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Items where Year is 2004

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Number of items: 147.


Altmann, Eva, Jacob, Sandra and Missbach, Martin (2004) Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K. Journal of Medicinal Chemistry, 47 (24). pp. 5833-5836. ISSN 0022-2623

Altmann, Karl-Heinz, Floersheimer, Andreas, O'Reilly, Terence and Wartmann, Markus (2004) 4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. Progress in Medicinal Chemistry, 42. pp. 171-205. ISSN 0079-6468

Atadja, Peter, Gao, Lin, Kwon, Paul, Trogani, Nancy, Walker, Heather, Hsu, Meier, Yeleswarapu, N., Chandramouli, Nagarajan, Perez, Lawrence, Versace, Richard, Wu, Arthur, Sambucetti, Lidia, Lassota, Piotr, Cohen, Dalia, Bair, Kenneth, Wood, Alexander and Remiszewski, Stacy (2004) Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Research, 64 (2). pp. 689-695. ISSN 0008-5472

Atadja, Peter, Hsu, Meier, Kwon, Paul, Trogani, Nancy, Bhalla, Kapil and Remiszewski, Stacy (2004) Molecular and cellular basis for the anti-proliferative effects of the HDAC inhibitor LAQ824. Novartis Foundation Symposium, 259. 249-266; discussion 266-268; 285-288. ISSN 1528-2511


Bakhtiar, Ray, Ramos, Luis and Tse, Francis (2004) Toxicokinetic assessment of methylphenidate (Ritalin) in a 13-week oral toxicity study in dogs. Biomedical Chromatography, 18 (1). pp. 45-50. ISSN 0269-3879

Bakhtiar, Ray and Tse, Francis (2004) Toxicokinetic assessment of methylphenidate (Ritalin) enantiomers in pregnant rats and rabbits. Biomedical chromatography : BMC, 18 (5). pp. 275-281. ISSN 0269-3879

Bandell, Michael, Story, Gina, Hwang, Sun Wook, Viswanath, Veena, Eid, Samer, Petrus, Matthew, Earley, Taryn and Patapoutian, Ardem (2004) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron, 41 (6). pp. 849-857. ISSN 0896-6273

Barrera, Leah, Benner, Chris, Tao, Yong-Chuan, Winzeler, Elizabeth and Zhou, Yingyao (2004) Leveraging two-way probe-level block design for identifying differential gene expression with high-density oligonucleotide arrays. BMC Bioinformatics, 5 (1). p. 42. ISSN 1471-2105

Beckmann, Nicolau, Cannet, Catherine, Zurbruegg, Stefan, Rudin, Markus and Tigani, Bruno (2004) Proton MRI of lung parenchyma reflects allergen-induced airway remodeling and endotoxin-aroused hyporesponsiveness: a step toward ventilation studies in spontaneously breathing rats. Magnetic Resonance in Medicine: official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 52 (2). pp. 258-268. ISSN 0740-3194

Beckmann, Nicolau, Laurent, Didier, Tigani, Bruno, Panizzutti, Rogerio and Rudin, Markus (2004) Magnetic resonance imaging in drug discovery: lessons from disease areas. Drug Discovery today, 9 (1). pp. 35-42. ISSN 1359-6446

Bernhard, Michel, Takeda, Kenneth, Keller, Caroline, Haslebacher, Mirko, Lambrou, George N. and Trendelenburg, Anne-Ulrike (2004) 3H-Noradrenaline release from mouse iris-ciliary body: role of presynaptic muscarinic heteroreceptors. Naunyn-Schmiedeberg's Archives of Pharmacology, 370 (4). pp. 305-313. ISSN 0028-1298

Billich, Andreas, Bilban, Melitta, Meisner, Nicole-Claudia, Nussbaumer, Peter, Neubauer, Andreas, Jager, Stefan and Auer, Manfred (2004) Confocal fluorescence detection expanded to UV excitation: the first continuous fluorimetric assay of human steroid sulfatase in nanoliter volume. Assay and Drug Development Technologies, 2 (1). pp. 21-30. ISSN 1540-658X

Billich, Andreas, Meingassner, Josef, Nussbaumer, Peter, Desrayaud, Sandrine, Lam, Charles, Winiski, Anthony and Schreiner, Erwin (2004) 6-[2-(adamantylidene)-hydroxybenzoxazole]-O-sulfamate, a steroid sulfatase inhibitor for the treatment of androgen- and estrogen-dependent diseases. The Journal of Steroid Biochemistry and Molecular Biology, 92 (1-2). pp. 29-37. ISSN 0960-0760

Bittinger, Mark, McWhinnie, Elizabeth, Meltzer, Jodi, Iourgenko, Vadim, Latario, Brian, Liu, Xiulin, Chen, Chein Hwa, Song, Chuanzheng, Garza, Dan and Labow, Mark (2004) Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Current Biology : CB, 14 (23). pp. 2156-2161. ISSN 0960-9822

Brill, Laurence, Salomon, Arthur, Ficarro, Scott, Mukherji, Mridul, Stettler-Gill, Michelle and Peters, Eric (2004) Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. Analytical Chemistry, 76 (10). pp. 2763-2772. ISSN 0003-2700

Brinkmann, Volker (2004) FTY720: mechanism of action and potential benefit in organ transplantation. Yonsei Medical Journal, 45 (6). pp. 991-997. ISSN 0513-5796

Brinkmann, Volker, Cyster, Jason G and Hla, Timothy (2004) FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. American Journal of Transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 4 (7). pp. 1019-1025. ISSN 1600-6135

Burkhart, Christoph, Heusser, Christoph, Morris, Randall, Raulf, Friedrich, Weckbecker, Gisbert, Weitz Schmidt, Gabriele and Welzenbach, Karl (2004) Pharmacodynamics in the development of new immunosuppressive drugs. Therapeutic Drug Monitoring, 26 (6). pp. 588-592. ISSN 0163-4356

