, Michael and Uteng, Marianne and Kustermann, Stefan and Steel, David and Nicholds, Mike and Thomas, Robert and Treumann, Achim and Porter, Andrew and Sernagor, Evelyne and Armstrong, Lyle and Lako, Majlinda (2018) Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency. Stem Cells. ISSN 15494918

Han, Wooseok and Ma, Xiaolei and Uehara, Tsuyoshi (2018) Small molecule and fragment inhibitors of E. coli LpxA. Nature chemical biology.

Harding, James J. and Bauer, Todd M. and Tan, Daniel and Bedard, Philippe L. and Rodon, Jordi and Doi, Toshihiko and Schnell, Christian and Iyer, Varsha and Baffert, Fabienne and Radhakrishnan, Rajkumar and Fabre, Claire and Juric, Dejan (2018) Characterization and first-in-human data of CLR457, an orally bioavailable pan-class I PI3-Kinase inhibitor. Investigational new drugs. ISSN 1573-0646; 0167-6997

Hartmann, Stephanie and Zheng, Fang and Kyncl, Michele Constanze and Karch, Sandra and Voelkl, Kerstin and Zott, Benedikt and D'Avanzo, Carla and Lomoio, Selene and Tesco, Giuseppina and Kim, Doo Yeon and Alzheimer, Christian and Huth, Tobias (2018) Beta secretase BACE1 promotes surface expression and function of Kv3.4 potassium channels in hippocampal mossy fiber synapses. Journal of Neuroscience. ISSN 0270-6474

Hauptmann, Astrid and Podgoršek, Katja and Kuzman, Drago and Srčič, Stanko and Hoelzl, Georg and Loerting, Thomas (2018) Impact of Buffer, Protein Concentration and Sucrose Addition on the Aggregation and Particle Formation during Freezing and Thawing. Pharmaceutical Research, 35 (5). ISSN 0724-8741

Ho, Pei-I and Casalena, Dominick and Auld, Douglas (2018) Characterization and use of Turbo Luciferase as a reporter for high-throughput assays. Biochemistry. ISSN 10.1021/acs.biochem.8b00290

Hoffman, Ben and Baba, Yoshichika and Griffith, Theanne and Masharov, Eugene and Woo, Seung and Roybal, Daniel and Karsenty, Gerard and Patapoutian, Ardem and Sulzer, David and Lumpkin, Ellen (2018) Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses. Neuron, 100 (6). pp. 1401-1413. ISSN 10974199

Hong, E. Erica and Qiu, Qifeng and Wu, Rui and Wilhelm, Alan and Erickson, Hans and Abrams, Tinya and Deeds, Jim and Wang, Zhen and Ghoddusi, Majid and Schleyer, Siew (2018) Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors. Clinical Cancer Research, 24 (17). pp. 4297-4308. ISSN 15573265

Hsiao, Hsiu-Ling and Langenickel, Thomas Heiko and Petruck, Jesika and Kode, Kiran Kumar and Ayalasomayajula, Surya and Schuehly, Uwe and Greeley, Michael and Pal, Parasar and Zhou, Wei and Prescott, Margaret and Sunkara, Gangadhar and Rajman, Iris (2018) Evaluation of Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction of Sacubitril/Valsartan (LCZ696) and Sildenafil in Patients With Mild-to-Moderate Hypertension. Clinical Pharmacology and Therapeutics, 103 (3). pp. 468-476. ISSN 1532-6535

Hsiao, Hsiu-Ling and Langenickel, Thomas Heiko and Petruck, Jesika and Kode, Kiran Kumar and Ayalasomayajula, Surya and Schuehly, Uwe and Greeley, Michael and Pal, Parasar and Zhou, Wei and Prescott, Margaret and Sunkara, Gangadhar and Rajman, Iris (2018) Evaluation of Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction of Sacubitril/Valsartan (LCZ696) and Sildenafil in Patients With Mild-to-Moderate Hypertension. Clinical Pharmacology and Therapeutics, 103 (3). pp. 468-476. ISSN 1532-6535

Hsieh, Hsiao-Wu and Robinson, Richard and Coley, Connor and Jensen, Klavs and Baumgartner, Lorenz (2018) Photoredox Iridium-Nickel Dual Catalyzed Decarboxylative Arylation Cross-Coupling: From Batch to Continuous Flow via Self-Optimizing Segmented Flow Reactor. Organic process research & development, 22 (4). pp. 542-550. ISSN 1520-586X; 1083-6160

Hu, Lu and Liu, Yahu and Liao, Xuebin (2018) Recent Progress in Methylation of (Hetero)Arenes by Cross-Coupling or C-H Activation. Synlett, 29 (4). pp. 375-382. ISSN 14372096

Huels, DJ and McLaughlin, Margaret and Bruens, L and Hodder, MC and Cammareri, P and Campbell, AD and Ridgway, RA and Gay, DM and Solar-Abboud, M and Faller, WJ and Nixon, C and Zeiger, LB and Morrissey, E and Winton, DJ and Snippert, HJ and Rheenen van, J and Sansom, OJ (2018) Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nature Communications, 9 (1). ISSN 20411723

Hurley, Timothy and Kerrigan, John and Shu, Lei and Shen, Yiping and Sung, Moo and O'Brien, Gary and Hou, Ying and Axford, Jake and Deng, Lin and Hoffmaster, Keith and Shin, Youngah and Servais, Rebecca and Towler, Christopher and Hild, Marc and Briner, Karin and Dietrich, Bill and Sivasankaran, Rajeev and Dales, Natalie and Chin, Donovan and Sun, Robert and Cody, Emma and Fazal, Aleem and Tomlinson, Ronald and Song, Cheng and Jain, Monish and Van Hoosear, Mailin and Hamann, Lawrence and Curtis, Daniel and Kobayashi, Dione and Chen, Karen and Fridrich, Cary and Sanchez, Carina (2018) Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA). Journal of medicinal chemistry, 61 (24). pp. 11021-11036. ISSN 0022-2623

Huth, Felix and Einolf, Heidi (2018) Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective. Clinical Pharmacology and Therapeutics. ISSN 15326535

Huynh, Hung and Lee, Liek Yeow and Ong, Richard and Hao, Huaixiang and Huang, Alan and Wang, Youzhen and Graus Porta, Diana and Chow, Pierce and Ong, Hock Soo and Chung, Alexander (2018) Infigratinib mediates vascular normalization, impairs metastasis and improves chemotherapy in hepatocellular carcinoma. Hepatology. ISSN 1527-3350; 0270-9139


Isaacs, Randi and Chen, Xueying and Graus Porta, Diana and Parker, Katie and Yu, Kun and Porter, Dale (2018) Efficacy of BGJ398, a fibroblast growth factor receptor (FGFR) 1-3 inhibitor, in patients with previously treated advanced urothelial carcinoma with FGFR3 alterations. Cancer discovery. ISSN 2159-8290; 2159-8274

Isbell, John and Yuan, Ding and Reis Da Silva Torrao, Leonel and Gatlik, Ewa and Hoffmann, Laurent and Wipfli, Peter (2018) Plasma protein binding of highly bound drugs determined with equilibrium gel filtration of non-radiolabeled compounds and LC-MS/MS detection. J Pharmaceutical Sciences.

Israel, Laura and Bardet, Maureen and Huppertz, Antje and Mercado, Nicolas and Ginster, Stefanie and Unterreiner, Adeline and Schlierf, Anita and Goetschy, Jean Francois and Zerwes, Hans-Guenter and Roth, Lukas and Kolbinger, Frank and Bornancin, Frederic (2018) A CARD10-dependent tonic signalosome activates MALT1 paracaspase and regulates IL-17/TNF-a driven keratinocyte inflammation. Journal of investigative dermatology: Symposium proceedings.. ISSN 1529-1774; 1087-0024

Israel, Laura and Bornancin, Frederic (2018) Ways and waves of MALT1 paracaspase activation. Cellular & molecular immunology :.


Jacquemont, S and Pacini, L and Cencelli, G and Jønch, E and Andrea, D and Willemsen, R and Tassone, F and Hagerman, R and Bagni, C and Gasparini, Fabrizio and He, Yunsheng and Rozenberg, Izabela and Gomez-Mancilla, Baltazar (2018) Altered and normal levels of protein synthesis in fragile X syndrome, studies in humans and mice. Science translational medicine, 27 (12). pp. 2039-2051. ISSN 10.1093/hmg/ddy099

Jerby-Arnon, Livnat and Shah, Parin and Cuoco, Michael S and Rodman, Christopher and Su, Mei-Ju and Melms, Johannes C and Leeson, Rachel and Kanodia, Abhay and Mei, Shaolin and Lin, Jia-Ren and Wang, Shu and Rabasha, Bokang and Liu, David and Zhang, Gao and Margolais, Claire and Ashenberg, Orr and Ott, Patrick A and Buchbinder, Elizabeth I and Haq, Rizwan and Hodi, F Stephen and Boland, Genevieve M and Sullivan, Ryan J and Frederick, Dennie T and Miao, Benchun and Moll, Tabea and Flaherty, Keith T and Herlyn, Meenhard and Jenkins, Russell W and Thummalapalli, Rohit and Kowalczyk, Monika S and Cañadas, Israel and Schilling, Bastian and Cartwright, Adam N R and Luoma, Adrienne M and Malu, Shruti and Hwu, Patrick and Bernatchez, Chantale and Forget, Marie-Andrée and Barbie, David A and Shalek, Alex K and Tirosh, Itay and Sorger, Peter K and Wucherpfennig, Kai and Van Allen, Eliezer M and Schadendorf, Dirk and Johnson, Bruce E and Rotem, Asaf and Rozenblatt-Rosen, Orit and Garraway, Levi A and Yoon, Charles H and Izar, Benjamin and Regev, Aviv (2018) A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell, 175 (4). 984-997.e24. ISSN 1097-4172

Ji, Yan and Jin , Jin Y. and Hyman, David and Kim, Geoffrey and Suri, Ajit (2018) Challenges and Opportunities in Dose Finding in Oncology and Immuno-oncology. Clinical and Translational Science, 00. pp. 1-7.

Jiang, Xiaomo (2018) INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. ELife., 7. ISSN 2050-084X

Johasz, Christian and Nassim , Rousset and Kasper, Renggli and Hierlemann, Andreas (2018) Scalable Microfluidic Platform for Flexible Configuration of and Experiments with Microtissue Multiorgan Models. SLAS. pp. 1-17.

Jones, Adriana and Ranjitkar, Srijan and Lopez, Sara and Li, Cindy and Blais, Johanne and Reck, Folkert and Dean, Charles (2018) Impact of inducible blaDHA-1 on susceptibility of Klebsiella pneumoniae clinical isolates to LYS228 and identification of chromosomal mpl mutations mediating upregulation of plasmid borne DHA-1 expression. Antimicrobial agents and chemotherapy, 62 (10).

