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Article

Abend, Andreas, Heimbach, Tycho, Cohen, Michael, Kesisoglou, Filippos, Pepin, Xavier and Suarez, Sandra (2018) DISSOLUTION AND TRANSLATIONAL MODELING STRATEGIES ENABLING PATIENT-CENTRIC PRODUCT DEVELOPMENT M-CERSI WORKSHOP SUMMARY REPORT. American Association of Pharmaceutical Scientists Journal.

Abrams, Tinya, Connor, Anu, Fanton, Christie, Cohen, Steven, Huber, Thomas, Miller, Kathy, Hong, E. Erica, Niu, Xiaohong, Kline, Janine, Ison-Dugenny, Marjorie, Harris, Sarah, Walker, Dana, Krauser, Klaus, Galimi, Francesco, Wang, Zhen, Ghoddusi, Majid, Mansfield, Keith, Lee-Hoeflich, Si Tuen, Holash, Jocelyn, Pryer, Nancy, Kluwe, William, Ettenberg, Seth, Sellers, William, Lees, Emma, Kwon, Paul, Abraham, Judy and Schleyer, Siew (2018) Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors. Clinical Cancer Research, 24 (17). pp. 4297-4308. ISSN 15573265

Adams, Christopher, Anderson, Karen, Artman Iii, Gerald, Cepeda, Rosemarie, Bizec, Jean-Claude, Elliott, Jason, Fassbender, Elizabeth, Ghosh, Malay, Hanks, Shawn, Hardegger, Leo, Hosagrahara, Vinayak, Jaffee, Bruce, Jendza, Keith, Ji, Nan, Johnson, Leland, Liu, Donglei, Liu, Fang, Long, Debby, Ma, Fupeng, Mainolfi, Nello, Meredith, Erik, Miranda, Karl, Peng, Penny, Poor, Stephen, Powers, James, Qiu, Yubin, Rao, Chang, Shen, Siyuan, Sivak, Jeremy, Solovay, Catherine, Tarsa, Peter, Woolfenden, Amber, Zhang, Chun and Zhang, Yiqin (2018) The discovery of N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (acrizanib), a VEGFR-2 inhibitor specifically designed for topical ocular delivery, as a therapy for neovascular age- related macular degeneration. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Adriana, Sánchez-Danés, Jean-Christophe , Larsimont, Mélanie, Liagre, Eva , Muñoz, Audrey, Brisebarre, Christine, Dubois, Josep, Tabernero and Cédric , Blanpain (2018) A slow cycling Lgr5 tumor cell population mediates resistance to Smoothened inhibitor in Basal Cell Carcinoma. Nature. ISSN 1476-4687

Akbar, Mohammad, Ahn, Mee, Bashaw, Dennis, Blithe, Diana, Berry-Bibee, Erin, Davis, Daniel, Day, Ruth, Edelman, Alison, Hochel, Joachim, Huang, Shiew-Mei, Jamshidi, Roxanne, Kim, Myong-Jin, Kim, Na Hyung, Lee, LaiMing, Li, Li, Purohit, Vivek, Turpin, Jim, Scott, Pamela, Shon, Jihong, Soule, Lisa, Strauss, David, Sun, Haiying, Tassinari, Melissa, Tepper, Naomi, Willett, Gerald, Zhang, Lei, Zhang, Nan, Zhao, Ping and Yu, Chongwoo (2018) FDA Public Meeting Report on “Drug Interactions with Hormonal Contraceptives: Public Health and Drug Development Implication”. Journal of Clinial Pharmacology.

Albiol, Laia, Cilla, Myriam, Pflanz, David, Kramer, Ina, Kneissel, Michaela, Duda, Georg N., Willie, Bettina M. and Checa, Sara (2018) Sost deficiency leads to reduced mechanical strains at the tibia midshaft in strain-matched in vivo loading experiments in mice. Journal of the Royal Society Interface.

Alexander, Schuhmacher, Oliver, Gassmann, Nigel, McCracken and Hinder, Markus (2018) Open innovation and external sources of innovation. An opportunity to fuel the R&D pipeline and enhance decision making? Journal of Translational Medicine, 16 (1). ISSN 14795876

Andersson, Martin, Lipshutz, Bruce and Gallou, Fabrice (2018) Nanoparticle structure in TPGS-750M surfactant based organic synthesis modeled by COSMO-RS. European journal of organic chemistry, 24. pp. 6778-6786.

Antonova-Koch, Yevgeniya, Meister, Stephan, Abraham, Matthew, Ottilie, Sabine, Vanaerschot, Manu, Rodriguez, Juan Carlos Jado, Calla, Jaeson, Plouffe, David, Luth, Madeline, Zhong, Yang, Chen, Kaisheng, Owen, Edward, Lukens, Amanda, Sakata-Kata, Tomoyo, Maher, Steven, Chaumeau, Victor, Serrano, Fernando Neria, Eribez, Korina, Taggard, Cullin McClean, Roullier, Melanie, Siegel, Dionicio, Nosten, Francois, Kyle, Dennis, Gamo, Francisco-Javier, Zhou, Yingyao, Llinas, Manuel, Fidock, David, Wirth, Dyann, Burrows, Jeremy, Campo, Brice and Winzeler, Elizabeth (2018) Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science, 362 (6419). ISSN 10959203

Appleton, Brent, Benton, Bret, De Vicente Fidalgo, Javier, Drumm Iii, Joseph, Feng, Brian, Geng, Mei, Lu, Yipin, Mamo, Mulugeta, Moreau, Bob, Mergo, Wosenu, Skepper, Colin, Steffek, Micah, Takeoka, Ken, Uehara, Kyoko, Wang, Lisha, Wei, Jun-Rong, Xie, Lili, Xu, Wenjian, Zhang, Qiong, Li, Cindy and Hu, Cheng (2018) Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity. Journal of Medicinal Chemistry, 61 (8). pp. 3325-3349. ISSN 15204804

Appleton, Brent, Blechschmidt, Anke, Balibar, Carl, Benton, Bret, De Vicente Fidalgo, Javier, Drumm Iii, Joseph, Feng, Brian, Geng, Mei, Lingel, Andreas, Lu, Yipin, Mamo, Mulugeta, Mergo, Wosenu, Moreau, Bob, Polyakov, Valery, Skepper, Colin, Smith, Thomas, Takeoka, Ken, Uehara, Kyoko, Wang, Lisha, Wei, Jun-Rong, Weiss, Andrew, Xie, Lili, Xu, Wenjian, Zhang, Qiong and Li, Cindy (2018) Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria. Journal of Medicinal Chemistry, 61 (8). pp. 3309-3324. ISSN 15204804

Argikar, Aneesh and Argikar, Upendra (2018) Mesentery: An ADME perspective on a 'new' organ. Drug metabolism reviews. pp. 1-8. ISSN 1097-9883

Argikar, Upendra (2018) Saccharolactone: the history, the myth, and the practice. Current drug metabolism, 19. pp. 304-309. ISSN 1875-5453

Arias, H R, Feuerbach, Dominik and Ortells, M (2018) Bupropion inhibits human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites. Neurotransmitter.

Arias, HR, Feuerbach, Dominik, Schmidt, Bernd, Heydenreich, Matthias, Paz, Christian and Ortells, MO (2018) Drimane sesquiterpenoids purified from Drimys winteri inhibit the human α4β2 nicotinic acetylcholine receptor by noncompetitive mechanisms. Journal of natural products. ISSN 1520-6025; 0163-3864

Arias, HR, Vázquez-Gómez, E, Hernández-Abrego, A, Gallino, S, Feuerbach, Dominik, Ortells, MO, Elgoyhen, AB and García-Colunga, J (2018) Tricyclic antidepressants inhibit hippocampal α7*and α9α10 nicotinic acetylcholine receptors by different mechanisms. The international journal of biochemistry & cell biology.

Auberson, Yves, Briard, Emmanuelle, Rudolph, Bettina, Kaupmann, Klemens, Smith, Paul and Oberhauser, Berndt (2018) PET Imaging of T Cells: Target Identification and Feasibility Assessment. ChemMedChem. ISSN 18607187

Auld, Douglas S., Narahari, Janaki, Ho, Pei-i, Casalena, Dominick, Nguyen, Vy, Cirbaite, Evelina, Hughes, Doug, Daly, John and Webb, Brian (2018) Characterization and Use of TurboLuc Luciferase as a Reporter for High-Throughput Assays. Biochemistry. ISSN 0006-2960

Avery, Danielle A, Kane, Elisa, Nguyen, Tina, Lau, Anthony, Nguyen, Akira, Payne, Kathryn, Lenthall, Ellen, Wei, Shi, Brigden, henry, French , Elise, Bier, Julia, Hermes, Jana R, Zahra, David, Sewell, William, Boztug, Kaan, Meyts, Isabelle, Choo, Sharon, Hsu, Peter, Wong, Melanie, Berglund, Lucinda, Gray, Paul, O'Sullivan, Michael, Cole, Therese, Holland, Steven M, Ma, Cindy S, Burkhart, Christoph, Corcoran, Lynn M, Phan, Tri G, Brink, Robert, Uzel, Gulbu, Deenick, Elissa K and Tanguye, Stuart G (2018) Pathogenic germline activating mutations in PIK3CD compromise B-cell development and function, underlying humoral defects in human primary immunodeficiency. Journal of Experimental Medicine.

Avery, Danielle A, Kane, Elisa, Nguyen, Tina, Lau, Anthony, Nguyen, Akira, Payne, Kathryn, Lenthall, Ellen, Wei, Shi, Brigden, henry, French , Elise, Bier, Julia, Hermes, Jana R, Zahra, David, Sewell, William, Boztug, Kaan, Meyts, Isabelle, Choo, Sharon, Hsu, Peter, Wong, Melanie, Berglund, Lucinda, Gray, Paul, O'Sullivan, Michael, Cole, Therese, Holland, Steven M, Ma, Cindy S, Burkhart, Christoph, Corcoran, Lynn M, Phan, Tri G, Brink, Robert, Uzel, Gulbu, Deenick, Elissa K and Tanguye, Stuart G (2018) Pathogenic germline activating mutations in PIK3CD intrinsically compromise B-cell development and function, underlying humoral defects in human primary immunodeficiency. Journal of Experimental Medicine.

Awale, Mahendra, Sirockin, Finton, Stiefl, Nikolaus and Reymond, Jean-Louis (2018) Drug Analogs from Fragment Based Long Short-Term Memory Generative Neural Networks. ChemRXiv.

Badal Tejedor, Maria, Pazesh, Samaneh, Nordgren, Niklas, Rutland, Mark, Schuleit, Michael, Alderborn, Göran and Millqvist Fureby, Anna (2018) Milling induced amorphisation and recrystallisation of α-lactose monohydrate. International journal of pharmaceutics, 537. pp. 140-147. ISSN 1873-3476; 0378-5173

Badaoui, Magd, Kells, Adam, Molteni, Carla, Dickson, Callum, Hornak, Viktor and Rosta, Edina (2018) Calculating kinetic rates and membrane permeability from biased simulation. The Journal of Physical Chemistry B. ISSN 1520-61061520-5207

Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frederique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glueck, Anton, Schneider, Martin Alexander, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Regnier, Catherine, Bold, Guido, Pissot Soldermann, Carole, Carballido, Jose, Kovarik, Jiri, Calzascia, Thomas and Bornancin, Frederic (2018) The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition. Immunology and cell biology.

Barkley, Deborah, Han, Sang Uk, Koga, Tadanori and Rudick, Jonathan G. (2018) Peptide–dendron hybrids that adopt sequence-encoded β-sheet conformations. Polymer Chemistry. ISSN 1759-9954

Barrow, Alexander/D, Edeling, Melissa/A, Trifonov, Vladimir, Luo, Jingqin, Goyal, Piyush, Bohl, Benjamin, Bando, Jennifer, Kim, Albert, Andahazy, Mary, Melocchi, Laura, Bugatti, Mattia, Vermi, Wiliam, Fremont, Daved, Cox, Sarah, Cella, Marina, Schmedt, Christian and Colonna, Marco (2018) Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor. Cell, 172 (3). 534-548.e19. ISSN 10974172

Beach, Aaron, Wassmann, Paul and Lorenz, Thorsten (2018) Analytical strategies for developability assessment of therapeutic proteins. American Pharmaceutical Review, 21 (4). ISSN 10998012

Beato, Stefania, Kourentas, Alexandros , Vertzoni, Maria , Barmpatsalou, Vicky, Butler, James , Holm, Rene, Rosenberg, Joerg, Tannergren, Christer, Symillides, Mira and Reppas, Christos (2018) The use of BioGIT system to assess the impact of dose and formulation on early exposure to low solubility drugs after oral administration. The AAPS journal, 20 (71). pp. 1-12. ISSN 10-1208

Beckmann, Nicolau, Giorgetti, Elisa, Neuhaus, Anna, Zurbruegg, Stefan, Accart Gris, Nathalie, Smith, Paul, Perdoux, Julien, Perrot, Ludovic, Nash, Mark, Desrayaud, Sandrine, Wipfli, Peter, Frieauff, Wilfried and Shimshek, Derya (2018) Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945. Acta neuropathologica communications.. ISSN 2051-5960

Beckwith, Rohan (2018) Reactive carbon species tamed for synthesis. Nature, 554 (7690). pp. 36-38. ISSN 14764687

Becquet, Mike, Laborde, Laurent, Texier, Celine, Sterker, Dario, Gschwind, Hans-Peter, Pfaar, Ulrike, Wartmann, Markus, O'Reilly, Terence and Mcsheehy, Paul M.J. (2018) Continuous low-dose infusion of patupilone increases the therapeutic index in mouse and rat tumour models. Anti-Cancer Drugs, 29 (7). pp. 691-701. ISSN 14735741

Beninson, Jennifer A, Lofgren, Jennifer L, Lester, Patrick A, Hileman, Madeline M, Berkowitz, Daniel J and Myers, Daniel D (2018) Analgesic Efficacy and Hematologic Effects of Robenacoxib in Mice. Journal of the American Association for Laboratory Animal Science : JAALAS, 57 (3). pp. 258-267. ISSN 1559-6109

Bennet, Bindu M., Regan, Karen S., Romeike, Annette, Schafer, Kenneth, Thibodeau, Michael, Thomas, Heath, Colman, Karyn, Fikes, James, Francke, Sabine, Geoly, Frank, Keirstead, Natalie, Schorsch, Frederic and Vahle, John (2018) The Pathology Community’s Interpretation of Settiagounder’s Proposals on GLP Process as Applied to Pathology Peer Review. Journal of Regulatory Science, 6 (1). v-xi.

Benton, Bret, de Vicente, Javier, Drumm, Joseph, Feng, Brian, Geng, Mei, Li, Cindy, Moreau, Bob, Rath, Christopher, Shen, Xiaoyu, Skepper, Colin, Steffek, Micah, Takeoka, Kenneth, Wang, Lisha, Wei, Jun-Rong, Xu, Wenjian and Zhang, Qiong (2018) Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics. ACS Infectious Diseases, 4 (3). pp. 391-402. ISSN 23738227

Bergsdorf, Christian, Kallen, Joerg, Galimberti, Ivan, Cobos-Correa, Amanda, Kaufmann, Markus, Roma, Guglielmo, Elhajouji, Azeddine, Uteng, Marianne, Hunziker, Juerg, Arnaud, Bertrand, Guibourdenche, Christel, Stiefl, Nikolaus, Roethlisberger, Patrik, Polyakov, Valery, Von Matt, Peter, Martus, Hans-Joerg, Izaac, Aude, Leder, Lukas, Holzinger, Sandra, Haenni, Simon, Freuler, Felix, Brichet, Murielle, Bernhard, Mario and Lerchner, Andreas (2018) X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan–McDermid Syndrome. ChemMedChem, 13 (18). pp. 1997-2007. ISSN 18607187

Bitter, Hans, Orlando, Elena, Marco, Ruella, Jun, Xu, David, Barrett, Joseph, Fraietta, Tyler , Reich, David , Ambrose, Michael, Klichinsky, Olga, Shestova, Prachi, Patel, Irina, Kulikovskaya, Farzana, Nazimuddin, Vijay, Bhoj, Shannon, Maude, Bruce, Levine, Christopher, Nobles, Frederic, Bushman, Regina, Young, John, Scholler, Saar, Gill, Carl, June, Stephan, Grupp, Joseph, Melenhorst and Simon, Lacey (2018) Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nature Medicine, 24 (10). pp. 1499-1503. ISSN 1546170X

Blais, Johanne, Lopez, Sara, Li, Cindy, Ruzin, Alexey, Ranjikar, Srijan, Dean, Charles, Leeds, Jennifer, Casarez, Anthony, Simmons, Bob and Reck, Folkert (2018) In Vitro Activity of LYS228, a Novel Monobactam Antibiotic, against Multidrug-resistant Enterobacteriaceae. Antimicrobial agents and chemotherapy. ISSN 1098-6596

Blais, Johanne, Lopez, Sara, Li, Cindy, Ruzin, Alexey, Ranjikar, Srijan, Dean, Charles, Leeds, Jennifer, Casarez, Anthony, Simmons, Bob and Reck, Folkert (2018) In vitro activity of LYS228, a novel monobactam antibiotic, against multidrug-resistant enterobacteriaceae. Antimicrobial Agents and Chemotherapy, 62 (10). pp. 1-10. ISSN 10986596

Blasko, Andrei, Tam, Yat Kong, Haidar Ahmad, Imad A. , Sajeevi, Gunasekera, Irina, Oshchepkova, Alexey, Galin, Andrey, Vazhentsev, Vadim, Tashlitsky and David, Adams (2018) A Four-Dimensional (4D) Stability Indicating Analytical Method Optimization and Potency Assay Prediction Using MS and UV Peak Tracking. Journal of Applied Pharmacy, 10 (1). pp. 1-11. ISSN 1920-4159

Blasko, Andrei, Tam, Yat Kong, Kadrichu, Nani and Ahmad, Imad A. Haidar (2018) Amikacin analysis and aerosol particle size distribution (aPSD) determination using charged aerosol detector (CAD). Atlas of Science, - (April ). pp. 1-3.

