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Items where Year is 2018

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Number of items: 341.

Abend, Andreas, Heimbach, Tycho, Cohen, Michael, Kesisoglou, Filippos, Pepin, Xavier and Suarez, Sandra (2018) DISSOLUTION AND TRANSLATIONAL MODELING STRATEGIES ENABLING PATIENT-CENTRIC PRODUCT DEVELOPMENT M-CERSI WORKSHOP SUMMARY REPORT. American Association of Pharmaceutical Scientists Journal.

Abrams, Tinya, Connor, Anu, Fanton, Christie, Cohen, Steven, Huber, Thomas, Miller, Kathy, Hong, E. Erica, Niu, Xiaohong, Kline, Janine, Ison-Dugenny, Marjorie, Harris, Sarah, Walker, Dana, Krauser, Klaus, Galimi, Francesco, Wang, Zhen, Ghoddusi, Majid, Mansfield, Keith, Lee-Hoeflich, Si Tuen, Holash, Jocelyn, Pryer, Nancy, Kluwe, William, Ettenberg, Seth, Sellers, William, Lees, Emma, Kwon, Paul, Abraham, Judy and Schleyer, Siew (2018) Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors. Clinical Cancer Research, 24 (17). pp. 4297-4308. ISSN 15573265

Adams, Christopher, Anderson, Karen, Artman Iii, Gerald, Cepeda, Rosemarie, Bizec, Jean-Claude, Elliott, Jason, Fassbender, Elizabeth, Ghosh, Malay, Hanks, Shawn, Hardegger, Leo, Hosagrahara, Vinayak, Jaffee, Bruce, Jendza, Keith, Ji, Nan, Johnson, Leland, Liu, Donglei, Liu, Fang, Long, Debby, Ma, Fupeng, Mainolfi, Nello, Meredith, Erik, Miranda, Karl, Peng, Penny, Poor, Stephen, Powers, James, Qiu, Yubin, Rao, Chang, Shen, Siyuan, Sivak, Jeremy, Solovay, Catherine, Tarsa, Peter, Woolfenden, Amber, Zhang, Chun and Zhang, Yiqin (2018) The discovery of N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (acrizanib), a VEGFR-2 inhibitor specifically designed for topical ocular delivery, as a therapy for neovascular age- related macular degeneration. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Adriana, Sánchez-Danés, Jean-Christophe , Larsimont, Mélanie, Liagre, Eva , Muñoz, Audrey, Brisebarre, Christine, Dubois, Josep, Tabernero and Cédric , Blanpain (2018) A slow cycling Lgr5 tumor cell population mediates resistance to Smoothened inhibitor in Basal Cell Carcinoma. Nature. ISSN 1476-4687

Akbar, Mohammad, Ahn, Mee, Bashaw, Dennis, Blithe, Diana, Berry-Bibee, Erin, Davis, Daniel, Day, Ruth, Edelman, Alison, Hochel, Joachim, Huang, Shiew-Mei, Jamshidi, Roxanne, Kim, Myong-Jin, Kim, Na Hyung, Lee, LaiMing, Li, Li, Purohit, Vivek, Turpin, Jim, Scott, Pamela, Shon, Jihong, Soule, Lisa, Strauss, David, Sun, Haiying, Tassinari, Melissa, Tepper, Naomi, Willett, Gerald, Zhang, Lei, Zhang, Nan, Zhao, Ping and Yu, Chongwoo (2018) FDA Public Meeting Report on “Drug Interactions with Hormonal Contraceptives: Public Health and Drug Development Implication”. Journal of Clinial Pharmacology.

Albiol, Laia, Cilla, Myriam, Pflanz, David, Kramer, Ina, Kneissel, Michaela, Duda, Georg N., Willie, Bettina M. and Checa, Sara (2018) Sost deficiency leads to reduced mechanical strains at the tibia midshaft in strain-matched in vivo loading experiments in mice. Journal of the Royal Society Interface.

Alexander, Schuhmacher, Oliver, Gassmann, Nigel, McCracken and Hinder, Markus (2018) Open innovation and external sources of innovation. An opportunity to fuel the R&D pipeline and enhance decision making? Journal of Translational Medicine, 16 (1). ISSN 14795876

Andersson, Martin, Lipshutz, Bruce and Gallou, Fabrice (2018) Nanoparticle structure in TPGS-750M surfactant based organic synthesis modeled by COSMO-RS. European journal of organic chemistry, 24. pp. 6778-6786.

Antonova-Koch, Yevgeniya, Meister, Stephan, Abraham, Matthew, Ottilie, Sabine, Vanaerschot, Manu, Rodriguez, Juan Carlos Jado, Calla, Jaeson, Plouffe, David, Luth, Madeline, Zhong, Yang, Chen, Kaisheng, Owen, Edward, Lukens, Amanda, Sakata-Kata, Tomoyo, Maher, Steven, Chaumeau, Victor, Serrano, Fernando Neria, Eribez, Korina, Taggard, Cullin McClean, Roullier, Melanie, Siegel, Dionicio, Nosten, Francois, Kyle, Dennis, Gamo, Francisco-Javier, Zhou, Yingyao, Llinas, Manuel, Fidock, David, Wirth, Dyann, Burrows, Jeremy, Campo, Brice and Winzeler, Elizabeth (2018) Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science, 362 (6419). ISSN 10959203

Appleton, Brent, Benton, Bret, De Vicente Fidalgo, Javier, Drumm Iii, Joseph, Feng, Brian, Geng, Mei, Lu, Yipin, Mamo, Mulugeta, Moreau, Bob, Mergo, Wosenu, Skepper, Colin, Steffek, Micah, Takeoka, Ken, Uehara, Kyoko, Wang, Lisha, Wei, Jun-Rong, Xie, Lili, Xu, Wenjian, Zhang, Qiong, Li, Cindy and Hu, Cheng (2018) Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity. Journal of Medicinal Chemistry, 61 (8). pp. 3325-3349. ISSN 15204804

Appleton, Brent, Blechschmidt, Anke, Balibar, Carl, Benton, Bret, De Vicente Fidalgo, Javier, Drumm Iii, Joseph, Feng, Brian, Geng, Mei, Lingel, Andreas, Lu, Yipin, Mamo, Mulugeta, Mergo, Wosenu, Moreau, Bob, Polyakov, Valery, Skepper, Colin, Smith, Thomas, Takeoka, Ken, Uehara, Kyoko, Wang, Lisha, Wei, Jun-Rong, Weiss, Andrew, Xie, Lili, Xu, Wenjian, Zhang, Qiong and Li, Cindy (2018) Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria. Journal of Medicinal Chemistry, 61 (8). pp. 3309-3324. ISSN 15204804

Argikar, Aneesh and Argikar, Upendra (2018) Mesentery: An ADME perspective on a 'new' organ. Drug metabolism reviews. pp. 1-8. ISSN 1097-9883

Argikar, Upendra (2018) Saccharolactone: the history, the myth, and the practice. Current drug metabolism, 19. pp. 304-309. ISSN 1875-5453

Arias, H R, Feuerbach, Dominik and Ortells, M (2018) Bupropion inhibits human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites. Neurotransmitter.

Arias, HR, Feuerbach, Dominik, Schmidt, Bernd, Heydenreich, Matthias, Paz, Christian and Ortells, MO (2018) Drimane sesquiterpenoids purified from Drimys winteri inhibit the human α4β2 nicotinic acetylcholine receptor by noncompetitive mechanisms. Journal of natural products. ISSN 1520-6025; 0163-3864

Arias, HR, Vázquez-Gómez, E, Hernández-Abrego, A, Gallino, S, Feuerbach, Dominik, Ortells, MO, Elgoyhen, AB and García-Colunga, J (2018) Tricyclic antidepressants inhibit hippocampal α7*and α9α10 nicotinic acetylcholine receptors by different mechanisms. The international journal of biochemistry & cell biology.

Auberson, Yves, Briard, Emmanuelle, Rudolph, Bettina, Kaupmann, Klemens, Smith, Paul and Oberhauser, Berndt (2018) PET Imaging of T Cells: Target Identification and Feasibility Assessment. ChemMedChem. ISSN 18607187

Auld, Douglas S., Narahari, Janaki, Ho, Pei-i, Casalena, Dominick, Nguyen, Vy, Cirbaite, Evelina, Hughes, Doug, Daly, John and Webb, Brian (2018) Characterization and Use of TurboLuc Luciferase as a Reporter for High-Throughput Assays. Biochemistry. ISSN 0006-2960

Avery, Danielle A, Kane, Elisa, Nguyen, Tina, Lau, Anthony, Nguyen, Akira, Payne, Kathryn, Lenthall, Ellen, Wei, Shi, Brigden, henry, French , Elise, Bier, Julia, Hermes, Jana R, Zahra, David, Sewell, William, Boztug, Kaan, Meyts, Isabelle, Choo, Sharon, Hsu, Peter, Wong, Melanie, Berglund, Lucinda, Gray, Paul, O'Sullivan, Michael, Cole, Therese, Holland, Steven M, Ma, Cindy S, Burkhart, Christoph, Corcoran, Lynn M, Phan, Tri G, Brink, Robert, Uzel, Gulbu, Deenick, Elissa K and Tanguye, Stuart G (2018) Pathogenic germline activating mutations in PIK3CD compromise B-cell development and function, underlying humoral defects in human primary immunodeficiency. Journal of Experimental Medicine.

Avery, Danielle A, Kane, Elisa, Nguyen, Tina, Lau, Anthony, Nguyen, Akira, Payne, Kathryn, Lenthall, Ellen, Wei, Shi, Brigden, henry, French , Elise, Bier, Julia, Hermes, Jana R, Zahra, David, Sewell, William, Boztug, Kaan, Meyts, Isabelle, Choo, Sharon, Hsu, Peter, Wong, Melanie, Berglund, Lucinda, Gray, Paul, O'Sullivan, Michael, Cole, Therese, Holland, Steven M, Ma, Cindy S, Burkhart, Christoph, Corcoran, Lynn M, Phan, Tri G, Brink, Robert, Uzel, Gulbu, Deenick, Elissa K and Tanguye, Stuart G (2018) Pathogenic germline activating mutations in PIK3CD intrinsically compromise B-cell development and function, underlying humoral defects in human primary immunodeficiency. Journal of Experimental Medicine.

Awale, Mahendra, Sirockin, Finton, Stiefl, Nikolaus and Reymond, Jean-Louis (2018) Drug Analogs from Fragment Based Long Short-Term Memory Generative Neural Networks. ChemRXiv.

Badal Tejedor, Maria, Pazesh, Samaneh, Nordgren, Niklas, Rutland, Mark, Schuleit, Michael, Alderborn, Göran and Millqvist Fureby, Anna (2018) Milling induced amorphisation and recrystallisation of α-lactose monohydrate. International journal of pharmaceutics, 537. pp. 140-147. ISSN 1873-3476; 0378-5173

Badaoui, Magd, Kells, Adam, Molteni, Carla, Dickson, Callum, Hornak, Viktor and Rosta, Edina (2018) Calculating kinetic rates and membrane permeability from biased simulation. The Journal of Physical Chemistry B. ISSN 1520-61061520-5207

Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frederique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glueck, Anton, Schneider, Martin Alexander, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Regnier, Catherine, Bold, Guido, Pissot Soldermann, Carole, Carballido, Jose, Kovarik, Jiri, Calzascia, Thomas and Bornancin, Frederic (2018) The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition. Immunology and cell biology.