Jourdain, Marie and Melly, Stefan and Summermatter, Serge and Hatakeyama, Shinji (2018) Mouse models of cancer-induced cachexia: Hind limb muscle mass and evoked force as readouts. Biochemical and biophysical research communications : BBRC. ISSN 1090-2104

Juric, Dejan and Janku, Filip and Rodon, Jordi and Burris, Howard A. and Mayer, Ingrid A. and Schuler, Martin and Seggewiss-Bernhard, Ruth and Gil-Martin, Marta and Middleton, Mark R. and Baselga, Jose and Bootle, Douglas and Demanse, David and Blumenstein, Lars and Schumacher, Karl and Huang, Alan and Quadt, Cornelia and Rugo, Hope S. (2018) Alpelisib (BYL719) plus Fulvestrant in PIK3CA-altered and PIK3CA wild-type ER+ advanced breast cancer. An open-label, phase 1b dose-escalation and expansion study. JAMA oncology, Oncol.. E1-E9. ISSN 2374-2437


Kaesler, Nadine and Verhulst, Anja and De Maré, Annelies and Deck, Annika and Behets, Geert J. and Hyusein, Ayshe and Evenepoel, Pieter and Floege, Jürgen and Marx, Nikolaus and Babler, Anne and Kramer, Ina and Kneissel, Michaela and Kramann, Rafael and Weis, Daniel and D`Haese, Patrick C. and Brandenburg, Vincent M. (2018) Sclerostin-deficiency modifies the development of CKD-MBD in mice. Bone, 107. pp. 115-123. ISSN 1873-2763; 8756-3282

Kall, Morten A. and Michi, Marco and Van der Strate, Barry and Freisleben, Achim and Stoellner, Daniela and Timmerman, Philip (2018) Incurred sample reproducibility: 10 years of experiences: Views and recommendations from the European Bioanalysis Forum. Bioanalysis, 10 (21). pp. 1723-1732. ISSN 17576199

Kapur, Reuben and Cai, Zhigang and Pandey, Ruchi and Mali, Rahuveer and Ramdas, Baskar and Sandusky, George and Kelley, Mark and Mohseni, Mori (2018) Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cell Stem Cell, 23 (6). 833-849.e5. ISSN 18759777

Karpov, Alexei and Abrams, Tinya and Clark, Suzy and Raikar, Ankita and D'Alessio, Tony and Gesner, Tom and Jones, Darryl and Lacaud-Baumlin, Marion and Martyniuk, Piotr and Meredith, Erik and Mohseni, Mori and Nieto-Oberhuber, Cristina and Palacios, Daniel and Perruccio, Francesca and Zurini, Mauro and Bialucha, Carl (2018) Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Medicinal Chemistry Letters. ISSN 19485875

Katoli, Parvaneh and Godbole, Adarsh and Romanowski, Michael and Clark, Kirk and Meredith, Erik and Saenz-Vash, Veronica and Wang, Yingqi and Lewicki, Nancy and Nguyen, Andrew and Lynch, Jeffrey (2018) Full-length myocilin (MYOC) protein is purified from mammalian cells as a dimer. Protein expression and purification, 147 (2018). pp. 38-48. ISSN 1096-0279; 1046-5928

Katsumiti, Alberto and Thorley, Andrew J and Arostegui, Inmaculada and Reip, Paul and Valsami-Jones, Eugenia and Tetley, Teresa D and Cajaraville, Miren P (2018) Cytotoxicity and cellular mechanisms of toxicity of CuO NPs in mussel cells in vitro and comparative sensitivity with human cells. Toxicology in vitro : an international journal published in association with BIBRA, 48. pp. 146-158. ISSN 1879-3177

Kenny, Jane and Ramsden, Diane and Buckley, David and Dallas, Shannon and Fung, Conrad and Mohutsky, Michael and Einolf, Heidi and Chen, Liangfu and Dekeyser, Joshua and Fitzgerald, Maria and Goosen, Theunis and Siu, Y. Amy and Walsky, Robert and Zhang, George and Tweedie, Donald and Hariparsad, Niresh (2018) Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevance. Drug Metabolism and Disposition, 46 (9). pp. 1285-1303. ISSN 0090-95561521-009X

Kim, Kwang Soo and Marcogliese, Paul C. and Yang, Jungwoo and Callaghan, Steve and Resende, Virginia and Abdel-Messih, Elizabeth and Marras, Connie and Visanji, Naomi P. and Huang, Jana and Schlossmacher, Michael G. and Tinkle-Mulcahy, Laura and Slack, Ruth S. and Lang, Anthony E. and Park, David S. (2018) Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease. Proceedings of the National Academy of Sciences, 115 (22). ISSN 0027-84241091-6490

King, Daniel and Nguyen, Zachary and Jimenez, Marta and Auld, Douglas and Kool, Eric and Tahara, Yu-ki and Ji, Debin and Beharry, Andrew and Kietrys, Anna M. and Wilson, David M. (2018) Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. Journal of the American Chemical Society, 140 (6). pp. 2105-2114. ISSN 15205126

Kittelmann, Matthias and Worsch, Anne and Girhard, Marco and von Bühler, Clemens and Tieves, Florian and Czaja, Rico and Vogel, Andreas and Grumaz, Christian and Sohn, Kai and Lütz, Stephan and Urlacher, Vlada (2018) A novel cytochrome P450 monooxygenase from Streptomyces platensis resembles activities of human drug metabolizing P450s. Biotechnol Bioeng..

Klopp, Julia and Winterhalter, Aurelie and Gebleux, Remy and Scherer-Becker, Daniela and Ostermeier, Christian and Gossert, Alvar (2018) Cost-effective large-scale expression of proteins for NMR studies. Journal of Biomolecular NMR. pp. 1-16. ISSN 15735001

Knoepfel, Thomas and Furet, Pascal and Mah, Robert and Buschmann, Nicole and Leblanc, Catherine and Ripoche, Sebastien and Graus Porta, Diana and Wartmann, Markus and Galuba, Inga (2018) 2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4. ACS Medicinal Chemistry Letters, 9 (3). pp. 215-220. ISSN 19485875

Koga, Tadanori and Barkley, Deborah and Nagao, Michihiro and Taniguchi, Takashi and Carrillo, Jan-Michael Y. and Sumpter, Bobby G. and Masui, Tomomi and Kishimoto, Hiroyuki and Koga, Maho and Rudick, Jonathan G. and Endoh, Maya K. (2018) Interphase Structures and Dynamics near Nanofiller Surfaces in Polymer Solutions. Macromolecules, 51 (23). pp. 9462-9470. ISSN 0024-9297

Kou, Jianqun and Staal, Ben and Musich, Phillip and Kang, Liang and Qin, Yuan and Yao, Zhi and Zhang, Boheng and Tam, Angela and Huang, Alan and Hao, Huaixiang and Vande Woude, George and Xie, Qian (2018) Differential Therapeutic Responses of MET Oncogenic Activations to MET Kinase Inhibitor and Neutralizing Antibody. Journal of translational medicine, 16 (253 ). ISSN 1479-5876

Krantz, Carsten and Warren, Andrew Paul and Miess, Christian (2018) Development of an automated, interference-free, immunoaffinity-based mass spectrometric assay for quantification a therapeutic monoclonal antibody in human sera. Bioanalysis, 10 (13). pp. 1023-1037. ISSN 1757-6180

Krischuns, Tim and Günl, Franziska and Henschel, Lea and Binder, Marco and Willemsen, Joschka and Schloer, Sebastian and Rescher, Ursula and Gerlt, Vanessa and Zimmer, Gert and Nordhoff, Carolin and Ludwig, Stephan and Brunotte, Linda (2018) Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Frontiers in immunology, 9. p. 2229. ISSN 1664-3224

Kucher, Klaus and Johns, Donald and Maier, Doris and Abel, Rainer and Badke, Andreas and Baron, Hagen and Thietje, Roland and Casha, Steven and Meindl, Renate and Gomez-Mancilla, Baltazar and Pfister, Christian and Mir, Anis Khusro and Rupp, Rüdiger and Weidner, Norbert and Schwab, Martin and Curt, Armin (2018) First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury. Neurorehabilitation and Neural Repair, 32 (6-7). pp. 578-589. ISSN 1545-96831552-6844


L'Italien, Lawrence and Orozco, Olivia and Abrams, Tinya and Cantagallo, Lisa and Connor, Anu and Desai, Jayesh and Ebersbach, Hilmar and Gelderblom, Hans and Hoffmaster, Keith and Maacke, Heiko and Schleyer, Siew and Skegro, Darko and Lee-Hoeflich, Si Tuen (2018) Mechanistic insights of an immunological adverse event induced by an anti-KIT antibody drug conjugate and mitigation strategies. Clinical Cancer Research, 24 (14). pp. 3465-3474. ISSN 15573265

LaRochelle, Jonathan R. and Fodor, Michelle and Vemulapalli, Vidyasiri and Mohseni, Mori and Wang, Ping and Stams, Travis and Lamarche, Matthew and Chopra, Rajiv and Acker, Michael and Blacklow, Stephen C. (2018) Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nature Communications, 9 (1). ISSN 20411723

Labarbarie, Bertrand (2018) Engineering of Mouse Embryonic Fibroblasts (MEFs) derived from Cas9 animals for in vitro and in vivo studies of resistance. Internship report.

Lamb, John and Horman, Shane and Trifonov, Vladimir and Orth, Anthony and Lesley, Scott and To, Jeremy and Zhang, Jia and Jennings, Lori and Emilsson, Valur and IIkov, M and Aspelund, Thor and Gudmundsson, EF and Jakobsdottir, J and Manolescu, A and Harris, TB and Launer, LJ and Eiriksdottir, G and Gudnason, Vilmandur and Finkel, Nancy and Pitts, Rebecca and Hoover, Heather and Gudmundsdottir, Valborg and Shu, Le and Sigurdsson, Sigurdur and Zhu, Jun and Olafsson, Orn and Harris, Tamara and Zhang, Bin and Yang, Xia (2018) Co-regulatory networks of human serum proteins link genetics to disease. Science, 361 (6404). pp. 769-773. ISSN 10959203

Langevin, Nicholas and Schafer, Kenneth and Turner, Oliver and McPherson, Brittany and Rose, Robert (2018) Historical Data: Histopathology Lesions Observed in the Eyes of Control Rabbits in Topical Ocular Administration and Contact Lens Studies. Toxicologic Pathology, 46 (7). pp. 799-820. ISSN 15331601

Lapp, Stefanie and Bube, Axel and Ernst, Heinrich and Colbatzky, Florian and Kellner, Rupert and Nolte , Thomas and Rinke, Matthias (2018) Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*). Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*).

Laternser, Sandra and Keller, Hansjoerg and Leupin, Olivier and Rausch, Martin and Graf-Hausner, Ursula and Rimann, Markus (2018) A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues. SLAS TECHNOLOGY: Translating Life Sciences Innovation. ISSN 2472-63032472-6311

Laura, Magil and Marsilio, Adriani and Véronique, Berthou and Keguan, Chen and Aude, Gleizes and Salima, Hacein-Bey-Abina and Agnes, Hincelin-Mery and Xavier, Mariette and Marc, Pallardy and Spindeldreher, Sebastian and Natacha, Szely and David, Isenberg and Jessica, Manson and Elizabeth, Jury and Claudia, Mauri (2018) Low Percentage of Signal Regulatory Protein α/β+ Memory B Cells in Blood Predicts Development of Anti-drug Antibodies (ADA) in Adalimumab-Treated Rheumatoid Arthritis Patients. Frontiers in immunology, 9. ISSN 16643224

Laux, Holger and Romand, Sandrine and Nuciforo, Sandro and Farady, Christopher and Tapparel, Joel Alois Rene and Buechmann-Moeller, Stine and Sommer, Benjamin and Oakeley, Edward James and Bodendorf, Ursula (2018) Degradation of recombinant proteins by CHO host cell proteases is prevented by Matriptase-1 knock-out. Biotechnology and bioengineering. ISSN 00063592

Laux, Holger and Romand, Sandrine and Tapparel, Joel Alois Rene and Nuciforo, Sandro and Buechmann-Moller, Stine and Dogrusoez, Guelay and Probst, Claudia Monika and Sommer, Benjamin and Oakeley, Edward James and Bodendorf, Ursula (2018) Degradation of recombinant proteins of diverse formats by CHO host cell proteases is circumvented via knock-out of CHO matriptase. BMC proceedings., 12(Sup (3). pp. 2-3.

