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Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke

Linton, Steven D and Aja, Teresa and Allegrini, Peter Roland and Deckwerth, Thomas L and Diaz, Jose-Luis and Hengerer, Bastian and Herrmann, Julia and Jahangiri, Kathy G and Kallen, Joerg and Karanewsky, Donald S and Meduna, Steven P and Nalley, Kip and Robinson, Edward D and Roggo, Silvio and Rovelli, Giorgio and Sauter, Andre and Sayers, Robert O and Schmitz, Albert and Smidt, Robert and Ternansky, Robert J and Tomaselli, Kevin J and Ullman, Brett R and Wiessner, Christoph and Wu, Joe C (2004) Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke. Bioorganic & Medicinal Chemistry Letters, 14 (10). pp. 2685-2691. ISSN 0960-894X


Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein.

Item Type: Article
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Additional Information: Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
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Date Deposited: 29 Apr 2010 23:45
Last Modified: 01 Feb 2013 00:49


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