Barkley, Deborah, Han, Sang Uk, Koga, Tadanori and Rudick, Jonathan G. (2018) Peptide–dendron hybrids that adopt sequence-encoded β-sheet conformations. Polymer Chemistry. ISSN 1759-9954

Barrow, Alexander/D, Edeling, Melissa/A, Trifonov, Vladimir, Luo, Jingqin, Goyal, Piyush, Bohl, Benjamin, Bando, Jennifer, Kim, Albert, Andahazy, Mary, Melocchi, Laura, Bugatti, Mattia, Vermi, Wiliam, Fremont, Daved, Cox, Sarah, Cella, Marina, Schmedt, Christian and Colonna, Marco (2018) Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor. Cell, 172 (3). 534-548.e19. ISSN 10974172

Beach, Aaron, Wassmann, Paul and Lorenz, Thorsten (2018) Analytical strategies for developability assessment of therapeutic proteins. American Pharmaceutical Review, 21 (4). ISSN 10998012

Beato, Stefania, Kourentas, Alexandros , Vertzoni, Maria , Barmpatsalou, Vicky, Butler, James , Holm, Rene, Rosenberg, Joerg, Tannergren, Christer, Symillides, Mira and Reppas, Christos (2018) The use of BioGIT system to assess the impact of dose and formulation on early exposure to low solubility drugs after oral administration. The AAPS journal, 20 (71). pp. 1-12. ISSN 10-1208

Beckmann, Nicolau, Giorgetti, Elisa, Neuhaus, Anna, Zurbruegg, Stefan, Accart Gris, Nathalie, Smith, Paul, Perdoux, Julien, Perrot, Ludovic, Nash, Mark, Desrayaud, Sandrine, Wipfli, Peter, Frieauff, Wilfried and Shimshek, Derya (2018) Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945. Acta neuropathologica communications.. ISSN 2051-5960

Beckwith, Rohan (2018) Reactive carbon species tamed for synthesis. Nature, 554 (7690). pp. 36-38. ISSN 14764687

Becquet, Mike, Laborde, Laurent, Texier, Celine, Sterker, Dario, Gschwind, Hans-Peter, Pfaar, Ulrike, Wartmann, Markus, O'Reilly, Terence and Mcsheehy, Paul M.J. (2018) Continuous low-dose infusion of patupilone increases the therapeutic index in mouse and rat tumour models. Anti-Cancer Drugs, 29 (7). pp. 691-701. ISSN 14735741

Beninson, Jennifer A, Lofgren, Jennifer L, Lester, Patrick A, Hileman, Madeline M, Berkowitz, Daniel J and Myers, Daniel D (2018) Analgesic Efficacy and Hematologic Effects of Robenacoxib in Mice. Journal of the American Association for Laboratory Animal Science : JAALAS, 57 (3). pp. 258-267. ISSN 1559-6109

Bennet, Bindu M., Regan, Karen S., Romeike, Annette, Schafer, Kenneth, Thibodeau, Michael, Thomas, Heath, Colman, Karyn, Fikes, James, Francke, Sabine, Geoly, Frank, Keirstead, Natalie, Schorsch, Frederic and Vahle, John (2018) The Pathology Community’s Interpretation of Settiagounder’s Proposals on GLP Process as Applied to Pathology Peer Review. Journal of Regulatory Science, 6 (1). v-xi.

Benton, Bret, de Vicente, Javier, Drumm, Joseph, Feng, Brian, Geng, Mei, Li, Cindy, Moreau, Bob, Rath, Christopher, Shen, Xiaoyu, Skepper, Colin, Steffek, Micah, Takeoka, Kenneth, Wang, Lisha, Wei, Jun-Rong, Xu, Wenjian and Zhang, Qiong (2018) Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics. ACS Infectious Diseases, 4 (3). pp. 391-402. ISSN 23738227

Bergsdorf, Christian, Kallen, Joerg, Galimberti, Ivan, Cobos-Correa, Amanda, Kaufmann, Markus, Roma, Guglielmo, Elhajouji, Azeddine, Uteng, Marianne, Hunziker, Juerg, Arnaud, Bertrand, Guibourdenche, Christel, Stiefl, Nikolaus, Roethlisberger, Patrik, Polyakov, Valery, Von Matt, Peter, Martus, Hans-Joerg, Izaac, Aude, Leder, Lukas, Holzinger, Sandra, Haenni, Simon, Freuler, Felix, Brichet, Murielle, Bernhard, Mario and Lerchner, Andreas (2018) X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan–McDermid Syndrome. ChemMedChem, 13 (18). pp. 1997-2007. ISSN 18607187

Bitter, Hans, Orlando, Elena, Marco, Ruella, Jun, Xu, David, Barrett, Joseph, Fraietta, Tyler , Reich, David , Ambrose, Michael, Klichinsky, Olga, Shestova, Prachi, Patel, Irina, Kulikovskaya, Farzana, Nazimuddin, Vijay, Bhoj, Shannon, Maude, Bruce, Levine, Christopher, Nobles, Frederic, Bushman, Regina, Young, John, Scholler, Saar, Gill, Carl, June, Stephan, Grupp, Joseph, Melenhorst and Simon, Lacey (2018) Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nature Medicine, 24 (10). pp. 1499-1503. ISSN 1546170X

Blais, Johanne, Lopez, Sara, Li, Cindy, Ruzin, Alexey, Ranjikar, Srijan, Dean, Charles, Leeds, Jennifer, Casarez, Anthony, Simmons, Bob and Reck, Folkert (2018) In Vitro Activity of LYS228, a Novel Monobactam Antibiotic, against Multidrug-resistant Enterobacteriaceae. Antimicrobial agents and chemotherapy. ISSN 1098-6596

Blais, Johanne, Lopez, Sara, Li, Cindy, Ruzin, Alexey, Ranjikar, Srijan, Dean, Charles, Leeds, Jennifer, Casarez, Anthony, Simmons, Bob and Reck, Folkert (2018) In vitro activity of LYS228, a novel monobactam antibiotic, against multidrug-resistant enterobacteriaceae. Antimicrobial Agents and Chemotherapy, 62 (10). pp. 1-10. ISSN 10986596

Blasko, Andrei, Tam, Yat Kong, Haidar Ahmad, Imad A. , Sajeevi, Gunasekera, Irina, Oshchepkova, Alexey, Galin, Andrey, Vazhentsev, Vadim, Tashlitsky and David, Adams (2018) A Four-Dimensional (4D) Stability Indicating Analytical Method Optimization and Potency Assay Prediction Using MS and UV Peak Tracking. Journal of Applied Pharmacy, 10 (1). pp. 1-11. ISSN 1920-4159

Blasko, Andrei, Tam, Yat Kong, Kadrichu, Nani and Ahmad, Imad A. Haidar (2018) Amikacin analysis and aerosol particle size distribution (aPSD) determination using charged aerosol detector (CAD). Atlas of Science, - (April ). pp. 1-3.

Blatter, Markus, Sellier, Chantal, Cerro-Herreros, Estefanía, Allain, Frédéric H.T. , Llamusi, Beatriz and Charlet-Berguerand, Nicolas (2018) RbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences. Nature Communications, 9 (1). ISSN 20411723

Boehme, Philip, Hansen, Arne, Roubenoff, Ronenn, Scheeren, Joseph, Herrmann, Maximilian, Mondritzki, Thomas, Ehlers, Jan and Truebel, Hubert (2018) How soon will digital endpoints become a cornerstone for future drug development? Drug Discovery Today. ISSN 18785832

Bonhoeffer, Bastian, Kwade, Arno and Juhnke, Michael (2018) Alternative manufacturing concepts for solid oral dosage forms from drug nanosuspensions using fluid dispensing and forced drying technology. Journal of pharmaceutical sciences, 107 (3). pp. 909-921. ISSN 00223549

Bot, Corina T., Juhasz, Krisztina, Häusermann, Fabian, Liudmila , Polonchuk, Traebert, Martin and Stölzle-Feix2, Sonja (2018) Cross - site comparison of excitation-contraction coupling using impedance and field potential recordings in hiPSC cardiomyocytes. Journal of pharmacological and toxicological methods. ISSN 10568719

Bourgoint, Clelia, Rispal , Delphine, Berti, Marina, Filipuzzi, Ireos, Helliwell, Stephen, Prouteau, Manuel and Loewith, Robbie (2018) The Target of Rapamycin Complex 2-dependent phosphorylation of Pan1 by Akl1 controls endocytosis dynamics. Journal of Biological Chemistry, 293 (31). ISSN 0021-92581083-351X

Brocklehurst, Cara, Hartwieg, Constanze, Palmieri, Marco, Rufle, Dominik and Gallou, Fabrice (2018) Microtiter Plate (MTP) Reaction Screening and Optimization of Surfactant Chemistry: Examples of Suzuki-Miyaura and Buchwald-Hartwig Cross-Couplings in Water. Organic Process Research & Development. ISSN 1083-61601520-586X

Calabretta, Sara, Vogel, Gillian, Yu, Zhenbao, Choquet, Karine, Darbelli, Lama, Nicholson, Thomas, Kleinman, Claudia and Richard, Stephane (2018) Loss of PRMT5 promotes PDGFRa degradation during oligodendrocyte differentiation and myelination. Developmental cell, 46 (4). pp. 426-440. ISSN 15345807

Calvani, R, Bejuit, R, Roller-Wirnsberger, R, Barnebei, R, Vellas, B, Tosato, M, Jonsson , P, Grodzicki, T, Landi, F, Del Signore , S, Rodrigues-Manas, L, Skalska, A, Schols, A, Ryznarova , I, Msihid , J, Sinclair, A, Pahor, M, Maggio, M, Topinkova, E, Cruz-Jentoft, A, Roubenoff, Ronenn, Dantoine, T, Di Bari, M, Freiberger, E, Cesari, M, Marzetti, E, Sieber, C, Strandberg, T and Cherubini, A (2018) The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: Case finding, screening and characteristics of eligible participants. Experimental Gerontology, 113. pp. 48-57. ISSN 18736815

Capparelli, Claudia, Purwin , Timothy J., Heilman , Shea, Chervoneva, Inna, McCue, Peter, Davies, Michael A., Gershenwald, Jeffrey and Aplin, Andrew E. (2018) Stromal neuregulin-1 modulates the response to MEK inhibitors in WT BRAF/WT NRAS (WT/WT) melanomas. Molecular Cancer Therapeutics, 17 (1). ISSN 15388514

Carcache, David, Vulpetti, Anna, Kallen, Joerg, Mattes, Henri, Orain, David, Stringer, Rowan, Vangrevelinghe, Eric, Wolf, Romain, Kaupmann, Klemens, Ottl, Johannes, Dawson King, Janet, Cooke, Nigel Graham, Hoegenauer, Klemens, Billich, Andreas, Wagner, Juergen, Guntermann, Christine and Hintermann, Samuel (2018) Optimizing a weakly binding fragment into a potent RORγt inverse agonist with efficacy in an in vivo inflammation model. Journal of medicinal chemistry.

