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TRP channels in airway smooth muscle as therapeutic targets.

Gosling, Martin and Poll, Chris and Li, Su (2005) TRP channels in airway smooth muscle as therapeutic targets. Naunyn-Schmiedeberg's Archives of Pharmacology, 371 (4). pp. 277-284. ISSN 0028-1298

Abstract

Cation channels are of fundamental importance in regulating the function of airway smooth cells especially bronchoconstriction in response to spasmogens, and are therefore key players in the pathogenesis of asthma. To date, the identity of these cation channels remains a mystery. However, the recently emerged transient receptor potential (TRP) cation channel family has provided several promising channel candidates. The identification of the key TRP channels involved in regulating airway smooth muscle contractility, and therefore airway tone, could provide new and exciting prospects for the development of novel therapies for the treatment of airway diseases such as asthma.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Airway smooth muscle; Asthma; Bronchoconstriction; Bronchodilator; Non-selective cation channel; Receptor-activated calcium entry; TRP channel
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Date Deposited: 14 Dec 2009 13:56
Last Modified: 14 Dec 2009 13:56
URI: https://oak.novartis.com/id/eprint/633

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