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Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters.

Sandham, David and Barker, Lucy and Beattie, David and Beer, David and Bidlake, Louise and Bentley, David and Butler, Keith and Craig, Sarah and Farr, David Colin and Ffoulkes-Jones, Claire and Fozard, John R. and Haberthuer, Sandra and Howes, Colin and Hynx, Deborah and Jeffers, Sarah and Keller, Thomas and Kirkham, Paul and Maas, Janet and Mazzoni, Lazzaro and Nicholls, Andy and Pilgrim, Gaynor and Schaebulin, Elisabeth and Spooner, Gillian M and Stringer, Rowan and Tranter, Pamela and Turner, Katharine and Tweed, Morris and Walker, Christoph and Watson, Simon and Cuenoud, Bernard (2004) Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters. Bioorganic & Medicinal Chemistry, 12 (19). pp. 5213-5224. ISSN 0968-0896

Abstract

A series of novel corticosteroid derivatives featuring C-17 furoate ester functionality have been synthesised. Profiling in vitro and in vivo has resulted in the identification of a compound with a longer duration of action and a lower oral side effect profile in rodents compared to budesonide.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Glucocorticoids; Asthma; Duration of action; Side effects
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Date Deposited: 14 Dec 2009 13:55
Last Modified: 31 Jan 2013 01:08
URI: https://oak.novartis.com/id/eprint/729

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