Blatter, Markus, Sellier, Chantal, Cerro-Herreros, Estefanía, Allain, Frédéric H.T. , Llamusi, Beatriz and Charlet-Berguerand, Nicolas (2018) RbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences. Nature Communications, 9 (1). ISSN 20411723

Boehme, Philip, Hansen, Arne, Roubenoff, Ronenn, Scheeren, Joseph, Herrmann, Maximilian, Mondritzki, Thomas, Ehlers, Jan and Truebel, Hubert (2018) How soon will digital endpoints become a cornerstone for future drug development? Drug Discovery Today. ISSN 18785832

Bonhoeffer, Bastian, Kwade, Arno and Juhnke, Michael (2018) Alternative manufacturing concepts for solid oral dosage forms from drug nanosuspensions using fluid dispensing and forced drying technology. Journal of pharmaceutical sciences, 107 (3). pp. 909-921. ISSN 00223549

Bot, Corina T., Juhasz, Krisztina, Häusermann, Fabian, Liudmila , Polonchuk, Traebert, Martin and Stölzle-Feix2, Sonja (2018) Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes. Journal of pharmacological and toxicological methods. ISSN 10568719

Bourgoint, Clelia, Rispal , Delphine, Berti, Marina, Filipuzzi, Ireos, Helliwell, Stephen, Prouteau, Manuel and Loewith, Robbie (2018) The Target of Rapamycin Complex 2-dependent phosphorylation of Pan1 by Akl1 controls endocytosis dynamics. Journal of Biological Chemistry, 293 (31). ISSN 0021-92581083-351X

Brocklehurst, Cara (2018) Supplimentary information for: Microtiter Plate (MTP) Reaction Screening and Optimization of Surfactant Chemistry: Examples of Suzuki–Miyaura and Buchwald–Hartwig Cross-Couplings in Water. Organic Process Research & Development, 22 (10). pp. 1453-1457. ISSN 1083-61601520-586X

Brocklehurst, Cara, Hartwieg, Constanze, Palmieri, Marco, Rufle, Dominik and Gallou, Fabrice (2018) Microtiter Plate (MTP) Reaction Screening and Optimization of Surfactant Chemistry: Examples of Suzuki-Miyaura and Buchwald-Hartwig Cross-Couplings in Water. Organic Process Research & Development. ISSN 1083-61601520-586X

Calabretta, Sara, Vogel, Gillian, Yu, Zhenbao, Choquet, Karine, Darbelli, Lama, Nicholson, Thomas, Kleinman, Claudia and Richard, Stephane (2018) Loss of PRMT5 promotes PDGFRa degradation during oligodendrocyte differentiation and myelination. Developmental cell, 46 (4). pp. 426-440. ISSN 15345807

Calvani, R, Bejuit, R, Roller-Wirnsberger, R, Barnebei, R, Vellas, B, Tosato, M, Jonsson , P, Grodzicki, T, Landi, F, Del Signore , S, Rodrigues-Manas, L, Skalska, A, Schols, A, Ryznarova , I, Msihid , J, Sinclair, A, Pahor, M, Maggio, M, Topinkova, E, Cruz-Jentoft, A, Roubenoff, Ronenn, Dantoine, T, Di Bari, M, Freiberger, E, Cesari, M, Marzetti, E, Sieber, C, Strandberg, T and Cherubini, A (2018) The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants. Experimental Gerontology, 113. pp. 48-57. ISSN 18736815

Capparelli, Claudia, Purwin , Timothy J., Heilman , Shea, Chervoneva, Inna, McCue, Peter, Davies, Michael A., Gershenwald, Jeffrey and Aplin, Andrew E. (2018) Stromal neuregulin-1 modulates the response to MEK inhibitors in WT BRAF/WT NRAS (WT/WT) melanomas. Molecular Cancer Therapeutics, 17 (1). ISSN 15388514

Carcache, David, Vulpetti, Anna, Kallen, Joerg, Mattes, Henri, Orain, David, Stringer, Rowan, Vangrevelinghe, Eric, Wolf, Romain, Kaupmann, Klemens, Ottl, Johannes, Dawson King, Janet, Cooke, Nigel Graham, Hoegenauer, Klemens, Billich, Andreas, Wagner, Juergen, Guntermann, Christine and Hintermann, Samuel (2018) Optimizing a weakly binding fragment into a potent RORγt inverse agonist with efficacy in an in vivo inflammation model. Journal of medicinal chemistry.

Cardoso, Ana-Luisa, Fernandes, Adelaide, Aguilar-Pimentel, Juan Antonio, Hrabě de Angelis, Martin, Ribeiro Guedes, , Joana, Brito, Maria Alexandra, Ortolano, Saida, Pani, Giovambattista, Athanasopoulou, Sophia, Gonos, Efstathios S., Schosserer, Markus, Grillari, Johannes, Peterson, Pärt, Guvenc Tuna, Bilge, Dogan, Soner, van Os, Ronald, Meyer, Angelika and Trendelenburg, Anne-Ulrike (2018) Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Research Reviews, 47. pp. 214-277. ISSN 18729649

Cardoso, Ana-Luisa, Fernandes, Adelaide, Aguilar-Pimentel, Juan Antonio, Hrabě de Angelis, Martin, Ribeiro Guedes, , Joana, Brito, Maria Alexandra, Ortolano, Saida, Pani, Giovambattista, Athanasopoulou, Sophia, Gonos, Efstathios S., Schosserer, Markus, Grillari, Johannes, Peterson, Pärt, Guvenc Tuna, Bilge, Dogan, Soner, van Os, Ronald, Meyer, Angelika and Trendelenburg, Anne-Ulrike (2018) Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Research Reviews, 47. pp. 214-277. ISSN 18729649

Cardoso, Ana-Luisa, Fernandes, Adelaide, Aguilar-Pimentel, Juan Antonio, Hrabě de Angelis, Martin, Ribeiro Guedes, , Joana, Brito, Maria Alexandra, Ortolano, Saida, Pani, Giovambattista, Athanasopoulou, Sophia, Gonos, Efstathios S., Schosserer, Markus, Grillari, Johannes, Peterson, Pärt, Guvenc Tuna, Bilge, Dogan, Soner, van Os, Ronald, Meyer, Angelika and Trendelenburg, Anne-Ulrike (2018) Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Research Reviews, 47. pp. 214-277. ISSN 18729649

Clarke, Brian, Cruz Jr, Joseph, Wilson, Liz, Hupper, Nicole, Wang, Yuan, Patora-Komisarska, Krystyna, Oberhauser, Berndt, Concannon, John, Glass, David, Trendelenburg, Anne-Ulrike and Zhang, Yunyu (2018) Protein kinase A activation inhibits DUX4 gene expression in facioscapulohumeral muscular dystrophy patient myotubes. Journal of Biological Chemistry. ISSN 0021-92581083-351X

Clayton, Gemma, Schachter, Asher, Magnusson, Baldur, Li, Yue and Colin, Laurence (2018) How often do safety signals occur by chance in first-in-human trials? Clinical and translational science, 11 (5). pp. 471-476. ISSN 1752-8062; 1752-8054

De Pascale, Gianfranco and Uehara, Tsuyoshi (2018) Target identification of cystobactamid and albicidin. ACS infectious diseases.

Dean, Charles, Barkan, Dave, Bermingham, Alun, Blais, Johanne, Casey, Fergal, Casarez, Anthony, Colvin, Richard, Fuller, John, Jones, Adriana, Li, Cindy, Lopez, Sara, Metzger Iv, Louis, Mostafavi, Mina, Prathapam, Ramadevi, Rasper, Dita, Reck, Folkert, Ruzin, Alexey, Shaul, Jacob, Shen, Xiaoyu, Simmons, Robert, Skewes-Cox, Peter, Takeoka, Ken, Tamrakar, Pramila, Uehara, Tsuyoshi and Wei, Jun-Rong (2018) The monobactam LYS228: mode of action and mechanisms decreasing in vitro susceptibility of Escherichia coli and Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 62 (10). ISSN 1098-6596

Deurinck, Mark, Schindler, Stefanie, Zeiter, Stephan, Desbaillets, Isabelle, Gyger, Marcel, Bugnon, Philippe, Heimann, Maike, Ferrand, Gisele and Wyss, Stefanie (2018) Report from the 2017 Annual SGV Meeting. Laboratory Animals, 52 (2). pp. 211-213. ISSN 0023-67721758-1117

Dickson, Callum, Hornak, Viktor, Bednarczyk, Dallas and Duca, Jose (2018) Using membrane partitioning simulations to predict permeability of forty-nine drug-like molecules. Journal of Chemical Information and Modeling. ISSN 1549-95961549-960X

Dincer, Zuhal, Piccicuto, Virginie, Junker Walker, Ursula, Mahl, Joerg Andreas and McKeag, Sean (2018) Spontaneous and Drug-induced Arteritis/Polyarteritis in the Göttingen Minipig—Review. Toxicologic Pathology, 46 (2). pp. 121-130. ISSN 15331601

Donovan, Katherine and Fischer, Eric (2018) CRL4CRBN Mediated Degradation of SALL4 Links Thalidomide Syndrome to Duane Radial Ray Syndrome. ELife., 7. ISSN 2050-084X

Dumouchel, Jennifer, Chemuturi, Nagendra, Milton, Mark, Camenisch, Gian P., Chastain, Jim, Walles, Markus, Sasseville, Vito, Gunduz, Mithat, Iyer, Ganesh and Argikar, Upendra (2018) Models and approaches describing metabolism, transport, and toxicity of drugs administered by the ocular route. Drug metabolism and disposition, 46. pp. 1670-1683. ISSN 1521-009X

Dutta, Priyanka, Dargahi, Leila, O'Connell, Kara, Bolina, Ashini, Ozkan, Sefika, Sailer, Andreas and Dev, Kumlesh (2018) A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease. Neuroscience Letters, 673. pp. 12-18. ISSN 18727972

Dégardin, Klara, Guillemain, Aurélie, Klespe, Philippe, Hindelang, Florine, Zurbach, Raphaël and Roggo, Yves (2018) Packaging analysis of counterfeit medicines. Forensic Science International, 291. pp. 144-157. ISSN 03790738

Ehara, Takeru, Adams, Christopher, Bevan Jr, Doug, Ji, Nan, Meredith, Erik, Belanger, David, Powers, James, Kato, Mitsunori, Solovay, Catherine, Liu, Donglei, Capparelli, Michael, Bolduc, Philippe, Grob, Jonathan, Daniels, Matthew, Ferrara, Luciana, Yang, Louis, Towler, Christopher, Li, Byron, Stacy, Rebecca, Prasanna, Ganesh and Mogi, Muneto (2018) The discovery of (S)-1-(6-(3-((4-(1-(cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid, an sGC activator specifically designed for topical ocular delivery as a therapy for glaucoma. Journal of medicinal chemistry. ISSN DOI: 10.1021/acs.jmedchem.8b00007

Erlanson, Daniel A, de Esch, Iwan JP, Jahnke, Wolfgang, Johnson, Christopher N and Mortenson, Paul N (2018) Fragment-to-Lead Medicinal Chemistry Publications in 2016. Journal of Medicinal Chemistry, 61 (5). pp. 1774-1784. ISSN 15204804

Faller, Bernard, Berben, Philippe, Bauer-Brandl, Annette, Flaten, Goril Eide, Jacobsen, Christin, Brouwers, Joachim and Augustijins, Patrick (2018) Drug permeability profiling using cell-free permeation tools: Overview and applications. European Journal of Pharmaceutical Sciences, 119. pp. 219-233. ISSN 18790720

Ferretti, Stephane Raymond, Holzer, Philipp, Fuchs, Jeannette, Chapeau, Emilie, Wartmann, Markus, Sterker, Dario, Romanet, Vincent, Kerr, Grainne, Durand, Eric, Gaulis, Swann, Kallen, Joerg, Furet, Pascal, Cortes-Cros, Marta, Guerreiro, Nelson, Halilovic, Ensar, Jullion, Astrid, Kuriakose, Emil, Wiesmann, Marion, Jensen, Michael Rugaard, Hofmann, Francesco, Sellers, William, Jeay, Sebastien, Murakami, Masato and Wuerthner, Jens (2018) Dose and schedules determines distinct molecular mechanism underlying the efficacy of the p53-MDM2 inhibitor NVP-HDM201. Cancer research. ISSN 1538-7445; 0008-5472

Fodor, Michelle, Price, Edmund, Wang, Ping, Lu, Henry, Argintaru, Andreea, Chen, Zhuoliang, Glick, Meir, Hao, Huaixiang, Kato, Mitsunori, Koenig, Robert, Jonathan, LaRochelle, Liu, Gang, Mcneill, Eric, Majumdar, Dyuti, Nishiguchi, Gisele, Perez, Lawrence, Paris, Greg, Quinn, Christopher, Ramsey, Timothy, Sendzik, Martin, Shultz, Michael, Williams, Sarah, Stams, Travis, Stephen, Blacklow, Acker, Michael and Lamarche, Matthew (2018) Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chemical Biology.

Galli, Giorgio and Dirk, Schuebeler (2018) Job description for Post-doc position. Distributed to academic collaborator.

Gallou, Fabrice (2018) Copper-Catalyzed Oxidative Cleavage of Electron-Rich Olefins in Wa-ter at Room Temperature. Organic letters, 20 (17). pp. 5094-5097.

Gallou, Fabrice (2018) Forewords of Symposium in Print issue on Process Chemistry for Bioorganic and Medicinal Chemistry. Bioorganic and medicinal chemistry.

Gallou, Fabrice (2018) Inspiring process innovation via a breakthrough green manufacturing metric: iGAL. Green chemistry, 20. pp. 2206-2211.

Gallou, Fabrice (2018) Journal highlight for the article: π-Allylpalladium Species in Micelles of FI-750-M for Sustainable and General Suzuki-Miyaura Couplings of Unactivated Quinoline Systems in Water. ChemCatChem., 10 (19). pp. 4229-4233.

Gallou, Fabrice (2018) PQS-Enabled Visible-Light Photoredox Ir Catalysis in Water at Room Temperature. Green chemistry, 20 (Green ). pp. 1233-1237.

Gallou, Fabrice and Handa, Sachin (2018) π-Allyl Palladium Species in Micelles of FI-750-M for Sustainable and General Suzuki-Miyaura Couplings of Quinoline Systems in Water. ChemCatChem, 10 (19). pp. 4229-4233.

Gallou, Fabrice and Handa, Sachin (2018) Micelle-Enabled Clean Sulfonylation of Polyfluoroarenes in Water Under Mild Conditions. Green chemistry. ISSN 1463-9270; 1463-9262

Gallou, Fabrice and Lipshutz, Bruce (2018) B-Alkyl sp3-sp2 Suzuki-Miyaura Couplings Under Mild Aqueous Micellar Conditions. Organic letters, 20 (10). pp. 2902-2905. ISSN 1523-7052; 1523-7060

Gallou, Fabrice and Walde, Peter (2018) Aqueous soft dispersed interface-rich systems that promote and guide chemical reactions. Nature reviews chemistry, 2. pp. 306-327.