Butler, Jeannene, Lana, Diana, Round, Oliver and La Montagne, Kenneth (2004) Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells. Prostaglandins & other Lipid Mediators, 73 (1-2). pp. 29-45. ISSN 1098-8823


Carre, Adeline, Graf, Christine, Stora, Samantha, Mechtcheriakova, Diana, Csonga, Robert, Urtz, Nicole, Billich, Andreas, Baumruker, Thomas and Bornancin, Frederic (2004) Ceramide kinase targeting and activity determined by its N-terminal pleckstrin homology domain. Biochemical and Biophysical Research Communications, 324 (4). pp. 1215-1219. ISSN 0006-291X

Chao, Sheng Hao, Harada, Josephine, Hyndman, Francie, Gao, Xiaoqi, Nelson, Christian, Chanda, Sumit and Caldwell, Jeremy (2004) PDX1, a cellular homeoprotein, binds to and regulates the activity of human cytomegalovirus immediate early promoter. The Journal of Biological Chemistry, 279 (16). pp. 16111-16120. ISSN 0021-9258

Cryan, John F., Kelly, Peter, Chaperon, Frederique, Gentsch, Conrad, Mombereau, Cedric, Lingenhoehl, Kurt, Froestl, Wolfgang, Bettler, Bernhard, Kaupmann, Klemens and Spooren, Will P J M (2004) Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines. The Journal of Pharmacology and Experimental therapeutics, 310 (3). pp. 952-963. ISSN 0022-3565

Cryan, John F. and Mombereau, Cedric (2004) In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Molecular Psychiatry, 9 (4). pp. 326-357. ISSN 1359-4184


Dev, Kumlesh K. (2004) Making protein interactions druggable: targeting PDZ domains. Nature Reviews Drug Discovery, 3 (12). pp. 1047-1056. ISSN 1474-1776

Dorn, Gabriele, Patel, Sadhana, Wotherspoon, Glen, Hemmings-Mieszczak, Maja, Barclay, Jane, Natt, Francois, Martin, Pierre, Bevan, Stuart, Fox, Alyson, Ganju, Pam, Wishart, William L. and Hall, Jonathan (2004) siRNA relieves chronic neuropathic pain. Nucleic Acids Research, 32 (5). e49. ISSN 1362-4962


Ellis, Karen Margaret, Cannet, Catherine, Mazzoni, Lazzaro and Fozard, John R. (2004) Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 369 (2). pp. 166-178. ISSN 0028-1298

End, Nicole, Furet, Pascal, Vancampenhout, Nathalie, Wartmann, Markus and Altmann, Karl-Heinz (2004) Total synthesis and biological evaluation of a C(10)/C(12)-phenylene-bridged analog of epothilone D. Chemistry & Biodiversity, 1 (11). pp. 1771-1784. ISSN 1612-1880

Enz, Albert, Chappuis, Alain and Dattler, Andre (2004) A simple, rapid and sensitive method for simultaneous determination of rivastigmine and its major metabolite NAP 226-90 in rat brain and plasma by reversed-phase liquid chromatography coupled to electrospray ionization mass spectrometry. Biomedical Chromatography, 18 (3). pp. 160-166. ISSN 0269-3879

Enz, Albert and Gentsch, Conrad (2004) Co-administration of memantine has no effect on the in vitro or ex vivo determined acetylcholinesterase inhibition of rivastigmine in the rat brain. Neuropharmacology, 47 (3). pp. 408-413. ISSN 0028-3908

Ettmayer, Peter, Amidon, Gordon, Clement, Bernd and Testa, Bernard (2004) Lessons learned from marketed and investigational prodrugs. Journal of Medicinal Chemistry, 47 (10). pp. 2393-2404. ISSN 0022-2623

Ettmayer, Peter, Billich, Andreas, Baumruker, Thomas, Mechtcheriakova, Diana, Schmid, Heide and Nussbaumer, Peter (2004) Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2. Bioorganic & Medicinal Chemistry Letters, 14 (6). pp. 1555-1558. ISSN 0960-894X


Finelli, Alyce, Kelkar, Anju, Song, Ho-Juhn, Yang, Haidi and Konsolaki, Mary (2004) A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster. Molecular and Cellular Neurosciences, 26 (3). pp. 365-375. ISSN 1044-7431

Fozard, John R., Buescher, Heinz, Farr, David Colin and Mazzoni, Lazzaro (2004) Suppression of histamine-induced tachypnoea in the rhesus monkey by sibenadet: no role for dopamine D2 receptors. Autonomic & Autacoid Pharmacology, 24 (1). pp. 9-16. ISSN 1474-8665

Furet, Pascal, Imbach, Patricia, Noorani, Maria, Koeppler, Juergen, Laumen, Kurt, Lang, Marc, Guagnano, Vito, Fuerst, Peter, Roesel, Johannes, Zimmermann, Johann and Garcia-Echeverria, Carlos (2004) Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design. Journal of Medicinal Chemistry, 47 (20). pp. 4810-4813. ISSN 0022-2623


Ganju, Pam and Hall, Jonathan (2004) Potential applications of siRNA for pain therapy. Expert Opinion on Biological Therapy, 4 (4). pp. 531-542. ISSN 1471-2598

Garcia-Echeverria, Carlos, Pearson, Mark Andrew, Marti, Andreas, Meyer, Thomas, Mestan, Juergen, Zimmermann, Johann, Gao, Jiaping, Brueggen, Josef, Capraro, Hans-Georg, Cozens, Robert, Evans, Dean Brent, Fabbro, Doriano, Furet, Pascal, Porta, Diana Graus, Liebetanz, Janis, Martiny-Baron, Georg, Ruetz, Stephan and Hofmann, Francesco (2004) In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell, 5 (3). pp. 231-239. ISSN 1535-6108

Glick, Meir, Klon, Anthony, Acklin, Pierre and Davies, John (2004) Enrichment of extremely noisy high-throughput screening data using a naïve Bayes classifier. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 9 (1). pp. 32-36. ISSN 1087-0571

