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Mesentery: An ADME perspective on a 'new' organ

Argikar, Aneesh and Argikar, Upendra (2018) Mesentery: An ADME perspective on a 'new' organ. Drug metabolism reviews. pp. 1-8. ISSN 1097-9883


With the inclusion of mesentery, the total number of human organs has recently increased by one. Mesentery was formerly construed to be a complex, discontinuous anatomical structure simply serving as a support for organs in abdominal cavity. However, the recent research has established mesentery to be a far more simple and unfragmented organ. The newly emerged information on mesentery has challenged the older pathophysiological concepts. This review briefly discusses the anatomy of the mesentery, historical perspective on mesentery, embryology, drug metabolizing enzymes and transporters of the mesentery, and mesentery’s role in diseases. The possible impact of mesentery on absorption, distribution, metabolism and excretion (ADME) is also discussed.

Item Type: Article
Keywords: mesentery, drug metabolizing enzymes, transporters, intestine, ADME
Date Deposited: 09 Oct 2018 00:45
Last Modified: 09 Oct 2018 00:45


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