Gallou, Fabrice and lipshutz, Bruce (2018) Sustainable, Copper-Free HandaPhos-ppm Palladium Technology for Sonogashira Couplings in Water Under Mild Conditions. Organic letters, 20. pp. 542-545. ISSN 1523-7052; 1523-7060

Gallou, Fabrice and lipshutz, Bruce (2018) Transition Metal Synergy in Fe Nanoparticles Doped with ppm Levels of (Pd + Ni). A New Catalyst for Nitro Group Reductions under Environmentally Responsible Conditions. Green chemistry, 20. pp. 130-135. ISSN 1463-9270; 1463-9262

Galyan, Keith and Reilly, John (2018) Green Chemistry Approaches for the Purification of Pharmaceuticals. Current Opinion in Green and Sustainable Chemistry.

Gampe, Christian, White, Amy, Siva, Swetha, Zecri, Frederic and Diener, John (2018) 3′-Modification stabilizes mRNA and increases translation in cells. Bioorganic and Medicinal Chemistry Letters. ISSN 1464-3405

Garito, Tania (2018) PhD Thesis of Tania Garito, MD: THE METABOLIC IMPLICATIONS OF CHANGES IN BODY COMPOSITION. Thesis, University of Milan.

Gauthier, Anne, Fisch, Andreas, Seuwen, Klaus, Baumgarten, Birgit, Ruffner, Heinz, Aebi, Alexandra, Rausch, Martin, Bartneck, Matthias, Weiskirchen, Ralf, Tacke, Franck, Storm, Gert, Lammers, Twan and Ludwig, Marie-Gabrielle (2018) Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials.

Gauthier, Anne, Fisch, Andreas, Seuwen, Klaus, Baumgarten, Birgit, Ruffner, Heinz, Aebi, Alexandra, Rausch, Martin, Bartneck, Matthias, Weiskirchen, Ralf, Tacke, Frank, Storm, Gert, Lammers, Twan and Ludwig, Marie-Gabrielle (2018) Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials.

Geneste , Olivier, Clapéron, Audrey, Colland, Frédéric, Kraus-Berthier, Laurence, Le Toumelin-Braizat, Gaëtane, Studeny, Aurélie, Guasconi, Ghislaine, Bruno, Alain, Chanrion, Maia, Lysiak-Auvity, Gaelle, Girard, Anne-Marie, Schneider, Emilie, Gravé, Fabienne, Casara, Patrick, Le Diguarher, Thierry, Starck, Jérome-Benoit, Henlin, Jean-Michel, Murray, James, Davidson, James, Chen, Ijen, Whitehead, Neil, Graham, Christopher, Matassova, Natalia, Dokurno, Pawel, Pedder, Christopher, Hubbard, Roderick, Wood, Mike, Morris, Erick, Wang, Youzhen, Qiu, Shumei, Amiot, Martine, Maïga, Sophie, Le Gouill, Steven, Vogler, Meike, Cohen, Gerry M, Dyer, Martin JS, Rocchetti, Franscesca and Hickman, John A. (2018) S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget, 9 (28). pp. 20075-20088. ISSN 19492553

Glaenzel, Ulrike, Jin, Yi, Nufer, Robert, Li, Wenkui, Schroer, Kirsten, Adam, Sylvie, van Marle, Sjoerd Peter, Legangneux, Eric, Borell, Hubert, James, Alexander David, Meissner, Axel, Camenisch, Gian P. and Gardin, Anne (2018) Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism. Drug metabolism and disposition, 46 (7). pp. 1001-1013. ISSN 1521-009X

Glowienke, Susanne (2018) Potential impurities in drug substances: Compound-specific toxicology limits for 20 synthetic reagents and by-products, and a class-specific toxicology limit for alkyl bromides. Regulatory Toxicology and Pharmacology, 94. pp. 172-182. ISSN 10960295

Glowienke, Susanne and Glogovac, Milica (2018) Making reliable negative predictions of human skin sensitisation using an in silico fragmentation approach. Regulatory toxicology and pharmacology.

Gordillo-Sala, Marta, Auberson, Yves and Adell, Albert (2018) Signaling pathways responsible for the rapid anti-depressant effects of a GluN2A-preferring NMDA receptor antagonist. Translational psychiatry. ISSN 2158-3188

Gounarides, John and Cook, Frank (2018) Sample Preparation and LC-MS methods for the measurement of NAD, NADP, NADPH. NADH and NMN. no journal, none (none). ISSN none

Groot Kormelink, Paul, Bouhelal, Rochdi, Corminboeuf , Olivier, Kenakin , Terry, Durroux , Thierry, Pin , Jean-Philippe, Roux, Thomas, Bdioui, Sara, Trinquet, Eric, Pierre, Pierre, Scholler , Pauline and Degorce, Francois (2018) Sharing meaningful and relevant assay data – the experts' opinion. CisBio Expert Opinion.

Growcott, Ellena, Bamba, Douty, Galarneau, Jean-Rene, Leonard, Vincent, Schul, Wouter, Stein, Daniel and Osborne, Colin (2018) The Effect of P38 MAP Kinase Inhibition in a Mouse Model of Influenza. Journal of Medical Microbiology. ISSN 0022-26151473-5644

Grunseich, Christopher, Miller, Ram, Swan, Therese, Glass, David, El Mouelhi, Mohamed, Fornaro, Mara, Petricoul, Olivier, Vostiar, Igor, Roubenoff, Ronenn, Meriggioli, Matthew, Kokkinis, Angela, Guber, Robert D., Budron, Maher S. , Vissing, John, Soraru, Gianni, Mozaffar, Tahseen, Ludolph, Albert, Kissel, John T and Fischbeck, Kenneth H. (2018) A placebo-controlled study to evaluate the safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy. Lancet Neurology.

Guo, Chenying, Qu, Paul, Rangaswamy, Nalini, Leehy, Barrett, Xiang, Chuanxi, Rice, Dennis and Prasanna, Ganesh (2018) A murine glaucoma model induced by rapid in vivo photopolymerization of hyaluronic acid glycidyl methacrylate. PLoS ONE, 13 (6). N/A-N/A. ISSN 19326203

Haidar Ahmad, Imad and Blasko, Andrei (2018) Two Dimensional Liquid Chromatography (2DLC) in pharmaceutical analysis. Applications beyond increasing peak capacity. Chromatographia, 81. pp. 401-418. ISSN 0009-5893

Haiser, Henry, Oakeley, Edward James, Porter, Jeffrey, Rudolph, Sabine, Ke, Xiaobo and Young, Rachel (2018) Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life. Nature Microbiology. ISSN 20585276

Hallam, Dean, Hilgen2, Gerrit , Dorgau, Birthe , Yu, Min , Zhu, Lili , Bojic, Sanja , Hewitt, Philip , Schmitt, Michael , Uteng, Marianne, Kustermann, Stefan , Steel, David , Nicholds, Mike , Thomas, Robert , Treumann, Achim , Porter, Andrew , Sernagor, Evelyne , Armstrong, Lyle and Lako, Majlinda (2018) Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency. Stem Cells. ISSN 15494918

Han, Wooseok, Ma, Xiaolei and Uehara, Tsuyoshi (2018) Small molecule and fragment inhibitors of E. coli LpxA. Nature chemical biology.

Harding, James J. , Bauer, Todd M., Tan, Daniel, Bedard, Philippe L. , Rodon, Jordi, Doi, Toshihiko, Schnell, Christian, Iyer, Varsha, Baffert, Fabienne, Radhakrishnan, Rajkumar, Fabre, Claire and Juric, Dejan (2018) Characterization and first-in-human data of CLR457, an orally bioavailable pan-class I PI3-Kinase inhibitor. Investigational new drugs. ISSN 1573-0646; 0167-6997

Hartmann, Stephanie, Zheng, Fang, Kyncl, Michele Constanze, Karch, Sandra, Voelkl, Kerstin, Zott, Benedikt, D'Avanzo, Carla, Lomoio, Selene, Tesco, Giuseppina, Kim, Doo Yeon, Alzheimer, Christian and Huth, Tobias (2018) Beta secretase BACE1 promotes surface expression and function of Kv3.4 potassium channels in hippocampal mossy fiber synapses. Journal of Neuroscience. ISSN 0270-6474

Hauptmann, Astrid, Podgoršek, Katja, Kuzman, Drago, Srčič, Stanko, Hoelzl, Georg and Loerting, Thomas (2018) Impact of Buffer, Protein Concentration and Sucrose Addition on the Aggregation and Particle Formation during Freezing and Thawing. Pharmaceutical Research, 35 (5). ISSN 0724-8741

Ho, Pei-I, Casalena, Dominick and Auld, Douglas (2018) Characterization and use of Turbo Luciferase as a reporter for high-throughput assays. Biochemistry. ISSN 10.1021/acs.biochem.8b00290

Hoffman, Ben, Baba, Yoshichika, Griffith, Theanne, Masharov, Eugene, Woo, Seung, Roybal, Daniel, Karsenty, Gerard, Patapoutian, Ardem, Sulzer, David and Lumpkin, Ellen (2018) Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses. Neuron, 100 (6). pp. 1401-1413. ISSN 10974199

Hong, E. Erica, Qiu, Qifeng, Wu, Rui, Wilhelm, Alan, Erickson, Hans, Abrams, Tinya, Deeds, Jim, Wang, Zhen, Ghoddusi, Majid and Schleyer, Siew (2018) Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors. Clinical Cancer Research, 24 (17). pp. 4297-4308. ISSN 15573265

Hsiao, Hsiu-Ling, Langenickel, Thomas Heiko, Petruck, Jesika, Kode, Kiran Kumar, Ayalasomayajula, Surya, Schuehly, Uwe, Greeley, Michael, Pal, Parasar, Zhou, Wei, Prescott, Margaret, Sunkara, Gangadhar and Rajman, Iris (2018) Evaluation of Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction of Sacubitril/Valsartan (LCZ696) and Sildenafil in Patients With Mild-to-Moderate Hypertension. Clinical Pharmacology and Therapeutics, 103 (3). pp. 468-476. ISSN 1532-6535

Hsiao, Hsiu-Ling, Langenickel, Thomas Heiko, Petruck, Jesika, Kode, Kiran Kumar, Ayalasomayajula, Surya, Schuehly, Uwe, Greeley, Michael, Pal, Parasar, Zhou, Wei, Prescott, Margaret, Sunkara, Gangadhar and Rajman, Iris (2018) Evaluation of Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction of Sacubitril/Valsartan (LCZ696) and Sildenafil in Patients With Mild-to-Moderate Hypertension. Clinical Pharmacology and Therapeutics, 103 (3). pp. 468-476. ISSN 1532-6535

Hsieh, Hsiao-Wu, Robinson, Richard, Coley, Connor, Jensen, Klavs and Baumgartner, Lorenz (2018) Photoredox Iridium-Nickel Dual Catalyzed Decarboxylative Arylation Cross-Coupling: From Batch to Continuous Flow via Self-Optimizing Segmented Flow Reactor. Organic process research & development, 22 (4). pp. 542-550. ISSN 1520-586X; 1083-6160

Hu, Lu, Liu, Yahu and Liao, Xuebin (2018) Recent Progress in Methylation of (Hetero)Arenes by Cross-Coupling or C-H Activation. Synlett, 29 (4). pp. 375-382. ISSN 14372096

Huels, DJ, McLaughlin, Margaret, Bruens, L, Hodder, MC, Cammareri, P, Campbell, AD, Ridgway, RA, Gay, DM, Solar-Abboud, M, Faller, WJ, Nixon, C, Zeiger, LB, Morrissey, E, Winton, DJ, Snippert, HJ, Rheenen van, J and Sansom, OJ (2018) Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nature Communications, 9 (1). ISSN 20411723

Hurley, Timothy, Kerrigan, John, Shu, Lei, Shen, Yiping, Sung, Moo, O'Brien, Gary, Hou, Ying, Axford, Jake, Deng, Lin, Hoffmaster, Keith, Shin, Youngah, Servais, Rebecca, Towler, Christopher, Hild, Marc, Briner, Karin, Dietrich, Bill, Sivasankaran, Rajeev, Dales, Natalie, Chin, Donovan, Sun, Robert, Cody, Emma, Fazal, Aleem, Tomlinson, Ronald, Song, Cheng, Jain, Monish, Van Hoosear, Mailin, Hamann, Lawrence, Curtis, Daniel, Kobayashi, Dione, Chen, Karen, Fridrich, Cary and Sanchez, Carina (2018) Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA). Journal of medicinal chemistry, 61 (24). pp. 11021-11036. ISSN 0022-2623

Huth, Felix and Einolf, Heidi (2018) Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective. Clinical Pharmacology and Therapeutics. ISSN 15326535

Huynh, Hung, Lee, Liek Yeow , Ong, Richard, Hao, Huaixiang, Huang, Alan, Wang, Youzhen, Graus Porta, Diana, Chow, Pierce, Ong, Hock Soo and Chung, Alexander (2018) Infigratinib mediates vascular normalization, impairs metastasis and improves chemotherapy in hepatocellular carcinoma. Hepatology. ISSN 1527-3350; 0270-9139

Isaacs, Randi, Chen, Xueying, Graus Porta, Diana, Parker, Katie, Yu, Kun and Porter, Dale (2018) Efficacy of BGJ398, a fibroblast growth factor receptor (FGFR) 1-3 inhibitor, in patients with previously treated advanced urothelial carcinoma with FGFR3 alterations. Cancer discovery. ISSN 2159-8290; 2159-8274

Isbell, John, Yuan, Ding, Reis Da Silva Torrao, Leonel, Gatlik, Ewa, Hoffmann, Laurent and Wipfli, Peter (2018) Plasma protein binding of highly bound drugs determined with equilibrium gel filtration of non-radiolabeled compounds and LC-MS/MS detection. J Pharmaceutical Sciences.

Israel, Laura, Bardet, Maureen, Huppertz, Antje, Mercado, Nicolas, Ginster, Stefanie, Unterreiner, Adeline, Schlierf, Anita, Goetschy, Jean Francois, Zerwes, Hans-Guenter, Roth, Lukas, Kolbinger, Frank and Bornancin, Frederic (2018) A CARD10-dependent tonic signalosome activates MALT1 paracaspase and regulates IL-17/TNF-a driven keratinocyte inflammation. Journal of investigative dermatology: Symposium proceedings.. ISSN 1529-1774; 1087-0024

Israel, Laura and Bornancin, Frederic (2018) Ways and waves of MALT1 paracaspase activation. Cellular & molecular immunology :.

Jacquemont, S, Pacini, L, Cencelli, G, Jønch, E, Andrea, D, Willemsen, R, Tassone, F, Hagerman, R, Bagni, C, Gasparini, Fabrizio, He, Yunsheng, Rozenberg, Izabela and Gomez-Mancilla, Baltazar (2018) Altered and normal levels of protein synthesis in fragile X syndrome, studies in humans and mice. Science translational medicine, 27 (12). pp. 2039-2051. ISSN 10.1093/hmg/ddy099

Jerby-Arnon, Livnat, Shah, Parin, Cuoco, Michael S, Rodman, Christopher, Su, Mei-Ju, Melms, Johannes C, Leeson, Rachel, Kanodia, Abhay, Mei, Shaolin, Lin, Jia-Ren, Wang, Shu, Rabasha, Bokang, Liu, David, Zhang, Gao, Margolais, Claire, Ashenberg, Orr, Ott, Patrick A, Buchbinder, Elizabeth I, Haq, Rizwan, Hodi, F Stephen, Boland, Genevieve M, Sullivan, Ryan J, Frederick, Dennie T, Miao, Benchun, Moll, Tabea, Flaherty, Keith T, Herlyn, Meenhard, Jenkins, Russell W, Thummalapalli, Rohit, Kowalczyk, Monika S, Cañadas, Israel, Schilling, Bastian, Cartwright, Adam N R, Luoma, Adrienne M, Malu, Shruti, Hwu, Patrick, Bernatchez, Chantale, Forget, Marie-Andrée, Barbie, David A, Shalek, Alex K, Tirosh, Itay, Sorger, Peter K, Wucherpfennig, Kai, Van Allen, Eliezer M, Schadendorf, Dirk, Johnson, Bruce E, Rotem, Asaf, Rozenblatt-Rosen, Orit, Garraway, Levi A, Yoon, Charles H, Izar, Benjamin and Regev, Aviv (2018) A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell, 175 (4). 984-997.e24. ISSN 1097-4172

Ji, Yan, Jin , Jin Y., Hyman, David, Kim, Geoffrey and Suri, Ajit (2018) Challenges and Opportunities in Dose Finding in Oncology and Immuno-oncology. Clinical and Translational Science, 00. pp. 1-7.