Grassberger, Maximilian, Steinhoff, M, Schneider, Dirk and Luger, T A (2004) Pimecrolimus -- an anti-inflammatory drug targeting the skin. Experimental Dermatology, 13 (12). pp. 721-730. ISSN 0906-6705

Gremlich, Hans-Ulrich, Martinez, Vicente, Kneuer, Rainer, Kinzy, Willy, Weber, Eckhard, Pfannkuche, Hans-Juergen and Rudin, Markus (2004) Noninvasive assessment of gastric emptying by near-infrared fluorescence reflectance imaging in mice: pharmacological validation with tegaserod, cisapride, and clonidine. Molecular Imaging : official journal of the Society for Molecular Imaging, 3 (4). pp. 303-311. ISSN 1535-3508


Harant, Hanna and Lindley, Ivan-J.D. (2004) Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. Nucleic Acids Research, 32 (17). pp. 5280-5290. ISSN 1362-4962

Hersperger, Rene, Buchheit, Karl-Heinz, Cammisuli, Salvatore, Enz, Albert, Lohse, Olivier, Ponelle, Monique, Schuler, Walter, Schweitzer, Alain, Walker, Christoph, Zehender, Hartmut, Zenke, Gerhard, Zimmerlin, Alfred Gilbert, Zollinger, Markus, Mazzoni, Lazzaro and Fozard, John R. (2004) A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma. Journal of Medicinal Chemistry, 47 (20). pp. 4950-4957. ISSN 0022-2623

Hofbauer, Christian, Lohninger, Hans and Aszodi, Andras (2004) SURFCOMP: a novel graph-based approach to molecular surface comparison. Journal of Chemical Information and Computer Sciences, 44 (3). pp. 837-847. ISSN 0095-2338

Horvath, Amarylla, Nussbaumer, Peter, Wolkin, Barbara and Billich, Andreas (2004) 2-(1-adamantyl)-4-(thio)chromenone-6-carboxylic acids: potent reversible inhibitors of human steroid sulfatase. Journal of Medicinal Chemistry, 47 (17). pp. 4268-4276. ISSN 0022-2623

Hoyer, Daniel, Nunn, Caroline, Hannon, Jason, Schoeffter, Philippe, Feuerbach, Dominik, Schuepbach, Edi, Langenegger, Daniel, Bouhelal, Rochdi, Hurth, Konstanze, Neumann, Peter, Troxler, Thomas J. and Pfaeffli, Paul (2004) SRA880, in vitro characterization of the first non-peptide somatostatin sst(1) receptor antagonist. Neuroscience Letters, 361 (1-3). pp. 132-135. ISSN 0304-3940

Hu, Chii-Whei, Webb, Randy and Jeng, Arco (2004) Synergistic stimulation of aldosterone production in human adrenocortical carcinoma NCI-H295R cells by endothelin-1 and angiotensin II. Journal of Cardiovascular Pharmacology, 44 Suppl 1. S289-S292. ISSN 1533-4023


Jenkins, Jeremy, Glick, Meir and Davies, John (2004) A 3D similarity method for scaffold hopping from known drugs or natural ligands to new chemotypes. Journal of Medicinal Chemistry, 47 (25). pp. 6144-6159. ISSN 0022-2623


Kallen, Joerg, Schlaeppi, Jean-Marc, Bitsch, Francis, Filipuzzi, Ireos, Schilb, Alain, Riou, Virginie, Graham, Alexander, Strauss, Andre, Geiser, Martin and Fournier, Brigitte (2004) Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha. The Journal of Biological Chemistry, 279 (47). pp. 49330-49337. ISSN 0021-9258

Kirkham, Paul, Spooner, Gillian, Rahman, Irfan and Rossi, Adriano (2004) Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products. Biochemical and Biophysical Research Communications, 318 (1). pp. 32-37. ISSN 0006-291X

Klon, Anthony, Glick, Meir and Davies, John (2004) Application of machine learning to improve the results of high-throughput docking against the HIV-1 protease. Journal of Chemical Information and Computer Sciences, 44 (6). pp. 2216-2224. ISSN 0095-2338

Klon, Anthony, Glick, Meir and Davies, John (2004) Combination of a naive Bayes classifier with consensus scoring improves enrichment of high-throughput docking results. Journal of Medicinal Chemistry, 47 (18). pp. 4356-4359. ISSN 0022-2623

Klon, Anthony, Glick, Meir, Thoma, Mathis, Acklin, Pierre and Davies, John (2004) Finding more needles in the haystack: A simple and efficient method for improving high-throughput docking results. Journal of Medicinal Chemistry, 47 (11). pp. 2743-2749. ISSN 0022-2623

Kneissel, Michaela, Luong-Nguyen, Ngoc-Hong, Baptist, Myma, Cortesi, Reto, Zumstein-Mecker, Sabine, Kossida, Sophia, O'Reilly, Terry, Lane, Heidi and Susa Spring, Mira (2004) Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts. Bone, 35 (5). pp. 1144-1156. ISSN 8756-3282

Knochenmuss, Richard (2004) Photoionization pathways and free electrons in UV-MALDI. Analytical Chemistry, 76 (11). pp. 3179-3184. ISSN 0003-2700

Kramer, Richard and Cohen, Dalia (2004) Functional genomics to new drug targets. Nature Reviews Drug Discovery, 3 (11). pp. 965-972. ISSN 1474-1776

Kretz, Olivier, Weiss, Markus, Schumacher, Martin and Gross, Gerhard (2004) In vitro blood distribution and plasma protein binding of the tyrosine kinase inhibitor imatinib and its active metabolite, CGP74588, in rat, mouse, dog, monkey, healthy humans and patients with acute lymphatic leukaemia. British journal of clinical pharmacology, 58 (2). pp. 212-216. ISSN 0306-5251


Lake, Philip, De Leo, Jeffrey, Cerasoli, Frank, Logdberg, Lennart, Weetall, Marla and Handley, Dean (2004) Pharmacodynamic evaluation of the neutralization of endotoxin by PMX622 in mice. Antimicrobial Agents and Chemotherapy, 48 (8). pp. 2987-2992. ISSN 0066-4804