Lee, Patrick and Lapointe, Guillaume and Madera, Ann Marie and Simmons, Bob and Xu, Wenjian and Yifru, Aregahegn and Tjandra, Meiliana and Karur, Subramanian and Rico, Alice and Thompson, Katherine and Bojkovic, Jade and Xie, Lili and Uehara, Kyoko and Liu, Amy and Shu, Wei and Bellamacina, Cornelia and Mckenney, David and Morris, Laura and Osborne, Colin and Benton, Bret and McDowell, Laura and Fu, Jiping and Sweeney, Zachary (2018) Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline. Journal of medicinal chemistry.

Leeds, Jennifer (2018) LpxD project. various.

Lehmann, Hansjoerg (2018) Diazomethane and Flow Chemistry: Filling a Gap in Pharma R&D. Chimica oggi : = Chemistry today..

Lei, Weiwei and Ren, Wenwen and Ohmoto, Makoto and Redding, Kevin and Littlewood-Evans, Amanda and Carballido, Jose and Urban, Joseph and Margolskee, Robert and Matsumoto, Ichiro and Jiang, Peihua (2018) Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proceedings of the National Academy of Sciences. ISSN 0027-84241091-6490

Li, Jianyu and Weber, Eckhard and Guth-Gundel, Sabine and Schuleit, Michael and Kuttler, Andreas and Halleux, Christine and Accart Gris, Nathalie and Doelemeyer, Arno and Basler, Anne and Tigani, Bruno and Wuersch, Kuno and Fornaro, Mara and Kneissel, Michaela and Stafford, Alexander and Freedman, Benjamin R and Mooney, David J (2018) Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs. Advanced Healthcare Materials, 7 (9). 1701393 (1) -1701393 (10). ISSN 21922640

Li, Wenkui and Doherty, John and Fu, Yunlin and Flarakos, Jimmy (2018) Quantitative analysis of clofazimine (Lamprene®), an antileprosy agent, in human dried blood spots using liquid chromatography–tandem mass spectrometry. Biomedical Chromatography, 32 (2). ISSN 10990801

Lightfoot, Helen and Frederick, Goldberg and Sedelmeier, Joerg Mathias (2018) Evolution of Small Molecule Kinase Drugs. Journal of Medicinal Chemistry Letters (ACS).

Lima, Fabio and Grunenberg, Lars and Husaini, Mohamed and Labes, Ricardo and Sedelmeier, Joerg Mathias and Ley, Steven (2018) Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow. Chemical Communications, 54 (44). pp. 5606-5609. ISSN 1364548X

Lindner, John Michael and Friedensohn, Simon and Cornacchione, Vanessa and Iazeolla, Mariavittoria and Miho, Enkelejda and Zingg, Andreas and Meng, Simon and Traggiai, Elisabetta and Reddy, Sai (2018) High-throughput sequencing error and bias correction increases the quantitative resolution of human naïve and memory B-cell receptor repertoires. BioRxiv Preprint Server, NA (NA). ISSN NA

Liu, Xin (2018) Profile-QSAR的发展. Undergraduate thesis, Fudan University, Shanghai, China.

Lofgren, Jennie (2018) AALAS Seminar Series: The Laboratory Animal Medical Professional’s Guide to How the 3R’s Enhance Rigor and Reproducibility. Laboratory Animal Science Professional.

Lopez, John (2018) N-Butylpyrrolidone as a green solvent for Solid Phase Peptide Synthesis. Organic process research & development, 22. pp. 494-503. ISSN 1520-586X; 1083-6160

Loren, Jon and Herath, Ananda and Molteni, Valentina and Pan, Shifeng (2018) Generation and Cross-Coupling of Organozinc Reagents in Flow. Organic Letters. ISSN 1523-70601523-7052

Luen, SJ and Lee, CK and Savas, P and Kammler, R and Dell’Orto, P and Biasi, OM and Demanse , D and JeBailey , J and Dolan, S and Hackl, W and Thuerlimann, B and Viale, G and Colleoni , M and Regan, MM and Loi, S (2018) Association of somatic driver alterations with prognosis in postmenopausal, hormone receptor-positive, HER2-negative early breast cancer - A secondary analysis of the BIG 1-98 randomized clinical trial. JAMA Oncology, Publis (June 1). E1-E9. ISSN n.a.

Lynch, Jeffrey and Dolman, Andrew and Guo, Chenying and Li, Bing and Prasanna, Ganesh (2018) A pathologic MYOC mutation results in a novel skeletal muscle phenotype. PLoS ONE, 13 (11). e0206801. ISSN 1932-6203

Lynch, Jeffrey and Li, Bing and Katoli, Parvaneh and Xiang, Chuanxi and Leehy, Barrett and Rangaswamy, Nalini and Saenz-Vash, Veronica and Wang, Yingqi and Lei, Hong and Nicholson, Thomas and Meredith, Erik and Chen, Amy and Prasanna, Ganesh and Rice, Dennis (2018) Myocilin binding to a-b-crystallin sheds light on an old and blinding disease. Journal of Biological Chemistry, 293 (52). pp. 20137-20156.


Ma, Shang and Cahalan, Stuart and Rakhee, Lohia and Gregory, LaMonte and Weizheng, Zeng and Swetha, Murthy and Emma, Paytas and Nathan D, Grubaugh and Ramya, Gamini and Laurence, Berry and Viktor, Lukacs and Tess, Whitwam and Meaghan, Loud and Schmedt, Christian and Andrew I, Su and Kristian G, Andersen and Elizabeth A, Winzeler and Eric, Honore and Kai, Wengelnik and Ardem, Patapoutian (2018) Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell, 173 (2). 443-455.e12. ISSN 10974172

Mac Donald, Alisdair J and Miller, Janice and Ramage, Michael I and Greig, Carolyn and Stephans, Nathan A and Jacobi, Carsten and Preston, Thomas and Fearon, Kenneth CH and Skipworth, Richard JE (2018) Cross sectional imaging of truncal and quadriceps muscles relates to different functional outcomes in cancer. Clinical nutrition.. ISSN 1878-3368; 1744-1161

Maclachlan, Timothy and Milton, Mark and Turner, Oliver and Bigelow, Chad and Tukov, Francis and Choi, Vivian and Penraat, Jan and Delmotte, Marie Helene and Michaut, Lydia and Jaffe, Bruce (2018) Nonclinical safety evaluation of scAAV8-RLBP1 (CPK850) for treatment of RLBP1 retinitis pigmentosa. Human gene therapy - Clinical Development.

Manjunatha, Ujjini Havaldar and Chao, Alexander and Lee, Boon Heng and Wan, Kah Fei and Selva, Jeremy and Zou, Bin and Gedeck, Peter and Beer, David John and Diagana, Thierry Tidiane and Bonamy, Ghislain (2018) Development of a novel cytopathic effect-based phenotypic screening assay against Cryptosporidium. ACS infectious diseases. ISSN 2373-8227

Mannschott, Thomas and Krumme, Markus and Kreimer, Manuel and Aigner, Isabella and Sacher, Stephan and van der Wel, Peter and Kaptein, Albert and Schroettner, Hartmuth and Brenn, Guenter and Khinast, Johannes G. (2018) Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets. Powder Technology, 325. pp. 247-260. ISSN 1873328X

Marcomini, Isabella and Shimada, Kenji and Delgoshaie, Neda and Yamamoto, Io and Seeber, Andrew and Cheblal, Anais and Naumann, Ulrike and Horigome, Chihiro and Gasser, Susan (2018) Asymmetric Processing of DNA Ends at a Double-Strand Break Leads to Unconstrained Dynamics and Ectopic Translocation. Cell Reports, 24 (10). 2614-2628.e4. ISSN 22111247

Martin, Benjamin and Ganiek, Maximilian and Ivanova, Maria and Knochel, Paul (2018) Mild Homologation of Esters via Continuous Flow Chloroacetate Claisen Reactions. Angewandte Chemie. International edition, 57. pp. 1-6. ISSN 14337851

Martin, Benjamin and Lehmann, Hansjoerg and Yang, Hongwei and Chen, Like and Tian, Xiangguang and Polenk, Jutta and Schenkel, Berthold (2018) Continuous manufacturing as an enabling tool with green credentials in early-phase pharmaceutical chemistry. Current Opinion in Green and Sustainable Chemistry, 11. pp. 27-33.

Martin, Eric and Daga, Pankaj and Bolger, Michael and Haworth, Ian and Clark, Robert (2018) Physiologically-Based Pharmacokinetic Modeling in Lead Optimization I: Evaluation and Adaptation of GastroPlus® to Predict Bioavailability of Medchem Series. Molecular Pharmaceutics. ISSN 1543-83841543-8392

Martina, Maritan and Danielle, Veggi and Roberta , Cozi and Lucia, Ianaco and Erika, Bartolini and Paola, La Surdo and Giulietta, Maruggi and Spraggon, Glen and Matthew, Bottomley and Enrico, Malito (2018) Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody. PLoS ONE, 13 (8). ISSN 19326203

Masliah, Gregoire and Maris, Christophe and Koenig, Sebastian L.B. and Yulikov, Maxim and Aeschimann, Florian and Malinowska, Anna L. and Mabille, Julie and Weiler, Jan and Holla, Andrea and Hunziker, Juerg and Meisner Kober, Nicole-Claudia and Schuler, Benjamin and Jeschke, Gunnar and Allain, Frederic H.-T. (2018) Structural basis of siRNA recognition by TRBP double-stranded RNA binding domains. The EMBO Journal, 37. ISSN 0261-41891460-20750261-41891460-2075

Mathews Griner, Lesley and Gampa, Kalyani and Do, Toan and Hartkopf, Huyen and Farley, David and Auld, Douglas and Silver-Brown, Serena (2018) Generation of high-throughput three dimensional tumor spheroids for drug screening. Generation of high-throughput three dimensional tumor spheroids for drug screening , 3 (139).

McKenna, Jeffrey and Schirle, Markus and Thomas, Jason (2018) Disclosure of compounds to UCB for NB-CPACT. undetermined at present.

McMahon, Michael and Ding, Shaohong and Acosta Jimenez, Lourdes and Terranova, Remi and Gerard, Marie-Apolline and Vitobello, Antonio and Moggs, Jonathan and J. Henderson, Colin and Wolf, C. Roland (2018) CONSTITUTIVE ANDROSTANE RECEPTOR 1 IS CONSTITUTIVELY BOUND TO CHROMATIN AND ‘PRIMED’ FOR TRANSACTIVATION IN HEPATOCYTES. Molecular pharmacology. ISSN 1521-0111; 0026-895X

Mckenna, Jeffrey and Feng, Yan and Zheng, Lianxing and Bender, Steven and Cho, Charles and McWhirter, Sarah and Dubensky, Thomas and van Elsas, Andrea and Ndubaku, Chudi and Sivik, Kelsey and Desbien, Anthony and Hix-Glickman, Laura (2018) Magnitude of Therapeutic STING Activation Determines CD8<sup>+</sup> T Cell-Mediated Anti-tumor Immunity. Cell reports, 25 (11). p. 3074. ISSN 22111247

Meier, Silvio R and Syveanen, Stina and Hultquist, Greta and Fang, Xiaotiasn T and Roshanbin, Sahar and Lannfelt, Lars and Neumann, Ulf and Sehlin, Dag (2018) Antibody-based in vivo PET imaging detects amyloid-ß reduction in Alzheimer transgenic mice after BACE-1 inhibition. Journal of Nuclear Medicine, 59 (12). pp. 1901-1906. ISSN 2159662X

Messer, J.G. and Mendieta Calle, J.L. and Jiron, J.M. and Castillo, E.J. and Van Poznak, C. and Bhattacharyya, N. and Kimmel, D.B. and Aguirre, J.I. (2018) Zoledronic Acid Increases the Prevalence of Medication-related Osteonecrosis of the Jaw in Rice Rats (Oryzomys palustris) in a Dose Dependent Manner. Bone, 108 (3). pp. 79-88. ISSN 1873-2763; 8756-3282

Metz, Martin and Torene, Rebecca and Kaiser, Sergio and Beste, Michael and Staubach, Petra and Bauer, Andrea and Brehler, Randolf and Gericke, Janine and Letzkus, Martin and Hartmann, Nicole and Erpenbeck, Veit and Maurer, Marcus (2018) Omalizumab normalizes the gene expression signature of lesional skin in patients with chronic spontaneous urticaria: a randomized, double-blind, placebo-controlled study. Allergy. pp. 1-29. ISSN 1398-9995; 0105-4538

Milovanov, Maxim (2018) NEXT UI: evolution story. NEXT UI: Evolution story.