Jiang, Xiaomo (2018) INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. ELife., 7. ISSN 2050-084X

Johasz, Christian, Nassim , Rousset, Kasper, Renggli and Hierlemann, Andreas (2018) Scalable Microfluidic Platform for Flexible Configuration of and Experiments with Microtissue Multiorgan Models. SLAS. pp. 1-17.

Jones, Adriana, Ranjitkar, Srijan, Lopez, Sara, Li, Cindy, Blais, Johanne, Reck, Folkert and Dean, Charles (2018) Impact of inducible blaDHA-1 on susceptibility of Klebsiella pneumoniae clinical isolates to LYS228 and identification of chromosomal mpl mutations mediating upregulation of plasmid borne DHA-1 expression. Antimicrobial agents and chemotherapy, 62 (10).

Jourdain, Marie, Melly, Stefan, Summermatter, Serge and Hatakeyama, Shinji (2018) Mouse models of cancer-induced cachexia: Hind limb muscle mass and evoked force as readouts. Biochemical and biophysical research communications : BBRC. ISSN 1090-2104

Juric, Dejan, Janku, Filip, Rodon, Jordi, Burris, Howard A., Mayer, Ingrid A., Schuler, Martin, Seggewiss-Bernhard, Ruth, Gil-Martin, Marta, Middleton, Mark R., Baselga, Jose, Bootle, Douglas, Demanse, David, Blumenstein, Lars, Schumacher, Karl, Huang, Alan, Quadt, Cornelia and Rugo, Hope S. (2018) Alpelisib (BYL719) plus Fulvestrant in PIK3CA-altered and PIK3CA wild-type ER+ advanced breast cancer. An open-label, phase 1b dose-escalation and expansion study. JAMA oncology, Oncol.. E1-E9. ISSN 2374-2437

Kaesler, Nadine, Verhulst, Anja, De Maré, Annelies, Deck, Annika, Behets, Geert J., Hyusein, Ayshe, Evenepoel, Pieter, Floege, Jürgen, Marx, Nikolaus, Babler, Anne, Kramer, Ina, Kneissel, Michaela, Kramann, Rafael, Weis, Daniel, D`Haese, Patrick C. and Brandenburg, Vincent M. (2018) Sclerostin-deficiency modifies the development of CKD-MBD in mice. Bone, 107. pp. 115-123. ISSN 1873-2763; 8756-3282

Kall, Morten A., Michi, Marco, Van der Strate, Barry, Freisleben, Achim, Stoellner, Daniela and Timmerman, Philip (2018) Incurred sample reproducibility: 10 years of experiences: Views and recommendations from the European Bioanalysis Forum. Bioanalysis, 10 (21). pp. 1723-1732. ISSN 17576199

Kapur, Reuben, Cai, Zhigang, Pandey, Ruchi, Mali, Rahuveer, Ramdas, Baskar, Sandusky, George, Kelley, Mark and Mohseni, Mori (2018) Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cell Stem Cell, 23 (6). 833-849.e5. ISSN 18759777

Karpov, Alexei, Abrams, Tinya, Clark, Suzy, Raikar, Ankita, D'Alessio, Tony, Gesner, Tom, Jones, Darryl, Lacaud-Baumlin, Marion, Martyniuk, Piotr, Meredith, Erik, Mohseni, Mori, Nieto-Oberhuber, Cristina, Palacios, Daniel, Perruccio, Francesca, Zurini, Mauro and Bialucha, Carl (2018) Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Medicinal Chemistry Letters. ISSN 19485875

Katoli, Parvaneh, Godbole, Adarsh, Romanowski, Michael, Clark, Kirk, Meredith, Erik, Saenz-Vash, Veronica, Wang, Yingqi, Lewicki, Nancy, Nguyen, Andrew and Lynch, Jeffrey (2018) Full-length myocilin (MYOC) protein is purified from mammalian cells as a dimer. Protein expression and purification, 147 (2018). pp. 38-48. ISSN 1096-0279; 1046-5928

Katsumiti, Alberto, Thorley, Andrew J, Arostegui, Inmaculada, Reip, Paul, Valsami-Jones, Eugenia, Tetley, Teresa D and Cajaraville, Miren P (2018) Cytotoxicity and cellular mechanisms of toxicity of CuO NPs in mussel cells in vitro and comparative sensitivity with human cells. Toxicology in vitro : an international journal published in association with BIBRA, 48. pp. 146-158. ISSN 1879-3177

Kenny, Jane, Ramsden, Diane, Buckley, David, Dallas, Shannon, Fung, Conrad, Mohutsky, Michael, Einolf, Heidi, Chen, Liangfu, Dekeyser, Joshua, Fitzgerald, Maria, Goosen, Theunis, Siu, Y. Amy, Walsky, Robert, Zhang, George, Tweedie, Donald and Hariparsad, Niresh (2018) Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevance. Drug Metabolism and Disposition, 46 (9). pp. 1285-1303. ISSN 0090-95561521-009X

Kim, Kwang Soo, Marcogliese, Paul C., Yang, Jungwoo, Callaghan, Steve, Resende, Virginia, Abdel-Messih, Elizabeth, Marras, Connie, Visanji, Naomi P., Huang, Jana, Schlossmacher, Michael G., Tinkle-Mulcahy, Laura, Slack, Ruth S., Lang, Anthony E. and Park, David S. (2018) Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease. Proceedings of the National Academy of Sciences, 115 (22). ISSN 0027-84241091-6490

King, Daniel, Nguyen, Zachary, Jimenez, Marta, Auld, Douglas, Kool, Eric, Tahara, Yu-ki, Ji, Debin, Beharry, Andrew, Kietrys, Anna M. and Wilson, David M. (2018) Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. Journal of the American Chemical Society, 140 (6). pp. 2105-2114. ISSN 15205126

Kittelmann, Matthias, Worsch, Anne, Girhard, Marco, von Bühler, Clemens , Tieves, Florian , Czaja, Rico , Vogel, Andreas , Grumaz, Christian , Sohn, Kai , Lütz, Stephan and Urlacher, Vlada (2018) A novel cytochrome P450 monooxygenase from Streptomyces platensis resembles activities of human drug metabolizing P450s. Biotechnol Bioeng..

Klopp, Julia, Winterhalter, Aurelie, Gebleux, Remy, Scherer-Becker, Daniela, Ostermeier, Christian and Gossert, Alvar (2018) Cost-effective large-scale expression of proteins for NMR studies. Journal of Biomolecular NMR. pp. 1-16. ISSN 15735001

Knoepfel, Thomas, Furet, Pascal, Mah, Robert, Buschmann, Nicole, Leblanc, Catherine, Ripoche, Sebastien, Graus Porta, Diana, Wartmann, Markus and Galuba, Inga (2018) 2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4. ACS Medicinal Chemistry Letters, 9 (3). pp. 215-220. ISSN 19485875

Koga, Tadanori, Barkley, Deborah, Nagao, Michihiro, Taniguchi, Takashi, Carrillo, Jan-Michael Y., Sumpter, Bobby G., Masui, Tomomi, Kishimoto, Hiroyuki, Koga, Maho, Rudick, Jonathan G. and Endoh, Maya K. (2018) Interphase Structures and Dynamics near Nanofiller Surfaces in Polymer Solutions. Macromolecules, 51 (23). pp. 9462-9470. ISSN 0024-9297

Kou, Jianqun, Staal, Ben, Musich, Phillip, Kang, Liang , Qin, Yuan, Yao, Zhi, Zhang, Boheng, Tam, Angela, Huang, Alan, Hao, Huaixiang, Vande Woude, George and Xie, Qian (2018) Differential Therapeutic Responses of MET Oncogenic Activations to MET Kinase Inhibitor and Neutralizing Antibody. Journal of translational medicine, 16 (253 ). ISSN 1479-5876

Krantz, Carsten, Warren, Andrew Paul and Miess, Christian (2018) Development of an automated, interference-free, immunoaffinity-based mass spectrometric assay for quantification a therapeutic monoclonal antibody in human sera. Bioanalysis, 10 (13). pp. 1023-1037. ISSN 1757-6180

Krischuns, Tim, Günl, Franziska, Henschel, Lea, Binder, Marco, Willemsen, Joschka, Schloer, Sebastian, Rescher, Ursula, Gerlt, Vanessa, Zimmer, Gert, Nordhoff, Carolin, Ludwig, Stephan and Brunotte, Linda (2018) Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Frontiers in immunology, 9. p. 2229. ISSN 1664-3224

Kucher, Klaus, Johns, Donald, Maier, Doris, Abel, Rainer, Badke, Andreas, Baron, Hagen, Thietje, Roland, Casha, Steven, Meindl, Renate, Gomez-Mancilla, Baltazar, Pfister, Christian, Mir, Anis Khusro, Rupp, Rüdiger, Weidner, Norbert, Schwab, Martin and Curt, Armin (2018) First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury. Neurorehabilitation and Neural Repair, 32 (6-7). pp. 578-589. ISSN 1545-96831552-6844

L'Italien, Lawrence, Orozco, Olivia, Abrams, Tinya, Cantagallo, Lisa, Connor, Anu, Desai, Jayesh, Ebersbach, Hilmar, Gelderblom, Hans, Hoffmaster, Keith, Maacke, Heiko, Schleyer, Siew, Skegro, Darko and Lee-Hoeflich, Si Tuen (2018) Mechanistic insights of an immunological adverse event induced by an anti-KIT antibody drug conjugate and mitigation strategies. Clinical Cancer Research, 24 (14). pp. 3465-3474. ISSN 15573265

LaRochelle, Jonathan R., Fodor, Michelle, Vemulapalli, Vidyasiri, Mohseni, Mori, Wang, Ping, Stams, Travis, Lamarche, Matthew, Chopra, Rajiv, Acker, Michael and Blacklow, Stephen C. (2018) Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nature Communications, 9 (1). ISSN 20411723

Labarbarie, Bertrand (2018) Engineering of Mouse Embryonic Fibroblasts (MEFs) derived from Cas9 animals for in vitro and in vivo studies of resistance. Internship report.

Lamb, John, Horman, Shane, Trifonov, Vladimir, Orth, Anthony, Lesley, Scott, To, Jeremy, Zhang, Jia, Jennings, Lori, Emilsson, Valur, IIkov, M, Aspelund, Thor, Gudmundsson, EF, Jakobsdottir, J, Manolescu, A, Harris, TB, Launer, LJ, Eiriksdottir, G, Gudnason, Vilmandur, Finkel, Nancy, Pitts, Rebecca, Hoover, Heather, Gudmundsdottir, Valborg, Shu, Le, Sigurdsson, Sigurdur, Zhu, Jun, Olafsson, Orn, Harris, Tamara, Zhang, Bin and Yang, Xia (2018) Co-regulatory networks of human serum proteins link genetics to disease. Science, 361 (6404). pp. 769-773. ISSN 10959203

Langevin, Nicholas, Schafer, Kenneth, Turner, Oliver, McPherson, Brittany and Rose, Robert (2018) Historical Data: Histopathology Lesions Observed in the Eyes of Control Rabbits in Topical Ocular Administration and Contact Lens Studies. Toxicologic Pathology, 46 (7). pp. 799-820. ISSN 15331601

Lapp, Stefanie, Bube, Axel, Ernst, Heinrich, Colbatzky, Florian, Kellner, Rupert, Nolte , Thomas and Rinke, Matthias (2018) Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*). Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*).

Laternser, Sandra, Keller, Hansjoerg, Leupin, Olivier, Rausch, Martin, Graf-Hausner, Ursula and Rimann, Markus (2018) A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues. SLAS TECHNOLOGY: Translating Life Sciences Innovation. ISSN 2472-63032472-6311

Laura, Magil, Marsilio, Adriani, Véronique, Berthou, Keguan, Chen, Aude, Gleizes, Salima, Hacein-Bey-Abina, Agnes, Hincelin-Mery, Xavier, Mariette, Marc, Pallardy, Spindeldreher, Sebastian, Natacha, Szely, David, Isenberg, Jessica, Manson, Elizabeth, Jury and Claudia, Mauri (2018) Low Percentage of Signal Regulatory Protein α/β+ Memory B Cells in Blood Predicts Development of Anti-drug Antibodies (ADA) in Adalimumab-Treated Rheumatoid Arthritis Patients. Frontiers in immunology, 9. ISSN 16643224

Laux, Holger, Romand, Sandrine, Nuciforo, Sandro, Farady, Christopher, Tapparel, Joel Alois Rene, Buechmann-Moeller, Stine, Sommer, Benjamin, Oakeley, Edward James and Bodendorf, Ursula (2018) Degradation of recombinant proteins by CHO host cell proteases is prevented by Matriptase-1 knock-out. Biotechnology and bioengineering. ISSN 00063592

Laux, Holger, Romand, Sandrine, Tapparel, Joel Alois Rene, Nuciforo, Sandro, Buechmann-Moller, Stine, Dogrusoez, Guelay, Probst, Claudia Monika, Sommer, Benjamin, Oakeley, Edward James and Bodendorf, Ursula (2018) Degradation of recombinant proteins of diverse formats by CHO host cell proteases is circumvented via knock-out of CHO matriptase. BMC proceedings., 12(Sup (3). pp. 2-3.

Lee, Patrick, Lapointe, Guillaume, Madera, Ann Marie, Simmons, Bob, Xu, Wenjian, Yifru, Aregahegn, Tjandra, Meiliana, Karur, Subramanian, Rico, Alice, Thompson, Katherine, Bojkovic, Jade, Xie, Lili, Uehara, Kyoko, Liu, Amy, Shu, Wei, Bellamacina, Cornelia, Mckenney, David, Morris, Laura, Osborne, Colin, Benton, Bret, McDowell, Laura, Fu, Jiping and Sweeney, Zachary (2018) Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline. Journal of medicinal chemistry.

Leeds, Jennifer (2018) LpxD project. various.

Lehmann, Hansjoerg (2018) Diazomethane and Flow Chemistry: Filling a Gap in Pharma R&D. Chimica oggi : = Chemistry today..

Lei, Weiwei, Ren, Wenwen, Ohmoto, Makoto, Redding, Kevin, Littlewood-Evans, Amanda, Carballido, Jose, Urban, Joseph, Margolskee, Robert, Matsumoto, Ichiro and Jiang, Peihua (2018) Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proceedings of the National Academy of Sciences. ISSN 0027-84241091-6490

Li, Jianyu , Weber, Eckhard, Guth-Gundel, Sabine, Schuleit, Michael, Kuttler, Andreas, Halleux, Christine, Accart Gris, Nathalie, Doelemeyer, Arno, Basler, Anne, Tigani, Bruno, Wuersch, Kuno, Fornaro, Mara, Kneissel, Michaela, Stafford, Alexander , Freedman, Benjamin R and Mooney, David J (2018) Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs. Advanced Healthcare Materials, 7 (9). 1701393 (1) -1701393 (10). ISSN 21922640

Li, Wenkui, Doherty, John, Fu, Yunlin and Flarakos, Jimmy (2018) Quantitative analysis of clofazimine (Lamprene®), an antileprosy agent, in human dried blood spots using liquid chromatography–tandem mass spectrometry. Biomedical Chromatography, 32 (2). ISSN 10990801

Lightfoot, Helen, Frederick, Goldberg and Sedelmeier, Joerg Mathias (2018) Evolution of Small Molecule Kinase Drugs. Journal of Medicinal Chemistry Letters (ACS).

Lima, Fabio, Grunenberg, Lars, Husaini, Mohamed, Labes, Ricardo, Sedelmeier, Joerg Mathias and Ley, Steven (2018) Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow. Chemical Communications, 54 (44). pp. 5606-5609. ISSN 1364548X

Lindner, John Michael, Friedensohn, Simon, Cornacchione, Vanessa, Iazeolla, Mariavittoria, Miho, Enkelejda, Zingg, Andreas, Meng, Simon, Traggiai, Elisabetta and Reddy, Sai (2018) High-throughput sequencing error and bias correction increases the quantitative resolution of human naïve and memory B-cell receptor repertoires. BioRxiv Preprint Server, NA (NA). ISSN NA

Liu, Xin (2018) Profile-QSAR的发展. Undergraduate thesis, Fudan University, Shanghai, China.

Lofgren, Jennie (2018) AALAS Seminar Series: The Laboratory Animal Medical Professional’s Guide to How the 3R’s Enhance Rigor and Reproducibility. Laboratory Animal Science Professional.