Lametschwandtner, Guenther, Biedermann, Tilo, Schwaerzler, Christoph, Gunther, Claudia, kund, julia, Fassl, Sandra, Hinteregger, Sonja, Carballido-Perrig, Nicole, Szabo, Susanne, Glimcher, Laurie and Carballido, Jose (2004) Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities. The Journal of Allergy and Clinical Immunology, 113 (5). pp. 987-994. ISSN 0091-6749

Lecourtier, Lucas, Neijt, Hans Ch. and Kelly, Peter (2004) Habenula lesions cause impaired cognitive performance in rats: implications for schizophrenia. The European Journal of Neuroscience, 19 (9). pp. 2551-2560. ISSN 0953-816X

Lee, Christian, Wood, Michelle, Ng, Kenneth, Andersen, Carsten, Liu, Yi, Luginbuhl, Peter, Spraggon, Glen and Katagiri, Fumiaki (2004) Crystal structure of the type III effector AvrB from Pseudomonas syringae. Structure (London, England : 1993), 12 (3). pp. 487-494. ISSN 0969-2126

Li, Bing, Liu, Y, Uno, Tetsuo and Gray, Nathanael (2004) Creating chemical diversity to target protein kinases. Combinatorial Chemistry & High Throughput Screening, 7 (5). pp. 453-472. ISSN 1386-2073

Linton, Steven D, Aja, Teresa, Allegrini, Peter Roland, Deckwerth, Thomas L, Diaz, Jose-Luis, Hengerer, Bastian, Herrmann, Julia, Jahangiri, Kathy G, Kallen, Joerg, Karanewsky, Donald S, Meduna, Steven P, Nalley, Kip, Robinson, Edward D, Roggo, Silvio, Rovelli, Giorgio, Sauter, Andre, Sayers, Robert O, Schmitz, Albert, Smidt, Robert, Ternansky, Robert J, Tomaselli, Kevin J, Ullman, Brett R, Wiessner, Christoph and Wu, Joe C (2004) Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke. Bioorganic & Medicinal Chemistry Letters, 14 (10). pp. 2685-2691. ISSN 0960-894X


Mahe, Cecile, Bernhard, Michel, Bobirnac, Ionel, Keser, Corinna, Loetscher, Erika, Feuerbach, Dominik, Dev, Kumlesh K. and Schoeffter, Philippe (2004) Functional expression of the serotonin 5-HT7 receptor in human glioblastoma cell lines. British Journal of Pharmacology, 143 (3). pp. 404-410. ISSN 0007-1188

Mahe, Cecile, Loetscher, Erika, Feuerbach, Dominik, Mueller, Werner, Seiler, Max Peter and Schoeffter, Philippe (2004) Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors. European Journal of Pharmacology, 495 (2-3). pp. 97-102. ISSN 0014-2999

Majumdar, Tapan, Vedananda, Sunanda and Tse, Francis (2004) Rapid analysis of MMI270B, an inhibitor of matrix metalloproteases in human plasma by liquid chromatography-tandem mass spectrometry: matrix interference in patient samples. Biomedical Chromatography, 18 (2). pp. 77-85. ISSN 0269-3879

Majumdar, Tapan, Wu, Shari, Vedananda, Sunanda and Tse, Francis (2004) Determination of LAG078, a lipid-lowering compound, in dog plasma using liquid chromatography-tandem mass spectrometry: application in a toxicokinetic study. Journal of Pharmaceutical and Biomedical Analysis, 35 (4). pp. 853-866. ISSN 0731-7085

Manley, Paul W., Breitenstein, Werner, Brueggen, Josef, Cowan-Jacob, Sandra W, Furet, Pascal, Mestan, Juergen and Meyer, Thomas (2004) Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases. Bioorganic & Medicinal Chemistry Letters, 14 (23). pp. 5793-5797. ISSN 0960-894X

Mason, Daniel, Ek, Jared, Peters, Eric and Harris, Jennifer (2004) Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometry. Biochemistry, 43 (21). pp. 6535-6544. ISSN 0006-2960

Mastyugin, Vladimir, McWhinnie, Elizabeth, Labow, Mark and Buxton, Francis (2004) A quantitative high-throughput endothelial cell migration assay. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 9 (8). pp. 712-718. ISSN 1087-0571

Matsumoto, Yuji, Hof, Akiko, Baumlin, Yves, Mueller, Matthias and Hof, Robert (2004) Differential effects of everolimus and cyclosporine A on intimal alpha-actin-positive cell dynamics of carotid allografts in mice. Transplantation, 78 (3). pp. 345-351. ISSN 0041-1337

Mccombie, Gregor and Knochenmuss, Richard (2004) Small-molecule MALDI using the matrix suppression effect to reduce or eliminate matrix background interferences. Analytical Chemistry, 76 (17). pp. 4990-4997. ISSN 0003-2700

Meisner, Nicole-Claudia, Hackermüller, Jörg, Uhl, Volker, Aszódi, András, Jaritz, Markus and Auer, Manfred (2004) mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure. ChemBioChem : a European journal of chemical biology, 5 (10). pp. 1432-1447. ISSN 1439-4227

Meisner, Nicole-Claudia, Hintersteiner, Martin, Uhl, Volker, Weidemann, Thomas, Schmied, Mario, Gstach, Hubert and Auer, Manfred (2004) The chemical hunt for the identification of drugable targets. Current Opinion in Chemical Biology, 8 (4). pp. 424-431. ISSN 1367-5931

Metzler, Barbara, Gfeller, Patrick, Bigaud, Marc, Li, Jianping, Wieczorek, Grazyna, Heusser, Christoph, Lake, Philip and Katopodis, Andreas (2004) Combinations of anti-LFA-1, everolimus, anti-CD40 ligand, and allogeneic bone marrow induce central transplantation tolerance through hemopoietic chimerism, including protection from chronic heart allograft rejection. Journal of Immunology (Baltimore, Md. : 1950), 173 (11). pp. 7025-7036. ISSN 0022-1767

