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1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.

Wattanasin, Sompong, Kallen, Joerg, Myers, Stewart, Guo, Qin, Sabio, Michael, Ehrhardt, Claus, Albert, Rainer, Hommel, Ulrich, Weckbecker, Gisbert, Welzenbach, Karl and Weitz Schmidt, Gabriele (2005) 1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1. Bioorganic & Medicinal Chemistry Letters, 15 (4). pp. 1217-1220. ISSN 0960-894X


1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Integrin; LFA-1; Diazepanediones; I-domain; L-site binding
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Date Deposited: 14 Dec 2009 13:56
Last Modified: 31 Jan 2013 01:10


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