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Green Chemistry Approaches for the Purification of Pharmaceuticals

Galyan, Keith and Reilly, John (2018) Green Chemistry Approaches for the Purification of Pharmaceuticals. Current Opinion in Green and Sustainable Chemistry.


To enable R&D of new drug products with a more green process emphasis, a full understanding of the impact of chromatography in the discovery phase of drug development is crucial. With large quantities of small scale (<1000mg) separations typically evaluated and purified, a chromatographic technique needs to be easily integrated into workflows and readily robust. At Novartis, integration of supercritical fluid chromatography (SFC) has allowed for increases in productivity, decreases in toxic/hazardous solvent consumption and a more green approach to chromatography. The purpose of this review is to introduce the reader to new techniques available to organizations for the analysis and purification of mg-kg scale purifications that are routinely handled within discovery. Evaluation of a variety of techniques available to the industry has led to the implementation of SFC, with some of the pros of each technique noted below: An overview of enantiomeric purification methodologies is highlighted below in Table 1.

Item Type: Article
Keywords: SFC, Chromatography, purification, green
Date Deposited: 06 Jun 2018 00:45
Last Modified: 06 Jun 2018 00:45