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Number of items: 161.


Albert, Rainer and Hinterding, Klaus and Brinkmann, Volker and Guerini, Danilo and Mueller-Hartwieg, Constanze and Knecht, Helmut and Simeon, Corina and Streiff, Markus and Wagner, Beatrix and Welzenbach, Karl and Zecri, Frederic and Zollinger, Markus and Cooke, Nigel Graham and Francotte, Eric (2005) Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer. Journal of Medicinal Chemistry, 48 (16). pp. 5373-5377. ISSN 0022-2623

Arvidsson, Per I and Ryder, Neil and Weiss, Markus and Hook, David and Escalante, Jaime and Seebach, Dieter (2005) Exploring the antibacterial and hemolytic activity of shorter- and longer-chain beta-, alpha,beta-, and gamma-peptides, and of beta-peptides from beta2-3-aza- and beta3-2-methylidene-amino acids bearing proteinogenic side chains--a survey. Chemistry & biodiversity, 2 (3). pp. 401-420. ISSN 1612-1880


Bahia, Daljit and Cheung, Robert and Buchs, Mirjam and Geisse, Sabine and Hunt, Ian (2005) Optimisation of insect cell growth in deep-well blocks: development of a high-throughput insect cell expression screen. Protein Expression and Purification, 39 (1). pp. 61-70. ISSN 1046-5928

Bartels, Christian and Widmer, Armin and Ehrhardt, Claus (2005) Absolute free energies of binding of peptide analogs to the HIV-1 protease from molecular dynamics simulations. Journal of Computational Chemistry, 26 (12). pp. 1294-1305. ISSN 0192-8651

Baumruker, Thomas and Bornancin, Frederic and Billich, Andreas (2005) The role of sphingosine and ceramide kinases in inflammatory responses. Immunology Letters, 96 (2). pp. 175-185. ISSN 0165-2478

Besemer, Juergen and Harant, Hanna and Wang, Shirley and Oberhauser, Berndt and Marquardt, Kathi and Foster, Carolyn-Ann and Schreiner, Erwin and De Vries, Jan Egbert and Dascher, Christiane and Lindley, Ivan-J.D. (2005) Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1. Nature, 436 (7048). pp. 290-293. ISSN 1476-4687

Beuvink, Iwan and Boulay, Anne and Fumagalli, Stefano and Zilbermann, Frederic and Ruetz, Stephan and O'Reilly, Terence and Natt, Francois and Hall, Jonathan and Lane, Heidi A and Thomas, George (2005) The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell, 120 (6). pp. 747-759. ISSN 0092-8674

Billich, Andreas and Bornancin, Frederic and Mechtcheriakova, Diana and Natt, Francois and Huesken, Dieter and Baumruker, Thomas (2005) Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. Cellular Signalling, 17 (10). pp. 1203-1217. ISSN 0898-6568

Billich, Andreas and Vyplel, Hermann and Grassberger, Maximilian and Schmook, Fritz-Peter and Steck, Andrea and Stuetz, Anton (2005) Novel cyclosporin derivatives featuring enhanced skin penetration despite increased molecular weight. Bioorganic & Medicinal Chemistry, 13 (9). pp. 3157-3167. ISSN 0968-0896

Bornancin, Frederic and Mechtcheriakova, Diana and Stora, Samantha and Graf, Christine and Wlachos, Alexander and Devay, Piroska and Urtz, Nicole and Baumruker, Thomas and Billich, Andreas (2005) Characterization of a ceramide kinase-like protein. Biochimica et Biophysica Acta, 1687 (1-3). pp. 31-43. ISSN 0006-3002

Boulay, Anne and Rudloff, Joelle and Ye, Jingjing and Zumstein-Mecker, Sabine and O'Reilly, Terence and Evans, Dean Brent and Chen, Shiuan and Lane, Heidi (2005) Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clinical Cancer Research : an official journal of the American Association for Cancer Research, 11 (14). pp. 5319-5328. ISSN 1078-0432

Brecht, Karin and Simonen, Marjo and Heim, Jutta (2005) Upregulation of alpha globin promotes apoptotic cell death in the hematopoietic cell line FL5.12. Apoptosis: an international journal on programmed cell death, 10 (5). pp. 1043-1062. ISSN 1360-8185

Brecht, Karin and Simonen, Marjo and Kamke, Marion and Heim, Jutta (2005) Hematopoietic transcription factor GATA-2 promotes upregulation of alpha globin and cell death in FL5.12 cells. Apoptosis: an international journal on programmed cell death, 10 (5). pp. 1063-1078. ISSN 1360-8185

Brittain, Scott and Ficarro, Scott and Brock, Ansgar and Peters, Eric (2005) Enrichment and analysis of peptide subsets using fluorous affinity tags and mass spectrometry. Nature Biotechnology, 23 (4). pp. 463-468. ISSN 1087-0156

Buehler, Christof and Dreessen, Joerg and Mueller, Kurt and So, Peter T C and Schilb, Alain and Hassiepen, Ulrich and Stoeckli, Kurt and Auer, Manfred (2005) Multi-photon excitation of intrinsic protein fluorescence and its application to pharmaceutical drug screening. Assay and Drug Development Technologies, 3 (2). pp. 155-167. ISSN 1540-658X

Burkey, Bryan and Li, X and Bolognese, Lori and Balkan, Bork and Mone, Manisha and Russell, Mary and Hughes, Thomas and Wang, Pei-Ran (2005) Acute and chronic effects of the incretin enhancer vildagliptin in insulin-resistant rats. The Journal of Pharmacology and Experimental Therapeutics, 315 (2). pp. 688-695. ISSN 0022-3565

Butz, Nicole and Ruetz, Stephan and Natt, Francois and Hall, Jonathan and Weiler, Jan and Mestan, Juergen and Ducarre, Monique and Grossenbacher, Rita and Hauser, Patrick and Kempf, Dominique and Hofmann, Francesco (2005) The human ubiquitin-conjugating enzyme Cdc34 controls cellular proliferation through regulation of p27Kip1 protein levels. Experimental Cell Research, 303 (2). pp. 482-493. ISSN 0014-4827


Chamberlain, Philip and Sandberg, Mark and Sauer, Karsten and Cooke, Michael and Lesley, Scott and Spraggon, Glen (2005) Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B. Biochemistry, 44 (44). pp. 14486-14493. ISSN 0006-2960

