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Microtiter Plate (MTP) Reaction Screening and Optimization of Surfactant Chemistry: Examples of Suzuki-Miyaura and Buchwald-Hartwig Cross-Couplings in Water

Brocklehurst, Cara and Hartwieg, Constanze and Palmieri, Marco and Rufle, Dominik and Gallou, Fabrice (2018) Microtiter Plate (MTP) Reaction Screening and Optimization of Surfactant Chemistry: Examples of Suzuki-Miyaura and Buchwald-Hartwig Cross-Couplings in Water. Organic Process Research & Development. ISSN 1083-61601520-586X

Abstract

A screening method to evaluate Suzuki-Miyaura and Buchwald-Hartwig coupling reactions under aqueous surfactant conditions has been established, leading to high yielding and highly selective Suzuki-Miyaura and Buchwald-Hartwig reactions under mild reaction temperatures and ecologically improved conditions. The screening method highlighted the utility of Buchwald-Hartwig 3rd generation pre-catalysts for unprecedented high conversion Buchwald-Hartwig C-N coupling reactions in water.

Item Type: Article
Date Deposited: 27 Oct 2018 00:45
Last Modified: 27 Oct 2018 00:45
URI: https://oak.novartis.com/id/eprint/35698

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