Milton, Mark and Maclachlan, Timothy and Brennan, Frank and Andrews, Laura and Arulanandam, Tony and Fikes, Jim and Grimaldi, Christine and Lansita, Janice and Loberg, Lise and Parker, Suezanne and Tibbitts, Jay and Wolf, Jayanthi and Allamneni, Krishna (2018) Current Strategies in the non-clinical safety assessment of biologics: New Targets, New Molecules, New Challenges (A report of the 2016 Annual US BioSafe General Membership meeting). Regulatory toxicology and pharmacology, 98. pp. 98-107.

Moggs, Jonathan and Terranova, Remi (2018) Chromatin dynamics underlying latent responses to xenobiotics. Toxicology research, 7. pp. 606-617.

Mol, Vivienne (2018) Master thesis: "Development of half-life extended GDF15 for therapeutic applications; expression and secretion in mammalian cells.". Master thesis to be submitted at University Wageningen, Netherlands.

Morse, Alyson and Cheng, Tegan L and Schindeler, Aaron and McDonald, Michelle M and Mohanty, Sindhu and Kneissel, Michaela and Kramer, Ina and Little, David G (2018) Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume. Calcified tissue international.

Mostafavi, Mina and Wang, Lisha and Xie, Lili and Takeoka, Ken and Richie, Daryl and Casey, Fergal and Ruzin, Alexey and Sawyer, William and Rath, Christopher and Wei, Jun-Rong and Dean, Charles (2018) Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis. mSphere.

Moujalled, Donia and Pomilio, Giovanna and Ghiurau, Corina and Ivey, Adam and Salmon, Jessica and Rijal, Sewa and Macraild, Sarah and Zhang, Lan and Teh, Tse-Chieh and Tiong, Ing-Soo and Lan, Ping and Schaeffer, Fabienne and Von Arx, Fabian and Chanrion, Maia and Claperon, Audrey and Rocchetti, Francesca and Kraus-Berthier, Laurence and Wang, Youzhen and Halilovic, Ensar and Morris, Erick and Colland, Frederic and Segal, David and Mistry, Prakash and Huang, David and Roberts, Andrew and Maragno, Ana Leticia and Lessene, Guillaume and Geneste, Olivier and Wei, Andrew (2018) Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia. Leukemia. ISSN 14765551

Mrak, Peter and Moore, Charles and Krastel, Philipp and Pivk-Lukancic, Petra and Tao, Jianshi (2018) Discovery of the actinoplanic acid pathway in Streptomyces rapamycinicus reveals a genetically conserved synergism with rapamycin. The Journal of biological chemistry, 293 (52). pp. 19982-19995. ISSN 1083351X

Mueller, Arne and Hoefling, Holger and Nuritdinow, Timur and Holway, Nicholas and Schieker, Matthias and Daumer, Martin and Clay, Ieuan (2018) Continuous monitoring of patient mobility for 18 months using inertial sensors following serious knee injury: a case study. Digital Biomarkers. pp. 79-89. ISSN 2504-110X

Murgasova, Renata and Tor Carreras, Ester and Bourgailh, Julien (2018) In Vitro Monitoring of the Mitochondrial Beta-Oxidation Flux of Palmitic Acid and Investigation of Its Pharmacological Alteration by Therapeutics. European Journal of Drug Metabolism and Pharmacokinetics. pp. 1-10. ISSN 2107-0180

Murgasova, Renata and Tor Carreras, Ester and Bourgailh, Julien (2018) In Vitro Monitoring of the Mitochondrial Beta-Oxidation Flux of Palmitic Acid and Investigation of Its Pharmacological Alteration by Therapeutics. European Journal of Drug Metabolism and Pharmacokinetics. pp. 1-10. ISSN 21070180

Murgasova, Renata and Tor Carreras, Ester and Bourgailh, Julien (2018) In Vitro Monitoring of the Mitochondrial Beta-Oxidation Flux of Palmitic Acid and Investigation of Its Pharmacological Alteration by Therapeutics. European journal of drug metabolism and pharmacokinetics. ISSN 2107-0180

Mustoe, Anthony M and Busan, Steven and Rice, Gregg and Hajdin, Christine and Peterson, Brant and Ruda, Vera and Kubica, Neil and Nutiu, Razvan and Baryza, Jeremy and Weeks, Kevin M (2018) Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing. Cell, 173 (1). pp. 181-195. ISSN 00928674



Namoto, Kenji and Sirockin, Finton and Sellner, Holger and Wiesmann, Christian and Villard, Frederic and Valeur, Eric and Robinson, Michael and Moreau, Bob and Paulding, Stephanie and Schleeger, Simone and Schipp, Kathrin and Loup, Joachim and Andrews, Lori and O'Neill, Ryann and Farady, Christopher (2018) Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors. Bioorganic and Medicinal Chemistry Letters, 28 (5). pp. 906-909. ISSN 14643405

Nett, Ryan and Guan , Xin and Smith, Kevin and Faust, Ann Marie and Sattely, Elizabeth S. and Fischer, Curt R. (2018) D2O labeling to measure active biosynthesis of natural products in medicinal plants. AIChE journal. ISSN 00011541

Neumann, Ulf and Ufer, Mike and Jacobson, Laura and Rouzade-Dominguez, Marie-Laure and Huledal, Gunilla and Kolly, Carine and Lueoend, Rainer Martin and Machauer, Rainer and Veenstra, Siem and Hurth, Konstanze and Shimshek, Derya and Staufenbiel, Matthias and Perrot, Ludovic and Frieauff, Wilfried and Dubost, Valerie and Schiller, Hilmar and Vogg, Barbara and Beltz, Karen and Avrameas, Alexandre and Kretz, Sandrine and Pezous, Nicole and Rondeau, Jean-Michel and Beckmann, Nicolau and Hartmann, Andreas and David, Olivier and Galli, Bruno and Ramos, Rita and Graf, Ana and Lopez Lopez, Cristina and Vormfelde, Stefan (2018) The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease. EMBO molecular medicine, 10 (11). S227-S228. ISSN 17574684

Nigsch, Florian (2018) Postdoc internet site mentor profile. Novartis internet site.

Nigsch, Florian (2018) Postdoc position advertisement. Novartis postdoc internet site.

Nilsson, Inga and Prathapam, Ramadevi and Grove, Kerri and Lapointe, Guillaume and Six, David (2018) The sialic acid transporter NanT is necessary and sufficient for uptake of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) and its azido analog in Escherichia coli. Molecular microbiology. ISSN 1365-2958

Novello, Salvatore and Arcuri, Ludovico and Dovero, Sandra and Dutheil, Nathalie and Shimshek, Derya and Bezard, Erwan and Morari, Michele (2018) G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice. Neurobiology of disease, 120. pp. 21-33. ISSN 09699961

Novgorodov, Sergei A. and Voltin, Joshua R. and Gooz, Monika A. and Li, Li and Lemasters, John, J. and Tatyana I., Gudz (2018) A novel role of acid sphingomyelinase in mitochondrial dysfunction due to glutamate-induced programmed necrosis. Journal of Lipid Research, 59 (2). pp. 312-329. ISSN 0022-22751539-7262

Nunez, Fabiana and Taura, Jaume and Camacho, Juan and Lopez-Cano, Marc and Fernandez-Duenas, Victor and Castro, Naomi and Castro, Julio and Ciruela, Francisco (2018) PBF509, an adenosine A2A receptor antagonist with efficacy in rodent models of movement disorders. Frontiers in Pharmacology, 9 (OCT). ISSN 16639812


Occhetta, P and Pigeot, S and Halleux, Christine and Rasponi, M and Dasen, B and Ullrich, Thomas and Kramer, Ina and Guth-Gundel, Sabine and Barbero, A and Martin, I (2018) Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis. Proceedings of the National Academy of Sciences of the United States of America, 115 (18). pp. 4625-4630. ISSN 10916490

Oliver, Vanessa L and Thurston, Sarah E and Lofgren, Jennifer L (2018) Using Cageside Measures to Evaluate Analgesic Efficacy in Mice () after Surgery. Journal of the American Association for Laboratory Animal Science : JAALAS, 57 (2). pp. 186-201. ISSN 1559-6109

Orlando, Elena and Brogdon, Jennifer and Bitter, Hans and Joseph, Fraietta and Simon , Lacey and David, Ambrose and Nicholas, Wilcox and Felipe, Bedoya and Corin, Dofrmeier and Fang, Chen and Noelle, Frey and Wei-Ting, Hwang and Harit, Parakandi and Minnal, Gupta and A., Huang and Brad, Johnson and Irina, Kulikovskaya and Bruce , Levine and Li, Liu and Stefan, Lundh and Edward, Pequignot and Donald, Siegel and Yan, Wang and E.J., Wherry and Jun, Xu and Regina, Young and David, Porter and Carl, June and Jan, Melenhorst and Pruteanu-Malinici, Iulian (2018) Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature Medicine, 24 (5). pp. 563-571. ISSN 1546170X

Orlando, Elena and Han, Xia and Wood, Patricia and Leary, Rebecca and Pierog, Peter and Brogdon, Jennifer and Bitter, Hans and Morrissey, Michael and Pantano, Serafino and Adamovich, Wendy and Tribouley, Catherine and Kevin, Nguyen and John, Levine and Muna, Qayad and Stephan, Grupp and Michael, Boyer and Barbara, DeMoerloose and Eneida, Nemecek and Henrique, Bittencourt and Hidefumi, Hiramatsu and Jochen, Büchner and Stella, Davies and Michael, Verneris and Engelman, Jeffrey (2018) Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia. Nature Medicine, 24. pp. 1504-1506. ISSN 1546170X

Ostrov, David A. and Alkanani, Aimon and McDaniel, Kristen A. and Case, Stephanie and Baschal, Erin E. and Pyle, Laura and Ellis, Sam and Seidl, Katherine J. and Shah, Viral N. and Garg, Satish K. and Atkinson, Mark A. and Gottlieb, Peter A. and Michels, Aaron W. (2018) Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. Journal of Clinical Investigation. ISSN 0021-9738

Otto, Heike (2018) Uncover the limitations of PM 2.0 - Project Management in 10-year progression. Fleming PPM Conference 2018, Berlin.

Ou, Weijia and Bursulaya, Badry and Didonato, Michael and Herath, Ananda and Jin, Yunho and Hao, Xueshi and Loren, Jon and Brock, Ansgar and Uno, Tetsuo and Geierstanger, Bernhard and Cellitti, Susan and Mortenson, Grace (2018) Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation. ChemBioChem, 19 (8). pp. 799-804. ISSN 14397633


Pacifici, Maurizio and Decker, Rebekah and Koyama, Eiki (2018) Limb Synovial Joint Development From the Hips Down: Implications for Articular Cartilage Repair and Regeneration. Developmental Biology and Musculoskeletal Tissue Engineering. pp. 67-101.

