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Evolution of Small Molecule Kinase Drugs

Lightfoot, Helen and Frederick, Goldberg and Sedelmeier, Joerg Mathias (2018) Evolution of Small Molecule Kinase Drugs. Journal of Medicinal Chemistry Letters (ACS).

Abstract

The development of small molecule kinase drugs is a rapidly evolving field and represents one of the most important research areas within oncology. This innovation letter provides an overview and analysis of approved kinase drugs according to their WHO registration (INN) dates, primary biological targets, selectivity and structural similarities. It also discusses new trends in kinase drug discovery programs such as new kinase targets, novel mechanisms of action and diverse indications.

Item Type: Article
Date Deposited: 15 Jan 2019 00:45
Last Modified: 15 Jan 2019 00:45
URI: https://oak.novartis.com/id/eprint/37466

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