Chiu, Hsiling and Ring, Brian and Sorrentino, Richard Paul and Kalamarz, Marta and Garza, Dan and Govind, Shubha (2005) dUbc9 negatively regulates the Toll-NF-kappa B pathways in larval hematopoiesis and drosomycin activation in Drosophila. Developmental Biology, 288 (1). pp. 60-72. ISSN 0012-1606

Chuchalin, Alexander G and Manjra, Ahmed I and Rozinova, Nadezhda N and Skopková, Olga and Cioppa, Giovanni Della and Till, Denise and Kaiser, Guenther and Fashola, Taiwo and Kottakis, John (2005) Formoterol delivered via a new multi-dose dry powder inhaler (Certihaler) is as effective and well tolerated as the formoterol dry powder inhaler (Aerolizer) in children with persistent asthma. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine, 18 (1). pp. 63-73. ISSN 0894-2684

Cohen, Steven and Gaskins, Chris and Nasoff, Marc (2005) Generation of a monoclonal antibody agonist to toll-like receptor 4. Hybridoma, 24 (1). pp. 27-35. ISSN 1554-0014

Coppola, Gary and Damon Ii, Robert and Eskesen, J and France, Dennis and Paterniti, James (2005) 1-Hydroxyalkyl-3-phenylthioureas as novel HDL-elevating agents. Bioorganic & Medicinal Chemistry Letters, 15 (3). pp. 809-812. ISSN 0960-894X

Coppola, Gary and Kukkola, Paivi and Stanton, James and Neubert, Alan and Marcopulos, Nicholas and Bilci, Natalie and Wang, Hua and Tomaselli, Hollis and Tan, Jenny and Aicher, Thomas and Knorr, Douglas and Jeng, Arco and Dardik, Beatriz and Chatelain, Ricardo (2005) Perhydroquinolylbenzamides as novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Journal of Medicinal Chemistry, 48 (21). pp. 6696-6712. ISSN 0022-2623

Cowan-Jacob, Sandra W and Fendrich, Gabriele and Manley, Paul W. and Jahnke, Wolfgang and Fabbro, Doriano and Liebetanz, Janis and Meyer, Thomas (2005) The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation. Structure (London, England : 1993), 13 (6). pp. 861-871. ISSN 0969-2126

Cryan, John F. and Holmes, Andrew (2005) The ascent of mouse: advances in modelling human depression and anxiety. Nature Reviews: Drug Discovery, 4 (9). pp. 775-790. ISSN 1474-1776

Cryan, John F. and Kaupmann, Klemens (2005) Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. Trends in Pharmacological Sciences, 26 (1). pp. 36-43. ISSN 0165-6147

Cryan, John F. and Mombereau, Cedric and Vassout, Annick (2005) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neuroscience and Biobehavioral Reviews, 29 (4-5). pp. 571-625. ISSN 0149-7634


Danahay, Henry and Jackson, Alan (2005) Epithelial mucus-hypersecretion and respiratory disease. Current Drug Targets. Inflammation and Allergy, 4 (6). pp. 651-664. ISSN 1568-010X

Daouti, Sherif and Latario, Brian and Nagulapalli, Sujatha and Buxton, Francis and Uziel-Fusi, Susan and Chirn, Gung-Wei and Bodian, Dale and Song, Cheng and Labow, Mark and Lotz, M and Quintavalla, Joseph and Kumar, C (2005) Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis. Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society, 13 (6). pp. 508-518. ISSN 1063-4584

Dartois, Veronique and Sanchez-Quesada, Jorge and Cabezas, Edelmira and Chi, Ellen and Dubbelde, Chad and Dunn, Carrie and Granja, Juan and Gritzen, Colleen and Weinberger, Dana and Ghadiri, M Reza and Parr, Thomas R (2005) Systemic antibacterial activity of novel synthetic cyclic peptides. Antimicrobial Agents and Chemotherapy, 49 (8). pp. 3302-3310. ISSN 0066-4804

Dartois, Veronique and Sanchez-Quesada, Jorge and Cabezas, Edelmira and Chi, Ellen and Dubbelde, Chad and Dunn, Carrie and Granja, Juan and Gritzen, Colleen and Weinberger, Dana and Ghadiri, M Reza and Parr, Thomas R (2005) Systemic antibacterial activity of novel synthetic cyclic peptides. Antimicrobial Agents and Chemotherapy, 49 (8). pp. 3302-3310. ISSN 0066-4804

Dean, Charles and Narayan, Shubha and Daigle, Denis and Dzink-Fox, Joann and Puyang, Xiaoling and Bracken, Kathryn and Dean, Karl and Weidmann, Beat and Yuan, Zhengyu and Jain, Rakesh and Ryder, Neil (2005) Role of the AcrAB-TolC efflux pump in determining susceptibility of Haemophilus influenzae to the novel peptide deformylase inhibitor LBM415. Antimicrobial Agents and Chemotherapy, 49 (8). pp. 3129-3135. ISSN 0066-4804

Digan, Mary and Pou, Chantevy and Niu, Honglin and Zhang, Ji (2005) Evaluation of division-arrested cells for cell-based high-throughput screening and profiling. Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening, 10 (6). pp. 615-623. ISSN 1087-0571

Dyson, Alex and Peacock, Marcus and Chen, Alice and Courade, Jean-Philippe and Yaqoob, Mohammed and Groarke, Alex and Brain, Christopher and Loong, Yvonne and Fox, Alyson (2005) Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat. Pain, 116 (1-2). pp. 129-137. ISSN 0304-3959


Esser, Ronald and Miserendino-Molteni, Rocca and Sharr, Michele and Zhang, Xiaoli and Porter, Wilma and Ramos, Luis and Cramer, Jeffrey and Zhuang, Shumin and Georgieva, Anna and Maniara, Wieslawa (2005) Pharmacodynamic behaviour of the selective cyclooxygenase-2 inhibitor lumiracoxib in the lipopolysaccharide-stimulated rat air pouch model. European Journal of Pharmaceutical Sciences : official journal of the European Federation for Pharmaceutical Sciences, 25 (1). pp. 25-30. ISSN 0928-0987


Fairhurst, Robin and Janus, Diana and Lawrence, Annabel (2005) Synthesis of the marine sponge derived beta2-adrenoceptor agonist S1319. Organic Letters, 7 (21). pp. 4697-4700. ISSN 1523-7060

Faller, Bernard and Grimm, Hans Peter and Loeuillet-Ritzler, Frederique and Arnold, Sabine E. and Briand, Xavier (2005) High-throughput lipophilicity measurement with immobilized artificial membranes. Journal of Medicinal Chemistry, 48 (7). pp. 2571-2576. ISSN 0022-2623

