Snajdrova, Radka, Rudroff, Florian, Mihovilovic , Marko, Groeger, Harald, Iding, Hans and Bornscheuer, Uwe (2018) Opportunities and challenges for combining chemo- and biocatalysis. Nature Catalysis, 1. pp. 12-22. ISSN doi:10.1038/s41929-017-0010-4

Abstract

The last decade has seen a substantial increase of successful examples for the combination of chemo- and biocatalysis for multistep syntheses. This is driven by obvious advantages such as higher yields, decreased costs, environmental benefits and high selectivity. On the downside, efforts must be undertaken to combine the divergent reaction conditions, reagent tolerance, and solvent systems of the 'different worlds of catalysis'. Thanks to progress in enzyme discovery and engineering as well as in the development of milder and more compatible conditions for various chemocatalysts, many limitations could already be overcome. This review highlights the opportunities by prominent examples for combined syntheses, but also the current challenges and emerging solutions keeping in mind the fast progress in transition metal-, organo-, photo- electro-, and biocatalysis.

Item Type:	Article
Date Deposited:	22 Feb 2018 00:45
Last Modified:	22 Feb 2018 00:45
URI:	https://oak.novartis.com/id/eprint/34338