Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads
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Ullman, Brett R and Aja, Teresa and Chen, Ning and Diaz, Jose-Luis and Gu, Xin and Herrmann, Julia and Kalish, Vincent J and Karanewsky, Donald S and Kodandapani, Lalitha and Krebs, Joseph J and Linton, Steven D and Meduna, Steven P and Nalley, Kip and Robinson, Edward D and Roggo, Silvio and Sayers, Robert O and Schmitz, Albert and Ternansky, Robert J and Tomaselli, Kevin J and Wu, Joe C (2005) Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads. Bioorganic & Medicinal Chemistry Letters, 15 (15). pp. 3632-3636. ISSN 0960-894X
Abstract
Various heterocyclic hetero-methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A study of their structure-activity relationship (SAR) related to caspase-1, -3, -6, and -8 is reported. Their efficacy in a cellular model of cell death is also discussed. Potent broad-spectrum caspase inhibitors have been identified.
| Item Type: | Article |
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| Additional Information: | Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
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| Date Deposited: | 29 Apr 2010 23:45 |
| Last Modified: | 01 Feb 2013 00:49 |
| URI: | https://oak.novartis.com/id/eprint/2859 |