Ferrand, Sandrine and Schmid, Andres and Engeloch, Caroline and Glickman, Fraser (2005) Statistical evaluation of a self-deconvoluting matrix strategy for high-throughput screening of the CXCR3 receptor. Assay and Drug Development Technologies, 3 (4). pp. 413-424. ISSN 1540-658X

Ferretti, Stephane Raymond and Allegrini, Peter Roland and O'Reilly, Terence and Schnell, Christian and Stumm, Michael and Wartmann, Markus and Wood, Jeanette and Mcsheehy, Paul M.J. (2005) Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure. Clinical Cancer Research : an official journal of the American Association for Cancer Research, 11 (21). pp. 7773-7784. ISSN 1078-0432

Feuerbach, Dominik and Lingenhoehl, Kurt and Dobbins, Peter and Mosbacher, Johannes and Corbett, Nicola and Nozulak, Joachim and Hoyer, Daniel (2005) Coupling of human nicotinic acetylcholine receptors alpha 7 to calcium channels in GH3 cells. Neuropharmacology, 48 (2). pp. 215-227. ISSN 0028-3908

Ficarro, Scott and Salomon, Arthur and Brill, Laurence and Mason, Daniel and Stettler-Gill, Michelle and Brock, Ansgar and Peters, Eric (2005) Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites. Rapid Communications in Mass Spectrometry, 19 (1). pp. 57-71. ISSN 0951-4198

Fox, Alyson and Bevan, Stuart (2005) Therapeutic potential of cannabinoid receptor agonists as analgesic agents. Expert Opinion on Investigational Drugs, 14 (6). pp. 695-703. ISSN 1744-7658

Fox, Alyson and Kaur, Satbir and Li, Bifang and Panesar, Moh and Saha, Uma and Davis, Clare and Dragoni, Ilaria and Colley, Sian and Ritchie, Tim and Bevan, Stuart and Burgess, Gillian and Mcintyre, Peter (2005) Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor. British Journal of Pharmacology, 144 (7). pp. 889-899. ISSN 0007-1188


Gasser, Juerg Andreas and Ingold, Peter and Grosios, Konstantina and Laib, Andres and Hämmerle, Stephan and Koller, Bruno (2005) Noninvasive monitoring of changes in structural cancellous bone parameters with a novel prototype micro-CT. Journal of Bone and Mineral Metabolism, 23 Suppl. pp. 90-96. ISSN 0914-8779

Geisse, Sabine and Henke, Mario (2005) Large-scale transient transfection of mammalian cells: a newly emerging attractive option for recombinant protein production. Journal of Structural and Functional Genomics, 6 (2-3). pp. 165-170. ISSN 1345-711X

Gerspacher, Marc (2005) Selective and combined neurokinin receptor antagonists. Progress in Medicinal Chemistry, 43. pp. 49-103. ISSN 0079-6468

Glass, David (2005) A signaling role for dystrophin: inhibiting skeletal muscle atrophy pathways. Cancer Cell, 8 (5). pp. 351-352. ISSN 1535-6108

Gosling, Martin and Poll, Chris and Li, Su (2005) TRP channels in airway smooth muscle as therapeutic targets. Naunyn-Schmiedeberg's Archives of Pharmacology, 371 (4). pp. 277-284. ISSN 0028-1298

Green, Jonathan (2005) Skeletal complications of prostate cancer: pathophysiology and therapeutic potential of bisphosphonates. Acta Oncologica (Stockholm, Sweden), 44 (3). pp. 282-292. ISSN 0284-186X

Gschwind, Hans-Peter and Pfaar, Ulrike and Waldmeier, Felix and Zollinger, Markus and Sayer, Claudia and Zbinden, Peter and Hayes, Michael and Pokorny, Rolf and Seiberling, Michael and Ben-Am, Monique and Peng, Bin and Gross, Gerhard (2005) Metabolism and disposition of imatinib mesylate in healthy volunteers. Drug metabolism and disposition: the biological fate of chemicals, 33 (10). pp. 1503-1512. ISSN 0090-9556

Guenther, Claudia and Bello-Fernandez, Concha and Kopp, Tamara and Kund, Julia and Carballido-Perrig, Nicole and Hinteregger, Sonja and Fassl, Sandra and Schwaerzler, Christoph and Lametschwandtner, Guenther and Stingl, Georg and Biedermann, Tilo and Carballido, Jose (2005) CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. Journal of Immunology (Baltimore, Md. : 1950), 174 (3). pp. 1723-1728. ISSN 0022-1767


Hackermueller, Joerg and Meisner, Nicole-Claudia and Auer, Manfred and Jaritz, Markus and Stadler, Peter F (2005) The effect of RNA secondary structures on RNA-ligand binding and the modifier RNA mechanism: a quantitative model. Gene, 345 (1). pp. 3-12. ISSN 0378-1119

Han, Shulin and Zhou, Vicki and Pan, Shifeng and Liu, Yi and Hornsby, Michael and Mcmullan, Daniel and Klock, Heath and Haugen, Justin and Lesley, Scott and Gray, Nathanael and Caldwell, Jeremy and Gu, Xiang-Ju (2005) Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 15 (24). pp. 5467-5473. ISSN 0960-894X

Harada, Josephine and Bower, Kristen and Orth, Anthony and Callaway, Scott and Nelson, Christian and Laris, Casey and Hogenesch, John and Vogt, Peter and Chanda, Sumit (2005) Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis. Genome Research, 15 (8). pp. 1136-1144. ISSN 1088-9051

Harris, Jennifer and Winssinger, Nicolas (2005) PNA encoding (PNA=peptide nucleic acid): from solution-based libraries to organized microarrays. Chemistry, 11 (23). pp. 6792-6801. ISSN 0947-6539

Hauser, Patrick and Hofmann, Francesco (2005) High-throughput assay to monitor formation of the E2-ubiquitin thioester intermediate. Methods in Enzymology, 398. pp. 87-100. ISSN 0076-6879

Hintersteiner, Martin and Enz, Albert and Frey, Peter and Jaton, Anne-Lise and Kinzy, Willy and Kneuer, Rainer and Neumann, Ulf and Rudin, Markus and Staufenbiel, Matthias and Stoeckli, Markus and Wiederhold, Karl-Heinz and Gremlich, Hans-Ulrich (2005) In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe. Nature Biotechnology, 23 (5). pp. 577-583. ISSN 1087-0156