Pancholi, Alpa and Iacobini, Greg and Clarkson, Guy and Porter, David and Shipman, Michael (2018) Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues. Journal of Organic Chemistry, 83 (1). pp. 491-498. ISSN 15206904

Papillon, Julien and Nakajima, Katsumasa and Hempel, Jonathan and Karki, Rajeshri and Moebitz, Henrik and Ntaganda, Rukundo and Smith, Troy and Visser, Michael and Hill, Sue and Kellermann Hurtado, Felipe and Chenail, Gregg and Bhang, Hyo-Eun and Xiang, Xiaoqin and Bushold, Geoffrey and Gilbert, Tamara and Vattay, Anthony and Dooley, Julie and Costa, Emily and Adair, Chris and Jouk, Andriana and Li, Jingzhou and Bric, Anka and Park, Isabel and Li, Ailing and Farley, David and Lounkine, Eugen and Yue, Qing and Xie, Xiaoling and Kulathila, Raviraj and King, Daniel and Hu, Tiancen and Vulic, Katarina and Cantwell, John and Luu, Catherine and Jagani, Zainab (2018) Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. Journal of Medicinal Chemistry, 61 (22). pp. 10155-10172. ISSN 15204804

Pauli, Victoria Isabell and Elbaz, Frantz and Kleinebudde, Peter and Krumme, Markus (2018) Methodology for a variable rate Control Strategy development in Continuous Manufacturing applied to twin-screw wet-granulation and continuous fluid-bed drying. Journal of Pharmaceutical Innovation.

Pearson, David and Garnier, Maxime and Luneau, Alexandre and James, Alexander David and Walles, Markus (2018) 19F-NMR based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers. Xenobiotica. pp. 1-24. ISSN 0049-82541366-5928

Pearson, David and Garnier, Maxime and Luneau, Alexandre and James, Alexander David and Walles, Markus (2018) 19F-NMR based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers. Xenobiotica. pp. 1-24. ISSN 0049-82541366-5928

Peruzzotti-Jametti, Luca and Bernstock, Joshua D and Vicario, Nunzio and Costa, Ana SH and Kwok, Chee-Keong and Leonardi, Tommaso and Booty, Lee and Bicci, Iacopo and Balzarotti, Beatrice and Volpe, Giulio and Mallucci, Giulia and Manferrari, Giulia and Donega, Matteo and Iraci, Nunzio and Braga, Alice and Hallenbeck, John M and Murphy, Michael P and Edenhofer, Frank and Freeza, Christian and Pluchino, Stefano (2018) Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell, 22 (3). 355-368.e13. ISSN 18759777

Peter, Koch and Miller, Howard and Yu, Gary and Tallarico, John and Peter, Sorger and Wang, Yuan and Feng, Yan and Thomas, Jason and Nathan, Ross and Timothy, Mitchison (2018) A high content screen in primary human macrophages identifies small molecule modulators of STING-IRF3 and NFkB signaling. ACS Chemical Biology. ISSN 1554-89291554-8937

Peters, Finn and Salihoglu, Hazal and Rodriguez, Eva and Herzog, Etienne and Blume, Tanja and Filser, Severin and Dorostkar, Mario and Shimshek, Derya and Brose, Nils and Neumann, Ulf and Herms, Jochen (2018) BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology. Acta Neuropathologica, 135 (5). pp. 695-710. ISSN 14320533

Pihl, Susanne and van der Strate, Barry and Golob, Michaela and Vermet, Laurent and Jaitner, Birgit and Goodman, Joanne and Scheel Fjording, Marianne and Timmerman, Philip (2018) EBF recommendation on practical management of critical reagents for PK ligand-binding assays. Bioanalysis, 10 (19). pp. 1557-1565. ISSN 17576199

Plappert Helbig, Ulla and Libertini, Silvana and Frieauff, Wilfried and Theil, Diethilde and Martus, Hans-Joerg (2018) Gamma-H2AX immunofluorescence for the detection of tissue-specific genotoxicity in vivo. Environmental and molecular mutagenesis, 31 (6). pp. 732-733. ISSN 08936692

Plappert-Helbig, Ulla and Libertini, Silvana and Frieauff, Wilfried and Theil, Diethilde and Martus, Hans-Jörg (2018) Gamma-H2AX immunofluorescence for the detection of tissue-specific genotoxicity in vivo. Environmental and Molecular Mutagenesis. ISSN 08936692

Pognan, Francois and Beilmann, Mario and Boonen, Harrie and Czich, Andreas and Dear, Gordon and Hewitt, Philip and Mow, Tomas and Newham, Peter and Oinonen, Teija and Roth, Adrian and Valentin, Jean-Pierre and van Goethem, Freddy and Weaver, Richard (2018) Optimizing drug discovery by Investigative Toxicology: Current and future trends – Report of CAAT-ITL Forum Think Tank. ALTEX, 36 (2). pp. 289-313.

Pognan, Francois and Mahl, Joerg Andreas and Papoutsi, Maria and Ledieu, David and Raccuglia, Marc and Theil, Diethilde and Voytek, Sarah and Devine, Pj and Cordier, Andre and Heier, Annabelle and Kolly, Carine and Hartmann, Andreas and Chibout, Salah-Dine and Trendelenburg, Christian (2018) Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod appears irrelevant to rat and human. Archives of toxicology. ISSN 1432-0738; 0340-5761

Pognan, Francois and Steger-Hartmann, Thomas (2018) Improving the safety assessment of chemicals and drug candidates by the integrating bioinformatics and chemoinformatics. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7843

Pomerantz, Andrea and Sari-Sarraf, Farid and Grove, Kerri and Pedro, Liliana and Rudewicz, Patrick and Fathman, John and Krucker, Thomas (2018) Enabling drug discovery and development through single-cell imaging. Expert Opinion on Drug Discovery. pp. 1-11. ISSN 1746-04411746-045X

Pracht, Philipp and Wilcken, Rainer and Udvarhelyi, Aniko and Rodde, Stephane and Grimme, Stefan (2018) High accuracy quantum-chemistry-based calculation and blind prediction of macroscopic pKa values in the context of the SAMPL6 challenge. Journal of Computer-Aided Molecular Design, 32 (10). pp. 1139-1149. ISSN 15734951

Prescott, Thomas A.K. and Jaeg, Tiphaine and Hoepfner, Dominic (2018) Yeast Chemogenomic Profiling Reveals Iron Chelation to Be the Principle Cell Inhibitory Mode of Action of Gossypol. Journal of Medicinal Chemistry, 61 (16). pp. 7381-7386. ISSN 15204804

Pries, Verena and Nöcker, Christina and Khan, Danish and Ashutosh, Tripathi and Perruccio, Francesca and Jonen, Philipp and Filipuzzi, Ireos and Thavam, Sasikala and Aust, Thomas and Riedl, Ralph and Ziegler, Slava and Schaaf, Gabriel and Bankaitis, Vytas and Waldmann, Herbert and Hoepfner, Dominic (2018) High-resolution chemogenomics identifies Litrafungin, a fungal-selective inhibitor of the lipid transfer protein Sec14p. Cell Chemical Biology, 25. pp. 1-12.

Publicover, Jean and Gaggar, Anuj and Jespersen, Jillian and Halac, Ugar and Johnson, Audra and Goodsell, Amanda and Avanesyan, Lia and Nishimura, Stephen and Holdorf, Meghan and Mansfield, Keith and Judge, Joyce and Croft, Michael and Wakil, Adil and Rosenthal, Philip and Pai, Eric and Cooper, Stewart and Baron, Jody (2018) An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Science Translational Medicine, 10 (433). ISSN 1946-62341946-6242

Pugsley, M.K. and Authier, S. and Koerner, J.E. and Redfern, W.S. and Markgraf, C.G. and Brabham, T. and Correll, K. and Soloviev, M.V. and Botchway, A. and Engwall, M. and Traebert, M. and Valentin, J.-P. and Mow, T.J. and Greiter-Wilke, A. and Leishman, D.J. and Vargas, H.M. (2018) An overview of the safety pharmacology society strategic plan. Journal of Pharmacological and Toxicological Methods. ISSN 1873488X


Rageot, Denise and Bohnacker, Thomas and Melone, Anna and Langlois, Jean-Baptiste and Borsari, Chiara and Hillmann, Petra and Sele, Alexander M. and Beaufils, Florent and Zvelebil, Marketa and Hebeisen, Paul and Löscher, Wolfgang and Burke, John and Fabbro, Doriano and Wymann, Matthias P. (2018) Discovery and preclinical characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a highly potent and selective mTORC1/2 Inhibitor for cancer and neurological disorders. Journal of Medicinal Chemistry, 61 (22). pp. 10084-10105. ISSN 0022-2623

Rago, Florencia and DiMare, Matt and Elliott, Ginell and Ruddy, David and Sovath, Sosathya and Kerr, Grainne and Bhang, Hyo-eun and Jagani, Zainab (2018) Degron mediated BRM/SMARCA2 depletion uncovers novel combination partners for treatment of BRG1/SMARCA4-mutant cancers. Biochemical and biophysical research communications : BBRC. ISSN 0006291X

Ramirez, Yesid and Adler, Thomas and Altmann, Eva and Klemm, Theresa and Tiesmeyer, Christian and Sauer, Florian and Sotriffer , Christoph and Kisker, Caroline (2018) Structural basis of substrate recognition and covalent inhibition of Cdu1 from Chlamydia trachomatis. ChemMedChem : chemistry enabling drug discovery, 13 (19). pp. 2014-2023. ISSN 1860-7179

Rao, Raj and Ament, Brian and Richard, Parmee and J, Cameron and Martin, Mayo (2018) Rapid, non-destructive inspection and classification of inhalation blisters using low-energy x-ray imaging. Journal of pharmaceutical innovation. ISSN 1939-8042; 1872-5120

Rao, Srinivasa and Diagana, Thierry (2018) Drug Discovery for Kinetoplastid Diseases: Future Directions. ACS Infectious Diseases. ISSN 23738227

Reck, Folkert and Bermingham, Alun and Blais, Johanne and Capka, Vladimir and Cariaga, Taryn and Casarez, Anthony and Colvin, Richard and Dean, Charles and Fekete, Alexander and Growcott, Ellena and Guo, Hongqiu and Gong, Wanben and Jones, Adriana and Li, Cindy and Li, Fengxia and Lin, Xiaodong and Lindvall, Mika and Lopez, Sara and Mckenney, David and Metzger Iv, Louis and Moser, Heinz and Prathapam, Ramadevi and Rasper, Dita and Rudewicz, Patrick and Sethuraman, Vijay and Shen, Xiaoyu and Shaul, Jacob and Simmons, Bob and Tashiro, Kyuto and Tang, Dazhi and Tjandra, Meiliana and Turner, Nancy and Uehara, Tsuyoshi and Vitt, Charles and Whitebread, Steven and Yifru, Aregahegn and Zang, Richard and Zhu, Qingming (2018) Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. Bioorganic and Medicinal Chemistry Letters. ISSN 14643405

Reggane, Maude and Wiest, Johannes and Saedtler, Marco and Harlacher, Cornelius and Gutmann, Marcus and Zottnick, Sven and Piechon, Philippe and Dix, Ina and Müller-Buschbaum, Klaus and Holzgrabe, Ulrike and Meinel, Lorenz and Galli, Bruno (2018) Bioinspired co-crystals of Imatinib providing enhanced kinetic solubility. European Journal of Pharmaceutics and Biopharmaceutics, 128. pp. 290-299. ISSN 18733441

Renaud, Jean-Paul and Chari, Ashwin and Ciferri, Claudio and Liu, Wen-ti and Remigy, Herve (2018) Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery, 17 (7). pp. 471-492. ISSN 14741784