Molteni, Valentina, He, Xiaohui, Nabakka, Juliet, Yang, Kunyong, Kreusch, Andreas, Gordon, P., Bursulaya, Badry, Warner, Ian, Shin, Tanya, Biorac, Tanya, Ryder, Neil, Goldberg, Ronald, Doughty, John and He, Yun (2004) Identification of novel potent bicyclic peptide deformylase inhibitors. Bioorganic & Medicinal Chemistry Letters, 14 (6). pp. 1477-1481. ISSN 0960-894X

Mombereau, Cedric, Kaupmann, Klemens, Froestl, Wolfgang, Sansig, Gilles, Van Der Putten, P. Herman and Cryan, John F. (2004) Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, 29 (6). pp. 1050-1062. ISSN 0893-133X

Mombereau, Cedric, Kaupmann, Klemens, Van Der Putten, P. Herman and Cryan, John F. (2004) Altered response to benzodiazepine anxiolytics in mice lacking GABA B(1) receptors. European Journal of Pharmacology, 497 (1). pp. 119-120. ISSN 0014-2999

Muckenschnabel, Ingo, Falchetto, Rocco Angelo, Mayr, Lorenz and Filipuzzi, Ireos (2004) SpeedScreen: label-free liquid chromatography-mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands. Analytical Biochemistry, 324 (2). pp. 241-249. ISSN 0003-2697

Mueggler, Thomas, Meyer-Luehmann, Melanie, Rausch, Martin, Staufenbiel, Matthias, Jucker, Mathias and Rudin, Markus (2004) Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis. The European Journal of Neuroscience, 20 (3). pp. 811-817. ISSN 0953-816X


Neumann, Ulf, Kubota, Hisashi, Frei, Karl, Ganu, Vishwas and Leppert, David (2004) Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme. Analytical Biochemistry, 328 (2). pp. 166-173. ISSN 0003-2697

Nunn, Caroline, Cervia, Davide, Langenegger, Daniel, Tenaillon, Laurent, Bouhelal, Rochdi and Hoyer, Daniel (2004) Comparison of functional profiles at human recombinant somatostatin sst2 receptor: simultaneous determination of intracellular Ca2+ and luciferase expression in CHO-K1 cells. British Journal of Pharmacology, 142 (1). pp. 150-160. ISSN 0007-1188

Nussbaumer, Peter and Billich, Andreas (2004) Steroid sulfatase inhibitors. Medicinal Research Reviews, 24 (4). pp. 529-576. ISSN 0198-6325


Orth, Anthony, Batalov, Sergei, Perrone, Mark and Chanda, Sumit (2004) The promise of genomics to identify novel therapeutic targets. Expert Opinion on Therapeutic Targets, 8 (6). pp. 587-596. ISSN 1744-7631

Ostermann, Nils, Gerhartz, Bernd, Worpenberg-Pietruk, Susanne, Trappe, Joerg and Eder, Joerg (2004) Crystal structure of an activation intermediate of cathepsin E. Journal of Molecular Biology, 342 (3). pp. 889-899. ISSN 0022-2836


Parker, Christian and Schreyer, Suzanne (2004) Application of chemoinformatics to high-throughput screening: practical considerations. Methods in Molecular Biology, 275. pp. 85-110. ISSN 1064-3745

Pearson, Mark Andrew and Fabbro, Doriano (2004) Targeting protein kinases in cancer therapy: a success? Expert Review of Anticancer Therapy, 4 (6). pp. 1113-1124. ISSN 1744-8328

Peters, Eric, Brock, Ansgar and Ficarro, Scott (2004) Exploring the phosphoproteome with mass spectrometry. Mini Reviews in Medicinal Chemistry, 4 (3). pp. 313-324. ISSN 1389-5575

Pletcher, Mathew, Mcclurg, Phillip, Batalov, Sergei, Su, Andrew, Barnes, Whitney, Lagler, Erica, Korstanje, Ron, Wang, Xiaosong, Nusskern, Deborah, Bogue, Molly, Mural, Richard, Paigen, Beverly and Wiltshire, Timothy (2004) Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS biology, 2 (12). e393. ISSN 1545-7885

Pletcher, Mathew and Wiltshire, Timothy (2004) Can we find the genes involved in complex traits? Genome Biology, 5 (10). p. 347. ISSN 1465-6914

Prashad, Mahavir, Lu, Yansong and Repic, Oljan (2004) A novel two-carbon homologation with N-vinylacetamides and ethyl vinyl ether as acetaldehyde anion equivalents in the synthesis of 9H-xanthene, 9H-thioxanthene, and 9,10-dihydro-9-acridine carboxaldehydes. The Journal of Organic Chemistry, 69 (2). pp. 584-586. ISSN 0022-3263


Rausch, Martin, Hiestand, Peter, Foster, Carolyn-Ann, Baumann, Diana, Cannet, Catherine and Rudin, Markus (2004) Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. Journal of Magnetic Resonance Imaging : JMRI, 20 (1). pp. 16-24. ISSN 1053-1807

Ren, Yan-Guo, Wagner, Klaus, Knee, Deborah, Aza-Blanc, Pedro, Nasoff, Marc and Deveraux, Quinn (2004) Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle. Molecular Biology of the Cell, 15 (11). pp. 5064-5074. ISSN 1059-1524

Revesz, Laszlo, Blum, Ernst, Di Padova, Franco E., Buhl, Thomas, Feifel, Roland, Gram, Hermann, Hiestand, Peter, Manning, Ute and Rucklin, Gerard (2004) Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis. Bioorganic & Medicinal Chemistry Letters, 14 (13). pp. 3595-3599. ISSN 0960-894X

Revesz, Laszlo, Blum, Ernst, Di Padova, Franco E., Buhl, Thomas, Feifel, Roland, Gram, Hermann, Hiestand, Peter, Manning, Ute and Rucklin, Gerard (2004) SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity. Bioorganic & Medicinal Chemistry Letters, 14 (13). pp. 3601-3605. ISSN 0960-894X

