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Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T

Stewart, N.J., Chan, H-F, Hughes, P.J.C., Horn, F.C., Norquay, G., Parra-Robles, J., Rao, M., Yates, Denise, Ford, P., Collini, P., Ireland, R., Lawson, R., Marshall, H., Collier, G.J. and Wild, J.M. (2018) Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T. Journal of magnetic resonance imaging. ISSN 10531807


Purpose: To evaluate the sensitivity and reproducibility of quantitative metrics of lung ventilation and microstructure from hyperpolarized 129Xe MRI alongside equivalent 3He MRI measurements at 1.5 T.

Materials & Methods: MR data from eleven healthy volunteers (HV), five ex-smokers (ES), five patients with COPD and fourteen patients with non-small-cell lung cancer (LC) were analyzed in this retrospective study. LC and COPD patients underwent 3D MRI of lung ventilation, and HV, ES and COPD patients underwent 2D multi-slice diffusion-weighted lung MRI using both 3He and 129Xe gases. Ventilated volume percentage (VV%) and mean apparent diffusion coefficient (ADC) were derived from ventilation and diffusion-weighted imaging, respectively. COPD patients performed the complete MR protocol in four separate scan sessions to assess reproducibility. MR measurements were compared to same-day pulmonary function tests.

Results: A positive correlation between 3He and 129Xe VV% was identified (r=0.798, P=0.001). VV% was larger for 3He than 129Xe (P=0.001), with an average bias of 11%. A strong correlation between mean 3He and 129Xe ADC was obtained (r=0.922, P<0.001), and ADCs of both nuclei exhibited good correlations with PFTs. In COPD patients, mean coefficient of variation (CV) values of 3He and 129Xe VV% over repeated scans were 5.78% and 13.01%, respectively, with intra-class correlation (ICC) coefficients (significances) of 0.576 (P=0.025); 0.458 (P=0.095). Mean 3He and 129Xe ADC values were both highly reproducible (CV<3%; ICC significance, P<0.001).

Conclusion: 129Xe lung MRI is approaching readiness as an alternative to 3He for quantitative clinical MRI of lung microstructure and ventilation at 1.5 T.

Item Type: Article
Date Deposited: 12 May 2018 00:45
Last Modified: 12 May 2018 00:45


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