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FT-ICR mass spectrometry in the drug discovery process.

Zhang, Juan and Mccombie, Gregor and Guenat, Christian and Knochenmuss, Richard (2005) FT-ICR mass spectrometry in the drug discovery process. Drug Discovery Today, 10 (9). pp. 635-642. ISSN 1359-6446

Abstract

The high mass accuracy and resolution of Fourier transform (FT)-ion cyclotron resonance (ICR) mass spectrometry are making it an increasingly useful tool in drug discovery and development. The basics of FT-ICR are described here, including modern ion sources and fragmentation methods. Although FT-ICR is not a high-throughput method in the traditional sense, previously difficult and complex problems are being efficiently approached using steadily improving instruments and magnets. Applications are surveyed in fields such as proteomics, metabonomics, natural product analysis and non-covalent complexes.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Target validation; Proteomics; Noncovalent complexes; Lead optimization; Natural products; Drug Discovery; Pharmaceutical Science; Techniques & Methods
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Date Deposited: 14 Dec 2009 13:56
Last Modified: 14 Dec 2009 13:56
URI: https://oak.novartis.com/id/eprint/636

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