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Altered response to benzodiazepine anxiolytics in mice lacking GABA B(1) receptors.

Mombereau, Cedric and Kaupmann, Klemens and Van Der Putten, P. Herman and Cryan, John F. (2004) Altered response to benzodiazepine anxiolytics in mice lacking GABA B(1) receptors. European Journal of Pharmacology, 497 (1). pp. 119-120. ISSN 0014-2999

Abstract

Recently, we demonstrated that mice lacking the GABA(B(1)) subunit were more anxious than wild-type animals in several behavioural paradigms, most notably in the light-dark test. In an attempt to assess the effects of classical benzodiazepine anxiolytics on anxiety-like behaviour observed in these mice, animals were administered either chlordiazepoxide (10 mg/kg, p.o.) or diazepam (7.5 mg/kg, p.o.) prior to testing in the light-dark box. Surprisingly, in contrast with the wild-type mice, neither benzodiazepines decreased anxiety-like behaviour in GABA(B(1))(-/-) mice. These data suggest that targeted deletion of GABA(B(1)) subunit alters GABA(A) receptor function in vivo.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Anxiety; GABAB; Anxiolytics
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Date Deposited: 14 Dec 2009 13:55
Last Modified: 31 Jan 2013 01:08
URI: https://oak.novartis.com/id/eprint/738

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