Lopez, John (2018) N-Butylpyrrolidone as a green solvent for Solid Phase Peptide Synthesis. Organic process research & development, 22. pp. 494-503. ISSN 1520-586X; 1083-6160

Loren, Jon, Herath, Ananda, Molteni, Valentina and Pan, Shifeng (2018) Generation and Cross-Coupling of Organozinc Reagents in Flow. Organic Letters. ISSN 1523-70601523-7052

Luen, SJ, Lee, CK, Savas, P, Kammler, R, Dell’Orto, P, Biasi, OM, Demanse , D, JeBailey , J, Dolan, S, Hackl, W, Thuerlimann, B, Viale, G, Colleoni , M, Regan, MM and Loi, S (2018) Association of somatic driver alterations with prognosis in postmenopausal, hormone receptor-positive, HER2-negative early breast cancer - A secondary analysis of the BIG 1-98 randomized clinical trial. JAMA Oncology, Publis (June 1). E1-E9. ISSN n.a.

Lynch, Jeffrey, Dolman, Andrew, Guo, Chenying, Li, Bing and Prasanna, Ganesh (2018) A pathologic MYOC mutation results in a novel skeletal muscle phenotype. PLoS ONE, 13 (11). e0206801. ISSN 1932-6203

Lynch, Jeffrey, Li, Bing, Katoli, Parvaneh, Xiang, Chuanxi, Leehy, Barrett, Rangaswamy, Nalini, Saenz-Vash, Veronica, Wang, Yingqi, Lei, Hong, Nicholson, Thomas, Meredith, Erik, Chen, Amy, Prasanna, Ganesh and Rice, Dennis (2018) Myocilin binding to a-b-crystallin sheds light on an old and blinding disease. Journal of Biological Chemistry, 293 (52). pp. 20137-20156.

Ma, Shang, Cahalan, Stuart, Rakhee, Lohia, Gregory, LaMonte, Weizheng, Zeng, Swetha, Murthy, Emma, Paytas, Nathan D, Grubaugh, Ramya, Gamini, Laurence, Berry, Viktor, Lukacs, Tess, Whitwam, Meaghan, Loud, Schmedt, Christian, Andrew I, Su, Kristian G, Andersen, Elizabeth A, Winzeler, Eric, Honore, Kai, Wengelnik and Ardem, Patapoutian (2018) Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell, 173 (2). 443-455.e12. ISSN 10974172

Mac Donald, Alisdair J, Miller, Janice, Ramage, Michael I, Greig, Carolyn, Stephans, Nathan A, Jacobi, Carsten, Preston, Thomas, Fearon, Kenneth CH and Skipworth, Richard JE (2018) Cross sectional imaging of truncal and quadriceps muscles relates to different functional outcomes in cancer. Clinical nutrition.. ISSN 1878-3368; 1744-1161

Maclachlan, Timothy, Milton, Mark, Turner, Oliver, Bigelow, Chad, Tukov, Francis, Choi, Vivian, Penraat, Jan, Delmotte, Marie Helene, Michaut, Lydia and Jaffe, Bruce (2018) Nonclinical safety evaluation of scAAV8-RLBP1 (CPK850) for treatment of RLBP1 retinitis pigmentosa. Human gene therapy - Clinical Development.

Manjunatha, Ujjini Havaldar, Chao, Alexander, Lee, Boon Heng, Wan, Kah Fei, Selva, Jeremy, Zou, Bin, Gedeck, Peter, Beer, David John, Diagana, Thierry Tidiane and Bonamy, Ghislain (2018) Development of a novel cytopathic effect-based phenotypic screening assay against Cryptosporidium. ACS infectious diseases. ISSN 2373-8227

Mannschott, Thomas, Krumme, Markus, Kreimer, Manuel, Aigner, Isabella, Sacher, Stephan, van der Wel, Peter, Kaptein, Albert, Schroettner, Hartmuth, Brenn, Guenter and Khinast, Johannes G. (2018) Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets. Powder Technology, 325. pp. 247-260. ISSN 1873328X

Marcomini, Isabella, Shimada, Kenji, Delgoshaie, Neda, Yamamoto, Io, Seeber, Andrew, Cheblal, Anais, Naumann, Ulrike, Horigome, Chihiro and Gasser, Susan (2018) Asymmetric Processing of DNA Ends at a Double-Strand Break Leads to Unconstrained Dynamics and Ectopic Translocation. Cell Reports, 24 (10). 2614-2628.e4. ISSN 22111247

Martin, Benjamin, Ganiek, Maximilian, Ivanova, Maria and Knochel, Paul (2018) Mild Homologation of Esters via Continuous Flow Chloroacetate Claisen Reactions. Angewandte Chemie. International edition, 57. pp. 1-6. ISSN 14337851

Martin, Benjamin, Lehmann, Hansjoerg, Yang, Hongwei, Chen, Like, Tian, Xiangguang, Polenk, Jutta and Schenkel, Berthold (2018) Continuous manufacturing as an enabling tool with green credentials in early-phase pharmaceutical chemistry. Current Opinion in Green and Sustainable Chemistry, 11. pp. 27-33.

Martin, Eric, Daga, Pankaj, Bolger, Michael, Haworth, Ian and Clark, Robert (2018) Physiologically-Based Pharmacokinetic Modeling in Lead Optimization I: Evaluation and Adaptation of GastroPlus® to Predict Bioavailability of Medchem Series. Molecular Pharmaceutics. ISSN 1543-83841543-8392

Martina, Maritan, Danielle, Veggi, Roberta , Cozi, Lucia, Ianaco, Erika, Bartolini, Paola, La Surdo, Giulietta, Maruggi, Spraggon, Glen, Matthew, Bottomley and Enrico, Malito (2018) Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody. PLoS ONE, 13 (8). ISSN 19326203

Masliah, Gregoire, Maris, Christophe, Koenig, Sebastian L.B., Yulikov, Maxim, Aeschimann, Florian, Malinowska, Anna L., Mabille, Julie, Weiler, Jan, Holla, Andrea, Hunziker, Juerg, Meisner Kober, Nicole-Claudia, Schuler, Benjamin, Jeschke, Gunnar and Allain, Frederic H.-T. (2018) Structural basis of siRNA recognition by TRBP double-stranded RNA binding domains. The EMBO Journal, 37. ISSN 0261-41891460-20750261-41891460-2075

Mathews Griner, Lesley, Gampa, Kalyani, Do, Toan, Hartkopf, Huyen, Farley, David, Auld, Douglas and Silver-Brown, Serena (2018) Generation of high-throughput three dimensional tumor spheroids for drug screening. Generation of high-throughput three dimensional tumor spheroids for drug screening , 3 (139).

McKenna, Jeffrey, Schirle, Markus and Thomas, Jason (2018) Disclosure of compounds to UCB for NB-CPACT. undetermined at present.

McMahon, Michael, Ding, Shaohong, Acosta Jimenez, Lourdes, Terranova, Remi, Gerard, Marie-Apolline, Vitobello, Antonio, Moggs, Jonathan, J. Henderson, Colin and Wolf, C. Roland (2018) CONSTITUTIVE ANDROSTANE RECEPTOR 1 IS CONSTITUTIVELY BOUND TO CHROMATIN AND ‘PRIMED’ FOR TRANSACTIVATION IN HEPATOCYTES. Molecular pharmacology. ISSN 1521-0111; 0026-895X

Mckenna, Jeffrey, Feng, Yan, Zheng, Lianxing, Bender, Steven, Cho, Charles, McWhirter, Sarah, Dubensky, Thomas, van Elsas, Andrea, Ndubaku, Chudi, Sivik, Kelsey, Desbien, Anthony and Hix-Glickman, Laura (2018) Magnitude of Therapeutic STING Activation Determines CD8<sup>+</sup> T Cell-Mediated Anti-tumor Immunity. Cell reports, 25 (11). p. 3074. ISSN 22111247

Meier, Silvio R, Syveanen, Stina, Hultquist, Greta, Fang, Xiaotiasn T, Roshanbin, Sahar, Lannfelt, Lars, Neumann, Ulf and Sehlin, Dag (2018) Antibody-based in vivo PET imaging detects amyloid-ß reduction in Alzheimer transgenic mice after BACE-1 inhibition. Journal of Nuclear Medicine, 59 (12). pp. 1901-1906. ISSN 2159662X

Messer, J.G., Mendieta Calle, J.L., Jiron, J.M., Castillo, E.J., Van Poznak, C., Bhattacharyya, N., Kimmel, D.B. and Aguirre, J.I. (2018) Zoledronic Acid Increases the Prevalence of Medication-related Osteonecrosis of the Jaw in Rice Rats (Oryzomys palustris) in a Dose Dependent Manner. Bone, 108 (3). pp. 79-88. ISSN 1873-2763; 8756-3282

Metz, Martin, Torene, Rebecca, Kaiser, Sergio, Beste, Michael, Staubach, Petra, Bauer, Andrea, Brehler, Randolf, Gericke, Janine, Letzkus, Martin, Hartmann, Nicole, Erpenbeck, Veit and Maurer, Marcus (2018) Omalizumab normalizes the gene expression signature of lesional skin in patients with chronic spontaneous urticaria: a randomized, double-blind, placebo-controlled study. Allergy. pp. 1-29. ISSN 1398-9995; 0105-4538

Milovanov, Maxim (2018) NEXT UI: evolution story. NEXT UI: Evolution story.

Milton, Mark, Maclachlan, Timothy, Brennan, Frank, Andrews, Laura, Arulanandam, Tony, Fikes, Jim, Grimaldi, Christine, Lansita, Janice, Loberg, Lise, Parker, Suezanne, Tibbitts, Jay, Wolf, Jayanthi and Allamneni, Krishna (2018) Current Strategies in the non-clinical safety assessment of biologics: New Targets, New Molecules, New Challenges (A report of the 2016 Annual US BioSafe General Membership meeting). Regulatory toxicology and pharmacology, 98. pp. 98-107.

Moggs, Jonathan and Terranova, Remi (2018) Chromatin dynamics underlying latent responses to xenobiotics. Toxicology research, 7. pp. 606-617.

Mol, Vivienne (2018) Master thesis: "Development of half-life extended GDF15 for therapeutic applications; expression and secretion in mammalian cells.". Master thesis to be submitted at University Wageningen, Netherlands.

Morse, Alyson, Cheng, Tegan L, Schindeler, Aaron, McDonald, Michelle M, Mohanty, Sindhu, Kneissel, Michaela, Kramer, Ina and Little, David G (2018) Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume. Calcified tissue international.

Mostafavi, Mina, Wang, Lisha, Xie, Lili, Takeoka, Ken, Richie, Daryl, Casey, Fergal, Ruzin, Alexey, Sawyer, William, Rath, Christopher, Wei, Jun-Rong and Dean, Charles (2018) Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis. mSphere.

Moujalled, Donia, Pomilio, Giovanna, Ghiurau, Corina, Ivey, Adam, Salmon, Jessica, Rijal, Sewa, Macraild, Sarah, Zhang, Lan, Teh, Tse-Chieh, Tiong, Ing-Soo, Lan, Ping, Schaeffer, Fabienne, Von Arx, Fabian, Chanrion, Maia, Claperon, Audrey, Rocchetti, Francesca, Kraus-Berthier, Laurence, Wang, Youzhen, Halilovic, Ensar, Morris, Erick, Colland, Frederic, Segal, David, Mistry, Prakash, Huang, David, Roberts, Andrew, Maragno, Ana Leticia, Lessene, Guillaume, Geneste, Olivier and Wei, Andrew (2018) Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia. Leukemia. ISSN 14765551

Mrak, Peter, Moore, Charles, Krastel, Philipp, Pivk-Lukancic, Petra and Tao, Jianshi (2018) Discovery of the actinoplanic acid pathway in Streptomyces rapamycinicus reveals a genetically conserved synergism with rapamycin. The Journal of biological chemistry, 293 (52). pp. 19982-19995. ISSN 1083351X

Mueller, Arne, Hoefling, Holger, Nuritdinow, Timur, Holway, Nicholas, Schieker, Matthias, Daumer, Martin and Clay, Ieuan (2018) Continuous monitoring of patient mobility for 18 months using inertial sensors following serious knee injury: a case study. Digital Biomarkers. pp. 79-89. ISSN 2504-110X

Murgasova, Renata, Tor Carreras, Ester and Bourgailh, Julien (2018) In Vitro Monitoring of the Mitochondrial Beta-Oxidation Flux of Palmitic Acid and Investigation of Its Pharmacological Alteration by Therapeutics. European Journal of Drug Metabolism and Pharmacokinetics. pp. 1-10. ISSN 2107-0180

Murgasova, Renata, Tor Carreras, Ester and Bourgailh, Julien (2018) In Vitro Monitoring of the Mitochondrial Beta-Oxidation Flux of Palmitic Acid and Investigation of Its Pharmacological Alteration by Therapeutics. European Journal of Drug Metabolism and Pharmacokinetics. pp. 1-10. ISSN 21070180

Murgasova, Renata, Tor Carreras, Ester and Bourgailh, Julien (2018) In Vitro Monitoring of the Mitochondrial Beta-Oxidation Flux of Palmitic Acid and Investigation of Its Pharmacological Alteration by Therapeutics. European journal of drug metabolism and pharmacokinetics. ISSN 2107-0180

Mustoe, Anthony M, Busan, Steven, Rice, Gregg, Hajdin, Christine, Peterson, Brant, Ruda, Vera, Kubica, Neil, Nutiu, Razvan, Baryza, Jeremy and Weeks, Kevin M (2018) Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing. Cell, 173 (1). pp. 181-195. ISSN 00928674

Nadine , Heimhofer and Mueller, Matthias (2018) OPTIMISING A CELLULAR SYSTEM FOR MONITORING THE CALCIUM DYNAMICS IN THE SARCOPLASMIC RETICULUM. Bachelor thesis.

Namoto, Kenji, Sirockin, Finton, Sellner, Holger, Wiesmann, Christian, Villard, Frederic, Valeur, Eric, Robinson, Michael, Moreau, Bob, Paulding, Stephanie, Schleeger, Simone, Schipp, Kathrin, Loup, Joachim, Andrews, Lori, O'Neill, Ryann and Farady, Christopher (2018) Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors. Bioorganic and Medicinal Chemistry Letters, 28 (5). pp. 906-909. ISSN 14643405

Nett, Ryan, Guan , Xin, Smith, Kevin, Faust, Ann Marie, Sattely, Elizabeth S. and Fischer, Curt R. (2018) D2O labeling to measure active biosynthesis of natural products in medicinal plants. AIChE journal. ISSN 00011541

Neumann, Ulf, Ufer, Mike, Jacobson, Laura, Rouzade-Dominguez, Marie-Laure, Huledal, Gunilla, Kolly, Carine, Lueoend, Rainer Martin, Machauer, Rainer, Veenstra, Siem, Hurth, Konstanze, Shimshek, Derya, Staufenbiel, Matthias, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean-Michel, Beckmann, Nicolau, Hartmann, Andreas, David, Olivier, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina and Vormfelde, Stefan (2018) The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease. EMBO molecular medicine, 10 (11). S227-S228. ISSN 17574684

Nigsch, Florian (2018) Postdoc internet site mentor profile. Novartis internet site.

Nigsch, Florian (2018) Postdoc position advertisement. Novartis postdoc internet site.