Renziehausen, Alexander and Tzakos, Andreas and Wang, Hexiao and Rao, Bhavya and Weir, Lynda and Lo Nigro, Cristiana and Lattanzio, Laura and Merlano, Marco and Matin, Rubeta and Harwood, Catherine and Li, Su and Sim, Van Ren and O'Neill, Kevin and Evans, Alan and Thompson, Alastair and Szlosarek, Peter and Fleming, Colin and Proby, Charlotte and Syed, Nelofer and Crook, Tim (2018) The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic intervention. Oncogene. ISSN 14765594

Reuther, C and Heinzle, V and Nölting, S and Herterich, S and Hahner, S and Halilovic, Ensar and Jeay, Sebastien and Wuerthner, Jens and Spöttl, G and Maurer, J and Auernhammer, CJ (2018) The HDM2 (MDM2) Inhibitor NVP-CGM097 inhibits tumor cell proliferation and shows additive effects with 5-fluorouracil on the p53 - p21 - Rb - E2F1 cascade in the p53wildtype neuroendocrine tumor cell line GOT1. Neuroendocrinology : an international journal for brain-hormone interactions, 106. pp. 1-19. ISSN 1423-0194

Richardson, Elizabeth and Burnell, Jessica and Adams, Heather and Bohannon, Richard and Bush, Elizabeth and Campbell, Michelle and Chen, Wen Hung and Coons, Stephen Joel and Papadopoulos, Elektra and Rooks, Daniel and Reeve, Bryce and Daniel, Gregory (2018) Developing and Implementing Performance Outcome Assessments: Evidentiary, Methodological, and Operational Considerations. Therapeutic innovation & regulatory science. ISSN 2168-4804

Richie, Daryl and Wang, Lisha and Chan, Helen and De Pascale, Gianfranco and Six, David and Wei, Jun-Rong and Dean, Charles (2018) A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii. PLoS ONE, 13 (3). ISSN 1932-6203

Riley, John H. and Erpenbeck, Veit and Matthews, John G. and Holweg, Cecil T.J. and Compton, Chris and Seibold, Wolfgang and Higenbottam, Tim and Wagers, Scott S and Myles , David (2018) U-BIOPRED: evaluation of the value of a public–private partnership to industry. Drug Discovery Today. pp. 1-13. ISSN 18785832

Rodig, Scott J. and Gusenleitner, Daniel and Jackson, Donald G. and Gjini, Evisa and Giobbie-Hurder, Anita and Jin, Chelsea and Chang, Han and Lovitch, Scott B. and Horak, Christine and Weber, Jeffrey S. and Weirather, Jason L. and Wolchok, Jedd D. and Postow, Michael A. and Pavlick, Anna C. and Chesney, Jason and Hodi, F. Stephen (2018) MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma. Science Translational Medicine, 10 (450). eaar3342. ISSN 1946-6234

Rodon, Jordi and Pérez-Fidalgo , Alejandro and Krop , Ian E. and Burris, Howard and Guerrero-Zotano , Angel and Britten, Carolyn D. and Becerra, Carlos and Schellens, Jan and Richards, Donald A. and Schuler , Martin and Abu-Khalaf, Maysa and Johnson, Faye M. and Ranson , Malcolm and Edenfield, Jeff and Silva, Antonio P. and Hackl, Wolfgang and Quadt, Cornelia and Demanse, David and Duval, Vincent and Baselga, Jose (2018) Phase 1/1b dose escalation and expansion study of BEZ235, a dual PI3K/mTOR inhibitor, in patients with advanced solid tumors including patients with advanced breast cancer. Cancer Chemotherapy and Pharmacology, 82 (2). pp. 285-298. ISSN 14320843

Rue, Sarah and Anderson, Paul and Miller, Jessica and Fanale, Salvatore and Chang, Jim and Glaser, Scott and Lesley, Scott (2018) Mammalian cell culture density determination using a laser thru-beam sensor. BioTechniques, 65 (4). pp. 224-226. ISSN btn-2018-0059

Ruff, Yves and Berst, Frederic (2018) Efficient copper-catalyzed amination of DNA-conjugated aryl iodides under mild aqueous conditions. MedChemComm. ISSN 2040-2511; 2040-2503

Rutkowska, Aleksandra and Shimshek, Derya and Sailer, Andreas and Dev, Kumlesh (2018) EBI2 regulates pro-inflammatory signaling and cytokine release in astrocytes. Journal of neuroinflammation, 133. pp. 121-128. ISSN 0028-3908


Sampath, Srinath and Sampath, Srihari and Ho, Andrew and Corbel, Stephane and Millstone, Joshua and Lamb, John and Walker, John and Kinzel, Bernd and Schmedt, Christian and Blau, Helen (2018) Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M. Cell Stem Cell, 9 (1). pp. 1-9. ISSN 2041-1723

Sampath, Srinath and Sampath, Srihari and Millay, Douglas (2018) Myoblast fusion confusion: the resolution begins. Skeletal muscle, 8. p. 3. ISSN 2044-5040

Sandham, David and Erpenbeck, Veit and Dubois, Gerald and Shamri, Revital and Levi-Schaffer, Francesca (2018) Fevipiprant, a DP2 Receptor Antagonist, Inhibits Eosinophil Migration Towards Mast Cells. Clinical and experimental allergy. ISSN 09547894

Saraiva, André L and Veras, Flávio P and Peres, Raphael S and Talbot, Jhimmy and de Lima, Kalil A and Luiz, João Paulo and Carballido, Jose and Cunha, Thiago M and Cunha, Fernando Q and Ryffel, Bernhard and Alves-Filho, Jose C (2018) Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes. The FASEB Journal. ISSN 0892-66381530-6860

Sawyer, William and Wang, Lisha and Uehara, Tsuyoshi and Tamrakar, Pramila and Prathapam, Ramadevi and Mostafavi, Mina and Richie, Daryl and Metzger, Louis and Feng, Brian and Rath, Christopher (2018) Targeted lipopolysaccharide biosynthetic intermediate analysis with normal-phase liquid chromatography mass spectrometry. PLoS ONE.

Schadt, Heiko and Wolf, Armin and Mahl, Joerg Andreas and Wuersch, Kuno and Couttet, Philippe and Schwald, Marianne and Fischer, Audrey and Lienard, Mathilde and Emotte, Corinne and Teng, Chi-Hse and Skuba, Elizabeth and Richardson, Terrilyn and Manenti, Luigi and Weiss, Andreas and Graus Porta, Diana and Fairhurst, Robin and Kullak-Ublick, Gerd and Chibout, Salah-Dine and Pognan, Francois and Kluwe, William and Kinyamu-Akunda, Jacqueline (2018) Bile acid sequestration by cholestyramine mitigates FGFR4 inhibition-induced ALT elevation. Toxicological Sciences. ISSN 1096-60801096-0929

Schadt, Simone and Bister, Bojan and Chowdhury, Swapan K. and Funk, Christoph and Hop, Cornelis E.C.A and Humphreys, W. Griffith and Igarashi, Fumihiko and James, Alexander David and Kagan, Mark and Khojasteh, S. Cyrus and Nedderman, Angus N.R. and Prakash, Chandra and Runge, Frank and Scheible, Holger and Spracklin, Douglas K. and Swart, Piet and Tse, Susanna and Yuan, Josh and Obach, R. Scott (2018) A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development Under the “Metabolites in Safety Testing” Regulatory Guidances. Drug Metabolism and Disposition, 46 (6). pp. 865-878. ISSN 0090-95561521-009X

Schlapbach, Achim and Revesz, Laszlo and Pissot Soldermann, Carole and Zoller, Thomas and Regnier, Catherine and Bornancin, Frederic and Radimerski, Thomas and Blank, Jutta and Schuffenhauer, Ansgar and Renatus, Martin and Erbel, Paulus and Heng, Richard and Melkko, Samu and Simic, Oliver and Endres, Ralf and Wartmann, Markus and Quancard, Jean (2018) N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity. Bioorganic and Medicinal Chemistry Letters, 28. pp. 2153-2158. ISSN 14643405

Schlesinger, Ann (2018) Video of 2018 Novartis Open Framework Symposium: Fostering Applied Innovation. this video will be shared with externals but not published.

Schneider, Nadine and Stiefl, Nikolaus (2018) Surfing on the hype waves or drilling deep for knowledge? A perspective from industry. ETH Infozine, S2. pp. 26-27.

Schoepfer, Joseph and Jahnke, Wolfgang and Berellini, Giuliano and Buonamici, Silvia and Cotesta, Simona and Jacob, Sandra and Dodd, Stephanie and Drueckes, Peter and Fabbro, Doriano and Gabriel, Tobias and Groell, Jean-Marc and Grotzfeld, Robert and Hassan, Asm Quamrul and Henry, Christelle and Iyer, Varsha and Jones, Darryl and Lombardo, Franco and Loo, Alice and Manley, Paul W. and Pelle, Xavier and Rummel, Gabriele and Salem, Bahaa and Warmuth, Markus and Wylie, Andrew and Zoller, Thomas and Marzinzik, Andreas and Furet, Pascal (2018) Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1. Journal of Medicinal Chemistry, 61 (18). pp. 8120-8135. ISSN 15204804

Scotti, Celeste and Gobbi, Alberto and Nakamura, Norimasa and Peretti, Giuseppe M. (2018) Stem Cells for Cartilage Regeneration: A Roadmap to the Clinic. Stem cells international, 2018 (2018). pp. 1-2. ISSN 7348560

Sedelmeier, Joerg Mathias and Sedelmeier, Gottfried and Lightfoot, Helen (2018) WHO Listed Small Molecule Kinase Inhibitors 2001-2017. CHIMIA.

Sharma, Vaneet and Sharma, Ity and Glick, Jim (2018) The expanding role of mass spectrometry in the field of vaccine development. Mass spectrometry reviews, 99 (18). pp. 7417-7431. ISSN 02777037

Shirley, Bill and Kelley, Brian and Koschwanez, John and Potier, Yohann and Bruccoleri, Robert and Tarselli, Mike (2018) Unzipping Natural Products: Improved Natural Product Structure Predictions by Ensemble Modeling and Fingerprint Matching. ChemRxiv.

Sirockin, Finton and Stiefl, Nikolaus (2018) Practical Aspects of Machine Learning for the Design-Synthesis-Purify-Assay Workflow. Chimia, 72 (9). pp. 648-649. ISSN 00094293

Six, David and Krucker, Thomas and Leeds, Jennifer (2018) Advances and challenges in bacterial compound accumulation assays for drug discovery. Current Opinion in Chemical Biology, 44. pp. 9-15. ISSN 18790402

Smith, Paul A. and Schmid, Cindy and Zurbruegg, Stefan and Dubost, Valerie and Jivkov, Magali Natacha and Theil, Diethilde and Beckmann, Nicolau (2018) Fingolimod inhibits brain atrophy and promotes brain-derived neurotrophic factor in an animal model of multiple sclerosis. Journal of Neuroimmunology, 308 (5). pp. 103-113. ISSN 18728421

Snajdrova, Radka and Hunziker, Juerg and Eggimann, Fabian (2018) BM CDT Research Proposals 2018/19 from GDC BIR. Title: Stereoselective, scalable route towards phosphorothioate analogues of ATP. BM CDT Research Proposals .