Cardoso, Ana-Luisa, Fernandes, Adelaide, Aguilar-Pimentel, Juan Antonio, Hrabě de Angelis, Martin, Ribeiro Guedes, , Joana, Brito, Maria Alexandra, Ortolano, Saida, Pani, Giovambattista, Athanasopoulou, Sophia, Gonos, Efstathios S., Schosserer, Markus, Grillari, Johannes, Peterson, Pärt, Guvenc Tuna, Bilge, Dogan, Soner, van Os, Ronald, Meyer, Angelika and Trendelenburg, Anne-Ulrike (2018) Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Research Reviews, 47. pp. 214-277. ISSN 18729649

Cardoso, Ana-Luisa, Fernandes, Adelaide, Aguilar-Pimentel, Juan Antonio, Hrabě de Angelis, Martin, Ribeiro Guedes, , Joana, Brito, Maria Alexandra, Ortolano, Saida, Pani, Giovambattista, Athanasopoulou, Sophia, Gonos, Efstathios S., Schosserer, Markus, Grillari, Johannes, Peterson, Pärt, Guvenc Tuna, Bilge, Dogan, Soner, van Os, Ronald, Meyer, Angelika and Trendelenburg, Anne-Ulrike (2018) Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Research Reviews, 47. pp. 214-277. ISSN 18729649

Cardoso, Ana-Luisa, Fernandes, Adelaide, Aguilar-Pimentel, Juan Antonio, Hrabě de Angelis, Martin, Ribeiro Guedes, , Joana, Brito, Maria Alexandra, Ortolano, Saida, Pani, Giovambattista, Athanasopoulou, Sophia, Gonos, Efstathios S., Schosserer, Markus, Grillari, Johannes, Peterson, Pärt, Guvenc Tuna, Bilge, Dogan, Soner, van Os, Ronald, Meyer, Angelika and Trendelenburg, Anne-Ulrike (2018) Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Research Reviews, 47. pp. 214-277. ISSN 18729649

Clarke, Brian, Cruz Jr, Joseph, Wilson, Liz, Hupper, Nicole, Wang, Yuan, Patora-Komisarska, Krystyna, Oberhauser, Berndt, Concannon, John, Glass, David, Trendelenburg, Anne-Ulrike and Zhang, Yunyu (2018) Protein kinase A activation inhibits DUX4 gene expression in facioscapulohumeral muscular dystrophy patient myotubes. Journal of Biological Chemistry. ISSN 0021-92581083-351X

Clayton, Gemma, Schachter, Asher, Magnusson, Baldur, Li, Yue and Colin, Laurence (2018) How often do safety signals occur by chance in first-in-human trials? Clinical and translational science, 11 (5). pp. 471-476. ISSN 1752-8062; 1752-8054

De Pascale, Gianfranco and Uehara, Tsuyoshi (2018) Target identification of cystobactamid and albicidin. ACS infectious diseases.

Dean, Charles, Barkan, Dave, Bermingham, Alun, Blais, Johanne, Casey, Fergal, Casarez, Anthony, Colvin, Richard, Fuller, John, Jones, Adriana, Li, Cindy, Lopez, Sara, Metzger Iv, Louis, Mostafavi, Mina, Prathapam, Ramadevi, Rasper, Dita, Reck, Folkert, Ruzin, Alexey, Shaul, Jacob, Shen, Xiaoyu, Simmons, Robert, Skewes-Cox, Peter, Takeoka, Ken, Tamrakar, Pramila, Uehara, Tsuyoshi and Wei, Jun-Rong (2018) The monobactam LYS228: mode of action and mechanisms decreasing in vitro susceptibility of Escherichia coli and Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, 62 (10). ISSN 1098-6596

Deurinck, Mark, Schindler, Stefanie, Zeiter, Stephan, Desbaillets, Isabelle, Gyger, Marcel, Bugnon, Philippe, Heimann, Maike, Ferrand, Gisele and Wyss, Stefanie (2018) Report from the 2017 Annual SGV Meeting. Laboratory Animals, 52 (2). pp. 211-213. ISSN 0023-67721758-1117

Dickson, Callum, Hornak, Viktor, Bednarczyk, Dallas and Duca, Jose (2018) Using membrane partitioning simulations to predict permeability of forty-nine drug-like molecules. Journal of Chemical Information and Modeling. ISSN 1549-95961549-960X

Dincer, Zuhal, Piccicuto, Virginie, Junker Walker, Ursula, Mahl, Joerg Andreas and McKeag, Sean (2018) Spontaneous and Drug-induced Arteritis/Polyarteritis in the Göttingen Minipig—Review. Toxicologic Pathology, 46 (2). pp. 121-130. ISSN 15331601

Donovan, Katherine and Fischer, Eric (2018) CRL4CRBN Mediated Degradation of SALL4 Links Thalidomide Syndrome to Duane Radial Ray Syndrome. ELife., 7. ISSN 2050-084X

Dumouchel, Jennifer, Chemuturi, Nagendra, Milton, Mark, Camenisch, Gian P., Chastain, Jim, Walles, Markus, Sasseville, Vito, Gunduz, Mithat, Iyer, Ganesh and Argikar, Upendra (2018) Models and approaches describing metabolism, transport, and toxicity of drugs administered by the ocular route. Drug metabolism and disposition, 46. pp. 1670-1683. ISSN 1521-009X

Dutta, Priyanka, Dargahi, Leila, O'Connell, Kara, Bolina, Ashini, Ozkan, Sefika, Sailer, Andreas and Dev, Kumlesh (2018) A novel modelling mechanism of PAEL receptor and GABARAPL2 interaction involved in Parkinson's disease. Neuroscience Letters, 673. pp. 12-18. ISSN 18727972

Dégardin, Klara, Guillemain, Aurélie, Klespe, Philippe, Hindelang, Florine, Zurbach, Raphaël and Roggo, Yves (2018) Packaging analysis of counterfeit medicines. Forensic Science International, 291. pp. 144-157. ISSN 03790738

Ehara, Takeru, Adams, Christopher, Bevan Jr, Doug, Ji, Nan, Meredith, Erik, Belanger, David, Powers, James, Kato, Mitsunori, Solovay, Catherine, Liu, Donglei, Capparelli, Michael, Bolduc, Philippe, Grob, Jonathan, Daniels, Matthew, Ferrara, Luciana, Yang, Louis, Towler, Christopher, Li, Byron, Stacy, Rebecca, Prasanna, Ganesh and Mogi, Muneto (2018) The discovery of (S)-1-(6-(3-((4-(1-(cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid, an sGC activator specifically designed for topical ocular delivery as a therapy for glaucoma. Journal of medicinal chemistry. ISSN DOI: 10.1021/acs.jmedchem.8b00007

Erlanson, Daniel A, de Esch, Iwan JP, Jahnke, Wolfgang, Johnson, Christopher N and Mortenson, Paul N (2018) Fragment-to-Lead Medicinal Chemistry Publications in 2016. Journal of Medicinal Chemistry, 61 (5). pp. 1774-1784. ISSN 15204804

Faller, Bernard, Berben, Philippe, Bauer-Brandl, Annette, Flaten, Goril Eide, Jacobsen, Christin, Brouwers, Joachim and Augustijins, Patrick (2018) Drug permeability profiling using cell-free permeation tools: Overview and applications. European Journal of Pharmaceutical Sciences, 119. pp. 219-233. ISSN 18790720

Ferretti, Stephane Raymond, Holzer, Philipp, Fuchs, Jeannette, Chapeau, Emilie, Wartmann, Markus, Sterker, Dario, Romanet, Vincent, Kerr, Grainne, Durand, Eric, Gaulis, Swann, Kallen, Joerg, Furet, Pascal, Cortes-Cros, Marta, Guerreiro, Nelson, Halilovic, Ensar, Jullion, Astrid, Kuriakose, Emil, Wiesmann, Marion, Jensen, Michael Rugaard, Hofmann, Francesco, Sellers, William, Jeay, Sebastien, Murakami, Masato and Wuerthner, Jens (2018) Dose and schedules determines distinct molecular mechanism underlying the efficacy of the p53-MDM2 inhibitor NVP-HDM201. Cancer research. ISSN 1538-7445; 0008-5472

Fodor, Michelle, Price, Edmund, Wang, Ping, Lu, Henry, Argintaru, Andreea, Chen, Zhuoliang, Glick, Meir, Hao, Huaixiang, Kato, Mitsunori, Koenig, Robert, Jonathan, LaRochelle, Liu, Gang, Mcneill, Eric, Majumdar, Dyuti, Nishiguchi, Gisele, Perez, Lawrence, Paris, Greg, Quinn, Christopher, Ramsey, Timothy, Sendzik, Martin, Shultz, Michael, Williams, Sarah, Stams, Travis, Stephen, Blacklow, Acker, Michael and Lamarche, Matthew (2018) Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chemical Biology.

Galli, Giorgio and Dirk, Schuebeler (2018) Job description for Post-doc position. Distributed to academic collaborator.

Gallou, Fabrice (2018) Copper-Catalyzed Oxidative Cleavage of Electron-Rich Olefins in Wa-ter at Room Temperature. Organic letters, 20 (17). pp. 5094-5097.

Gallou, Fabrice (2018) Forewords of Symposium in Print issue on Process Chemistry for Bioorganic and Medicinal Chemistry. Bioorganic and medicinal chemistry.

Gallou, Fabrice (2018) Inspiring process innovation via a breakthrough green manufacturing metric: iGAL. Green chemistry, 20. pp. 2206-2211.

Gallou, Fabrice (2018) Journal highlight for the article: π-Allylpalladium Species in Micelles of FI-750-M for Sustainable and General Suzuki-Miyaura Couplings of Unactivated Quinoline Systems in Water. ChemCatChem., 10 (19). pp. 4229-4233.

Gallou, Fabrice (2018) PQS-Enabled Visible-Light Photoredox Ir Catalysis in Water at Room Temperature. Green chemistry, 20 (Green ). pp. 1233-1237.

Gallou, Fabrice and Handa, Sachin (2018) π-Allyl Palladium Species in Micelles of FI-750-M for Sustainable and General Suzuki-Miyaura Couplings of Quinoline Systems in Water. ChemCatChem, 10 (19). pp. 4229-4233.

Gallou, Fabrice and Handa, Sachin (2018) Micelle-Enabled Clean Sulfonylation of Polyfluoroarenes in Water Under Mild Conditions. Green chemistry. ISSN 1463-9270; 1463-9262

Gallou, Fabrice and Lipshutz, Bruce (2018) B-Alkyl sp3-sp2 Suzuki-Miyaura Couplings Under Mild Aqueous Micellar Conditions. Organic letters, 20 (10). pp. 2902-2905. ISSN 1523-7052; 1523-7060

Gallou, Fabrice and Walde, Peter (2018) Aqueous soft dispersed interface-rich systems that promote and guide chemical reactions. Nature reviews chemistry, 2. pp. 306-327.

