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SpeedScreen: The "missing link" between genomics and lead discovery.

Zehender, Hartmut, Le Goff, Francois, Lehmann, Natalie, Filipuzzi, Ireos and Mayr, Lorenz (2004) SpeedScreen: The "missing link" between genomics and lead discovery. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 9 (6). pp. 498-505. ISSN 1087-0571


SpeedScreen is a novel, label-free, in-solution, affinity-based selection methodology for high-throughput screening (HTS) developed at Novartis Pharma. The SpeedScreen protocol comprises in-solution affinity selection, followed by size exclusion chromatography in combination with microbore-liquid-chromatography/electrospray-ionization mass spectrometry (micro-LC/ESI-MS). The authors describe the basic concept behind assay development, HTS, and data analysis with the SpeedScreen technology. Advantages and limitations of SpeedScreen compared to alternative screening technologies are discussed, and an example is given from a SpeedScreen campaign applying this innovative affinity selection concept in HTS.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: affinity selection; mass spectrometry; high-throughput screening; orphan targets; nontractable targets; chemical genomics
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Date Deposited: 14 Dec 2009 13:55
Last Modified: 31 Jan 2013 01:08


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