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Generation of a monoclonal antibody agonist to toll-like receptor 4.

Cohen, Steven and Gaskins, Chris and Nasoff, Marc (2005) Generation of a monoclonal antibody agonist to toll-like receptor 4. Hybridoma, 24 (1). pp. 27-35. ISSN 1554-0014

Abstract

Toll-Like Receptor 4 (TLR4) has recently been identified as the lipopolysaccharide (LPS) receptor. Upon stimulation of TLR4 with LPS, a Th1 type cytokine response is observed. This immune modulation is thought to have a potential benefit in anti-tumor therapy. We have generated a TLR4 antibody agonist (5D24.D4) that mimics the action of the natural ligand. 5D24.D4 and LPS stimulation of TLR4 leads to a similar response, including IL-8 secretion, activation of NF-kB-mediated transcription, and the induced expression of an overlapping set of target genes. 5D24.D4 may be beneficial as an adjuvant anti-tumor therapy.

Item Type: Article
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Date Deposited: 14 Dec 2009 14:02
Last Modified: 31 Jan 2013 01:22
URI: https://oak.novartis.com/id/eprint/254

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