Gallou, Fabrice and lipshutz, Bruce (2018) Sustainable, Copper-Free HandaPhos-ppm Palladium Technology for Sonogashira Couplings in Water Under Mild Conditions. Organic letters, 20. pp. 542-545. ISSN 1523-7052; 1523-7060

Gallou, Fabrice and lipshutz, Bruce (2018) Transition Metal Synergy in Fe Nanoparticles Doped with ppm Levels of (Pd + Ni). A New Catalyst for Nitro Group Reductions under Environmentally Responsible Conditions. Green chemistry, 20. pp. 130-135. ISSN 1463-9270; 1463-9262

Galyan, Keith and Reilly, John (2018) Green Chemistry Approaches for the Purification of Pharmaceuticals. Current Opinion in Green and Sustainable Chemistry.

Gampe, Christian, White, Amy, Siva, Swetha, Zecri, Frederic and Diener, John (2018) 3′-Modification stabilizes mRNA and increases translation in cells. Bioorganic and Medicinal Chemistry Letters. ISSN 1464-3405

Garito, Tania (2018) PhD Thesis of Tania Garito, MD: THE METABOLIC IMPLICATIONS OF CHANGES IN BODY COMPOSITION. Thesis, University of Milan.

Gauthier, Anne, Fisch, Andreas, Seuwen, Klaus, Baumgarten, Birgit, Ruffner, Heinz, Aebi, Alexandra, Rausch, Martin, Bartneck, Matthias, Weiskirchen, Ralf, Tacke, Franck, Storm, Gert, Lammers, Twan and Ludwig, Marie-Gabrielle (2018) Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials.

Gauthier, Anne, Fisch, Andreas, Seuwen, Klaus, Baumgarten, Birgit, Ruffner, Heinz, Aebi, Alexandra, Rausch, Martin, Bartneck, Matthias, Weiskirchen, Ralf, Tacke, Frank, Storm, Gert, Lammers, Twan and Ludwig, Marie-Gabrielle (2018) Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing. Biomaterials.

Geneste , Olivier, Clapéron, Audrey, Colland, Frédéric, Kraus-Berthier, Laurence, Le Toumelin-Braizat, Gaëtane, Studeny, Aurélie, Guasconi, Ghislaine, Bruno, Alain, Chanrion, Maia, Lysiak-Auvity, Gaelle, Girard, Anne-Marie, Schneider, Emilie, Gravé, Fabienne, Casara, Patrick, Le Diguarher, Thierry, Starck, Jérome-Benoit, Henlin, Jean-Michel, Murray, James, Davidson, James, Chen, Ijen, Whitehead, Neil, Graham, Christopher, Matassova, Natalia, Dokurno, Pawel, Pedder, Christopher, Hubbard, Roderick, Wood, Mike, Morris, Erick, Wang, Youzhen, Qiu, Shumei, Amiot, Martine, Maïga, Sophie, Le Gouill, Steven, Vogler, Meike, Cohen, Gerry M, Dyer, Martin JS, Rocchetti, Franscesca and Hickman, John A. (2018) S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget, 9 (28). pp. 20075-20088. ISSN 19492553

Glaenzel, Ulrike, Jin, Yi, Nufer, Robert, Li, Wenkui, Schroer, Kirsten, Adam, Sylvie, van Marle, Sjoerd Peter, Legangneux, Eric, Borell, Hubert, James, Alexander David, Meissner, Axel, Camenisch, Gian P. and Gardin, Anne (2018) Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism. Drug metabolism and disposition, 46 (7). pp. 1001-1013. ISSN 1521-009X

Glowienke, Susanne (2018) Potential impurities in drug substances: Compound-specific toxicology limits for 20 synthetic reagents and by-products, and a class-specific toxicology limit for alkyl bromides. Regulatory Toxicology and Pharmacology, 94. pp. 172-182. ISSN 10960295

Glowienke, Susanne and Glogovac, Milica (2018) Making reliable negative predictions of human skin sensitisation using an in silico fragmentation approach. Regulatory toxicology and pharmacology.

Gordillo-Sala, Marta, Auberson, Yves and Adell, Albert (2018) Signaling pathways responsible for the rapid anti-depressant effects of a GluN2A-preferring NMDA receptor antagonist. Translational psychiatry. ISSN 2158-3188

Gounarides, John and Cook, Frank (2018) Sample Preparation and LC-MS methods for the measurement of NAD, NADP, NADPH. NADH and NMN. no journal, none (none). ISSN none

Groot Kormelink, Paul, Bouhelal, Rochdi, Corminboeuf , Olivier, Kenakin , Terry, Durroux , Thierry, Pin , Jean-Philippe, Roux, Thomas, Bdioui, Sara, Trinquet, Eric, Pierre, Pierre, Scholler , Pauline and Degorce, Francois (2018) Sharing meaningful and relevant assay data – the experts' opinion. CisBio Expert Opinion.

Growcott, Ellena, Bamba, Douty, Galarneau, Jean-Rene, Leonard, Vincent, Schul, Wouter, Stein, Daniel and Osborne, Colin (2018) The Effect of P38 MAP Kinase Inhibition in a Mouse Model of Influenza. Journal of Medical Microbiology. ISSN 0022-26151473-5644

Grunseich, Christopher, Miller, Ram, Swan, Therese, Glass, David, El Mouelhi, Mohamed, Fornaro, Mara, Petricoul, Olivier, Vostiar, Igor, Roubenoff, Ronenn, Meriggioli, Matthew, Kokkinis, Angela, Guber, Robert D., Budron, Maher S. , Vissing, John, Soraru, Gianni, Mozaffar, Tahseen, Ludolph, Albert, Kissel, John T and Fischbeck, Kenneth H. (2018) A placebo-controlled study to evaluate the safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy. Lancet Neurology.

Guo, Chenying, Qu, Paul, Rangaswamy, Nalini, Leehy, Barrett, Xiang, Chuanxi, Rice, Dennis and Prasanna, Ganesh (2018) A murine glaucoma model induced by rapid in vivo photopolymerization of hyaluronic acid glycidyl methacrylate. PLoS ONE, 13 (6). N/A-N/A. ISSN 19326203

Haidar Ahmad, Imad and Blasko, Andrei (2018) Two Dimensional Liquid Chromatography (2DLC) in pharmaceutical analysis. Applications beyond increasing peak capacity. Chromatographia, 81. pp. 401-418. ISSN 0009-5893

Haiser, Henry, Oakeley, Edward James, Porter, Jeffrey, Rudolph, Sabine, Ke, Xiaobo and Young, Rachel (2018) Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life. Nature Microbiology. ISSN 20585276

Hallam, Dean, Hilgen2, Gerrit , Dorgau, Birthe , Yu, Min , Zhu, Lili , Bojic, Sanja , Hewitt, Philip , Schmitt, Michael , Uteng, Marianne, Kustermann, Stefan , Steel, David , Nicholds, Mike , Thomas, Robert , Treumann, Achim , Porter, Andrew , Sernagor, Evelyne , Armstrong, Lyle and Lako, Majlinda (2018) Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency. Stem Cells. ISSN 15494918

Han, Wooseok, Ma, Xiaolei and Uehara, Tsuyoshi (2018) Small molecule and fragment inhibitors of E. coli LpxA. Nature chemical biology.

Harding, James J. , Bauer, Todd M., Tan, Daniel, Bedard, Philippe L. , Rodon, Jordi, Doi, Toshihiko, Schnell, Christian, Iyer, Varsha, Baffert, Fabienne, Radhakrishnan, Rajkumar, Fabre, Claire and Juric, Dejan (2018) Characterization and first-in-human data of CLR457, an orally bioavailable pan-class I PI3-Kinase inhibitor. Investigational new drugs. ISSN 1573-0646; 0167-6997

Hartmann, Stephanie, Zheng, Fang, Kyncl, Michele Constanze, Karch, Sandra, Voelkl, Kerstin, Zott, Benedikt, D'Avanzo, Carla, Lomoio, Selene, Tesco, Giuseppina, Kim, Doo Yeon, Alzheimer, Christian and Huth, Tobias (2018) Beta secretase BACE1 promotes surface expression and function of Kv3.4 potassium channels in hippocampal mossy fiber synapses. Journal of Neuroscience. ISSN 0270-6474

Hauptmann, Astrid, Podgoršek, Katja, Kuzman, Drago, Srčič, Stanko, Hoelzl, Georg and Loerting, Thomas (2018) Impact of Buffer, Protein Concentration and Sucrose Addition on the Aggregation and Particle Formation during Freezing and Thawing. Pharmaceutical Research, 35 (5). ISSN 0724-8741

Ho, Pei-I, Casalena, Dominick and Auld, Douglas (2018) Characterization and use of Turbo Luciferase as a reporter for high-throughput assays. Biochemistry. ISSN 10.1021/acs.biochem.8b00290

Hoffman, Ben, Baba, Yoshichika, Griffith, Theanne, Masharov, Eugene, Woo, Seung, Roybal, Daniel, Karsenty, Gerard, Patapoutian, Ardem, Sulzer, David and Lumpkin, Ellen (2018) Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses. Neuron, 100 (6). pp. 1401-1413. ISSN 10974199

Hong, E. Erica, Qiu, Qifeng, Wu, Rui, Wilhelm, Alan, Erickson, Hans, Abrams, Tinya, Deeds, Jim, Wang, Zhen, Ghoddusi, Majid and Schleyer, Siew (2018) Preclinical Antitumor Activity of a Novel Anti–c-KIT Antibody–Drug Conjugate against Mutant and Wild-type c-KIT–Positive Solid Tumors. Clinical Cancer Research, 24 (17). pp. 4297-4308. ISSN 15573265

Hsiao, Hsiu-Ling, Langenickel, Thomas Heiko, Petruck, Jesika, Kode, Kiran Kumar, Ayalasomayajula, Surya, Schuehly, Uwe, Greeley, Michael, Pal, Parasar, Zhou, Wei, Prescott, Margaret, Sunkara, Gangadhar and Rajman, Iris (2018) Evaluation of Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction of Sacubitril/Valsartan (LCZ696) and Sildenafil in Patients With Mild-to-Moderate Hypertension. Clinical Pharmacology and Therapeutics, 103 (3). pp. 468-476. ISSN 1532-6535

Hsiao, Hsiu-Ling, Langenickel, Thomas Heiko, Petruck, Jesika, Kode, Kiran Kumar, Ayalasomayajula, Surya, Schuehly, Uwe, Greeley, Michael, Pal, Parasar, Zhou, Wei, Prescott, Margaret, Sunkara, Gangadhar and Rajman, Iris (2018) Evaluation of Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction of Sacubitril/Valsartan (LCZ696) and Sildenafil in Patients With Mild-to-Moderate Hypertension. Clinical Pharmacology and Therapeutics, 103 (3). pp. 468-476. ISSN 1532-6535

