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Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design.

Furet, Pascal and Imbach, Patricia and Noorani, Maria and Koeppler, Juergen and Laumen, Kurt and Lang, Marc and Guagnano, Vito and Fuerst, Peter and Roesel, Johannes and Zimmermann, Johann and Garcia-Echeverria, Carlos (2004) Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design. Journal of Medicinal Chemistry, 47 (20). pp. 4810-4813. ISSN 0022-2623

Abstract

Proteasome inhibition is a therapeutic concept of current interest in anticancer research. We report here the design, synthesis, and biological characterization of prototypes of a new class of noncovalent proteasome inhibitors showing high activity in biochemical and cellular assays.

Item Type: Article
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Date Deposited: 14 Dec 2009 13:55
Last Modified: 31 Jan 2013 01:08
URI: https://oak.novartis.com/id/eprint/728

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