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Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*)

Lapp, Stefanie and Bube, Axel and Ernst, Heinrich and Colbatzky, Florian and Kellner, Rupert and Nolte , Thomas and Rinke, Matthias (2018) Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*). Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*).

Abstract

Microchip implantation is a common and widely employed means of animal identification in laboratory animal facilities. However, these devices have been associated with tumors of the skin and subcutis in rodents. While microchip-associated tumors are rare, they pose a challenge for accurate diagnosis and documentation in pre-clinical toxicity studies. Documentation of these tumors should differentiate microchip-associated lesions with spontaneously occurring or substance-induced tumors. Standardizing criteria for microchip-associated lesions will aid the diagnostic process and allow for pre-clinical regulatory standardization. To this end, the Registry of Industrial Toxicology Animal-data (RITA) has developed clear recommendations for diagnosis and documentation of microchip-associated lesions.

Item Type: Article
Keywords: INHAND; RITA; best practice recommendations; implantation; microchip-associated tumors; recording; sampling; soft tissue tumors
Date Deposited: 27 Nov 2018 00:45
Last Modified: 27 Nov 2018 00:45
URI: https://oak.novartis.com/id/eprint/35160

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