Hsieh, Hsiao-Wu, Robinson, Richard, Coley, Connor, Jensen, Klavs and Baumgartner, Lorenz (2018) Photoredox Iridium-Nickel Dual Catalyzed Decarboxylative Arylation Cross-Coupling: From Batch to Continuous Flow via Self-Optimizing Segmented Flow Reactor. Organic process research & development, 22 (4). pp. 542-550. ISSN 1520-586X; 1083-6160

Hu, Lu, Liu, Yahu and Liao, Xuebin (2018) Recent Progress in Methylation of (Hetero)Arenes by Cross-Coupling or C-H Activation. Synlett, 29 (4). pp. 375-382. ISSN 14372096

Huels, DJ, McLaughlin, Margaret, Bruens, L, Hodder, MC, Cammareri, P, Campbell, AD, Ridgway, RA, Gay, DM, Solar-Abboud, M, Faller, WJ, Nixon, C, Zeiger, LB, Morrissey, E, Winton, DJ, Snippert, HJ, Rheenen van, J and Sansom, OJ (2018) Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nature Communications, 9 (1). ISSN 20411723

Hurley, Timothy, Kerrigan, John, Shu, Lei, Shen, Yiping, Sung, Moo, O'Brien, Gary, Hou, Ying, Axford, Jake, Deng, Lin, Hoffmaster, Keith, Shin, Youngah, Servais, Rebecca, Towler, Christopher, Hild, Marc, Briner, Karin, Dietrich, Bill, Sivasankaran, Rajeev, Dales, Natalie, Chin, Donovan, Sun, Robert, Cody, Emma, Fazal, Aleem, Tomlinson, Ronald, Song, Cheng, Jain, Monish, Van Hoosear, Mailin, Hamann, Lawrence, Curtis, Daniel, Kobayashi, Dione, Chen, Karen, Fridrich, Cary and Sanchez, Carina (2018) Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA). Journal of medicinal chemistry, 61 (24). pp. 11021-11036. ISSN 0022-2623

Huth, Felix and Einolf, Heidi (2018) Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective. Clinical Pharmacology and Therapeutics. ISSN 15326535

Huynh, Hung, Lee, Liek Yeow , Ong, Richard, Hao, Huaixiang, Huang, Alan, Wang, Youzhen, Graus Porta, Diana, Chow, Pierce, Ong, Hock Soo and Chung, Alexander (2018) Infigratinib mediates vascular normalization, impairs metastasis and improves chemotherapy in hepatocellular carcinoma. Hepatology. ISSN 1527-3350; 0270-9139

Isaacs, Randi, Chen, Xueying, Graus Porta, Diana, Parker, Katie, Yu, Kun and Porter, Dale (2018) Efficacy of BGJ398, a fibroblast growth factor receptor (FGFR) 1-3 inhibitor, in patients with previously treated advanced urothelial carcinoma with FGFR3 alterations. Cancer discovery. ISSN 2159-8290; 2159-8274

Isbell, John, Yuan, Ding, Reis Da Silva Torrao, Leonel, Gatlik, Ewa, Hoffmann, Laurent and Wipfli, Peter (2018) Plasma protein binding of highly bound drugs determined with equilibrium gel filtration of non-radiolabeled compounds and LC-MS/MS detection. J Pharmaceutical Sciences.

Israel, Laura, Bardet, Maureen, Huppertz, Antje, Mercado, Nicolas, Ginster, Stefanie, Unterreiner, Adeline, Schlierf, Anita, Goetschy, Jean Francois, Zerwes, Hans-Guenter, Roth, Lukas, Kolbinger, Frank and Bornancin, Frederic (2018) A CARD10-dependent tonic signalosome activates MALT1 paracaspase and regulates IL-17/TNF-a driven keratinocyte inflammation. Journal of investigative dermatology: Symposium proceedings.. ISSN 1529-1774; 1087-0024

Israel, Laura and Bornancin, Frederic (2018) Ways and waves of MALT1 paracaspase activation. Cellular & molecular immunology :.

Jacquemont, S, Pacini, L, Cencelli, G, Jønch, E, Andrea, D, Willemsen, R, Tassone, F, Hagerman, R, Bagni, C, Gasparini, Fabrizio, He, Yunsheng, Rozenberg, Izabela and Gomez-Mancilla, Baltazar (2018) Altered and normal levels of protein synthesis in fragile X syndrome, studies in humans and mice. Science translational medicine, 27 (12). pp. 2039-2051. ISSN 10.1093/hmg/ddy099

Jerby-Arnon, Livnat, Shah, Parin, Cuoco, Michael S, Rodman, Christopher, Su, Mei-Ju, Melms, Johannes C, Leeson, Rachel, Kanodia, Abhay, Mei, Shaolin, Lin, Jia-Ren, Wang, Shu, Rabasha, Bokang, Liu, David, Zhang, Gao, Margolais, Claire, Ashenberg, Orr, Ott, Patrick A, Buchbinder, Elizabeth I, Haq, Rizwan, Hodi, F Stephen, Boland, Genevieve M, Sullivan, Ryan J, Frederick, Dennie T, Miao, Benchun, Moll, Tabea, Flaherty, Keith T, Herlyn, Meenhard, Jenkins, Russell W, Thummalapalli, Rohit, Kowalczyk, Monika S, Cañadas, Israel, Schilling, Bastian, Cartwright, Adam N R, Luoma, Adrienne M, Malu, Shruti, Hwu, Patrick, Bernatchez, Chantale, Forget, Marie-Andrée, Barbie, David A, Shalek, Alex K, Tirosh, Itay, Sorger, Peter K, Wucherpfennig, Kai, Van Allen, Eliezer M, Schadendorf, Dirk, Johnson, Bruce E, Rotem, Asaf, Rozenblatt-Rosen, Orit, Garraway, Levi A, Yoon, Charles H, Izar, Benjamin and Regev, Aviv (2018) A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell, 175 (4). 984-997.e24. ISSN 1097-4172

Ji, Yan, Jin , Jin Y., Hyman, David, Kim, Geoffrey and Suri, Ajit (2018) Challenges and Opportunities in Dose Finding in Oncology and Immuno-oncology. Clinical and Translational Science, 00. pp. 1-7.

Jiang, Xiaomo (2018) INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. ELife., 7. ISSN 2050-084X

Johasz, Christian, Nassim , Rousset, Kasper, Renggli and Hierlemann, Andreas (2018) Scalable Microfluidic Platform for Flexible Configuration of and Experiments with Microtissue Multiorgan Models. SLAS. pp. 1-17.

Jones, Adriana, Ranjitkar, Srijan, Lopez, Sara, Li, Cindy, Blais, Johanne, Reck, Folkert and Dean, Charles (2018) Impact of inducible blaDHA-1 on susceptibility of Klebsiella pneumoniae clinical isolates to LYS228 and identification of chromosomal mpl mutations mediating upregulation of plasmid borne DHA-1 expression. Antimicrobial agents and chemotherapy, 62 (10).

Jourdain, Marie, Melly, Stefan, Summermatter, Serge and Hatakeyama, Shinji (2018) Mouse models of cancer-induced cachexia: Hind limb muscle mass and evoked force as readouts. Biochemical and biophysical research communications : BBRC. ISSN 1090-2104

Juric, Dejan, Janku, Filip, Rodon, Jordi, Burris, Howard A., Mayer, Ingrid A., Schuler, Martin, Seggewiss-Bernhard, Ruth, Gil-Martin, Marta, Middleton, Mark R., Baselga, Jose, Bootle, Douglas, Demanse, David, Blumenstein, Lars, Schumacher, Karl, Huang, Alan, Quadt, Cornelia and Rugo, Hope S. (2018) Alpelisib (BYL719) plus Fulvestrant in PIK3CA-altered and PIK3CA wild-type ER+ advanced breast cancer. An open-label, phase 1b dose-escalation and expansion study. JAMA oncology, Oncol.. E1-E9. ISSN 2374-2437

Kaesler, Nadine, Verhulst, Anja, De Maré, Annelies, Deck, Annika, Behets, Geert J., Hyusein, Ayshe, Evenepoel, Pieter, Floege, Jürgen, Marx, Nikolaus, Babler, Anne, Kramer, Ina, Kneissel, Michaela, Kramann, Rafael, Weis, Daniel, D`Haese, Patrick C. and Brandenburg, Vincent M. (2018) Sclerostin-deficiency modifies the development of CKD-MBD in mice. Bone, 107. pp. 115-123. ISSN 1873-2763; 8756-3282

Kall, Morten A., Michi, Marco, Van der Strate, Barry, Freisleben, Achim, Stoellner, Daniela and Timmerman, Philip (2018) Incurred sample reproducibility: 10 years of experiences: Views and recommendations from the European Bioanalysis Forum. Bioanalysis, 10 (21). pp. 1723-1732. ISSN 17576199

Kapur, Reuben, Cai, Zhigang, Pandey, Ruchi, Mali, Rahuveer, Ramdas, Baskar, Sandusky, George, Kelley, Mark and Mohseni, Mori (2018) Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cell Stem Cell, 23 (6). 833-849.e5. ISSN 18759777

Karpov, Alexei, Abrams, Tinya, Clark, Suzy, Raikar, Ankita, D'Alessio, Tony, Gesner, Tom, Jones, Darryl, Lacaud-Baumlin, Marion, Martyniuk, Piotr, Meredith, Erik, Mohseni, Mori, Nieto-Oberhuber, Cristina, Palacios, Daniel, Perruccio, Francesca, Zurini, Mauro and Bialucha, Carl (2018) Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Medicinal Chemistry Letters. ISSN 19485875

Katoli, Parvaneh, Godbole, Adarsh, Romanowski, Michael, Clark, Kirk, Meredith, Erik, Saenz-Vash, Veronica, Wang, Yingqi, Lewicki, Nancy, Nguyen, Andrew and Lynch, Jeffrey (2018) Full-length myocilin (MYOC) protein is purified from mammalian cells as a dimer. Protein expression and purification, 147 (2018). pp. 38-48. ISSN 1096-0279; 1046-5928

Katsumiti, Alberto, Thorley, Andrew J, Arostegui, Inmaculada, Reip, Paul, Valsami-Jones, Eugenia, Tetley, Teresa D and Cajaraville, Miren P (2018) Cytotoxicity and cellular mechanisms of toxicity of CuO NPs in mussel cells in vitro and comparative sensitivity with human cells. Toxicology in vitro : an international journal published in association with BIBRA, 48. pp. 146-158. ISSN 1879-3177

Kenny, Jane, Ramsden, Diane, Buckley, David, Dallas, Shannon, Fung, Conrad, Mohutsky, Michael, Einolf, Heidi, Chen, Liangfu, Dekeyser, Joshua, Fitzgerald, Maria, Goosen, Theunis, Siu, Y. Amy, Walsky, Robert, Zhang, George, Tweedie, Donald and Hariparsad, Niresh (2018) Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevance. Drug Metabolism and Disposition, 46 (9). pp. 1285-1303. ISSN 0090-95561521-009X

Kim, Kwang Soo, Marcogliese, Paul C., Yang, Jungwoo, Callaghan, Steve, Resende, Virginia, Abdel-Messih, Elizabeth, Marras, Connie, Visanji, Naomi P., Huang, Jana, Schlossmacher, Michael G., Tinkle-Mulcahy, Laura, Slack, Ruth S., Lang, Anthony E. and Park, David S. (2018) Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease. Proceedings of the National Academy of Sciences, 115 (22). ISSN 0027-84241091-6490

King, Daniel, Nguyen, Zachary, Jimenez, Marta, Auld, Douglas, Kool, Eric, Tahara, Yu-ki, Ji, Debin, Beharry, Andrew, Kietrys, Anna M. and Wilson, David M. (2018) Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. Journal of the American Chemical Society, 140 (6). pp. 2105-2114. ISSN 15205126

Kittelmann, Matthias, Worsch, Anne, Girhard, Marco, von Bühler, Clemens , Tieves, Florian , Czaja, Rico , Vogel, Andreas , Grumaz, Christian , Sohn, Kai , Lütz, Stephan and Urlacher, Vlada (2018) A novel cytochrome P450 monooxygenase from Streptomyces platensis resembles activities of human drug metabolizing P450s. Biotechnol Bioeng..

