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Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow

Lima, Fabio and Grunenberg, Lars and Husaini, Mohamed and Labes, Ricardo and Sedelmeier, Joerg Mathias and Ley, Steven (2018) Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow. Chemical Communications, 54 (44). pp. 5606-5609. ISSN 1364548X

Abstract

We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to oxidise boronic acid derivatives by a single electron process. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A straightforward scale up approach using continuous flow photoreactors is also reported affording gram an hour throughput.

Item Type: Article
Date Deposited: 17 Jul 2018 00:45
Last Modified: 17 Jul 2018 00:45
URI: https://oak.novartis.com/id/eprint/35684

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