Nilsson, Inga, Prathapam, Ramadevi, Grove, Kerri, Lapointe, Guillaume and Six, David (2018) The sialic acid transporter NanT is necessary and sufficient for uptake of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) and its azido analog in Escherichia coli. Molecular microbiology. ISSN 1365-2958

Novello, Salvatore, Arcuri, Ludovico, Dovero, Sandra, Dutheil, Nathalie, Shimshek, Derya, Bezard, Erwan and Morari, Michele (2018) G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice. Neurobiology of disease, 120. pp. 21-33. ISSN 09699961

Novgorodov, Sergei A., Voltin, Joshua R., Gooz, Monika A., Li, Li, Lemasters, John, J. and Tatyana I., Gudz (2018) A novel role of acid sphingomyelinase in mitochondrial dysfunction due to glutamate-induced programmed necrosis. Journal of Lipid Research, 59 (2). pp. 312-329. ISSN 0022-22751539-7262

Nunez, Fabiana, Taura, Jaume, Camacho, Juan, Lopez-Cano, Marc, Fernandez-Duenas, Victor, Castro, Naomi, Castro, Julio and Ciruela, Francisco (2018) PBF509, an adenosine A2A receptor antagonist with efficacy in rodent models of movement disorders. Frontiers in Pharmacology, 9 (OCT). ISSN 16639812

Occhetta, P, Pigeot, S, Halleux, Christine, Rasponi, M, Dasen, B, Ullrich, Thomas, Kramer, Ina, Guth-Gundel, Sabine, Barbero, A and Martin, I (2018) Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis. Proceedings of the National Academy of Sciences of the United States of America, 115 (18). pp. 4625-4630. ISSN 10916490

Oliver, Vanessa L, Thurston, Sarah E and Lofgren, Jennifer L (2018) Using Cageside Measures to Evaluate Analgesic Efficacy in Mice () after Surgery. Journal of the American Association for Laboratory Animal Science : JAALAS, 57 (2). pp. 186-201. ISSN 1559-6109

Orlando, Elena, Brogdon, Jennifer, Bitter, Hans, Joseph, Fraietta, Simon , Lacey, David, Ambrose, Nicholas, Wilcox, Felipe, Bedoya, Corin, Dofrmeier, Fang, Chen, Noelle, Frey, Wei-Ting, Hwang, Harit, Parakandi, Minnal, Gupta, A., Huang, Brad, Johnson, Irina, Kulikovskaya, Bruce , Levine, Li, Liu, Stefan, Lundh, Edward, Pequignot, Donald, Siegel, Yan, Wang, E.J., Wherry, Jun, Xu, Regina, Young, David, Porter, Carl, June, Jan, Melenhorst and Pruteanu-Malinici, Iulian (2018) Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature Medicine, 24 (5). pp. 563-571. ISSN 1546170X

Orlando, Elena, Han, Xia, Wood, Patricia, Leary, Rebecca, Pierog, Peter, Brogdon, Jennifer, Bitter, Hans, Morrissey, Michael, Pantano, Serafino, Adamovich, Wendy, Tribouley, Catherine, Kevin, Nguyen, John, Levine, Muna, Qayad, Stephan, Grupp, Michael, Boyer, Barbara, DeMoerloose, Eneida, Nemecek, Henrique, Bittencourt, Hidefumi, Hiramatsu, Jochen, Büchner, Stella, Davies, Michael, Verneris and Engelman, Jeffrey (2018) Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia. Nature Medicine, 24. pp. 1504-1506. ISSN 1546170X

Ostrov, David A., Alkanani, Aimon , McDaniel, Kristen A. , Case, Stephanie , Baschal, Erin E. , Pyle, Laura, Ellis, Sam, Seidl, Katherine J., Shah, Viral N., Garg, Satish K., Atkinson, Mark A., Gottlieb, Peter A. and Michels, Aaron W. (2018) Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. Journal of Clinical Investigation. ISSN 0021-9738

Otto, Heike (2018) Uncover the limitations of PM 2.0 - Project Management in 10-year progression. Fleming PPM Conference 2018, Berlin.

Ou, Weijia, Bursulaya, Badry, Didonato, Michael, Herath, Ananda, Jin, Yunho, Hao, Xueshi, Loren, Jon, Brock, Ansgar, Uno, Tetsuo, Geierstanger, Bernhard, Cellitti, Susan and Mortenson, Grace (2018) Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation. ChemBioChem, 19 (8). pp. 799-804. ISSN 14397633

Pacifici, Maurizio, Decker, Rebekah and Koyama, Eiki (2018) Limb Synovial Joint Development From the Hips Down: Implications for Articular Cartilage Repair and Regeneration. Developmental Biology and Musculoskeletal Tissue Engineering. pp. 67-101.

Pancholi, Alpa, Iacobini, Greg, Clarkson, Guy, Porter, David and Shipman, Michael (2018) Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues. Journal of Organic Chemistry, 83 (1). pp. 491-498. ISSN 15206904

Papillon, Julien, Nakajima, Katsumasa, Hempel, Jonathan, Karki, Rajeshri, Moebitz, Henrik, Ntaganda, Rukundo, Smith, Troy, Visser, Michael, Hill, Sue, Kellermann Hurtado, Felipe, Chenail, Gregg, Bhang, Hyo-Eun, Xiang, Xiaoqin, Bushold, Geoffrey, Gilbert, Tamara, Vattay, Anthony, Dooley, Julie, Costa, Emily, Adair, Chris, Jouk, Andriana, Li, Jingzhou, Bric, Anka, Park, Isabel, Li, Ailing, Farley, David, Lounkine, Eugen, Yue, Qing, Xie, Xiaoling, Kulathila, Raviraj, King, Daniel, Hu, Tiancen, Vulic, Katarina, Cantwell, John, Luu, Catherine and Jagani, Zainab (2018) Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. Journal of Medicinal Chemistry, 61 (22). pp. 10155-10172. ISSN 15204804

Pauli, Victoria Isabell, Elbaz, Frantz, Kleinebudde, Peter and Krumme, Markus (2018) Methodology for a variable rate Control Strategy development in Continuous Manufacturing applied to twin-screw wet-granulation and continuous fluid-bed drying. Journal of Pharmaceutical Innovation.

Pearson, David, Garnier, Maxime, Luneau, Alexandre, James, Alexander David and Walles, Markus (2018) 19F-NMR based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers. Xenobiotica. pp. 1-24. ISSN 0049-82541366-5928

Pearson, David, Garnier, Maxime, Luneau, Alexandre, James, Alexander David and Walles, Markus (2018) 19F-NMR based determination of the absorption, metabolism and excretion of the oral phosphatidylinositol-3-kinase (PI3K) delta inhibitor leniolisib (CDZ173) in healthy volunteers. Xenobiotica. pp. 1-24. ISSN 0049-82541366-5928

Peruzzotti-Jametti, Luca, Bernstock, Joshua D, Vicario, Nunzio, Costa, Ana SH, Kwok, Chee-Keong , Leonardi, Tommaso, Booty, Lee, Bicci, Iacopo, Balzarotti, Beatrice, Volpe, Giulio, Mallucci, Giulia, Manferrari, Giulia, Donega, Matteo, Iraci, Nunzio, Braga, Alice, Hallenbeck, John M, Murphy, Michael P, Edenhofer, Frank, Freeza, Christian and Pluchino, Stefano (2018) Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell, 22 (3). 355-368.e13. ISSN 18759777

Peter, Koch, Miller, Howard, Yu, Gary, Tallarico, John, Peter, Sorger, Wang, Yuan, Feng, Yan, Thomas, Jason, Nathan, Ross and Timothy, Mitchison (2018) A high content screen in primary human macrophages identifies small molecule modulators of STING-IRF3 and NFkB signaling. ACS Chemical Biology. ISSN 1554-89291554-8937

Peters, Finn, Salihoglu, Hazal, Rodriguez, Eva, Herzog, Etienne, Blume, Tanja, Filser, Severin, Dorostkar, Mario, Shimshek, Derya, Brose, Nils, Neumann, Ulf and Herms, Jochen (2018) BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology. Acta Neuropathologica, 135 (5). pp. 695-710. ISSN 14320533

Pihl, Susanne, van der Strate, Barry, Golob, Michaela, Vermet, Laurent, Jaitner, Birgit, Goodman, Joanne , Scheel Fjording, Marianne and Timmerman, Philip (2018) EBF recommendation on practical management of critical reagents for PK ligand-binding assays. Bioanalysis, 10 (19). pp. 1557-1565. ISSN 17576199

Plappert Helbig, Ulla, Libertini, Silvana, Frieauff, Wilfried, Theil, Diethilde and Martus, Hans-Joerg (2018) Gamma-H2AX immunofluorescence for the detection of tissue-specific genotoxicity in vivo. Environmental and molecular mutagenesis, 31 (6). pp. 732-733. ISSN 08936692

Plappert-Helbig, Ulla, Libertini, Silvana, Frieauff, Wilfried, Theil, Diethilde and Martus, Hans-Jörg (2018) Gamma-H2AX immunofluorescence for the detection of tissue-specific genotoxicity in vivo. Environmental and Molecular Mutagenesis. ISSN 08936692

Pognan, Francois, Beilmann, Mario, Boonen, Harrie, Czich, Andreas, Dear, Gordon, Hewitt, Philip, Mow, Tomas, Newham, Peter, Oinonen, Teija, Roth, Adrian, Valentin, Jean-Pierre, van Goethem, Freddy and Weaver, Richard (2018) Optimizing drug discovery by Investigative Toxicology: Current and future trends – Report of CAAT-ITL Forum Think Tank. ALTEX, 36 (2). pp. 289-313.

Pognan, Francois, Mahl, Joerg Andreas, Papoutsi, Maria, Ledieu, David, Raccuglia, Marc, Theil, Diethilde, Voytek, Sarah, Devine, Pj, Cordier, Andre, Heier, Annabelle, Kolly, Carine, Hartmann, Andreas, Chibout, Salah-Dine and Trendelenburg, Christian (2018) Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod appears irrelevant to rat and human. Archives of toxicology. ISSN 1432-0738; 0340-5761

Pognan, Francois and Steger-Hartmann, Thomas (2018) Improving the safety assessment of chemicals and drug candidates by the integrating bioinformatics and chemoinformatics. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7843

Pomerantz, Andrea, Sari-Sarraf, Farid, Grove, Kerri, Pedro, Liliana, Rudewicz, Patrick, Fathman, John and Krucker, Thomas (2018) Enabling drug discovery and development through single-cell imaging. Expert Opinion on Drug Discovery. pp. 1-11. ISSN 1746-04411746-045X

Pracht, Philipp, Wilcken, Rainer, Udvarhelyi, Aniko, Rodde, Stephane and Grimme, Stefan (2018) High accuracy quantum-chemistry-based calculation and blind prediction of macroscopic pKa values in the context of the SAMPL6 challenge. Journal of Computer-Aided Molecular Design, 32 (10). pp. 1139-1149. ISSN 15734951

Prescott, Thomas A.K., Jaeg, Tiphaine and Hoepfner, Dominic (2018) Yeast Chemogenomic Profiling Reveals Iron Chelation to Be the Principle Cell Inhibitory Mode of Action of Gossypol. Journal of Medicinal Chemistry, 61 (16). pp. 7381-7386. ISSN 15204804

Pries, Verena, Nöcker, Christina, Khan, Danish, Ashutosh, Tripathi, Perruccio, Francesca, Jonen, Philipp, Filipuzzi, Ireos, Thavam, Sasikala, Aust, Thomas, Riedl, Ralph, Ziegler, Slava, Schaaf, Gabriel, Bankaitis, Vytas, Waldmann, Herbert and Hoepfner, Dominic (2018) High-resolution chemogenomics identifies Litrafungin, a fungal-selective inhibitor of the lipid transfer protein Sec14p. Cell Chemical Biology, 25. pp. 1-12.

Publicover, Jean, Gaggar, Anuj, Jespersen, Jillian, Halac, Ugar, Johnson, Audra, Goodsell, Amanda, Avanesyan, Lia, Nishimura, Stephen, Holdorf, Meghan, Mansfield, Keith, Judge, Joyce, Croft, Michael, Wakil, Adil, Rosenthal, Philip, Pai, Eric, Cooper, Stewart and Baron, Jody (2018) An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Science Translational Medicine, 10 (433). ISSN 1946-62341946-6242

Pugsley, M.K., Authier, S., Koerner, J.E., Redfern, W.S., Markgraf, C.G., Brabham, T., Correll, K., Soloviev, M.V., Botchway, A., Engwall, M., Traebert, M., Valentin, J.-P., Mow, T.J., Greiter-Wilke, A., Leishman, D.J. and Vargas, H.M. (2018) An overview of the safety pharmacology society strategic plan. Journal of Pharmacological and Toxicological Methods. ISSN 1873488X

Rageot, Denise, Bohnacker, Thomas, Melone, Anna, Langlois, Jean-Baptiste, Borsari, Chiara, Hillmann, Petra, Sele, Alexander M., Beaufils, Florent, Zvelebil, Marketa, Hebeisen, Paul, Löscher, Wolfgang, Burke, John, Fabbro, Doriano and Wymann, Matthias P. (2018) Discovery and preclinical characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a highly potent and selective mTORC1/2 Inhibitor for cancer and neurological disorders. Journal of Medicinal Chemistry, 61 (22). pp. 10084-10105. ISSN 0022-2623

Rago, Florencia, DiMare, Matt, Elliott, Ginell, Ruddy, David, Sovath, Sosathya, Kerr, Grainne, Bhang, Hyo-eun and Jagani, Zainab (2018) Degron mediated BRM/SMARCA2 depletion uncovers novel combination partners for treatment of BRG1/SMARCA4-mutant cancers. Biochemical and biophysical research communications : BBRC. ISSN 0006291X

Ramirez, Yesid, Adler, Thomas, Altmann, Eva, Klemm, Theresa, Tiesmeyer, Christian, Sauer, Florian, Sotriffer , Christoph and Kisker, Caroline (2018) Structural basis of substrate recognition and covalent inhibition of Cdu1 from Chlamydia trachomatis. ChemMedChem : chemistry enabling drug discovery, 13 (19). pp. 2014-2023. ISSN 1860-7179

Rao, Raj, Ament, Brian, Richard, Parmee, J, Cameron and Martin, Mayo (2018) Rapid, non-destructive inspection and classification of inhalation blisters using low-energy x-ray imaging. Journal of pharmaceutical innovation. ISSN 1939-8042; 1872-5120

Rao, Srinivasa and Diagana, Thierry (2018) Drug Discovery for Kinetoplastid Diseases: Future Directions. ACS Infectious Diseases. ISSN 23738227

Reck, Folkert, Bermingham, Alun, Blais, Johanne, Capka, Vladimir, Cariaga, Taryn, Casarez, Anthony, Colvin, Richard, Dean, Charles, Fekete, Alexander, Growcott, Ellena, Guo, Hongqiu, Gong, Wanben, Jones, Adriana, Li, Cindy, Li, Fengxia, Lin, Xiaodong, Lindvall, Mika, Lopez, Sara, Mckenney, David, Metzger Iv, Louis, Moser, Heinz, Prathapam, Ramadevi, Rasper, Dita, Rudewicz, Patrick, Sethuraman, Vijay, Shen, Xiaoyu, Shaul, Jacob, Simmons, Bob, Tashiro, Kyuto, Tang, Dazhi, Tjandra, Meiliana, Turner, Nancy, Uehara, Tsuyoshi, Vitt, Charles, Whitebread, Steven, Yifru, Aregahegn, Zang, Richard and Zhu, Qingming (2018) Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228. Bioorganic and Medicinal Chemistry Letters. ISSN 14643405

Reggane, Maude, Wiest, Johannes, Saedtler, Marco, Harlacher, Cornelius, Gutmann, Marcus, Zottnick, Sven, Piechon, Philippe, Dix, Ina, Müller-Buschbaum, Klaus, Holzgrabe, Ulrike, Meinel, Lorenz and Galli, Bruno (2018) Bioinspired co-crystals of Imatinib providing enhanced kinetic solubility. European Journal of Pharmaceutics and Biopharmaceutics, 128. pp. 290-299. ISSN 18733441

Renaud, Jean-Paul, Chari, Ashwin, Ciferri, Claudio, Liu, Wen-ti and Remigy, Herve (2018) Cryo-EM in drug discovery: Achievements, limitations and prospects. Nature Reviews Drug Discovery, 17 (7). pp. 471-492. ISSN 14741784

Renziehausen, Alexander, Tzakos, Andreas, Wang, Hexiao, Rao, Bhavya, Weir, Lynda, Lo Nigro, Cristiana, Lattanzio, Laura, Merlano, Marco, Matin, Rubeta, Harwood, Catherine, Li, Su, Sim, Van Ren, O'Neill, Kevin, Evans, Alan, Thompson, Alastair, Szlosarek, Peter, Fleming, Colin, Proby, Charlotte, Syed, Nelofer and Crook, Tim (2018) The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic intervention. Oncogene. ISSN 14765594

Reuther, C, Heinzle, V, Nölting, S, Herterich, S, Hahner, S, Halilovic, Ensar, Jeay, Sebastien, Wuerthner, Jens, Spöttl, G, Maurer, J and Auernhammer, CJ (2018) The HDM2 (MDM2) Inhibitor NVP-CGM097 inhibits tumor cell proliferation and shows additive effects with 5-fluorouracil on the p53 - p21 - Rb - E2F1 cascade in the p53wildtype neuroendocrine tumor cell line GOT1. Neuroendocrinology : an international journal for brain-hormone interactions, 106. pp. 1-19. ISSN 1423-0194

Richardson, Elizabeth, Burnell, Jessica, Adams, Heather, Bohannon, Richard, Bush, Elizabeth, Campbell, Michelle, Chen, Wen Hung, Coons, Stephen Joel, Papadopoulos, Elektra, Rooks, Daniel, Reeve, Bryce and Daniel, Gregory (2018) Developing and Implementing Performance Outcome Assessments: Evidentiary, Methodological, and Operational Considerations. Therapeutic innovation & regulatory science. ISSN 2168-4804

Richie, Daryl, Wang, Lisha, Chan, Helen, De Pascale, Gianfranco, Six, David, Wei, Jun-Rong and Dean, Charles (2018) A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii. PLoS ONE, 13 (3). ISSN 1932-6203