Klopp, Julia, Winterhalter, Aurelie, Gebleux, Remy, Scherer-Becker, Daniela, Ostermeier, Christian and Gossert, Alvar (2018) Cost-effective large-scale expression of proteins for NMR studies. Journal of Biomolecular NMR. pp. 1-16. ISSN 15735001

Knoepfel, Thomas, Furet, Pascal, Mah, Robert, Buschmann, Nicole, Leblanc, Catherine, Ripoche, Sebastien, Graus Porta, Diana, Wartmann, Markus and Galuba, Inga (2018) 2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4. ACS Medicinal Chemistry Letters, 9 (3). pp. 215-220. ISSN 19485875

Koga, Tadanori, Barkley, Deborah, Nagao, Michihiro, Taniguchi, Takashi, Carrillo, Jan-Michael Y., Sumpter, Bobby G., Masui, Tomomi, Kishimoto, Hiroyuki, Koga, Maho, Rudick, Jonathan G. and Endoh, Maya K. (2018) Interphase Structures and Dynamics near Nanofiller Surfaces in Polymer Solutions. Macromolecules, 51 (23). pp. 9462-9470. ISSN 0024-9297

Kou, Jianqun, Staal, Ben, Musich, Phillip, Kang, Liang , Qin, Yuan, Yao, Zhi, Zhang, Boheng, Tam, Angela, Huang, Alan, Hao, Huaixiang, Vande Woude, George and Xie, Qian (2018) Differential Therapeutic Responses of MET Oncogenic Activations to MET Kinase Inhibitor and Neutralizing Antibody. Journal of translational medicine, 16 (253 ). ISSN 1479-5876

Krantz, Carsten, Warren, Andrew Paul and Miess, Christian (2018) Development of an automated, interference-free, immunoaffinity-based mass spectrometric assay for quantification a therapeutic monoclonal antibody in human sera. Bioanalysis, 10 (13). pp. 1023-1037. ISSN 1757-6180

Krischuns, Tim, Günl, Franziska, Henschel, Lea, Binder, Marco, Willemsen, Joschka, Schloer, Sebastian, Rescher, Ursula, Gerlt, Vanessa, Zimmer, Gert, Nordhoff, Carolin, Ludwig, Stephan and Brunotte, Linda (2018) Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Frontiers in immunology, 9. p. 2229. ISSN 1664-3224

Kucher, Klaus, Johns, Donald, Maier, Doris, Abel, Rainer, Badke, Andreas, Baron, Hagen, Thietje, Roland, Casha, Steven, Meindl, Renate, Gomez-Mancilla, Baltazar, Pfister, Christian, Mir, Anis Khusro, Rupp, Rüdiger, Weidner, Norbert, Schwab, Martin and Curt, Armin (2018) First-in-Man Intrathecal Application of Neurite Growth-Promoting Anti-Nogo-A Antibodies in Acute Spinal Cord Injury. Neurorehabilitation and Neural Repair, 32 (6-7). pp. 578-589. ISSN 1545-96831552-6844

L'Italien, Lawrence, Orozco, Olivia, Abrams, Tinya, Cantagallo, Lisa, Connor, Anu, Desai, Jayesh, Ebersbach, Hilmar, Gelderblom, Hans, Hoffmaster, Keith, Maacke, Heiko, Schleyer, Siew, Skegro, Darko and Lee-Hoeflich, Si Tuen (2018) Mechanistic insights of an immunological adverse event induced by an anti-KIT antibody drug conjugate and mitigation strategies. Clinical Cancer Research, 24 (14). pp. 3465-3474. ISSN 15573265

LaRochelle, Jonathan R., Fodor, Michelle, Vemulapalli, Vidyasiri, Mohseni, Mori, Wang, Ping, Stams, Travis, Lamarche, Matthew, Chopra, Rajiv, Acker, Michael and Blacklow, Stephen C. (2018) Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nature Communications, 9 (1). ISSN 20411723

Labarbarie, Bertrand (2018) Engineering of Mouse Embryonic Fibroblasts (MEFs) derived from Cas9 animals for in vitro and in vivo studies of resistance. Internship report.

Lamb, John, Horman, Shane, Trifonov, Vladimir, Orth, Anthony, Lesley, Scott, To, Jeremy, Zhang, Jia, Jennings, Lori, Emilsson, Valur, IIkov, M, Aspelund, Thor, Gudmundsson, EF, Jakobsdottir, J, Manolescu, A, Harris, TB, Launer, LJ, Eiriksdottir, G, Gudnason, Vilmandur, Finkel, Nancy, Pitts, Rebecca, Hoover, Heather, Gudmundsdottir, Valborg, Shu, Le, Sigurdsson, Sigurdur, Zhu, Jun, Olafsson, Orn, Harris, Tamara, Zhang, Bin and Yang, Xia (2018) Co-regulatory networks of human serum proteins link genetics to disease. Science, 361 (6404). pp. 769-773. ISSN 10959203

Langevin, Nicholas, Schafer, Kenneth, Turner, Oliver, McPherson, Brittany and Rose, Robert (2018) Historical Data: Histopathology Lesions Observed in the Eyes of Control Rabbits in Topical Ocular Administration and Contact Lens Studies. Toxicologic Pathology, 46 (7). pp. 799-820. ISSN 15331601

Lapp, Stefanie, Bube, Axel, Ernst, Heinrich, Colbatzky, Florian, Kellner, Rupert, Nolte , Thomas and Rinke, Matthias (2018) Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*). Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*).

Laternser, Sandra, Keller, Hansjoerg, Leupin, Olivier, Rausch, Martin, Graf-Hausner, Ursula and Rimann, Markus (2018) A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues. SLAS TECHNOLOGY: Translating Life Sciences Innovation. ISSN 2472-63032472-6311

Laura, Magil, Marsilio, Adriani, Véronique, Berthou, Keguan, Chen, Aude, Gleizes, Salima, Hacein-Bey-Abina, Agnes, Hincelin-Mery, Xavier, Mariette, Marc, Pallardy, Spindeldreher, Sebastian, Natacha, Szely, David, Isenberg, Jessica, Manson, Elizabeth, Jury and Claudia, Mauri (2018) Low Percentage of Signal Regulatory Protein α/β+ Memory B Cells in Blood Predicts Development of Anti-drug Antibodies (ADA) in Adalimumab-Treated Rheumatoid Arthritis Patients. Frontiers in immunology, 9. ISSN 16643224

Laux, Holger, Romand, Sandrine, Nuciforo, Sandro, Farady, Christopher, Tapparel, Joel Alois Rene, Buechmann-Moeller, Stine, Sommer, Benjamin, Oakeley, Edward James and Bodendorf, Ursula (2018) Degradation of recombinant proteins by CHO host cell proteases is prevented by Matriptase-1 knock-out. Biotechnology and bioengineering. ISSN 00063592

Laux, Holger, Romand, Sandrine, Tapparel, Joel Alois Rene, Nuciforo, Sandro, Buechmann-Moller, Stine, Dogrusoez, Guelay, Probst, Claudia Monika, Sommer, Benjamin, Oakeley, Edward James and Bodendorf, Ursula (2018) Degradation of recombinant proteins of diverse formats by CHO host cell proteases is circumvented via knock-out of CHO matriptase. BMC proceedings., 12(Sup (3). pp. 2-3.

Lee, Patrick, Lapointe, Guillaume, Madera, Ann Marie, Simmons, Bob, Xu, Wenjian, Yifru, Aregahegn, Tjandra, Meiliana, Karur, Subramanian, Rico, Alice, Thompson, Katherine, Bojkovic, Jade, Xie, Lili, Uehara, Kyoko, Liu, Amy, Shu, Wei, Bellamacina, Cornelia, Mckenney, David, Morris, Laura, Osborne, Colin, Benton, Bret, McDowell, Laura, Fu, Jiping and Sweeney, Zachary (2018) Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline. Journal of medicinal chemistry.

Leeds, Jennifer (2018) LpxD project. various.

Lehmann, Hansjoerg (2018) Diazomethane and Flow Chemistry: Filling a Gap in Pharma R&D. Chimica oggi : = Chemistry today..

Lei, Weiwei, Ren, Wenwen, Ohmoto, Makoto, Redding, Kevin, Littlewood-Evans, Amanda, Carballido, Jose, Urban, Joseph, Margolskee, Robert, Matsumoto, Ichiro and Jiang, Peihua (2018) Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proceedings of the National Academy of Sciences. ISSN 0027-84241091-6490

Li, Jianyu , Weber, Eckhard, Guth-Gundel, Sabine, Schuleit, Michael, Kuttler, Andreas, Halleux, Christine, Accart Gris, Nathalie, Doelemeyer, Arno, Basler, Anne, Tigani, Bruno, Wuersch, Kuno, Fornaro, Mara, Kneissel, Michaela, Stafford, Alexander , Freedman, Benjamin R and Mooney, David J (2018) Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs. Advanced Healthcare Materials, 7 (9). 1701393 (1) -1701393 (10). ISSN 21922640

Li, Wenkui, Doherty, John, Fu, Yunlin and Flarakos, Jimmy (2018) Quantitative analysis of clofazimine (Lamprene®), an antileprosy agent, in human dried blood spots using liquid chromatography–tandem mass spectrometry. Biomedical Chromatography, 32 (2). ISSN 10990801

Lightfoot, Helen, Frederick, Goldberg and Sedelmeier, Joerg Mathias (2018) Evolution of Small Molecule Kinase Drugs. Journal of Medicinal Chemistry Letters (ACS).

