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Teaching cancer cells to die.

Zawel, Leigh (2004) Teaching cancer cells to die. Journal of Cellular Biochemistry, 92 (4). pp. 651-655. ISSN 0730-2312


Tumor cells have evolved numerous mechanisms to thwart apoptosis. As our understanding of the machinery which regulates cell-death evolves, these apoptotic defects have fallen into the crosshairs of cancer drug developers. The issues raised in exploiting these alterations for therapeutic benefit are discussed.

Item Type: Article
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Additional Information: archiving not allowed on institutional repository
Keywords: apoptosis; BCL2; IAPs; Smac; TRAIL; XIAP
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Date Deposited: 14 Dec 2009 14:07
Last Modified: 31 Jan 2013 01:31


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