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1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.

Wattanasin, Sompong and Kallen, Joerg and Myers, Stewart and Guo, Qin and Sabio, Michael and Ehrhardt, Claus and Albert, Rainer and Hommel, Ulrich and Weckbecker, Gisbert and Welzenbach, Karl and Weitz Schmidt, Gabriele (2005) 1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1. Bioorganic & Medicinal Chemistry Letters, 15 (4). pp. 1217-1220. ISSN 0960-894X


1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Integrin; LFA-1; Diazepanediones; I-domain; L-site binding
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Date Deposited: 14 Dec 2009 13:56
Last Modified: 31 Jan 2013 01:10


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