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Degradation of recombinant proteins of diverse formats by CHO host cell proteases is circumvented via knock-out of CHO matriptase

Laux, Holger and Romand, Sandrine and Tapparel, Joel Alois Rene and Nuciforo, Sandro and Buechmann-Moller, Stine and Dogrusoez, Guelay and Probst, Claudia Monika and Sommer, Benjamin and Oakeley, Edward James and Bodendorf, Ursula (2018) Degradation of recombinant proteins of diverse formats by CHO host cell proteases is circumvented via knock-out of CHO matriptase. BMC proceedings., 12(Sup (3). pp. 2-3.

Abstract

An increasing number of biologics are entering the pipeline of pharmaceutical companies. Today, the preferred production host for therapeutic proteins are CHO cells. However one of the major hurdles especially for the production of non-antibody glycoproteins is host cell-related proteolytic degradation which can drastically impact developability and timelines of pipeline projects.

Item Type: Article
Date Deposited: 05 Apr 2018 00:45
Last Modified: 05 Apr 2018 00:45
URI: https://oak.novartis.com/id/eprint/33786

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