Riley, John H., Erpenbeck, Veit, Matthews, John G., Holweg, Cecil T.J., Compton, Chris, Seibold, Wolfgang, Higenbottam, Tim, Wagers, Scott S and Myles , David (2018) U-BIOPRED: evaluation of the value of a public–private partnership to industry. Drug Discovery Today. pp. 1-13. ISSN 18785832

Rodig, Scott J., Gusenleitner, Daniel, Jackson, Donald G., Gjini, Evisa, Giobbie-Hurder, Anita, Jin, Chelsea, Chang, Han, Lovitch, Scott B., Horak, Christine, Weber, Jeffrey S., Weirather, Jason L., Wolchok, Jedd D., Postow, Michael A., Pavlick, Anna C., Chesney, Jason and Hodi, F. Stephen (2018) MHC proteins confer differential sensitivity to CTLA-4 and PD-1 blockade in untreated metastatic melanoma. Science Translational Medicine, 10 (450). eaar3342. ISSN 1946-6234

Rodon, Jordi, Pérez-Fidalgo , Alejandro, Krop , Ian E. , Burris, Howard, Guerrero-Zotano , Angel, Britten, Carolyn D., Becerra, Carlos , Schellens, Jan , Richards, Donald A., Schuler , Martin, Abu-Khalaf, Maysa, Johnson, Faye M. , Ranson , Malcolm , Edenfield, Jeff, Silva, Antonio P. , Hackl, Wolfgang, Quadt, Cornelia , Demanse, David , Duval, Vincent and Baselga, Jose (2018) Phase 1/1b dose escalation and expansion study of BEZ235, a dual PI3K/mTOR inhibitor, in patients with advanced solid tumors including patients with advanced breast cancer. Cancer Chemotherapy and Pharmacology, 82 (2). pp. 285-298. ISSN 14320843

Rue, Sarah, Anderson, Paul, Miller, Jessica, Fanale, Salvatore, Chang, Jim, Glaser, Scott and Lesley, Scott (2018) Mammalian cell culture density determination using a laser thru-beam sensor. BioTechniques, 65 (4). pp. 224-226. ISSN btn-2018-0059

Ruff, Yves and Berst, Frederic (2018) Efficient copper-catalyzed amination of DNA-conjugated aryl iodides under mild aqueous conditions. MedChemComm. ISSN 2040-2511; 2040-2503

Rutkowska, Aleksandra, Shimshek, Derya, Sailer, Andreas and Dev, Kumlesh (2018) EBI2 regulates pro-inflammatory signaling and cytokine release in astrocytes. Journal of neuroinflammation, 133. pp. 121-128. ISSN 0028-3908

Sampath, Srinath, Sampath, Srihari, Ho, Andrew, Corbel, Stephane, Millstone, Joshua, Lamb, John, Walker, John, Kinzel, Bernd, Schmedt, Christian and Blau, Helen (2018) Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M. Cell Stem Cell, 9 (1). pp. 1-9. ISSN 2041-1723

Sampath, Srinath, Sampath, Srihari and Millay, Douglas (2018) Myoblast fusion confusion: the resolution begins. Skeletal muscle, 8. p. 3. ISSN 2044-5040

Sandham, David, Erpenbeck, Veit, Dubois, Gerald, Shamri, Revital and Levi-Schaffer, Francesca (2018) Fevipiprant, a DP2 Receptor Antagonist, Inhibits Eosinophil Migration Towards Mast Cells. Clinical and experimental allergy. ISSN 09547894

Saraiva, André L, Veras, Flávio P, Peres, Raphael S, Talbot, Jhimmy, de Lima, Kalil A, Luiz, João Paulo, Carballido, Jose, Cunha, Thiago M, Cunha, Fernando Q, Ryffel, Bernhard and Alves-Filho, Jose C (2018) Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes. The FASEB Journal. ISSN 0892-66381530-6860

Sawyer, William, Wang, Lisha, Uehara, Tsuyoshi, Tamrakar, Pramila, Prathapam, Ramadevi, Mostafavi, Mina, Richie, Daryl, Metzger, Louis, Feng, Brian and Rath, Christopher (2018) Targeted lipopolysaccharide biosynthetic intermediate analysis with normal-phase liquid chromatography mass spectrometry. PLoS ONE.

Schadt, Heiko, Wolf, Armin, Mahl, Joerg Andreas, Wuersch, Kuno, Couttet, Philippe, Schwald, Marianne, Fischer, Audrey, Lienard, Mathilde, Emotte, Corinne, Teng, Chi-Hse, Skuba, Elizabeth, Richardson, Terrilyn, Manenti, Luigi, Weiss, Andreas, Graus Porta, Diana, Fairhurst, Robin, Kullak-Ublick, Gerd, Chibout, Salah-Dine, Pognan, Francois, Kluwe, William and Kinyamu-Akunda, Jacqueline (2018) Bile acid sequestration by cholestyramine mitigates FGFR4 inhibition-induced ALT elevation. Toxicological Sciences. ISSN 1096-60801096-0929

Schadt, Simone, Bister, Bojan, Chowdhury, Swapan K., Funk, Christoph, Hop, Cornelis E.C.A, Humphreys, W. Griffith, Igarashi, Fumihiko, James, Alexander David, Kagan, Mark, Khojasteh, S. Cyrus, Nedderman, Angus N.R., Prakash, Chandra, Runge, Frank, Scheible, Holger, Spracklin, Douglas K., Swart, Piet, Tse, Susanna, Yuan, Josh and Obach, R. Scott (2018) A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development Under the “Metabolites in Safety Testing” Regulatory Guidances. Drug Metabolism and Disposition, 46 (6). pp. 865-878. ISSN 0090-95561521-009X

Schlapbach, Achim, Revesz, Laszlo, Pissot Soldermann, Carole, Zoller, Thomas, Regnier, Catherine, Bornancin, Frederic, Radimerski, Thomas, Blank, Jutta, Schuffenhauer, Ansgar, Renatus, Martin, Erbel, Paulus, Heng, Richard, Melkko, Samu, Simic, Oliver, Endres, Ralf, Wartmann, Markus and Quancard, Jean (2018) N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity. Bioorganic and Medicinal Chemistry Letters, 28. pp. 2153-2158. ISSN 14643405

Schlesinger, Ann (2018) Video of 2018 Novartis Open Framework Symposium: Fostering Applied Innovation. this video will be shared with externals but not published.

Schneider, Nadine and Stiefl, Nikolaus (2018) Surfing on the hype waves or drilling deep for knowledge? A perspective from industry. ETH Infozine, S2. pp. 26-27.

Schoepfer, Joseph, Jahnke, Wolfgang, Berellini, Giuliano, Buonamici, Silvia, Cotesta, Simona, Jacob, Sandra, Dodd, Stephanie, Drueckes, Peter, Fabbro, Doriano, Gabriel, Tobias, Groell, Jean-Marc, Grotzfeld, Robert, Hassan, Asm Quamrul, Henry, Christelle, Iyer, Varsha, Jones, Darryl, Lombardo, Franco, Loo, Alice, Manley, Paul W., Pelle, Xavier, Rummel, Gabriele, Salem, Bahaa, Warmuth, Markus, Wylie, Andrew, Zoller, Thomas, Marzinzik, Andreas and Furet, Pascal (2018) Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1. Journal of Medicinal Chemistry, 61 (18). pp. 8120-8135. ISSN 15204804

Scotti, Celeste, Gobbi, Alberto, Nakamura, Norimasa and Peretti, Giuseppe M. (2018) Stem Cells for Cartilage Regeneration: A Roadmap to the Clinic. Stem cells international, 2018 (2018). pp. 1-2. ISSN 7348560

Sedelmeier, Joerg Mathias, Sedelmeier, Gottfried and Lightfoot, Helen (2018) WHO Listed Small Molecule Kinase Inhibitors 2001-2017. CHIMIA.

Sharma, Vaneet, Sharma, Ity and Glick, Jim (2018) The expanding role of mass spectrometry in the field of vaccine development. Mass spectrometry reviews, 99 (18). pp. 7417-7431. ISSN 02777037

Shirley, Bill, Kelley, Brian, Koschwanez, John, Potier, Yohann, Bruccoleri, Robert and Tarselli, Mike (2018) Unzipping Natural Products: Improved Natural Product Structure Predictions by Ensemble Modeling and Fingerprint Matching. ChemRxiv.

Sirockin, Finton and Stiefl, Nikolaus (2018) Practical Aspects of Machine Learning for the Design-Synthesis-Purify-Assay Workflow. Chimia, 72 (9). pp. 648-649. ISSN 00094293

Six, David, Krucker, Thomas and Leeds, Jennifer (2018) Advances and challenges in bacterial compound accumulation assays for drug discovery. Current Opinion in Chemical Biology, 44. pp. 9-15. ISSN 18790402

Smith, Paul A., Schmid, Cindy, Zurbruegg, Stefan, Dubost, Valerie, Jivkov, Magali Natacha, Theil, Diethilde and Beckmann, Nicolau (2018) Fingolimod inhibits brain atrophy and promotes brain-derived neurotrophic factor in an animal model of multiple sclerosis. Journal of Neuroimmunology, 308 (5). pp. 103-113. ISSN 18728421

Snajdrova, Radka, Hunziker, Juerg and Eggimann, Fabian (2018) BM CDT Research Proposals 2018/19 from GDC BIR. Title: Stereoselective, scalable route towards phosphorothioate analogues of ATP. BM CDT Research Proposals .

Snajdrova, Radka, Rudroff, Florian, Mihovilovic , Marko, Groeger, Harald, Iding, Hans and Bornscheuer, Uwe (2018) Opportunities and challenges for combining chemo- and biocatalysis. Nature Catalysis, 1. pp. 12-22. ISSN doi:10.1038/s41929-017-0010-4

Song, Shuang, Sahoo, Dipankar, Kumar, Manoj, Barkley, Deborah A., Heiney, Paul A. and Rudick, Jonathan G. (2018) Identifying Structural Determinants of Mesomorphism from Focused Libraries of Tripedal Mesogens Prepared via the Passerini Three-Component Reaction. European Journal of Organic Chemistry, 2019 (6). pp. 1195-1207. ISSN 1434193X

Soulieres, Denis, Licitra, Lisa, Mesia, Ricard, Remenar, Eve, Li, Shau-Hsuan, Karpenko, Andrey, Chol, Marie, Wang, Amanda, Solovieff, Nadia, Bourdeau, Laurence, Sellami, Dalila and Faivre, Sandrine (2018) Molecular Alterations and Buparlisib Efficacy in Patients with Squamous Cell Carcinoma of the Head and Neck: Biomarker Analysis from BERIL-1. Clinical cancer research.

Spangler, Ben, Dovala, Dustin, Sawyer, William, Thompson, Katherine, Six, David, Reck, Folkert and Feng, Brian (2018) Molecular probes for the determination of sub-cellular compound exposure profiles in Gram-negative bacteria. ACS Infectious Diseases. ISSN 23738227

Spangler, Benjamin, Dovala, Dustin, Sawyer, William S, Thompson, Katherine V, Six, David A, Reck, Folkert and Feng, Brian Y (2018) Molecular Probes for the Determination of Subcellular Compound Exposure Profiles in Gram-Negative Bacteria. ACS infectious diseases. ISSN 2373-8227

Spindeldreher, Sebastian, Maillère, Bernard, Correia, Evelyne, Tenon, Maxime, Karle, Anette, Jarvis, Philip and Kolbinger, Frank (2018) Secukinumab Demonstrates Significantly Lower Immunogenicity Potential Compared to Ixekizumab. Dermatology and therapy, 8 (1). pp. 57-68. ISSN 2193-8210

Splendiani, Andrea, Yasunori, Yamamoto and Atsuko, Yamaguchi (2018) YummyData: providing high-quality, open life science data. Database the journal of biological databases and curation.. ISSN 1758-0463

Stacy, Rebecca, Huttner, Kenneth, Watts, Jen, Peace, James, Wirta, David, Walters, Tom, Sall, Kenneth, Seaman Iii, John, Ni, Xiao, Prasanna, Ganesh, Mogi, Muneto, Adams, Christopher, Yan, Jing-He, Wald, Michael, He, Yunsheng, Newton, Ronald, Kolega, Randall and Grosskreutz, Cyndy (2018) A phase I/II study to evaluate the safety, tolerability and early efficacy of MGV354 in healthy subjects and in patients with ocular hypertension or glaucoma. American Journal of Ophthalmology.

Stein, Andrew and Peletier, Lambertus (2018) Predicting the Onset of Nonlinear Pharmacokinetics. CPT: Pharmacometrics and Systems Pharmacology, 7 (10). pp. 670-677. ISSN 21638306

Stein, Thomas, Wollschlegel, Audrey, Te, Helene, Weiss, Jessica, Joshi, Kushal, Kinzel, Bernd, Billich, Andreas, Guntermann, Christine and Lehmann, Joachim (2018) Interferon regulatory factor 5 and nuclear factor kappa-B exhibit cooperating but also divergent roles in the regulation of pro-inflammatory cytokines important for the development of TH1 and TH17 responses. FEBS Journal, 285 (16). pp. 3097-3113. ISSN 10.1111/febs.14600

Stewart, N.J., Chan, H-F, Hughes, P.J.C., Horn, F.C., Norquay, G., Parra-Robles, J., Rao, M., Yates, Denise, Ford, P., Collini, P., Ireland, R., Lawson, R., Marshall, H., Collier, G.J. and Wild, J.M. (2018) Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T. Journal of magnetic resonance imaging. ISSN 10531807

Sverdlov, Oleksandr, Van Dam, Joris, Hannesdottir, Kristin and Thornton-Wells, Tricia (2018) Digital Therapeutics—An Integral Component of Digital Innovation in Drug Development. Clinical pharmacology and therapeutics, 104 (1). pp. 72-80.

Tam, Yat Kong, Blasko, Andrei and Ahmed, Imad Haidar (2018) A four parameter optimization and troubleshooting of a RPLC – charged aerosol detection stability indicating method for determination of S-lysophosphatidylcholines in a phospholipid formulation. Journal of pharmaceutical and biomedical analysis, 155. pp. 288-297. ISSN 07317085

Tan, Kian and Robinson, Richard (2018) Oxford DTC proposals for 2019 brouchure. Oxford DTC brochure 2019.

Tarselli, Mike (2018) Nature "In Your Element" - Hidden Hassium. Nature chemistry, 10. p. 482.

Tarselli, Mike (2018) Tarselli Interview for UMass Goessmann Gazette. Goessmann Gazette.

Thomson, Christopher, Le Grand, Darren, Dowling, Mark, Brocklehurst, Cara, Chinn, Colin, Elphick, Lucy, Faller, Michael, Freeman, Mark, Furminger, Vikki, Gasser, Cornelia, Hamadi, Ahmed, Hardaker, Elizabeth, Head, Victoria, Hill, Johan, Janus, Diana, Pearce, David, Poulaud, Anne-Sophie, Stanley, Emily and Sviridenko, Lilya (2018) Development of Autotaxin Inhibitors Part 1: A Series of Zinc Binding Triazoles. Bioorganic and medicinal chemistry letters, 28 (13). pp. 2279-2284.

Ting, Pamela, Lee, Scott, Parker, Albert, Trussell, Christopher, Sharif, Orzala, Luna, Fabio, Federe, Glenn, Barnes, Whitney, Walker, John, Vance, Julie, Gao, Mu-Yun, Klock, Heath, Clarkson, Scott, Russ, Carsten, Miraglia, Loren, Cooke, Michael, Boitano, Anthony, Mcnamara, Peter, Lamb, John, Schmedt, Christian and Snead, Jennifer (2018) Guide Swap enables genome-scale pooled CRISPR–Cas9 screening in human primary cells. Nature Methods, 15 (11). pp. 941-946. ISSN 15487105

Toyoda, Masanori, Watanabe, Koichiro, AMAGASAKI, TARO, NATSUME, KAZUTO, TAKEUCHI, HIROMI, Quadt, Cornelia, Shirao, Kuniaki and Minami, Hironobu (2018) A phase I study of single-agent BEZ235 special delivery system sachet in Japanese patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology. ISSN Print ISSN 0344-5704 / Onlibe ISSN 1432-0843

Trendelenburg, Anne-Ulrike (2018) Find drugs that delay many diseases of old age. Nature.