Lima, Fabio, Grunenberg, Lars, Husaini, Mohamed, Labes, Ricardo, Sedelmeier, Joerg Mathias and Ley, Steven (2018) Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow. Chemical Communications, 54 (44). pp. 5606-5609. ISSN 1364548X

Lindner, John Michael, Friedensohn, Simon, Cornacchione, Vanessa, Iazeolla, Mariavittoria, Miho, Enkelejda, Zingg, Andreas, Meng, Simon, Traggiai, Elisabetta and Reddy, Sai (2018) High-throughput sequencing error and bias correction increases the quantitative resolution of human naïve and memory B-cell receptor repertoires. BioRxiv Preprint Server, NA (NA). ISSN NA

Liu, Xin (2018) Profile-QSAR的发展. Undergraduate thesis, Fudan University, Shanghai, China.

Lofgren, Jennie (2018) AALAS Seminar Series: The Laboratory Animal Medical Professional’s Guide to How the 3R’s Enhance Rigor and Reproducibility. Laboratory Animal Science Professional.

Lopez, John (2018) N-Butylpyrrolidone as a green solvent for Solid Phase Peptide Synthesis. Organic process research & development, 22. pp. 494-503. ISSN 1520-586X; 1083-6160

Loren, Jon, Herath, Ananda, Molteni, Valentina and Pan, Shifeng (2018) Generation and Cross-Coupling of Organozinc Reagents in Flow. Organic Letters. ISSN 1523-70601523-7052

Luen, SJ, Lee, CK, Savas, P, Kammler, R, Dell’Orto, P, Biasi, OM, Demanse , D, JeBailey , J, Dolan, S, Hackl, W, Thuerlimann, B, Viale, G, Colleoni , M, Regan, MM and Loi, S (2018) Association of somatic driver alterations with prognosis in postmenopausal, hormone receptor-positive, HER2-negative early breast cancer - A secondary analysis of the BIG 1-98 randomized clinical trial. JAMA Oncology, Publis (June 1). E1-E9. ISSN n.a.

Lynch, Jeffrey, Dolman, Andrew, Guo, Chenying, Li, Bing and Prasanna, Ganesh (2018) A pathologic MYOC mutation results in a novel skeletal muscle phenotype. PLoS ONE, 13 (11). e0206801. ISSN 1932-6203

Lynch, Jeffrey, Li, Bing, Katoli, Parvaneh, Xiang, Chuanxi, Leehy, Barrett, Rangaswamy, Nalini, Saenz-Vash, Veronica, Wang, Yingqi, Lei, Hong, Nicholson, Thomas, Meredith, Erik, Chen, Amy, Prasanna, Ganesh and Rice, Dennis (2018) Myocilin binding to a-b-crystallin sheds light on an old and blinding disease. Journal of Biological Chemistry, 293 (52). pp. 20137-20156.

Ma, Shang, Cahalan, Stuart, Rakhee, Lohia, Gregory, LaMonte, Weizheng, Zeng, Swetha, Murthy, Emma, Paytas, Nathan D, Grubaugh, Ramya, Gamini, Laurence, Berry, Viktor, Lukacs, Tess, Whitwam, Meaghan, Loud, Schmedt, Christian, Andrew I, Su, Kristian G, Andersen, Elizabeth A, Winzeler, Eric, Honore, Kai, Wengelnik and Ardem, Patapoutian (2018) Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell, 173 (2). 443-455.e12. ISSN 10974172

Mac Donald, Alisdair J, Miller, Janice, Ramage, Michael I, Greig, Carolyn, Stephans, Nathan A, Jacobi, Carsten, Preston, Thomas, Fearon, Kenneth CH and Skipworth, Richard JE (2018) Cross sectional imaging of truncal and quadriceps muscles relates to different functional outcomes in cancer. Clinical nutrition.. ISSN 1878-3368; 1744-1161

Maclachlan, Timothy, Milton, Mark, Turner, Oliver, Bigelow, Chad, Tukov, Francis, Choi, Vivian, Penraat, Jan, Delmotte, Marie Helene, Michaut, Lydia and Jaffe, Bruce (2018) Nonclinical safety evaluation of scAAV8-RLBP1 (CPK850) for treatment of RLBP1 retinitis pigmentosa. Human gene therapy - Clinical Development.

Manjunatha, Ujjini Havaldar, Chao, Alexander, Lee, Boon Heng, Wan, Kah Fei, Selva, Jeremy, Zou, Bin, Gedeck, Peter, Beer, David John, Diagana, Thierry Tidiane and Bonamy, Ghislain (2018) Development of a novel cytopathic effect-based phenotypic screening assay against Cryptosporidium. ACS infectious diseases. ISSN 2373-8227

Mannschott, Thomas, Krumme, Markus, Kreimer, Manuel, Aigner, Isabella, Sacher, Stephan, van der Wel, Peter, Kaptein, Albert, Schroettner, Hartmuth, Brenn, Guenter and Khinast, Johannes G. (2018) Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets. Powder Technology, 325. pp. 247-260. ISSN 1873328X

Marcomini, Isabella, Shimada, Kenji, Delgoshaie, Neda, Yamamoto, Io, Seeber, Andrew, Cheblal, Anais, Naumann, Ulrike, Horigome, Chihiro and Gasser, Susan (2018) Asymmetric Processing of DNA Ends at a Double-Strand Break Leads to Unconstrained Dynamics and Ectopic Translocation. Cell Reports, 24 (10). 2614-2628.e4. ISSN 22111247

Martin, Benjamin, Ganiek, Maximilian, Ivanova, Maria and Knochel, Paul (2018) Mild Homologation of Esters via Continuous Flow Chloroacetate Claisen Reactions. Angewandte Chemie. International edition, 57. pp. 1-6. ISSN 14337851

Martin, Benjamin, Lehmann, Hansjoerg, Yang, Hongwei, Chen, Like, Tian, Xiangguang, Polenk, Jutta and Schenkel, Berthold (2018) Continuous manufacturing as an enabling tool with green credentials in early-phase pharmaceutical chemistry. Current Opinion in Green and Sustainable Chemistry, 11. pp. 27-33.

Martin, Eric, Daga, Pankaj, Bolger, Michael, Haworth, Ian and Clark, Robert (2018) Physiologically-Based Pharmacokinetic Modeling in Lead Optimization I: Evaluation and Adaptation of GastroPlus® to Predict Bioavailability of Medchem Series. Molecular Pharmaceutics. ISSN 1543-83841543-8392

Martina, Maritan, Danielle, Veggi, Roberta , Cozi, Lucia, Ianaco, Erika, Bartolini, Paola, La Surdo, Giulietta, Maruggi, Spraggon, Glen, Matthew, Bottomley and Enrico, Malito (2018) Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody. PLoS ONE, 13 (8). ISSN 19326203

Masliah, Gregoire, Maris, Christophe, Koenig, Sebastian L.B., Yulikov, Maxim, Aeschimann, Florian, Malinowska, Anna L., Mabille, Julie, Weiler, Jan, Holla, Andrea, Hunziker, Juerg, Meisner Kober, Nicole-Claudia, Schuler, Benjamin, Jeschke, Gunnar and Allain, Frederic H.-T. (2018) Structural basis of siRNA recognition by TRBP double-stranded RNA binding domains. The EMBO Journal, 37. ISSN 0261-41891460-20750261-41891460-2075

Mathews Griner, Lesley, Gampa, Kalyani, Do, Toan, Hartkopf, Huyen, Farley, David, Auld, Douglas and Silver-Brown, Serena (2018) Generation of high-throughput three dimensional tumor spheroids for drug screening. Generation of high-throughput three dimensional tumor spheroids for drug screening , 3 (139).

McKenna, Jeffrey, Schirle, Markus and Thomas, Jason (2018) Disclosure of compounds to UCB for NB-CPACT. undetermined at present.

McMahon, Michael, Ding, Shaohong, Acosta Jimenez, Lourdes, Terranova, Remi, Gerard, Marie-Apolline, Vitobello, Antonio, Moggs, Jonathan, J. Henderson, Colin and Wolf, C. Roland (2018) CONSTITUTIVE ANDROSTANE RECEPTOR 1 IS CONSTITUTIVELY BOUND TO CHROMATIN AND ‘PRIMED’ FOR TRANSACTIVATION IN HEPATOCYTES. Molecular pharmacology. ISSN 1521-0111; 0026-895X

Mckenna, Jeffrey, Feng, Yan, Zheng, Lianxing, Bender, Steven, Cho, Charles, McWhirter, Sarah, Dubensky, Thomas, van Elsas, Andrea, Ndubaku, Chudi, Sivik, Kelsey, Desbien, Anthony and Hix-Glickman, Laura (2018) Magnitude of Therapeutic STING Activation Determines CD8<sup>+</sup> T Cell-Mediated Anti-tumor Immunity. Cell reports, 25 (11). p. 3074. ISSN 22111247

Meier, Silvio R, Syveanen, Stina, Hultquist, Greta, Fang, Xiaotiasn T, Roshanbin, Sahar, Lannfelt, Lars, Neumann, Ulf and Sehlin, Dag (2018) Antibody-based in vivo PET imaging detects amyloid-ß reduction in Alzheimer transgenic mice after BACE-1 inhibition. Journal of Nuclear Medicine, 59 (12). pp. 1901-1906. ISSN 2159662X

Messer, J.G., Mendieta Calle, J.L., Jiron, J.M., Castillo, E.J., Van Poznak, C., Bhattacharyya, N., Kimmel, D.B. and Aguirre, J.I. (2018) Zoledronic Acid Increases the Prevalence of Medication-related Osteonecrosis of the Jaw in Rice Rats (Oryzomys palustris) in a Dose Dependent Manner. Bone, 108 (3). pp. 79-88. ISSN 1873-2763; 8756-3282

Metz, Martin, Torene, Rebecca, Kaiser, Sergio, Beste, Michael, Staubach, Petra, Bauer, Andrea, Brehler, Randolf, Gericke, Janine, Letzkus, Martin, Hartmann, Nicole, Erpenbeck, Veit and Maurer, Marcus (2018) Omalizumab normalizes the gene expression signature of lesional skin in patients with chronic spontaneous urticaria: a randomized, double-blind, placebo-controlled study. Allergy. pp. 1-29. ISSN 1398-9995; 0105-4538

Milovanov, Maxim (2018) NEXT UI: evolution story. NEXT UI: Evolution story.

Milton, Mark, Maclachlan, Timothy, Brennan, Frank, Andrews, Laura, Arulanandam, Tony, Fikes, Jim, Grimaldi, Christine, Lansita, Janice, Loberg, Lise, Parker, Suezanne, Tibbitts, Jay, Wolf, Jayanthi and Allamneni, Krishna (2018) Current Strategies in the non-clinical safety assessment of biologics: New Targets, New Molecules, New Challenges (A report of the 2016 Annual US BioSafe General Membership meeting). Regulatory toxicology and pharmacology, 98. pp. 98-107.

Moggs, Jonathan and Terranova, Remi (2018) Chromatin dynamics underlying latent responses to xenobiotics. Toxicology research, 7. pp. 606-617.

Mol, Vivienne (2018) Master thesis: "Development of half-life extended GDF15 for therapeutic applications; expression and secretion in mammalian cells.". Master thesis to be submitted at University Wageningen, Netherlands.