Hoefinger, Siegfried (2005) Solving the Poisson-Boltzmann equation with the specialized computer chip MD-GRAPE-2. Journal of Computational Chemistry, 26 (11). pp. 1148-1154. ISSN 0192-8651

Hofbauer, Christian and Aszodi, Andras (2005) SH2 binding site comparison: a new application of the SURFCOMP method. Journal of chemical information and modeling, 45 (2). pp. 414-421. ISSN 1549-9596

Hofmann, Francesco and Garcia-Echeverria, Carlos (2005) Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discovery Today, 10 (15). pp. 1041-1047. ISSN 1359-6446

Huesken, Dieter and Lange, Joerg and Mickanin, Craig and Weiler, Jan and Asselbergs, Fred A.M. and Warner, Justin and Meloone, Brian and Engel, Sharon and Rosenberg, Avi and Cohen, Dalia and Labow, Mark and Reinhardt, Mischa and Natt, Francois and Hall, Jonathan (2005) Design of a genome-wide siRNA library using an artificial neural network. Nature Biotechnology, 23 (8). pp. 995-1001. ISSN 1087-0156

Hunt, Ian (2005) From gene to protein: a review of new and enabling technologies for multi-parallel protein expression. Protein Expression and Purification, 40 (1). pp. 1-22. ISSN 1046-5928

Höfinger, Siegfried and Zerbetto, Francesco (2005) Simple models for hydrophobic hydration. Chemical Society Reviews, 34 (12). pp. 1012-1020. ISSN 0306-0012


Isbell, John and Zhou, Yingyao and Guintu, Christina and Rynd, Matthew and Jiang, Shumei and Petrov, Dmitri and Micklash, Kenneth and Mainquist, James and Ek, Jared and Chang, Jim and Weselak, Mark and Backes, Bradley and Brailsford, Andrew and Shave, Darcy (2005) Purifying the masses: integrating prepurification quality control, high-throughput LC/MS purification, and compound plating to feed high-throughput screening. Journal of Combinatorial Chemistry, 7 (2). pp. 210-217. ISSN 1520-4766


Jacobson, Laura and Cryan, John F. (2005) Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains. Psychopharmacology, 179 (3). pp. 688-699. ISSN 0033-3158

Jacoby, Edgar and Schuffenhauer, Ansgar and Popov, Maxim and Azzaoui, Kamal and Havill, Benjamin and Schopfer, Ulrich and Engeloch, Caroline and Stanek, Jaroslav and Acklin, Pierre and Rigollier, Pascal and Stoll, Friederike and Koch, Guido and Meier, Peter and Orain, David and Giger, Rudolf K. A. and Hinrichs, Juergen and Malagu, Karine and Zimmermann, Juerg and Roth, Hans-Joerg (2005) Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection. Current Topics in Medicinal Chemistry, 5 (4). pp. 397-411. ISSN 1568-0266

Jahnke, Wolfgang and Blommers, Marcel J.J. and Fernandez, Cesar and Zwingelstein, Christian and Amstutz, Rene (2005) Strategies for the NMR-based identification and optimization of allosteric protein kinase inhibitors. Chembiochem : a European journal of Chemical Biology, 6 (9). pp. 1607-1610. ISSN 1439-4227

Jansma, Ariane and Chuan, Tiffany and Albrecht, Robert and Olson, Dean and Peck, Timothy and Geierstanger, Bernhard (2005) Automated microflow NMR: routine analysis of five-microliter samples. Analytical Chemistry, 77 (19). pp. 6509-6515. ISSN 0003-2700

Jones, Carol (2005) The OXE receptor: a new therapeutic approach for asthma? Trends in Molecular Medicine, 11 (6). pp. 266-270. ISSN 1471-4914


Kallen, Joerg and Sedrani, Richard and Zenke, Gerhard and Wagner, Juergen (2005) Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6 A resolution. The Journal of Biological Chemistry, 280 (23). pp. 21965-21971. ISSN 0021-9258

Kamb, Alexander (2005) What's wrong with our cancer models? Nature Reviews Drug Discovery, 4 (2). pp. 161-165. ISSN 1474-1776

Kaplan, Bruce and Meier-Kriesche, Herwig-Ulf and Minnick, Paula and Bastien, Marie-Claude and Sechaud, Romain and Yeh, Ching-Ming and Balez, Sebastien and Picard, Franck and Schmouder, Robert (2005) Randomized calcineurin inhibitor cross over study to measure the pharmacokinetics of co-administered enteric-coated mycophenolate sodium. Clinical transplantation, 19 (4). pp. 551-558. ISSN 0902-0063

Kaplan, Bruce and Meier-Kriesche, Herwig-Ulf and Minnick, Paula and Bastien, Marie-Claude and Sechaud, Romain and Yeh, Ching-Ming and Balez, Sebastien and Picard, Franck and Schmouder, Robert (2005) Randomized calcineurin inhibitor cross over study to measure the pharmacokinetics of co-administered enteric-coated mycophenolate sodium. Clinical transplantation, 19 (4). pp. 551-558. ISSN 0902-0063

Karmouty Quintana, Harry and Mazzoni, Lazzaro and Fozard, John R. (2005) Effects of endotoxin and allergen alone and in combination on the sensitivity of the rat airways to adenosine. Autonomic & Autacoid Pharmacology, 25 (4). pp. 167-170. ISSN 1474-8665

Keller, Hansjoerg and Kneissel, Michaela (2005) SOST is a target gene for PTH in bone. Bone, 37 (2). pp. 148-158. ISSN 8756-3282

Klock, Heath and White, Aprilfawn and Koesema, Eric and Lesley, Scott (2005) Methods and results for semi-automated cloning using integrated robotics. Journal of Structural and Functional Genomics, 6 (2-3). pp. 89-94. ISSN 1345-711X

Kneissel, Michaela and Studer, Anne and Cortesi, Reto and Susa Spring, Mira (2005) Retinoid-induced bone thinning is caused by subperiosteal osteoclast activity in adult rodents. Bone, 36 (2). pp. 202-214. ISSN 8756-3282

Knochenmuss, Richard and Zhigilei, Leonid V (2005) Molecular dynamics model of ultraviolet matrix-assisted laser desorption/ionization including ionization processes. The Journal of Physical Chemistry. B, 109 (48). pp. 22947-22957. ISSN 1520-6106

Korach-André, M and Gao, Jiaping and Gounarides, John and Deacon, Richard and Islam, Aminul and Laurent, Didier (2005) Relationship between visceral adiposity and intramyocellular lipid content in two rat models of insulin resistance. American Journal of Physiology. Endocrinology and metabolism, 288 (1). E106-E116. ISSN 0193-1849

