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Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2.

Ettmayer, Peter and Billich, Andreas and Baumruker, Thomas and Mechtcheriakova, Diana and Schmid, Heide and Nussbaumer, Peter (2004) Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2. Bioorganic & Medicinal Chemistry Letters, 14 (6). pp. 1555-1558. ISSN 0960-894X

Abstract

Fluorescently labeled d-erythro-sphingosines have been successfully synthesized in 9 and 12 steps starting from commercially available Garner aldehyde. Determining the influence of the nature, position and linkage of the label on the in vitro phosphorylation rate by sphingosine kinases 1 and 2 resulted in the identification of a pyrene- and a NBD-labeled sphingosine which are both phosphorylated with efficiency comparable to the natural substrate.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
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Date Deposited: 14 Dec 2009 14:01
Last Modified: 31 Jan 2013 01:20
URI: https://oak.novartis.com/id/eprint/322

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