Morse, Alyson, Cheng, Tegan L, Schindeler, Aaron, McDonald, Michelle M, Mohanty, Sindhu, Kneissel, Michaela, Kramer, Ina and Little, David G (2018) Dkk1 KO Mice Treated with Sclerostin Antibody Have Additional Increases in Bone Volume. Calcified tissue international.

Mostafavi, Mina, Wang, Lisha, Xie, Lili, Takeoka, Ken, Richie, Daryl, Casey, Fergal, Ruzin, Alexey, Sawyer, William, Rath, Christopher, Wei, Jun-Rong and Dean, Charles (2018) Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis. mSphere.

Moujalled, Donia, Pomilio, Giovanna, Ghiurau, Corina, Ivey, Adam, Salmon, Jessica, Rijal, Sewa, Macraild, Sarah, Zhang, Lan, Teh, Tse-Chieh, Tiong, Ing-Soo, Lan, Ping, Schaeffer, Fabienne, Von Arx, Fabian, Chanrion, Maia, Claperon, Audrey, Rocchetti, Francesca, Kraus-Berthier, Laurence, Wang, Youzhen, Halilovic, Ensar, Morris, Erick, Colland, Frederic, Segal, David, Mistry, Prakash, Huang, David, Roberts, Andrew, Maragno, Ana Leticia, Lessene, Guillaume, Geneste, Olivier and Wei, Andrew (2018) Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia. Leukemia. ISSN 14765551

Mrak, Peter, Moore, Charles, Krastel, Philipp, Pivk-Lukancic, Petra and Tao, Jianshi (2018) Discovery of the actinoplanic acid pathway in Streptomyces rapamycinicus reveals a genetically conserved synergism with rapamycin. The Journal of biological chemistry, 293 (52). pp. 19982-19995. ISSN 1083351X

Mueller, Arne, Hoefling, Holger, Nuritdinow, Timur, Holway, Nicholas, Schieker, Matthias, Daumer, Martin and Clay, Ieuan (2018) Continuous monitoring of patient mobility for 18 months using inertial sensors following serious knee injury: a case study. Digital Biomarkers. pp. 79-89. ISSN 2504-110X

Murgasova, Renata, Tor Carreras, Ester and Bourgailh, Julien (2018) In Vitro Monitoring of the Mitochondrial Beta-Oxidation Flux of Palmitic Acid and Investigation of Its Pharmacological Alteration by Therapeutics. European Journal of Drug Metabolism and Pharmacokinetics. pp. 1-10. ISSN 2107-0180

Murgasova, Renata, Tor Carreras, Ester and Bourgailh, Julien (2018) In Vitro Monitoring of the Mitochondrial Beta-Oxidation Flux of Palmitic Acid and Investigation of Its Pharmacological Alteration by Therapeutics. European Journal of Drug Metabolism and Pharmacokinetics. pp. 1-10. ISSN 21070180

Murgasova, Renata, Tor Carreras, Ester and Bourgailh, Julien (2018) In Vitro Monitoring of the Mitochondrial Beta-Oxidation Flux of Palmitic Acid and Investigation of Its Pharmacological Alteration by Therapeutics. European journal of drug metabolism and pharmacokinetics. ISSN 2107-0180

Mustoe, Anthony M, Busan, Steven, Rice, Gregg, Hajdin, Christine, Peterson, Brant, Ruda, Vera, Kubica, Neil, Nutiu, Razvan, Baryza, Jeremy and Weeks, Kevin M (2018) Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing. Cell, 173 (1). pp. 181-195. ISSN 00928674

Nadine , Heimhofer and Mueller, Matthias (2018) OPTIMISING A CELLULAR SYSTEM FOR MONITORING THE CALCIUM DYNAMICS IN THE SARCOPLASMIC RETICULUM. Bachelor thesis.

Namoto, Kenji, Sirockin, Finton, Sellner, Holger, Wiesmann, Christian, Villard, Frederic, Valeur, Eric, Robinson, Michael, Moreau, Bob, Paulding, Stephanie, Schleeger, Simone, Schipp, Kathrin, Loup, Joachim, Andrews, Lori, O'Neill, Ryann and Farady, Christopher (2018) Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors. Bioorganic and Medicinal Chemistry Letters, 28 (5). pp. 906-909. ISSN 14643405

Nett, Ryan, Guan , Xin, Smith, Kevin, Faust, Ann Marie, Sattely, Elizabeth S. and Fischer, Curt R. (2018) D2O labeling to measure active biosynthesis of natural products in medicinal plants. AIChE journal. ISSN 00011541

Neumann, Ulf, Ufer, Mike, Jacobson, Laura, Rouzade-Dominguez, Marie-Laure, Huledal, Gunilla, Kolly, Carine, Lueoend, Rainer Martin, Machauer, Rainer, Veenstra, Siem, Hurth, Konstanze, Shimshek, Derya, Staufenbiel, Matthias, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean-Michel, Beckmann, Nicolau, Hartmann, Andreas, David, Olivier, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina and Vormfelde, Stefan (2018) The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease. EMBO molecular medicine, 10 (11). S227-S228. ISSN 17574684

Nigsch, Florian (2018) Postdoc internet site mentor profile. Novartis internet site.

Nigsch, Florian (2018) Postdoc position advertisement. Novartis postdoc internet site.

Nilsson, Inga, Prathapam, Ramadevi, Grove, Kerri, Lapointe, Guillaume and Six, David (2018) The sialic acid transporter NanT is necessary and sufficient for uptake of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) and its azido analog in Escherichia coli. Molecular microbiology. ISSN 1365-2958

Novello, Salvatore, Arcuri, Ludovico, Dovero, Sandra, Dutheil, Nathalie, Shimshek, Derya, Bezard, Erwan and Morari, Michele (2018) G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice. Neurobiology of disease, 120. pp. 21-33. ISSN 09699961

Novgorodov, Sergei A., Voltin, Joshua R., Gooz, Monika A., Li, Li, Lemasters, John, J. and Tatyana I., Gudz (2018) A novel role of acid sphingomyelinase in mitochondrial dysfunction due to glutamate-induced programmed necrosis. Journal of Lipid Research, 59 (2). pp. 312-329. ISSN 0022-22751539-7262

Nunez, Fabiana, Taura, Jaume, Camacho, Juan, Lopez-Cano, Marc, Fernandez-Duenas, Victor, Castro, Naomi, Castro, Julio and Ciruela, Francisco (2018) PBF509, an adenosine A2A receptor antagonist with efficacy in rodent models of movement disorders. Frontiers in Pharmacology, 9 (OCT). ISSN 16639812

Occhetta, P, Pigeot, S, Halleux, Christine, Rasponi, M, Dasen, B, Ullrich, Thomas, Kramer, Ina, Guth-Gundel, Sabine, Barbero, A and Martin, I (2018) Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis. Proceedings of the National Academy of Sciences of the United States of America, 115 (18). pp. 4625-4630. ISSN 10916490

Oliver, Vanessa L, Thurston, Sarah E and Lofgren, Jennifer L (2018) Using Cageside Measures to Evaluate Analgesic Efficacy in Mice () after Surgery. Journal of the American Association for Laboratory Animal Science : JAALAS, 57 (2). pp. 186-201. ISSN 1559-6109

Orlando, Elena, Brogdon, Jennifer, Bitter, Hans, Joseph, Fraietta, Simon , Lacey, David, Ambrose, Nicholas, Wilcox, Felipe, Bedoya, Corin, Dofrmeier, Fang, Chen, Noelle, Frey, Wei-Ting, Hwang, Harit, Parakandi, Minnal, Gupta, A., Huang, Brad, Johnson, Irina, Kulikovskaya, Bruce , Levine, Li, Liu, Stefan, Lundh, Edward, Pequignot, Donald, Siegel, Yan, Wang, E.J., Wherry, Jun, Xu, Regina, Young, David, Porter, Carl, June, Jan, Melenhorst and Pruteanu-Malinici, Iulian (2018) Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature Medicine, 24 (5). pp. 563-571. ISSN 1546170X

Orlando, Elena, Han, Xia, Wood, Patricia, Leary, Rebecca, Pierog, Peter, Brogdon, Jennifer, Bitter, Hans, Morrissey, Michael, Pantano, Serafino, Adamovich, Wendy, Tribouley, Catherine, Kevin, Nguyen, John, Levine, Muna, Qayad, Stephan, Grupp, Michael, Boyer, Barbara, DeMoerloose, Eneida, Nemecek, Henrique, Bittencourt, Hidefumi, Hiramatsu, Jochen, Büchner, Stella, Davies, Michael, Verneris and Engelman, Jeffrey (2018) Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia. Nature Medicine, 24. pp. 1504-1506. ISSN 1546170X

Ostrov, David A., Alkanani, Aimon , McDaniel, Kristen A. , Case, Stephanie , Baschal, Erin E. , Pyle, Laura, Ellis, Sam, Seidl, Katherine J., Shah, Viral N., Garg, Satish K., Atkinson, Mark A., Gottlieb, Peter A. and Michels, Aaron W. (2018) Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. Journal of Clinical Investigation. ISSN 0021-9738

Otto, Heike (2018) Uncover the limitations of PM 2.0 - Project Management in 10-year progression. Fleming PPM Conference 2018, Berlin.

Ou, Weijia, Bursulaya, Badry, Didonato, Michael, Herath, Ananda, Jin, Yunho, Hao, Xueshi, Loren, Jon, Brock, Ansgar, Uno, Tetsuo, Geierstanger, Bernhard, Cellitti, Susan and Mortenson, Grace (2018) Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation. ChemBioChem, 19 (8). pp. 799-804. ISSN 14397633

Pacifici, Maurizio, Decker, Rebekah and Koyama, Eiki (2018) Limb Synovial Joint Development From the Hips Down: Implications for Articular Cartilage Repair and Regeneration. Developmental Biology and Musculoskeletal Tissue Engineering. pp. 67-101.

Pancholi, Alpa, Iacobini, Greg, Clarkson, Guy, Porter, David and Shipman, Michael (2018) Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues. Journal of Organic Chemistry, 83 (1). pp. 491-498. ISSN 15206904

Papillon, Julien, Nakajima, Katsumasa, Hempel, Jonathan, Karki, Rajeshri, Moebitz, Henrik, Ntaganda, Rukundo, Smith, Troy, Visser, Michael, Hill, Sue, Kellermann Hurtado, Felipe, Chenail, Gregg, Bhang, Hyo-Eun, Xiang, Xiaoqin, Bushold, Geoffrey, Gilbert, Tamara, Vattay, Anthony, Dooley, Julie, Costa, Emily, Adair, Chris, Jouk, Andriana, Li, Jingzhou, Bric, Anka, Park, Isabel, Li, Ailing, Farley, David, Lounkine, Eugen, Yue, Qing, Xie, Xiaoling, Kulathila, Raviraj, King, Daniel, Hu, Tiancen, Vulic, Katarina, Cantwell, John, Luu, Catherine and Jagani, Zainab (2018) Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. Journal of Medicinal Chemistry, 61 (22). pp. 10155-10172. ISSN 15204804

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