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Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads

Ullman, Brett R and Aja, Teresa and Chen, Ning and Diaz, Jose-Luis and Gu, Xin and Herrmann, Julia and Kalish, Vincent J and Karanewsky, Donald S and Kodandapani, Lalitha and Krebs, Joseph J and Linton, Steven D and Meduna, Steven P and Nalley, Kip and Robinson, Edward D and Roggo, Silvio and Sayers, Robert O and Schmitz, Albert and Ternansky, Robert J and Tomaselli, Kevin J and Wu, Joe C (2005) Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads. Bioorganic & Medicinal Chemistry Letters, 15 (15). pp. 3632-3636. ISSN 0960-894X

Abstract

Various heterocyclic hetero-methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A study of their structure-activity relationship (SAR) related to caspase-1, -3, -6, and -8 is reported. Their efficacy in a cellular model of cell death is also discussed. Potent broad-spectrum caspase inhibitors have been identified.

Item Type: Article
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Additional Information: Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
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Date Deposited: 29 Apr 2010 23:45
Last Modified: 01 Feb 2013 00:49
URI: https://oak.novartis.com/id/eprint/2859

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