Snajdrova, Radka and Rudroff, Florian and Mihovilovic , Marko and Groeger, Harald and Iding, Hans and Bornscheuer, Uwe (2018) Opportunities and challenges for combining chemo- and biocatalysis. Nature Catalysis, 1. pp. 12-22. ISSN doi:10.1038/s41929-017-0010-4

Song, Shuang and Sahoo, Dipankar and Kumar, Manoj and Barkley, Deborah A. and Heiney, Paul A. and Rudick, Jonathan G. (2018) Identifying Structural Determinants of Mesomorphism from Focused Libraries of Tripedal Mesogens Prepared via the Passerini Three-Component Reaction. European Journal of Organic Chemistry, 2019 (6). pp. 1195-1207. ISSN 1434193X

Soulieres, Denis and Licitra, Lisa and Mesia, Ricard and Remenar, Eve and Li, Shau-Hsuan and Karpenko, Andrey and Chol, Marie and Wang, Amanda and Solovieff, Nadia and Bourdeau, Laurence and Sellami, Dalila and Faivre, Sandrine (2018) Molecular Alterations and Buparlisib Efficacy in Patients with Squamous Cell Carcinoma of the Head and Neck: Biomarker Analysis from BERIL-1. Clinical cancer research.

Spangler, Ben and Dovala, Dustin and Sawyer, William and Thompson, Katherine and Six, David and Reck, Folkert and Feng, Brian (2018) Molecular probes for the determination of sub-cellular compound exposure profiles in Gram-negative bacteria. ACS Infectious Diseases. ISSN 23738227

Spangler, Benjamin and Dovala, Dustin and Sawyer, William S and Thompson, Katherine V and Six, David A and Reck, Folkert and Feng, Brian Y (2018) Molecular Probes for the Determination of Subcellular Compound Exposure Profiles in Gram-Negative Bacteria. ACS infectious diseases. ISSN 2373-8227

Spindeldreher, Sebastian and Maillère, Bernard and Correia, Evelyne and Tenon, Maxime and Karle, Anette and Jarvis, Philip and Kolbinger, Frank (2018) Secukinumab Demonstrates Significantly Lower Immunogenicity Potential Compared to Ixekizumab. Dermatology and therapy, 8 (1). pp. 57-68. ISSN 2193-8210

Splendiani, Andrea and Yasunori, Yamamoto and Atsuko, Yamaguchi (2018) YummyData: providing high-quality, open life science data. Database the journal of biological databases and curation.. ISSN 1758-0463

Stacy, Rebecca and Huttner, Kenneth and Watts, Jen and Peace, James and Wirta, David and Walters, Tom and Sall, Kenneth and Seaman Iii, John and Ni, Xiao and Prasanna, Ganesh and Mogi, Muneto and Adams, Christopher and Yan, Jing-He and Wald, Michael and He, Yunsheng and Newton, Ronald and Kolega, Randall and Grosskreutz, Cyndy (2018) A phase I/II study to evaluate the safety, tolerability and early efficacy of MGV354 in healthy subjects and in patients with ocular hypertension or glaucoma. American Journal of Ophthalmology.

Stein, Andrew and Peletier, Lambertus (2018) Predicting the Onset of Nonlinear Pharmacokinetics. CPT: Pharmacometrics and Systems Pharmacology, 7 (10). pp. 670-677. ISSN 21638306

Stein, Thomas and Wollschlegel, Audrey and Te, Helene and Weiss, Jessica and Joshi, Kushal and Kinzel, Bernd and Billich, Andreas and Guntermann, Christine and Lehmann, Joachim (2018) Interferon regulatory factor 5 and nuclear factor kappa-B exhibit cooperating but also divergent roles in the regulation of pro-inflammatory cytokines important for the development of TH1 and TH17 responses. FEBS Journal, 285 (16). pp. 3097-3113. ISSN 10.1111/febs.14600

Stewart, N.J. and Chan, H-F and Hughes, P.J.C. and Horn, F.C. and Norquay, G. and Parra-Robles, J. and Rao, M. and Yates, Denise and Ford, P. and Collini, P. and Ireland, R. and Lawson, R. and Marshall, H. and Collier, G.J. and Wild, J.M. (2018) Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T. Journal of magnetic resonance imaging. ISSN 10531807

Sverdlov, Oleksandr and Van Dam, Joris and Hannesdottir, Kristin and Thornton-Wells, Tricia (2018) Digital Therapeutics—An Integral Component of Digital Innovation in Drug Development. Clinical pharmacology and therapeutics, 104 (1). pp. 72-80.


Tam, Yat Kong and Blasko, Andrei and Ahmed, Imad Haidar (2018) A four parameter optimization and troubleshooting of a RPLC – charged aerosol detection stability indicating method for determination of S-lysophosphatidylcholines in a phospholipid formulation. Journal of pharmaceutical and biomedical analysis, 155. pp. 288-297. ISSN 07317085

Tan, Kian and Robinson, Richard (2018) Oxford DTC proposals for 2019 brouchure. Oxford DTC brochure 2019.

Tarselli, Mike (2018) Nature "In Your Element" - Hidden Hassium. Nature chemistry, 10. p. 482.

Tarselli, Mike (2018) Tarselli Interview for UMass Goessmann Gazette. Goessmann Gazette.

Thomson, Christopher and Le Grand, Darren and Dowling, Mark and Brocklehurst, Cara and Chinn, Colin and Elphick, Lucy and Faller, Michael and Freeman, Mark and Furminger, Vikki and Gasser, Cornelia and Hamadi, Ahmed and Hardaker, Elizabeth and Head, Victoria and Hill, Johan and Janus, Diana and Pearce, David and Poulaud, Anne-Sophie and Stanley, Emily and Sviridenko, Lilya (2018) Development of Autotaxin Inhibitors Part 1: A Series of Zinc Binding Triazoles. Bioorganic and medicinal chemistry letters, 28 (13). pp. 2279-2284.

Ting, Pamela and Lee, Scott and Parker, Albert and Trussell, Christopher and Sharif, Orzala and Luna, Fabio and Federe, Glenn and Barnes, Whitney and Walker, John and Vance, Julie and Gao, Mu-Yun and Klock, Heath and Clarkson, Scott and Russ, Carsten and Miraglia, Loren and Cooke, Michael and Boitano, Anthony and Mcnamara, Peter and Lamb, John and Schmedt, Christian and Snead, Jennifer (2018) Guide Swap enables genome-scale pooled CRISPR–Cas9 screening in human primary cells. Nature Methods, 15 (11). pp. 941-946. ISSN 15487105

Toyoda, Masanori and Watanabe, Koichiro and AMAGASAKI, TARO and NATSUME, KAZUTO and TAKEUCHI, HIROMI and Quadt, Cornelia and Shirao, Kuniaki and Minami, Hironobu (2018) A phase I study of single-agent BEZ235 special delivery system sachet in Japanese patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology. ISSN Print ISSN 0344-5704 / Onlibe ISSN 1432-0843

Trendelenburg, Anne-Ulrike (2018) Find drugs that delay many diseases of old age. Nature.

Trimble, AT and Brown, AW and Laube, BL and Lechtzin, N and Zeman, KL and Wu, J and Ceppe, AS and Waltz, D and Bennett, WD and Donaldson, SH (2018) Hypertonic saline has a prolonged effect on mucociliary clearance in adults with cystic fibrosis. Journal of Cystic Fibrosis. ISSN 18735010

Tsinman, Konstantin and Tsinman, Oksana and Lingamaneni, Ram and Zhu, Saijie and Riebesehl, Bernd and Grandeury, Arnaud and Juhnke, Michael and Van Eerdenbrugh, Bernard (2018) Ranking Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane. Pharmaceutical Research, 35 (8). ISSN 1573904X

Turner, Oliver and Aeffner, Famke and Adissu, Hibret and Boyle, Michael and Cardiff, Robert and Hagendorn,, Erik and Hoenerhoff, Mark and Klopfleisch, Robert and Newbigging, Susan and Schaudien, Dirk and Wilson, Kristin (2018) Digital Microscopy, Image Analysis, and Virtual Slide Repository. ILAR Journal, 58. pp. 1-14. ISSN 1084-2020


Uehara, Tsuyoshi and Prathapam, Ramadevi (2018) A temperature-sensitive replicon enables efficient gene inactivation in Pseudomonas aeruginosa. Journal of microbiological methods, 144. pp. 47-52. ISSN 01677012

Ulrich, Peter and Blaich, Guenter and Baumann, Andreas and Fagg, Rajni and Hey, Adam and Kiessling, Andrea and Kronenberg, Sven and Lindecrona, Rikke Hvid and Mohl, Silke and Richter, Wolfgang F and Tibbitts, Jay and Crameri, Flavio and Weir, Lucinda (2018) Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing. Regulatory Toxicology and Pharmacology, 94. pp. 91-100. ISSN 10960295

Ulrich, Peter and Flandre, Thierry and Espie, Pascal and Sickert, Denise and Rubic-Schneider, Tina and Shaw, David Andrew and Rush, James (2018) Non-clinical safety assessment of CFZ533, a Fc-silent anti-CD40 antibody, in non-human primates. Toxicological sciences, Epub a. ISSN 1096-0929; 1096-6080

Umehara, Ken-Ichi and Huth, Felix and Won, Christina and Heimbach, Tycho and He, Handan (2018) Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug–drug interaction potential of CYP3A4 substrates. Biopharmaceutics and Drug Disposition, 39 (3). pp. 152-163. ISSN 1099081X

Uteng, Marianne and Urban, Laszlo and Brees, Dominique and Mueller, Patrick and Kullak-Ublick, Gerd-Achim and Tougas, Gervais and Bouchard, Page and Chibout, Salah-Dine (2018) Safety differentiation: Emerging competitive edge in drug development. Drug discovery today.


Vahle, John L and Anderson, Ulf and Blomme, Eric AG and Hoflack, Jean-Christophe and Stiehl, Daniel Philipp (2018) Use of toxicogenomics in drug safety evaluation: Current status and an industry perspective. Regulatory Toxicology and Pharmacology, 96. pp. 18-29. ISSN 10960295

Veenstra, Siem and Rueeger, Heinrich and Voegtle, Markus and Lueoend, Rainer Martin and Holzer, Philipp and Hurth, Konstanze and Tintelnot-Blomley, Marina and Frederiksen, Mathias and Rondeau, Jean-Michel and Jacobson, Laura and Staufenbiel, Matthias and Neumann, Ulf and Machauer, Rainer (2018) Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors. Bioorganic and Medicinal Chemistry Letters, 28 (12). pp. 2195-2200. ISSN 14643405

Veit, Guido and Dreano, Elise and Avramescu, Radu and Bagdany, Miklos and Beitel, Lenore and Roldan, Ariel and Hancock, Mark and Lay, Cecilia and Li, Wei and Morin, Katie and Gao, Sandra and Puiying, Mak and Ainscow, Edward and Orth, Anthony and McNamara, Peter and Edelman, Aleksander and Frenkiel, Saul and Matouk, Elias and Sermet-Gaudelus, Isabelle and Barnes, William and Lukacs, Gergely (2018) Structure-guided combination therapy to potently improve the function of mutant CFTRs. Nature Medicine.

Velcicky, Juraj and Bodendorf, Ursula and Rigollier, Pascal and Epple, Robert and Beisner, Daniel and Guerini, Danilo and Smith, Philip and Liu, Bo and Feifel, Roland and Wipfli, Peter and Aichholz, Reiner and Couttet, Philippe and Dix, Ina and Widmer, Toni and Wen, Ben and Brandl, Trixi (2018) Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. Journal of Medicinal Chemistry, 61 (3). pp. 865-880. ISSN 0022-26231520-4804

Velcicky, Juraj and Schlapbach, Achim and Heng, Richard and Revesz, Laszlo and Pflieger, Daniel and Blum, Ernst and Huppertz, Christine and Feifel, Roland and Hersperger, Rene (2018) Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure. ACS Medicinal Chemistry Letters, 9 (4). pp. 392-396. ISSN 1948-58751948-5875

Vorherr, Thomas (2018) Peptide Therapeutics. Bioorganic and medicinal chemistry.