Korach-André, Marion and Gounarides, John and Deacon, Richard and Beil, Michael and Sun, Dongming and Gao, Jiaping and Laurent, Didier (2005) Age and muscle-type modulated role of intramyocellular lipids in the progression of insulin resistance in nondiabetic Zucker rats. Metabolism: Clinical and Experimental, 54 (4). pp. 522-528. ISSN 0026-0495

Kreusch, Andreas and Han, Shulin and Brinker, Achim and Zhou, Vicki and Choi, Ha-Soon and He, Yun and Lesley, Scott and Caldwell, Jeremy and Gu, Xiang-Ju (2005) Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles. Bioorganic & Medicinal Chemistry Letters, 15 (5). pp. 1475-1478. ISSN 0960-894X


Lecourtier, Lucas and Kelly, Peter H (2005) Bilateral lesions of the habenula induce attentional disturbances in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 30 (3). pp. 484-496. ISSN 0893-133X

Lecourtier, Lucas and Saboureau, Michel and Kelly, Christopher D and Pévet, Paul and Kelly, Peter (2005) Impaired cognitive performance in rats after complete epithalamus lesions, but not after pinealectomy alone. Behavioural Brain Research, 161 (2). pp. 276-285. ISSN 0166-4328

Lee, Jee and Kosinski, Penelope and Kemp, Daniel (2005) Contribution of human bone marrow stem cells to individual skeletal myotubes followed by myogenic gene activation. Experimental Cell Research, 307 (1). pp. 174-182. ISSN 0014-4827

Lehr, Philipp and Billich, Andreas and Wolff-Winiski, Barbara and Nussbaumer, Peter (2005) N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase. Bioorganic & Medicinal Chemistry Letters, 15 (4). pp. 1235-1238. ISSN 0960-894X

Lesley, Scott and Wilson, Ian (2005) Protein production and crystallization at the joint center for structural genomics. Journal of Structural and Functional Genomics, 6 (2-3). pp. 71-79. ISSN 1345-711X

Letot, Elodie and Koch, Guido and Falchetto, Rocco Angelo and Bovermann, Guenter and Oberer, Lukas and Roth, Hans-Joerg (2005) Quality control in combinatorial chemistry: determinations of amounts and comparison of the "purity" of LC-MS-purified samples by NMR, LC-UV and CLND. Journal of Combinatorial Chemistry, 7 (3). pp. 364-371. ISSN 1520-4766

Leung, Ray and Whittaker, Paul (2005) RNA interference: from gene silencing to gene-specific therapeutics. Pharmacology & Therapeutics, 107 (2). pp. 222-239. ISSN 0163-7258

Li, Jun and Lim, Siew Pheng and Beer, David and Patel, Viral and Wen, Daying and Tumanut, Christine and Tully, David and Williams, Jennifer and Jiricek, Jan and Priestle, John Peter and Harris, Jennifer and Vasudevan, Subhash (2005) Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries. The Journal of biological chemistry, 280 (31). pp. 28766-28774. ISSN 0021-9258

Li, Su and Gosling, Martin and Poll, Chris (2005) Determining the functional role of TRPC channels in primary cells. Pflügers Archiv : European Journal of Physiology, 451 (1). pp. 43-52. ISSN 0031-6768

Li, Su and Gosling, Martin and Poll, Chris and Westwick, John and Cox, Brian (2005) Therapeutic scope of modulation of non-voltage-gated cation channels. Drug Discovery Today, 10 (2). pp. 129-137. ISSN 1359-6446

Liu, Hong and Tully, David and Epple, Robert and Bursulaya, Badry and Li, Jun and Harris, Jennifer and Williams, Jennifer and Russo, Ross and Tumanut, Christine and Roberts, Michael and Alper, Phillip and He, Yun and Karanewsky, Donald (2005) Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1. Bioorganic & Medicinal Chemistry Letters, 15 (22). pp. 4979-4984. ISSN 0960-894X

Lloyd, David and Hall, Frank Wesley and Tarantino, Lisa and Gekakis, Nicholas (2005) Diabetes insipidus in mice with a mutation in aquaporin-2. PLoS Genetics, 1 (2). e20. ISSN 1553-7390


Ma, Qicheng and Chirn, Gung-Wei and Cai, Richard and Szustakowski, Joseph and Nirmala, Nanguneri (2005) Clustering protein sequences with a novel metric transformed from sequence similarity scores and sequence alignments with neural networks. BMC Bioinformatics, 6 (1). p. 242. ISSN 1471-2105

Mahe, Cecile and Loetscher, Erika and Dev, Kumlesh K. and Bobirnac, Ionel and Otten, Uwe and Schoeffter, Philippe (2005) Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells. Neuropharmacology, 49 (1). pp. 40-47. ISSN 0028-3908

Majumdar, Tapan and Bakhtiar, Ray and Chen, Cindy and Ramos, Luis and Tse, Francis (2005) High-throughput determination of ultra-low concentrations of LAG078, a lipid modulator, in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 37 (5). pp. 1039-1048. ISSN 0731-7085

Manley, Paul W. and Cowan-Jacob, Sandra W and Mestan, Juergen (2005) Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia. Biochimica et Biophysica Acta, 1754 (1-2). pp. 3-13. ISSN 0006-3002

Mccombie, Gregor and Staab, Dieter and Stoeckli, Markus and Knochenmuss, Richard (2005) Spatial and spectral correlations in MALDI mass spectrometry images by clustering and multivariate analysis. Analytical Chemistry, 77 (19). pp. 6118-6124. ISSN 0003-2700

Mcmullan, Daniel and Canaves, Jaume and Quijano, Kevin and Abdubek, Polat and Nigoghossian, Edward and Haugen, Justin and Klock, Heath and Vincent, Juli and Hale, Joanna and Paulsen, Jessica and Lesley, Scott (2005) High-throughput protein production for X-ray crystallography and use of size exclusion chromatography to validate or refute computational biological unit predictions. Journal of Structural and Functional Genomics, 6 (2-3). pp. 135-141. ISSN 1345-711X

Meindl, S and Rot, Antal and Hoetzenecker, W and Kato, S and Cross, H S and Elbe-Bürger, A (2005) Vitamin D receptor ablation alters skin architecture and homeostasis of dendritic epidermal T cells. The British Journal of Dermatology, 152 (2). pp. 231-241. ISSN 0007-0963

