Roth, Hans-Joerg (2005) There is no such thing as 'diversity'! Current Opinion in Chemical Biology, 9 (3). pp. 293-295. ISSN 1367-5931

Abstract

Within the context of the increasing application of combinatorial methodology, the term 'diversity' has gained significant importance. The general understanding of this term is that diversity describes the degree of dissimilarity within a set of chemical structures. This Opinion article proposes that this understanding is superficial at best and irrelevant at worst. It is argued that relevant diversity can only be measured by the application of external criteria (such as a biological assay), which can discriminate the different structures by their different behaviour within this external context. According to this understanding, the diversity of a collection is highly dependent on the applied criteria. Therefore, a relevant diversity of chemical structures, per se, does not exist.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.cbpa.2005.03.002
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.cbpa.2005.03.002
Date Deposited:	14 Dec 2009 13:57
Last Modified:	14 Dec 2009 13:57
URI:	https://oak.novartis.com/id/eprint/614