Rot, Antal and von Andrian, Ulrich (2004) Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annual Review of Immunology, 22. pp. 891-928. ISSN 0732-0582

Rudic, Daniel, Mcnamara, Peter, Curtis, Anne-Maria, Boston, Raymond, Panda, Satchidananda, Hogenesch, John and Fitzgerald, Garret (2004) BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biology, 2 (11). e377. ISSN 1545-7885

Rudin, M, Allegrini, Peter Roland, Beckmann, Nicolau, Gremlich, Hans-Ulrich, Kneuer, Rainer, Laurent, Didier, Rausch, Martin and Stoeckli, Markus (2004) Noninvasive imaging in drug discovery and development. Ernst Schering Research Foundation Workshop (48). pp. 47-75. ISSN 0947-6075

Rudin, Markus, Beckmann, Nicolau and Rausch, Martin (2004) Magnetic resonance imaging in biomedical research: imaging of drugs and drug effects. Methods in Enzymology, 385. pp. 240-256. ISSN 0076-6879

Rueeger, Heinrich, Gerspacher, Marc, Buehlmayer, Peter, Rigollier, Pascal, Yamaguchi, Yasuchika, Schmidlin, Tibur, Whitebread, Steven, Nuesslein-Hildesheim, Barbara, Nick, Hanspeter and Cricione, Leoluca (2004) Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 14 (10). pp. 2451-2457. ISSN 0960-894X


Sandham, David, Barker, Lucy, Beattie, David, Beer, David, Bidlake, Louise, Bentley, David, Butler, Keith, Craig, Sarah, Farr, David Colin, Ffoulkes-Jones, Claire, Fozard, John R., Haberthuer, Sandra, Howes, Colin, Hynx, Deborah, Jeffers, Sarah, Keller, Thomas, Kirkham, Paul, Maas, Janet, Mazzoni, Lazzaro, Nicholls, Andy, Pilgrim, Gaynor, Schaebulin, Elisabeth, Spooner, Gillian M, Stringer, Rowan, Tranter, Pamela, Turner, Katharine, Tweed, Morris, Walker, Christoph, Watson, Simon and Cuenoud, Bernard (2004) Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters. Bioorganic & Medicinal Chemistry, 12 (19). pp. 5213-5224. ISSN 0968-0896

Sato, Trey, Panda, Satchindananda, Miraglia, Loren, Reyes, Teresa, Rudic, Radu, Mcnamara, Peter, Naik, Kinnery, Fitzgerald, Garret, Kay, Steve and Hogenesch, John (2004) A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron, 43 (4). pp. 527-537. ISSN 0896-6273

Saviranta, Petri, Okon, Ryan, Brinker, Achim, Warashina, Masaki, Eppinger, Joerg and Geierstanger, Bernhard (2004) Evaluating sandwich immunoassays in microarray format in terms of the ambient analyte regime. Clinical Chemistry, 50 (10). pp. 1907-1920. ISSN 0009-9147

Schlapbach, Achim, Heng, Richard and Di Padova, Franco E. (2004) A novel Pd-catalyzed cyclization reaction of ureas for the synthesis of dihydroquinazolinone p38 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters, 14 (2). pp. 357-360. ISSN 0960-894X

Schmid, Herbert and Schoeffter, Philippe (2004) Functional activity of the multiligand analog SOM230 at human recombinant somatostatin receptor subtypes supports its usefulness in neuroendocrine tumors. Neuroendocrinology, 80 Suppl 1. pp. 47-50. ISSN 0028-3835

Scholz, Dieter, Baumann, Karl, Grassberger, Max, Wolff-Winiski, Barbara, Rihs, Grety, Walter, Hansrudolf and Meingassner, Josef (2004) Synthesis of dammarane-type triterpenoids with anti-inflammatory activity in vivo. Bioorganic & Medicinal Chemistry Letters, 14 (11). pp. 2983-2986. ISSN 0960-894X

Schreiner, Erwin and Billich, Andreas (2004) Estrone formate: a novel type of irreversible inhibitor of human steroid sulfatase. Bioorganic & Medicinal Chemistry Letters, 14 (19). pp. 4999-5002. ISSN 0960-894X

Schreiner, Erwin, Kern, Michael, Steck, Andrea and Foster, Carolyn-Ann (2004) Synthesis of ether analogues derived from HUN-7293 and evaluation as inhibitors of VCAM-1 expression. Bioorganic & Medicinal Chemistry Letters, 14 (19). pp. 5003-5006. ISSN 0960-894X

Schuffenhauer, Ansgar, Popov, Maxim, Schopfer, Ulrich, Acklin, Pierre, Stanek, Jaroslav and Jacoby, Edgar (2004) Molecular diversity management strategies for building and enhancement of diverse and focused lead discovery compound screening collections. Combinatorial Chemistry & High Throughput Screening, 7 (8). pp. 771-781. ISSN 1386-2073

Schuler, Walter, Bigaud, Marc, Brinkmann, Volker, Di Padova, Franco E., Geisse, Sabine, Gram, Hermann, Hungerford, Valerie, Kleuser, Beate, Kristofic, Colette, Menninger, Klaus, Tees, Reet, Wieczorek, Grazyna, Wilt, Corinne, Wioland, Catherine and Zurini, Mauro (2004) Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation. Transplantation, 77 (5). pp. 717-726. ISSN 0041-1337

Shanado, Yuka, Kometani, Motohiko, Uchiyama, Hidefumi, Koizumi, Shinichi and Teno, Naoki (2004) Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach. Biochemical and Biophysical Research Communications, 325 (4). pp. 1487-1494. ISSN 0006-291X

Shipway, Aaron, Danahay, Henry, Williams, Jennifer, Tully, David, Backes, Bradley and Harris, Jennifer (2004) Biochemical characterization of prostasin, a channel activating protease. Biochemical and Biophysical Research Communications, 324 (2). pp. 953-963. ISSN 0006-291X