Meingassner, Josef and Aschauer, Heinrich and Stuetz, Anton and Billich, Andreas (2005) Pimecrolimus permeates less than tacrolimus through normal, inflamed, or corticosteroid-pretreated skin. Experimental Dermatology, 14 (10). pp. 752-757. ISSN 0906-6705

Mitsukawa, Kayo and Yamamoto, Rina and Ofner, Silvio and Nozulak, Joachim and Pescott, Oliver and Lukic, Snezana and Stoehr, Natacha and Mombereau, Cedric and Kuhn, Rainer R and Mcallister, Kevin and Van Der Putten, P. Herman and Cryan, John F. and Flor, Peter Josef (2005) A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proceedings of the National Academy of Sciences of the United States of America, 102 (51). pp. 18712-18717. ISSN 0027-8424

Mombereau, Cedric and Kaupmann, Klemens and Gassmann, Martin and Bettler, Bernhard and Van Der Putten, P. Herman and Cryan, John F. (2005) Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits. Neuroreport, 16 (3). pp. 307-310. ISSN 0959-4965


Nussbaumer, Peter and Billich, Andreas (2005) Steroid sulfatase inhibitors: their potential in the therapy of breast cancer. Current Medicinal Chemistry. Anti-cancer Agents, 5 (5). pp. 507-528. ISSN 1568-0118

Nussbaumer, Peter and Ettmayer, Peter and Peters, Carsten and Rosenbeiger, Daniela and Hoegenauer, Klemens (2005) One-step labelling of sphingolipids via a scrambling cross-metathesis reaction. Chemical Communications (Cambridge, England) (40). pp. 5086-5087. ISSN 1359-7345


O'Reilly, Terence and Mcsheehy, Paul M.J. and Wenger, Fritz and Hattenberger, Marc and Muller, Melanie and Vaxelaire, Juliane and Altmann, Karl-Heinz and Wartmann, Markus (2005) Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo. The Prostate, 65 (3). pp. 231-240. ISSN 0270-4137

O'Reilly, Terence and Wartmann, Markus and Maira, Sauveur-Michel and Hattenberger, Marc and Vaxelaire, Juliane and Muller, M and Ferretti, Stephane Raymond and Buchdunger, Elisabeth and Altmann, Karl-Heinz and Mcsheehy, Paul M.J. (2005) Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma. Cancer Chemotherapy and Pharmacology, 55 (4). pp. 307-317. ISSN 0344-5704

Osborne, Colin and Leitner, Ingrid and Favre, Bertrand and Ryder, Neil (2005) Amino acid substitution in Trichophyton rubrum squalene epoxidase associated with resistance to terbinafine. Antimicrobial Agents and Chemotherapy, 49 (7). pp. 2840-2844. ISSN 0066-4804


Parker, Christian (2005) McMaster University data-mining and docking competition: computational models on the catwalk. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 10 (7). pp. 647-648. ISSN 1087-0571

Petrassi, Michael and Williams, Jennifer and Li, Jun and Tumanut, Christine and Ek, Jared and Nakai, Takashi and Masick, Brian and Backes, Bradley and Harris, Jennifer (2005) A strategy to profile prime and non-prime proteolytic substrate specificity. Bioorganic & Medicinal Chemistry Letters, 15 (12). pp. 3162-3166. ISSN 0960-894X

Philipps, Bjoern and Forstner, Michael and Mayr, Lorenz (2005) A baculovirus expression vector system for simultaneous protein expression in insect and mammalian cells. Biotechnology Progress, 21 (3). pp. 708-711. ISSN 8756-7938

Philipps, Bjoern and Rotmann, Daniel and Wicki, Micha and Mayr, Lorenz and Forstner, Michael (2005) Time reduction and process optimization of the baculovirus expression system for more efficient recombinant protein production in insect cells. Protein Expression and Purification, 42 (1). pp. 211-218. ISSN 1046-5928

Press, Neil and Taylor, Roger and Fullerton, Joe and Tranter, Pamela and Mccarthy, Clive and Keller, Thomas and Brown, Lyndon and Cheung, Robert and Christie, Julie and Haberthuer, Sandra and Hatto, Julia and Keenan, Mark and Mercer, Mark and Press, Nicola and Sahri, Helene and Tuffnell, Andrew and Tweed, Morris and Fozard, John R. (2005) A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential. Bioorganic & Medicinal Chemistry Letters, 15 (12). pp. 3081-3085. ISSN 0960-894X


Quintavalla, Joseph and Kumar, Chandrika and Daouti, Sherif and Slosberg, Eric and Uziel-Fusi, Susan (2005) Chondrocyte cluster formation in agarose cultures as a functional assay to identify genes expressed in osteoarthritis. Journal of Cellular Physiology, 204 (2). pp. 560-566. ISSN 0021-9541


Rausch, Martin and Gentsch, Conrad and Enz, Albert and Baumann, D and Rudin, M (2005) A study paradigm allowing comparison of multiple high-resolution rCBV-maps for the examination of drug effects. NMR in biomedicine, 18 (4). pp. 260-268. ISSN 0952-3480

Renaud, Johanne and Bischoff, Serge Francois and Buhl, Thomas and Floersheim, Philipp and Fournier, Brigitte and Geiser, Martin and Halleux, Christine and Kallen, Joerg and Keller, Hansjoerg and Ramage, Paul (2005) Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands. Journal of Medicinal Chemistry, 48 (2). pp. 364-379. ISSN 0022-2623

Revesz, Laszlo and Bollbuck, Birgit and Buhl, Thomas and Eder, Joerg and Esser, Ronald and Feifel, Roland and Heng, Richard and Hiestand, Peter and Jachez Demange, Benedicte and Loetscher, Pius and Sparrer, Helmut and Schlapbach, Achim and Waelchli, Rudolf (2005) Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorganic & Medicinal Chemistry Letters, 15 (23). pp. 5160-5164. ISSN 0960-894X

Rohner, Tatiana and Staab, Dieter and Stoeckli, Markus (2005) MALDI mass spectrometric imaging of biological tissue sections. Mechanisms of Ageing and Development, 126 (1). pp. 177-185. ISSN 0047-6374

Rot, Antal (2005) Contribution of Duffy antigen to chemokine function. Cytokine & Growth Factor Reviews, 16 (6). pp. 687-694. ISSN 1359-6101

Roth, Hans-Joerg (2005) There is no such thing as 'diversity'! Current Opinion in Chemical Biology, 9 (3). pp. 293-295. ISSN 1367-5931

