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Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T

Stewart, N.J. and Chan, H-F and Hughes, P.J.C. and Horn, F.C. and Norquay, G. and Parra-Robles, J. and Rao, M. and Yates, Denise and Ford, P. and Collini, P. and Ireland, R. and Lawson, R. and Marshall, H. and Collier, G.J. and Wild, J.M. (2018) Comparison of 3He and 129Xe MRI for evaluation of lung microstructure and ventilation at 1.5 T. Journal of magnetic resonance imaging. ISSN 10531807

Abstract

Purpose: To evaluate the sensitivity and reproducibility of quantitative metrics of lung ventilation and microstructure from hyperpolarized 129Xe MRI alongside equivalent 3He MRI measurements at 1.5 T.

Materials & Methods: MR data from eleven healthy volunteers (HV), five ex-smokers (ES), five patients with COPD and fourteen patients with non-small-cell lung cancer (LC) were analyzed in this retrospective study. LC and COPD patients underwent 3D MRI of lung ventilation, and HV, ES and COPD patients underwent 2D multi-slice diffusion-weighted lung MRI using both 3He and 129Xe gases. Ventilated volume percentage (VV%) and mean apparent diffusion coefficient (ADC) were derived from ventilation and diffusion-weighted imaging, respectively. COPD patients performed the complete MR protocol in four separate scan sessions to assess reproducibility. MR measurements were compared to same-day pulmonary function tests.

Results: A positive correlation between 3He and 129Xe VV% was identified (r=0.798, P=0.001). VV% was larger for 3He than 129Xe (P=0.001), with an average bias of 11%. A strong correlation between mean 3He and 129Xe ADC was obtained (r=0.922, P<0.001), and ADCs of both nuclei exhibited good correlations with PFTs. In COPD patients, mean coefficient of variation (CV) values of 3He and 129Xe VV% over repeated scans were 5.78% and 13.01%, respectively, with intra-class correlation (ICC) coefficients (significances) of 0.576 (P=0.025); 0.458 (P=0.095). Mean 3He and 129Xe ADC values were both highly reproducible (CV<3%; ICC significance, P<0.001).

Conclusion: 129Xe lung MRI is approaching readiness as an alternative to 3He for quantitative clinical MRI of lung microstructure and ventilation at 1.5 T.

Item Type: Article
Date Deposited: 12 May 2018 00:45
Last Modified: 12 May 2018 00:45
URI: https://oak.novartis.com/id/eprint/33392

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