Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits.
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Mombereau, Cedric, Kaupmann, Klemens, Gassmann, Martin, Bettler, Bernhard, Van Der Putten, P. Herman and Cryan, John F. (2005) Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits. Neuroreport, 16 (3). pp. 307-310. ISSN 0959-4965
Abstract
Metabotropic GABAB receptors predominantly function as heterodimers of GABAB(1) and GABAB(2) subunits, but GABAB(1) can also form functional receptors in the absence of GABAB(2). Mice lacking the GABAB(1) subunit have altered behavioural responses in tests for anxiety and depression. In these studies, we investigated anxiety and depression in GABAB(2)-deficient mice. We compared the effects directly with that of genetic deletion of the GABAB(1) receptor subunit. Both GABAB(1) and GABAB(2)-deficient mice were found to be more anxious than wild type in the light-dark box paradigm. In contrast, these mice exhibited an antidepressant-like behaviour in the forced swim test. Taken together, these data suggest that heterodimeric GABAB(1,2) receptors are required for the normal regulation of emotional behaviour.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
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| Date Deposited: | 14 Dec 2009 13:56 |
| Last Modified: | 31 Jan 2013 01:10 |
| URI: | https://oak.novartis.com/id/eprint/668 |