Rottmann, Sabine and Wang, Yan and Nasoff, Marc and Deveraux, Quinn L and Quon, Kim C (2005) A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function. Proceedings of the National Academy of Sciences of the United States of America, 102 (42). pp. 15195-15200. ISSN 0027-8424

Rudin, Markus and Rausch, Martin and Stoeckli, Markus (2005) Molecular imaging in drug discovery and development: potential and limitations of nonnuclear methods. Molecular Imaging and Biology : MIB : the official publication of the Academy of Molecular Imaging, 7 (1). pp. 5-13. ISSN 1536-1632


Sandberg, Mark and Sutton, Susan and Pletcher, Mathew and Wiltshire, Timothy and Tarantino, Lisa and Hogenesch, John and Cooke, Michael (2005) c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Developmental Cell, 8 (2). pp. 153-166. ISSN 1534-5807

Sawicka, Elzbieta and Dubois, Gerald and Jarai, Gabor and Edwards, Matthew and Thomas, Matthew and Nicholls, Andy and Albert, Rainer and Newson, Catherine and Brinkmann, Volker and Walker, Christoph (2005) The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity. Journal of Immunology (Baltimore, Md. : 1950), 175 (12). pp. 7973-7980. ISSN 0022-1767

Schmid, Herbert and Silva, Antonio (2005) Short- and long-term effects of octreotide and SOM230 on GH, IGF-I, ACTH, corticosterone and ghrelin in rats. Journal of Endocrinological Investigation, 28 (11 Suppl International). pp. 28-35. ISSN 0391-4097

Schopfer, Ulrich and Engeloch, Caroline and Stanek, Jaroslav and Girod, Michel and Schuffenhauer, Ansgar and Jacoby, Edgar and Acklin, Pierre (2005) The Novartis compound archive -- from concept to reality. Combinatorial Chemistry & High Throughput Screening, 8 (6). pp. 513-519. ISSN 1386-2073

Selzer, Paul and Roth, Hans-Joerg and Ertl, Peter and Schuffenhauer, Ansgar (2005) Complex molecules: do they add value? Current Opinion in Chemical Biology, 9 (3). pp. 310-316. ISSN 1367-5931

Siehler Wagner, Sandra and Nunn, C and Zupanc, G K H and Hoyer, D (2005) Fish somatostatin sst3 receptor: comparison of radioligand and GTPgammaS binding, adenylate cyclase and phospholipase C activities reveals different agonist-dependent pharmacological signatures. Autonomic & Autacoid Pharmacology, 25 (1). pp. 1-16. ISSN 1474-8665

Silva, Antonio and Bethmann-Rexha, Kerstin and Raulf, Friedrich and Schmid, Herbert (2005) Regulation of ghrelin secretion by somatostatin analogs in rats. European Journal of Endocrinology / European Federation of Endocrine Societies, 152 (6). pp. 887-894. ISSN 0804-4643

Silva, Antonio and Schoeffter, Philippe and Weckbecker, Gisbert and Bruns, Christian and Schmid, Herbert (2005) Regulation of CRH-induced secretion of ACTH and corticosterone by SOM230 in rats. European Journal of Endocrinology / European Federation of Endocrine Societies, 153 (3). R7-R10. ISSN 0804-4643

Sini, Patrizia and Wyder, Lorenza and Schnell, Christian and O'Reilly, Terence and Littlewood-Evans, Amanda Jane and Brandt, Ralph and Hynes, Nancy E. and Wood, Jeanette (2005) The antitumor and antiangiogenic activity of vascular endothelial growth factor receptor inhibition is potentiated by ErbB1 blockade. Clinical cancer research : an official journal of the American Association for Cancer Research, 11 (12). pp. 4521-4532. ISSN 1078-0432

Slattery, David Anthony and Desrayaud, Sandrine and Cryan, John F. (2005) GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent. The Journal of Pharmacology and Experimental Therapeutics, 312 (1). pp. 290-296. ISSN 0022-3565

Slattery, David Anthony and Markou, Athina and Froestl, Wolfgang and Cryan, John F. (2005) The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 30 (11). pp. 2065-2072. ISSN 0893-133X

Stauffer, Frederic and Holzer, Philipp and Garcia-Echeverria, Carlos (2005) Blocking the PI3K/PKB pathway in tumor cells. Current Medicinal Chemistry. Anti-cancer Agents, 5 (5). pp. 449-462. ISSN 1568-0118

Strauss, Andre and Bitsch, Francis and Fendrich, Gabriele and Graff, Patrick and Knecht, Rene and Meyhack, Bernd and Jahnke, Wolfgang (2005) Efficient uniform isotope labeling of Abl kinase expressed in Baculovirus-infected insect cells. Journal of Biomolecular NMR, 31 (4). pp. 343-349. ISSN 0925-2738


Thakker, Deepak and Natt, Francois and Huesken, Dieter and Van Der Putten, P. Herman and Maier, Rainer and Hoyer, Daniel and Cryan, John F. (2005) siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain. Molecular Psychiatry, 10 (8). pp. 782-789. ISSN 1359-4184

Thoma, Gebhard and Streiff, Markus and Katopodis, Andreas and Duthaler, Rudolf and Voelcker, Nicolas H and Ehrhardt, Claus and Masson, Christophe (2005) Non-covalent polyvalent ligands by self-assembly of small glycodendrimers: a novel concept for the inhibition of polyvalent carbohydrate-protein interactions in vitro and in vivo. Chemistry: a European journal, 12 (1). pp. 99-117. ISSN 0947-6539

Thomas, Matthew and Smith, Alexandra and Head, Denise and Milne, Laura and Nicholls, Andy and Pearce, Wayne and Vanhaesebroeck, Bart and Wymann, Matthias P and Hirsch, Emilio and Trifilieff, Alexandre and Walker, Christoph and Finan, Peter and Westwick, John (2005) Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases. European Journal of Immunology, 35 (4). pp. 1283-1291. ISSN 0014-2980

Tirat-Boeuf, Aline and Schilb, Alain and Riou, Virginie and Leder, Lukas and Gerhartz, Bernd and Zimmermann, Johann and Worpenberg-Pietruk, Susanne and Eidhoff, Ulf and Freuler, Felix and Stettler, Thomas and Mayr, Lorenz and Ottl, Johannes and Leuenberger, Beate and Filipuzzi, Ireos (2005) Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2. Analytical Biochemistry, 343 (2). pp. 244-255. ISSN 0003-2697

Turner, Robert and Charlton, Steven (2005) Assessing the minimum number of data points required for accurate IC50 determination. Assay and Drug Development Technologies, 3 (5). pp. 525-531. ISSN 1540-658X