Trimble, AT, Brown, AW, Laube, BL, Lechtzin, N, Zeman, KL, Wu, J, Ceppe, AS, Waltz, D, Bennett, WD and Donaldson, SH (2018) Hypertonic saline has a prolonged effect on mucociliary clearance in adults with cystic fibrosis. Journal of Cystic Fibrosis. ISSN 18735010

Tsinman, Konstantin, Tsinman, Oksana, Lingamaneni, Ram, Zhu, Saijie, Riebesehl, Bernd, Grandeury, Arnaud, Juhnke, Michael and Van Eerdenbrugh, Bernard (2018) Ranking Itraconazole Formulations Based on the Flux through Artificial Lipophilic Membrane. Pharmaceutical Research, 35 (8). ISSN 1573904X

Turner, Oliver, Aeffner, Famke, Adissu, Hibret, Boyle, Michael , Cardiff, Robert, Hagendorn,, Erik, Hoenerhoff, Mark, Klopfleisch, Robert, Newbigging, Susan, Schaudien, Dirk and Wilson, Kristin (2018) Digital Microscopy, Image Analysis, and Virtual Slide Repository. ILAR Journal, 58. pp. 1-14. ISSN 1084-2020

Uehara, Tsuyoshi and Prathapam, Ramadevi (2018) A temperature-sensitive replicon enables efficient gene inactivation in Pseudomonas aeruginosa. Journal of microbiological methods, 144. pp. 47-52. ISSN 01677012

Ulrich, Peter, Blaich, Guenter, Baumann, Andreas, Fagg, Rajni, Hey, Adam, Kiessling, Andrea, Kronenberg, Sven, Lindecrona, Rikke Hvid, Mohl, Silke, Richter, Wolfgang F, Tibbitts, Jay, Crameri, Flavio and Weir, Lucinda (2018) Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing. Regulatory Toxicology and Pharmacology, 94. pp. 91-100. ISSN 10960295

Ulrich, Peter, Flandre, Thierry, Espie, Pascal, Sickert, Denise, Rubic-Schneider, Tina, Shaw, David Andrew and Rush, James (2018) Non-clinical safety assessment of CFZ533, a Fc-silent anti-CD40 antibody, in non-human primates. Toxicological sciences, Epub a. ISSN 1096-0929; 1096-6080

Umehara, Ken-Ichi, Huth, Felix, Won, Christina, Heimbach, Tycho and He, Handan (2018) Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug–drug interaction potential of CYP3A4 substrates. Biopharmaceutics and Drug Disposition, 39 (3). pp. 152-163. ISSN 1099081X

Uteng, Marianne, Urban, Laszlo, Brees, Dominique, Mueller, Patrick, Kullak-Ublick, Gerd-Achim, Tougas, Gervais, Bouchard, Page and Chibout, Salah-Dine (2018) Safety differentiation: Emerging competitive edge in drug development. Drug discovery today.

Vahle, John L, Anderson, Ulf, Blomme, Eric AG, Hoflack, Jean-Christophe and Stiehl, Daniel Philipp (2018) Use of toxicogenomics in drug safety evaluation: Current status and an industry perspective. Regulatory Toxicology and Pharmacology, 96. pp. 18-29. ISSN 10960295

Veenstra, Siem, Rueeger, Heinrich, Voegtle, Markus, Lueoend, Rainer Martin, Holzer, Philipp, Hurth, Konstanze, Tintelnot-Blomley, Marina, Frederiksen, Mathias, Rondeau, Jean-Michel, Jacobson, Laura, Staufenbiel, Matthias, Neumann, Ulf and Machauer, Rainer (2018) Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors. Bioorganic and Medicinal Chemistry Letters, 28 (12). pp. 2195-2200. ISSN 14643405

Veit, Guido, Dreano, Elise, Avramescu, Radu, Bagdany, Miklos, Beitel, Lenore, Roldan, Ariel, Hancock, Mark, Lay, Cecilia, Li, Wei, Morin, Katie, Gao, Sandra, Puiying, Mak, Ainscow, Edward, Orth, Anthony, McNamara, Peter, Edelman, Aleksander, Frenkiel, Saul, Matouk, Elias, Sermet-Gaudelus, Isabelle, Barnes, William and Lukacs, Gergely (2018) Structure-guided combination therapy to potently improve the function of mutant CFTRs. Nature Medicine.

Velcicky, Juraj, Bodendorf, Ursula, Rigollier, Pascal, Epple, Robert, Beisner, Daniel, Guerini, Danilo, Smith, Philip, Liu, Bo, Feifel, Roland, Wipfli, Peter, Aichholz, Reiner, Couttet, Philippe, Dix, Ina, Widmer, Toni, Wen, Ben and Brandl, Trixi (2018) Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. Journal of Medicinal Chemistry, 61 (3). pp. 865-880. ISSN 0022-26231520-4804

Velcicky, Juraj, Schlapbach, Achim, Heng, Richard, Revesz, Laszlo, Pflieger, Daniel, Blum, Ernst, Huppertz, Christine, Feifel, Roland and Hersperger, Rene (2018) Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure. ACS Medicinal Chemistry Letters, 9 (4). pp. 392-396. ISSN 1948-58751948-5875

Vorherr, Thomas (2018) Peptide Therapeutics. Bioorganic and medicinal chemistry.

Vu, Hoan, Pedro, Liliana, Mak, Tin, McCormick, Brendan, Rowley, Jessica, Liu, Miaomiao, Di Capua, Angela, Williams-Noonan, Billy, Pham, Ngoc B, Pouwer, Rebecca, Nguyen, Bao, Andrews, Katherine T, Skinner-Adams, Tina, Kim, Jessica, Hol, Wim G J, Hui, Raymond, Crowther, Gregory J, Van Voorhis, Wesley C and Quinn, Ronald J (2018) Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry. ACS infectious diseases, 4 (4). pp. 431-444. ISSN 2373-8227

Vulpetti, Anna, Ostermann, Nils, Randl, Stefan, Yoon, Taeyoung, Mac Sweeney, Aengus, Cumin, Frederic, Lorthiois, Edwige, Ruedisser, Simon, Erbel, Paulus and Maibaum, Juergen Klaus (2018) Discovery and design of first benzylamine-based ligands binding to an unlocked conformation of the Complement Factor D. ACS Medicinal Chemistry Letters, 9 (5). pp. 490-495. ISSN 1948-58751948-5875

Walker, John, Zorrilla, Eric, Logrip, Marian, Ayanwuyi, Lydia, Sabino, Valentina, Ciccocioppo, Roberto and Koob, George (2018) Evaluation of alcohol preference and drinking in msP rats bearing a Crhr1 promoter polymorphism. Frontiers in psychiatry, 9 (FEB). p. 28. ISSN 1664-0640

Walpurgis, Katja , Thomas, Andreas , Schänzer, Wilhelm and Thevis, Mario (2018) Detection of the Human Anti-ActRII Antibody Bimagrumab in Serum by Means of Affinity Purification, Tryptic Digestion, and LC-HRMS. Proteomics - Clinical Applications. ISSN 18628354

Wang, Feng, Jeon, Kyu Ok, Salovich, James M, Macdonald, Jonathan D, Alvarado, Joseph, Gogliotti, Rocco D, Phan, Jason, Olejniczak, Edward T, Sun, Qi, Wang, Shidong, Camper, DeMarco, Yuh, Joannes P, Shaw, J Grace, Sai, Jiqing, Rossanese, Olivia W, Tansey, William P, Stauffer, Shaun R and Fesik, Stephen W (2018) Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. Journal of medicinal chemistry, 61 (13). pp. 5623-5642. ISSN 1520-4804

Watanabe, Keisuke, Luo, Yanping, Da, Tong, Guedan , Sonia, Ruella, Marco, Scholler, John, Keith, Brian, Young, Regina M, Engels, Boris, Sorsa, Suvi, Siurala, Mikko, Havunen, Riikka, Tahtinen, Siri, Hemminki, Akseli and June, Carl H (2018) Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses. JCI insight, 3 (7). ISSN 23793708

Weeden, Clare E , Ah-Cann, Casey , Holik, Aliaksei Z, Pasquet, Julie , Garnier, Jean-Marc , Merino, Delphine , Lessene, Guillaume and Asselin-Labat, Marie-Liesse (2018) Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition. Oncogene, 37 (32). pp. 4475-4488. ISSN 14765594

Weiersmüller, Dominique and Gruber, Florian (2018) Florian Gruber: Forschung ist spannend. Chancenheft Chemie, Berufsbertaungs- und Informationszentren des Kantons Bern.

Wilcken, Rainer (2018) SAMPL6: pKa prediction blind challenge submission. D3R Drug Design Data Resource - online resource.

Wilson, Aaron, Moutsatsos, Ioannis, Pineda, Javier, Feng, Yan, Yu, Gary and Auld, Douglas (2018) A Scalable Pipeline for High-Throughput Flow Cytometry. SLAS Discovery. ISSN 24725560

Wilson, Aaron, Moutsatsos, Ioannis, Yu, Gary, Pineda, Javier, Feng, Yan and Auld, Douglas (2018) A Scalable Pipeline for High-Throughput Flow Cytometry. SLAS DISCOVERY: Advancing Life Sciences R&D. ISSN 2472-55522472-5560

Wimmer , Laurin, Parmentier, Michael, Riss, Bernard, Kapferer, Tobias, Ye, Chao, Li, Lei, Kim, Hongyong and Li, Jialiang (2018) Water-promoted chlorination of 2-mercaptobenzothiazoles. Synthesis.

Wingert, Lindsey, Zilionis, Rapolas, Weinreb, Caleb, Savovas, Virginia, Choo-Wing, Rayman, Roma, Guglielmo, Knehr, Judith, Klein, Allon and Jaffe, Aron (2018) A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. Nature, 560 (7718). pp. 377-381. ISSN 14764687

Wong, Gabrielle, Zhou, Jin, Liu, Jie Bin, Xu, Xinsen, Wu, Zhong, Xu, David, Schumacher, Steven, Puschhof, Jens, Li, Tianxia, McFarland, James, Zou, Charles, Dulak, Austin, Henderson, Les, Xu, Peng, O'Day, Emily, Rendak, Rachel, Liao, Wei-li, Cecchi, Fabiola, Hembrough, Todd, Schwartz, Sarit, Szeto, Christopher, Rustgi, Anil, Wong, Kwok-kin, Diehl, J.Alan, Jensen, Karin, Graziano, Federico, Ruzzo, Annamaria, Fereshetian, Shaunt, Mertins, Philipp, Carr, Steven, Beroukhim, Rameen, Nakamura, Kenichi, Oki, Eiji, Watanabe, Masayuki, Baba, Hideo, Imamura, Yu, Catenacci, Daniel and Bass, Adam (2018) Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nature medicine. ISSN 1078-8956

Wong, Man Yan, Liu, Changliang, Wang, Shan Shan H, Roquas, Aram C F, Fowler, Stephen C and Kaeser, Pascal S (2018) Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses. Proceedings of the National Academy of Sciences of the United States of America, 115 (9). pp. 2234-2239. ISSN 1091-6490

Wong, Yan, Liu, Changliang, Wang, Shan Shan H, Roquas, Aram C F, Fowler, Stephen C and Kaeser, Pascal S (2018) Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses. Proceedings of the National Academy of Sciences of the United States of America, 115 (9). pp. 2234-2239. ISSN 1091-6490

Woollam, Grahame, Neumann, Marcus, Wagner, Beatrix and Davey, Roger (2018) The importance of configurational disorder in crystal structure prediction: the case of loratadine. Faraday Discussions, Advanc (Advanc). ISSN 1359-66401364-5498

Wright, Justin and Jones, Graham (2018) Visioning Pharma 2.0: Mapping our Digital Exhaust. Digital Biomarkers, 2 (1). pp. 31-46. ISSN 2504-110X

Xu, Jie, Vessieres, Emilie, Mathur, Jayanti, Hammack, Scott, Nonomura, Keiko, Favre, Julie, Grimaud, Linda, Petrus, Matthew, Francisco, Allain, Li, Jingyuan, Lee, Van, Xiang, Fuli, Mainquist, James, Cahalan, Stuart, Orth, Anthony, Walker, John, Ma, Shang, Lukacs, Viktor, Bordone, Laura, Bandell, Michael, Laffitte, Bryan, Xu, Yan, Chien, Shu, Henrion, Daniel and Patapoutian, Ardem (2018) GPR68 Senses Flow and Is Essential for Vascular Physiology. Cell, 173 (3). pp. 762-775. ISSN 00928674

Yap, Yoon-Sim, Singh, Angad, Lim, John, Ahn, J.H., Jung, K.H., Kim, J., Dent, R.A., Ng, R.C.H., Kim, Sung-Bae and Chiang, Derek (2018) Elucidating Therapeutic Molecular Targets in Premenopausal Asian Women with Recurrent Breast Cancers. npg breast cancer, 4. p. 19.

Ye, Baihua, Zhao, Jie, Zhao, Ke, Mckenna, Jeffrey and Toste, F Dean (2018) Chiral diaryliodonium phosphate enables light driven diastereoselective α- C(sp3)-H acetalization. Journal of the American Chemical Society JACS., 140.

Yeboah, Fred, Guo, Hongqiu and Bill, Anke (2018) A high-throughput calcium-flux assay to study NMDAR-receptors with sensitivity to Glycine/D-Serine an Glutamate. Journal of visualized experiments : JoVE, 137 (e58160). ISSN 1940-087X

Yeboah, Fred, Guo, Hongqiu and Bill, Anke (2018) A novel calcium-flux assay for the study of the NMDA-receptor. Journal of visualized experiments : JoVE (137). ISSN 1940-087X

Yen, Jonathan, Fiorino, Michael, Liu, Yi, Paula, Steve, Clarkson, Scott, Quinn, Lisa, Tschantz, Bill, Klock, Heath, Guo, Ning, Russ, Carsten, Yu, Vionnie, Mickanin, Craig, Stevenson, Susan, Lee, Cameron and Yang, Yi (2018) TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells. Scientific reports, 8 (16304 ). pp. 1-12. ISSN PMID: 30389991

Youngberg, Stephen, Brandt, Erin, Barve, Avantika, Machineni, Surendra Kumar, Jones, Christopher, Dabovic, Kristina, Jones, Catherine and Colvin, Richard (2018) A first-in-human, randomized, double-blind, placebo-controlled, single and multiple ascending oral dose study to assess the safety, tolerability, and pharmacokinetics of BZF961 with and without ritonavir in healthy adult volunteers. Journal of drug assessment, 7. pp. 66-74. ISSN 2155-6660

Zhang, Jiangwei, Xiao, Sean, Gao, Zhenting, Yu, Zhengtian and Zhang, Jeff (2018) Metabolism of quinoline containing C-Met kinase inhibitors by aldehyde oxidase, effect of electron donating group and steric hindrance. Drug metabolism and disposition. pp. 1-34. ISSN https://doi.org/10.1124/dmd.118.081919

Zhang, Qi and Konopleva, Marina (2018) Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven philadelphia chromosome-like acute B-cell lymphoblastic leukemia. Oncotarget, 9 (8). pp. 8027-8041. ISSN 19492553

Zhang, Zhipeng, Ratnikov, Max, Spraggon, Glen and Alper, Phillip (2018) Photoinduced Rearrangement of Dienones and Santonin Rerouted by Amines. Angewandte Chemie. International edition, 57 (4). pp. 904-908. ISSN 14337851

Zhao, Qian, Manning, James, Sutton, James, Costales, Abran, Sendzik, Martin, Shafer, Cynthia, Levell, Julian, Liu, Gang, Caferro, Thomas, Cho, Young, Palermo, Mark, Chenail, Gregg, Dooley, Julie, Villalba, Brian, Farsidjani, Alireza, Chen, Jinyun, Dodd, Stephanie, Gould, Ty, Liang, Guiqing, Slocum, Kelly, Pu, Minying, Firestone, Brant, Growney, Joseph, Heimbach, Tycho and Pagliarini, Raymond (2018) Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors. ACS Medicinal Chemistry Letters, 9. pp. 746-751. ISSN 19485875

Zheng, Wei, Dryja, Thaddeus P, Wei, Zhongyuan, Song, Dongying, Tian, Haijun, Kahler, Kristijan H and Khawaja, Anthony P (2018) Systemic Medication Associations with Presumed Advanced or Uncontrolled Primary Open-Angle Glaucoma. Ophthalmology, 125 (7). pp. 984-993. ISSN 1549-4713

Zhu, Wenya, Qiu, Wenlong, Clarke, Adrian, Kolarik, Christoph, Mozzo, Sebastiano and Liang, Guoyi (2018) A LEAN approach for the determination of residual solvents using headspace gas chromatography (HS-GC) with relative response factors. LC-GC Magazine (pharmaceutical supplement).

de Jong, Arthur P H, Roggero, Carlos M, Ho, Meng-Ru, Wong, Man Yan, Brautigam, Chad A, Rizo, Josep and Kaeser, Pascal S (2018) RIM CB Domains Target Presynaptic Active Zone Functions to PIP-Containing Membranes. Neuron, 98 (2). 335-349.e7. ISSN 1097-4199

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