Vu, Hoan and Pedro, Liliana and Mak, Tin and McCormick, Brendan and Rowley, Jessica and Liu, Miaomiao and Di Capua, Angela and Williams-Noonan, Billy and Pham, Ngoc B and Pouwer, Rebecca and Nguyen, Bao and Andrews, Katherine T and Skinner-Adams, Tina and Kim, Jessica and Hol, Wim G J and Hui, Raymond and Crowther, Gregory J and Van Voorhis, Wesley C and Quinn, Ronald J (2018) Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry. ACS infectious diseases, 4 (4). pp. 431-444. ISSN 2373-8227

Vulpetti, Anna and Ostermann, Nils and Randl, Stefan and Yoon, Taeyoung and Mac Sweeney, Aengus and Cumin, Frederic and Lorthiois, Edwige and Ruedisser, Simon and Erbel, Paulus and Maibaum, Juergen Klaus (2018) Discovery and design of first benzylamine-based ligands binding to an unlocked conformation of the Complement Factor D. ACS Medicinal Chemistry Letters, 9 (5). pp. 490-495. ISSN 1948-58751948-5875


Walker, John and Zorrilla, Eric and Logrip, Marian and Ayanwuyi, Lydia and Sabino, Valentina and Ciccocioppo, Roberto and Koob, George (2018) Evaluation of alcohol preference and drinking in msP rats bearing a Crhr1 promoter polymorphism. Frontiers in psychiatry, 9 (FEB). p. 28. ISSN 1664-0640

Walpurgis, Katja and Thomas, Andreas and Schänzer, Wilhelm and Thevis, Mario (2018) Detection of the Human Anti-ActRII Antibody Bimagrumab in Serum by Means of Affinity Purification, Tryptic Digestion, and LC-HRMS. Proteomics - Clinical Applications. ISSN 18628354

Wang, Feng and Jeon, Kyu Ok and Salovich, James M and Macdonald, Jonathan D and Alvarado, Joseph and Gogliotti, Rocco D and Phan, Jason and Olejniczak, Edward T and Sun, Qi and Wang, Shidong and Camper, DeMarco and Yuh, Joannes P and Shaw, J Grace and Sai, Jiqing and Rossanese, Olivia W and Tansey, William P and Stauffer, Shaun R and Fesik, Stephen W (2018) Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. Journal of medicinal chemistry, 61 (13). pp. 5623-5642. ISSN 1520-4804

Watanabe, Keisuke and Luo, Yanping and Da, Tong and Guedan , Sonia and Ruella, Marco and Scholler, John and Keith, Brian and Young, Regina M and Engels, Boris and Sorsa, Suvi and Siurala, Mikko and Havunen, Riikka and Tahtinen, Siri and Hemminki, Akseli and June, Carl H (2018) Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses. JCI insight, 3 (7). ISSN 23793708

Weeden, Clare E and Ah-Cann, Casey and Holik, Aliaksei Z and Pasquet, Julie and Garnier, Jean-Marc and Merino, Delphine and Lessene, Guillaume and Asselin-Labat, Marie-Liesse (2018) Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition. Oncogene, 37 (32). pp. 4475-4488. ISSN 14765594

Weiersmüller, Dominique and Gruber, Florian (2018) Florian Gruber: Forschung ist spannend. Chancenheft Chemie, Berufsbertaungs- und Informationszentren des Kantons Bern.

Wilcken, Rainer (2018) SAMPL6: pKa prediction blind challenge submission. D3R Drug Design Data Resource - online resource.

Wilson, Aaron and Moutsatsos, Ioannis and Pineda, Javier and Feng, Yan and Yu, Gary and Auld, Douglas (2018) A Scalable Pipeline for High-Throughput Flow Cytometry. SLAS Discovery. ISSN 24725560

Wilson, Aaron and Moutsatsos, Ioannis and Yu, Gary and Pineda, Javier and Feng, Yan and Auld, Douglas (2018) A Scalable Pipeline for High-Throughput Flow Cytometry. SLAS DISCOVERY: Advancing Life Sciences R&D. ISSN 2472-55522472-5560

Wimmer , Laurin and Parmentier, Michael and Riss, Bernard and Kapferer, Tobias and Ye, Chao and Li, Lei and Kim, Hongyong and Li, Jialiang (2018) Water-promoted chlorination of 2-mercaptobenzothiazoles. Synthesis.

Wingert, Lindsey and Zilionis, Rapolas and Weinreb, Caleb and Savovas, Virginia and Choo-Wing, Rayman and Roma, Guglielmo and Knehr, Judith and Klein, Allon and Jaffe, Aron (2018) A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. Nature, 560 (7718). pp. 377-381. ISSN 14764687

Wong, Gabrielle and Zhou, Jin and Liu, Jie Bin and Xu, Xinsen and Wu, Zhong and Xu, David and Schumacher, Steven and Puschhof, Jens and Li, Tianxia and McFarland, James and Zou, Charles and Dulak, Austin and Henderson, Les and Xu, Peng and O'Day, Emily and Rendak, Rachel and Liao, Wei-li and Cecchi, Fabiola and Hembrough, Todd and Schwartz, Sarit and Szeto, Christopher and Rustgi, Anil and Wong, Kwok-kin and Diehl, J.Alan and Jensen, Karin and Graziano, Federico and Ruzzo, Annamaria and Fereshetian, Shaunt and Mertins, Philipp and Carr, Steven and Beroukhim, Rameen and Nakamura, Kenichi and Oki, Eiji and Watanabe, Masayuki and Baba, Hideo and Imamura, Yu and Catenacci, Daniel and Bass, Adam (2018) Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nature medicine. ISSN 1078-8956

Wong, Man Yan and Liu, Changliang and Wang, Shan Shan H and Roquas, Aram C F and Fowler, Stephen C and Kaeser, Pascal S (2018) Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses. Proceedings of the National Academy of Sciences of the United States of America, 115 (9). pp. 2234-2239. ISSN 1091-6490

Wong, Yan and Liu, Changliang and Wang, Shan Shan H and Roquas, Aram C F and Fowler, Stephen C and Kaeser, Pascal S (2018) Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses. Proceedings of the National Academy of Sciences of the United States of America, 115 (9). pp. 2234-2239. ISSN 1091-6490

Woollam, Grahame and Neumann, Marcus and Wagner, Beatrix and Davey, Roger (2018) The importance of configurational disorder in crystal structure prediction: the case of loratadine. Faraday Discussions, Advanc (Advanc). ISSN 1359-66401364-5498

Wright, Justin and Jones, Graham (2018) Visioning Pharma 2.0: Mapping our Digital Exhaust. Digital Biomarkers, 2 (1). pp. 31-46. ISSN 2504-110X


Xu, Jie and Vessieres, Emilie and Mathur, Jayanti and Hammack, Scott and Nonomura, Keiko and Favre, Julie and Grimaud, Linda and Petrus, Matthew and Francisco, Allain and Li, Jingyuan and Lee, Van and Xiang, Fuli and Mainquist, James and Cahalan, Stuart and Orth, Anthony and Walker, John and Ma, Shang and Lukacs, Viktor and Bordone, Laura and Bandell, Michael and Laffitte, Bryan and Xu, Yan and Chien, Shu and Henrion, Daniel and Patapoutian, Ardem (2018) GPR68 Senses Flow and Is Essential for Vascular Physiology. Cell, 173 (3). pp. 762-775. ISSN 00928674


Yap, Yoon-Sim and Singh, Angad and Lim, John and Ahn, J.H. and Jung, K.H. and Kim, J. and Dent, R.A. and Ng, R.C.H. and Kim, Sung-Bae and Chiang, Derek (2018) Elucidating Therapeutic Molecular Targets in Premenopausal Asian Women with Recurrent Breast Cancers. npg breast cancer, 4. p. 19.

Ye, Baihua and Zhao, Jie and Zhao, Ke and Mckenna, Jeffrey and Toste, F Dean (2018) Chiral diaryliodonium phosphate enables light driven diastereoselective α- C(sp3)-H acetalization. Journal of the American Chemical Society JACS., 140.

Yeboah, Fred and Guo, Hongqiu and Bill, Anke (2018) A high-throughput calcium-flux assay to study NMDAR-receptors with sensitivity to Glycine/D-Serine an Glutamate. Journal of visualized experiments : JoVE, 137 (e58160). ISSN 1940-087X

Yeboah, Fred and Guo, Hongqiu and Bill, Anke (2018) A novel calcium-flux assay for the study of the NMDA-receptor. Journal of visualized experiments : JoVE (137). ISSN 1940-087X

Yen, Jonathan and Fiorino, Michael and Liu, Yi and Paula, Steve and Clarkson, Scott and Quinn, Lisa and Tschantz, Bill and Klock, Heath and Guo, Ning and Russ, Carsten and Yu, Vionnie and Mickanin, Craig and Stevenson, Susan and Lee, Cameron and Yang, Yi (2018) TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells. Scientific reports, 8 (16304 ). pp. 1-12. ISSN PMID: 30389991

Youngberg, Stephen and Brandt, Erin and Barve, Avantika and Machineni, Surendra Kumar and Jones, Christopher and Dabovic, Kristina and Jones, Catherine and Colvin, Richard (2018) A first-in-human, randomized, double-blind, placebo-controlled, single and multiple ascending oral dose study to assess the safety, tolerability, and pharmacokinetics of BZF961 with and without ritonavir in healthy adult volunteers. Journal of drug assessment, 7. pp. 66-74. ISSN 2155-6660


Zhang, Jiangwei and Xiao, Sean and Gao, Zhenting and Yu, Zhengtian and Zhang, Jeff (2018) Metabolism of quinoline containing C-Met kinase inhibitors by aldehyde oxidase, effect of electron donating group and steric hindrance. Drug metabolism and disposition. pp. 1-34. ISSN

Zhang, Qi and Konopleva, Marina (2018) Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven philadelphia chromosome-like acute B-cell lymphoblastic leukemia. Oncotarget, 9 (8). pp. 8027-8041. ISSN 19492553

Zhang, Zhipeng and Ratnikov, Max and Spraggon, Glen and Alper, Phillip (2018) Photoinduced Rearrangement of Dienones and Santonin Rerouted by Amines. Angewandte Chemie. International edition, 57 (4). pp. 904-908. ISSN 14337851

Zhao, Qian and Manning, James and Sutton, James and Costales, Abran and Sendzik, Martin and Shafer, Cynthia and Levell, Julian and Liu, Gang and Caferro, Thomas and Cho, Young and Palermo, Mark and Chenail, Gregg and Dooley, Julie and Villalba, Brian and Farsidjani, Alireza and Chen, Jinyun and Dodd, Stephanie and Gould, Ty and Liang, Guiqing and Slocum, Kelly and Pu, Minying and Firestone, Brant and Growney, Joseph and Heimbach, Tycho and Pagliarini, Raymond (2018) Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors. ACS Medicinal Chemistry Letters, 9. pp. 746-751. ISSN 19485875

Zheng, Wei and Dryja, Thaddeus P and Wei, Zhongyuan and Song, Dongying and Tian, Haijun and Kahler, Kristijan H and Khawaja, Anthony P (2018) Systemic Medication Associations with Presumed Advanced or Uncontrolled Primary Open-Angle Glaucoma. Ophthalmology, 125 (7). pp. 984-993. ISSN 1549-4713

Zhu, Wenya and Qiu, Wenlong and Clarke, Adrian and Kolarik, Christoph and Mozzo, Sebastiano and Liang, Guoyi (2018) A LEAN approach for the determination of residual solvents using headspace gas chromatography (HS-GC) with relative response factors. LC-GC Magazine (pharmaceutical supplement).

This list was generated on Thu Jun 30 10:37:39 2022 UTC.


Email Alerts

Register with OAK to receive email alerts for saved searches.