Ullman, Brett R and Aja, Teresa and Chen, Ning and Diaz, Jose-Luis and Gu, Xin and Herrmann, Julia and Kalish, Vincent J and Karanewsky, Donald S and Kodandapani, Lalitha and Krebs, Joseph J and Linton, Steven D and Meduna, Steven P and Nalley, Kip and Robinson, Edward D and Roggo, Silvio and Sayers, Robert O and Schmitz, Albert and Ternansky, Robert J and Tomaselli, Kevin J and Wu, Joe C (2005) Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads. Bioorganic & Medicinal Chemistry Letters, 15 (15). pp. 3632-3636. ISSN 0960-894X

Urwyler, Stephan and Gjoni, Tina and Koljatic, Jelena and Dupuis, Delphine (2005) Mechanisms of allosteric modulation at GABAB receptors by CGP7930 and GS39783: effects on affinities and efficacies of orthosteric ligands with distinct intrinsic properties. Neuropharmacology, 48 (3). pp. 343-353. ISSN 0028-3908


Vogtle, Markus and Marzinzik, Andreas (2005) An efficient protocol for the solid-phase synthesis of malondiamides. Molecules, 10 (12). pp. 1438-1445. ISSN 1420-3049

Voshol, Johannes and Brendlen, Nathalie and Mueller, Dieter and Inverardi, Bruno and Augustin, Angelique and Pally, Charles and Wieczorek, Grazyna and Morris, Randall and Raulf, Friedrich and Van Oostrum, Jan (2005) Evaluation of biomarker discovery approaches to detect protein biomarkers of acute renal allograft rejection. Journal of Proteome Research, 4 (4). pp. 1192-1199. ISSN 1535-3893


Wagner, Juergen and Andres, Hendrik and Rohrbach, Stefan and Wagner, Dieter and Oberer, Lukas and France, Julien (2005) Efficient synthesis of [3H]-sanglifehrin A via selective oxidation/reduction of alcohols at C31 and C35. The Journal of Organic Chemistry, 70 (23). pp. 9588-9590. ISSN 0022-3263

Walker, John and Hogenesch, John (2005) RNA profiling in circadian biology. Methods in Enzymology, 393. pp. 366-376. ISSN 1557-7988

Walmsley, Adrian Robert and Mir, Anis Khusro and Frentzel, Stefan (2005) Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc metalloproteinases. Biochemical and Biophysical Research Communications, 327 (1). pp. 112-116. ISSN 0006-291X

Wang, Yu and Klock, Heath and Yin, Hong and Wolff, Karen and Bieza, Kimberly and Niswonger, Kirk and Matzen, Jason and Gunderson, Drew and Hale, Joanna and Lesley, Scott and Kuhen, Kelli and Caldwell, Jeremy and Brinker, Achim (2005) Homogeneous high-throughput screening assays for HIV-1 integrase 3beta-processing and strand transfer activities. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 10 (5). pp. 456-462. ISSN 1087-0571

Wattanasin, Sompong and Kallen, Joerg and Myers, Stewart and Guo, Qin and Sabio, Michael and Ehrhardt, Claus and Albert, Rainer and Hommel, Ulrich and Weckbecker, Gisbert and Welzenbach, Karl and Weitz Schmidt, Gabriele (2005) 1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1. Bioorganic & Medicinal Chemistry Letters, 15 (4). pp. 1217-1220. ISSN 0960-894X

Whitebread, Steven and Hamon, Jacques and Bojanic, Dejan and Urban, Laszlo (2005) Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development. Drug discovery today, 10 (21). pp. 1421-1433. ISSN 1359-6446

Wilkens, Steven and Janes, Jeff and Su, Andrew (2005) HierS: hierarchical scaffold clustering using topological chemical graphs. Journal of medicinal chemistry, 48 (9). pp. 3182-3193. ISSN 0022-2623

Wolber, Cedric and Fozard, John R. (2005) The receptor mechanism mediating the contractile response to adenosine on lung parenchymal strips from actively sensitised, allergen-challenged Brown Norway rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 371 (2). pp. 158-168. ISSN 0028-1298

Wood, Jeanette and Schnell, Christian and Cumin, Frederic and Menard, Joel and Webb, Randy (2005) Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. Journal of Hypertension, 23 (2). pp. 417-426. ISSN 0263-6352

Wu, Xiang and Sills, Matthew and Zhang, Ji (2005) Further comparison of primary hit identification by different assay technologies and effects of assay measurement variability. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 10 (6). pp. 581-589. ISSN 1087-0571

Wyss, Daniel and Bonneau, Olivier and Trifilieff, Alexandre (2005) Mast cell involvement in the adenosine mediated airway hyper-reactivity in a murine model of ovalbumin-induced lung inflammation. British Journal of Pharmacology, 145 (7). pp. 845-852. ISSN 0007-1188


Yan, Frank and Asatryan, Hayk and Li, Jing and Zhou, Yingyao (2005) Novel statistical approach for primary high-throughput screening hit selection. Journal of Chemical Information and Modeling, 45 (6). pp. 1784-1790. ISSN 1549-9596

Yuan, Ding and Petersen, Christopher and Rynd, Matthew and Mainquist, James and Meyer, Andrew and Isbell, John (2005) A novel method for immediate post-purification purity determination of fractions collected during high-throughput purification. Journal of chromatography. A, 1092 (2). pp. 228-234. ISSN 0021-9673


Zhang, Ji and Wu, Xiang and Sills, Matthew (2005) Probing the primary screening efficiency by multiple replicate testing: a quantitative analysis of hit confirmation and false screening results of a biochemical assay. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 10 (7). pp. 695-704. ISSN 1087-0571

Zhang, Juan and Mccombie, Gregor and Guenat, Christian and Knochenmuss, Richard (2005) FT-ICR mass spectrometry in the drug discovery process. Drug Discovery Today, 10 (9). pp. 635-642. ISSN 1359-6446

Zheng, Haiyan and Hu, Ping and Quinn, D and Wang, Yingqi (2005) Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography. Molecular & Cellular Proteomics : MCP, 4 (6). pp. 721-730. ISSN 1535-9476

Zhou, Yingyao and Young, Jason and Santrosyan, Andrey and Chen, Kaisheng and Yan, Frank and Winzeler, Elizabeth (2005) In silico gene function prediction using ontology-based pattern identification. Bioinformatics, 21 (7). pp. 1237-1245. ISSN 1367-4803

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