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Limb Synovial Joint Development From the Hips Down: Implications for Articular Cartilage Repair and Regeneration

Pacifici, Maurizio and Decker, Rebekah and Koyama, Eiki (2018) Limb Synovial Joint Development From the Hips Down: Implications for Articular Cartilage Repair and Regeneration. Developmental Biology and Musculoskeletal Tissue Engineering. pp. 67-101.

Abstract

Synovial joints permit the distinct movement and functioning of the different skeletal elements in the limbs but share essential structural features, including articular cartilage, intra/perijoint ligaments, synovial lining, and lubricating fluids. Here, we review most recent advances in the developmental biology of synovial joints, paying particular attention to the following: the origin and diversification of joint progenitor cells; roles of signaling proteins in joint genesis and morphogenesis, including GDF5; mechanisms by which articular cartilage acquires its mature postnatal multizone organization; and defects in pediatric congenital joint conditions such as symphalangism. We include novel data on hip joint development that surprisingly has been understudied. At variance with their developmental prowess and dynamism, joint tissues have a frustratingly poor capacity to self-repair and regenerate after trauma or chronic disease. Thus, we discuss implications and insights from developmental studies that could suggest ways to design more effective bioengineered strategies for tissue repair and could also lead to means by which the regenerative activities of resident embryonic-lineage progenitors recently identified in adult joint tissues could be boosted.

Item Type: Article
Date Deposited: 17 Jan 2019 00:45
Last Modified: 17 Jan 2019 00:45
URI: https://oak.novartis.com/id/eprint/38700

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