Signor, Luca, Tigani, Bruno, Beckmann, Nicolau, Falchetto, Rocco Angelo and Stoeckli, Markus (2004) Two-dimensional electrophoresis protein profiling and identification in rat bronchoalveolar lavage fluid following allergen and endotoxin challenge. Proteomics, 4 (7). pp. 2101-2110. ISSN 1615-9853

Sottile, V, Seuwen, Klaus and Kneissel, Michaela (2004) Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARgamma agonist BRL49653 (rosiglitazone). Calcified Tissue International, 75 (4). pp. 329-337. ISSN 0171-967X

Spraggon, Glen, Pantazatos, Dennis, Klock, Heath, Wilson, Ian, Woods, Virgil and Lesley, Scott (2004) On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171. Protein Science : a publication of the Protein Society, 13 (12). pp. 3187-3199. ISSN 0961-8368

Su, Andrew, Wiltshire, Timothy, Batalov, Sergei, Lapp, Hilmar, Ching, Keith, Block, David, Zhang, Jie, Soden, Richard, Hayakawa, Mimi, Kreiman, Gabriel, Cooke, Michael, Walker, John and Hogenesch, John (2004) A gene atlas of the mouse and human protein-encoding transcriptomes. Proceedings of the National Academy of Sciences of the United States of America, 101 (16). pp. 6062-6067. ISSN 0027-8424

Susa Spring, Mira, Luong-Nguyen, Ngoc-Hong, Cappellen, David, Zamurovic Ribrioux, Natasa and Gamse, Rainer (2004) Human primary osteoclasts: in vitro generation and applications as pharmacological and clinical assay. Journal of Translational Medicine, 2 (1). p. 6. ISSN 1479-5876

Susa Spring, Mira, Luong-Nguyen, Ngoc-Hong, Cappellen, David, Zamurovic Ribrioux, Natasa and Gamse, Rainer (2004) Human primary osteoclasts: in vitro generation and applications as pharmacological and clinical assay. Journal of Translational Medicine, 2 (1). p. 6. ISSN 1479-5876


Takada, Tappei, Weiss, Markus, Kretz, Olivier, Gross, Gerhard and Sugiyama, Yuichi (2004) Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154. Drug metabolism and disposition: the biological fate of chemicals, 32 (11). pp. 1272-1278. ISSN 0090-9556

Takashima, Hiroyuki, Tamaoki, Haruhiko, Teno, Naoki, Nishi, Yoshinori, Uchiyama, Susumu, Fukui, Kiichi and Kobayashi, Yuji (2004) Hydrophobic core around tyrosine for human endothelin-1 investigated by photochemically induced dynamic nuclear polarization nuclear magnetic resonance and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Biochemistry, 43 (44). pp. 13932-13936. ISSN 0006-2960

Thakker, Deepak, Natt, Francois, Huesken, Dieter, Maier, Rainer, Mueller, Matthias, Van Der Putten, P. Herman, Hoyer, Daniel and Cryan, John F. (2004) Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. Proceedings of the National Academy of Sciences of the United States of America, 101 (49). pp. 17270-17275. ISSN 0027-8424

Thoma, Gebhard, Nuninger, Francois, Schaefer, Marc, Akyel, Kayhan Gabriel, Albert, Rainer, Beerli, Christian, Bruns, Christian, Francotte, Eric, Luyten, Marcel, Mackenzie, Duncan, Oberer, Lukas, Streiff, Markus, Wagner, Beatrix, Walter, Hansrudolf, Weckbecker, Gisbert and Zerwes, Hans-Guenter (2004) Orally bioavailable competitive CCR5 antagonists. Journal of Medicinal Chemistry, 47 (8). pp. 1939-1955. ISSN 0022-2623

Tigani, Bruno, Gremlich, Hans-Ulrich, Cannet, Catherine, Zurbruegg, Stefan, Quintana, Harry Karmouty and Beckmann, Nicolau (2004) Near-infrared fluorescence imaging and histology confirm anomalous edematous signal distribution detected in the rat lung by MRI after allergen challenge. Journal of Magnetic Resonance Imaging : JMRI, 20 (6). pp. 967-974. ISSN 1053-1807

Trapani, Angelo, Beil, Michael, Bruseo, Charles, Savage, Paula, Firooznia, Fariborz and Jeng, Arco (2004) CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme. Journal of Cardiovascular Pharmacology, 44 Suppl 1. S211-S215. ISSN 1533-4023

Traxler, Peter, Allegrini, Peter Roland, Brandt, Ralf, Brueggen, Josef, Cozens, Robert, Fabbro, Doriano, Grosios, Konstantina, Lane, Heidi, Mcsheehy, Paul M.J., Mestan, Juergen, Meyer, Thomas, Tang, Careen, Wartmann, Markus, Wood, Jeanette and Caravatti, Giorgio (2004) AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Research, 64 (14). pp. 4931-4941. ISSN 0008-5472


Ullrich, Thomas, Baumann, Karl, Welzenbach, Karl, Schmutz, Simone, Camenisch, Gian P., Meingassner, Josef and Weitz Schmidt, Gabriele (2004) Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain. Bioorganic & Medicinal Chemistry Letters, 14 (10). pp. 2483-2487. ISSN 0960-894X

Urtz, Nicole, Olivera, Ana, Bofill Cardona, Elisa, Csonga, Robert, Billich, Andreas, Mechtcheriakova, Diana, Bornancin, Frederic, Woisetschlaeger, Max, Rivera, Juan and Baumruker, Thomas (2004) Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase. Molecular and Cellular Biology, 24 (19). pp. 8765-8777. ISSN 0270-7306

Urwyler, Stephan, Gjoni, Tina, Kaupmann, Klemens, Pozza, Mario F. and Mosbacher, Johannes (2004) Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors. European Journal of Pharmacology, 483 (2-3). pp. 147-153. ISSN 0014-2999

