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Protein NMR in biomedical research.

Widmer, Hans and Jahnke, Wolfgang (2004) Protein NMR in biomedical research. Cellular and Molecular Life Sciences : CMLS, 61 (5). pp. 580-599. ISSN 1420-682X


Nuclear magnetic resonance (NMR) spectroscopy is a versatile biophysical technique with wide applicability in drug discovery research, particularly for the detection and characterization of molecular interactions. This review highlights in a comprehensive manner the aspects of biomolecular NMR which are most beneficial for pharmaceutical research and presents them as contributions to the different stages of a drug discovery program: target selection, assay development, lead generation and lead optimization. Emphasis is put on the concept of the particular NMR application, rather than on technical details, and on recent examples. Finally, an appendix of frequently asked questions is given.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Fragment-based screening; drug discovery; NMR screening; SAR-by-NMR; structure determination; high throughput screening; hit validation
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Date Deposited: 14 Dec 2009 13:54
Last Modified: 31 Jan 2013 01:07


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