Uzunov, Veska, Wrynn, Aileen, Kinnunen, Anu, Ceci, Melanie, Kohler, Christian and Uzunov, Doncho (2004) Chronic antidepressants reverse cerebrocortical allopregnanolone decline in the olfactory-bulbectomized rat. European Journal of Pharmacology, 486 (1). pp. 31-34. ISSN 0014-2999


Valencia, Jessica, Mone, Manisha, Koehne, Charles, Rediske, John and Hughes, Thomas (2004) Binding of receptor for advanced glycation end products (RAGE) ligands is not sufficient to induce inflammatory signals: lack of activity of endotoxin-free albumin-derived advanced glycation end products. Diabetologia, 47 (5). pp. 844-852. ISSN 0012-186X

Valencia, Jessica, Mone, Manisha, Zhang, Jin, Weetall, Marla, Buxton, Francis and Hughes, Thomas (2004) Divergent pathways of gene expression are activated by the RAGE ligands S100b and AGE-BSA. Diabetes, 53 (3). pp. 743-751. ISSN 0012-1797

Valencia, Jessica, Weldon, Stephen, Quinn, D, Kiers, Geesje H, DeGroot, Jeroen, TeKoppele, Johan M and Hughes, Thomas (2004) Advanced glycation end product ligands for the receptor for advanced glycation end products: biochemical characterization and formation kinetics. Analytical Biochemistry, 324 (1). pp. 68-78. ISSN 0003-2697


Wagner, Klaus, Engels, Ingo and Deveraux, Quinn (2004) Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway. The Journal of Biological Chemistry, 279 (33). pp. 35047-35052. ISSN 0021-9258

Wagner, Klaus, Sapinoso, Marie Lisa, El-Rifai, Wael, Frierson, Henry, Butz, Nicole, Mestan, Juergen, Hofmann, Francesco, Deveraux, Quinn and Hampton, Garret (2004) Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin. Oncogene, 23 (39). pp. 6621-6629. ISSN 0950-9232

Waldmeier, Peter and Tatton, William G. (2004) Interrupting apoptosis in neurodegenerative disease: potential for effective therapy? Drug Discovery Today, 9 (5). pp. 210-218. ISSN 1359-6446

Walker, John, Su, Andrew, Self, David, Hogenesch, John, Lapp, Hilmar, Maier, Rainer, Hoyer, Daniel and Bilbe, Graeme (2004) Applications of a rat multiple tissue gene expression data set. Genome Research, 14 (4). pp. 742-749. ISSN 1088-9051

Walmsley, Adrian Robert, Mccombie, Gregor, Neumann, Ulf, Marcellin, David, Hillenbrand, Rainer, Mir, Anis Khusro and Frentzel, Stefan (2004) Zinc metalloproteinase-mediated cleavage of the human Nogo-66 receptor. Journal of Cell science, 117 (Pt 19). pp. 4591-4602. ISSN 0021-9533

Wan, Yongqin, Hur, Wooyoung, Cho, Charles, Liu, Yi, Adrian, Francisco, Lozach, Olivier, Bach, Stephane, Mayer, Thomas, Fabbro, Doriano, Meijer, Laurent and Gray, Nathanael (2004) Synthesis and target identification of hymenialdisine analogs. Chemistry & Biology, 11 (2). pp. 247-259. ISSN 1074-5521

Wang, Shaowen, Yan-Neale, Yan, Zeremski-Seferovic, Marija and Cohen, Dalia (2004) Transcription regulation by histone deacetylases. Novartis Foundation Symposium, 259. 238-245; discussion 245-248; 285-288. ISSN 1528-2511

Wang, Yan, Engels, Ingo, Knee, Deborah, Nasoff, Marc, Deveraux, Quinn and Quon, Kim (2004) Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway. Cancer Cell, 5 (5). pp. 501-512. ISSN 1535-6108

Weitz Schmidt, Gabriele, Welzenbach, Karl, Dawson King, Janet and Kallen, Joerg (2004) Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo. The Journal of Biological Chemistry, 279 (45). pp. 46764-46771. ISSN 0021-9258

Welsch, Carole, Roth, Lukas, Goetschy, Jean Francois and Movva, Rao (2004) Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine. The Journal of Biological Chemistry, 279 (35). pp. 36720-36731. ISSN 0021-9258

Wen, Ben, Pletcher, Mathew, Warashina, Masaki, Choe, Sun Hui, Ziaee, Niusha, Wiltshire, Timothy, Sauer, Karsten and Cooke, Michael (2004) Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Proceedings of the National Academy of Sciences of the United States of America, 101 (15). pp. 5604-5609. ISSN 0027-8424

Widmer, Hans and Jahnke, Wolfgang (2004) Protein NMR in biomedical research. Cellular and Molecular Life Sciences : CMLS, 61 (5). pp. 580-599. ISSN 1420-682X


Xue, Song, McKenna, Joseph, Shieh, Wen-Chung and Repic, Oljan (2004) A facile synthesis of C2,N3-disubstituted-4-quinazolone. The Journal of Organic Chemistry, 69 (19). pp. 6474-6477. ISSN 0022-3263


Zamurovic Ribrioux, Natasa, Cappellen, David, Rohner, Daisy and Susa Spring, Mira (2004) Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity. The Journal of Biological Chemistry, 279 (36). pp. 37704-37715. ISSN 0021-9258

Zawel, Leigh (2004) Teaching cancer cells to die. Journal of Cellular Biochemistry, 92 (4). pp. 651-655. ISSN 0730-2312

Zehender, Hartmut, Le Goff, Francois, Lehmann, Natalie, Filipuzzi, Ireos and Mayr, Lorenz (2004) SpeedScreen: The "missing link" between genomics and lead discovery. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 9 (6). pp. 498-505. ISSN 1087-0571

Zhou, Vicki, Han, Shulin, Brinker, Achim, Klock, Heath, Caldwell, Jeremy and Gu, Xiang-Ju (2004) A time-resolved fluorescence resonance energy transfer-based HTS assay and a surface plasmon resonance-based binding assay for heat shock protein 90 inhibitors. Analytical Biochemistry, 331 (2). pp. 349-357. ISSN 0003-2697

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