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Number of items: 159.

B

Balatoni, Balazs and Storch, Maria and Swoboda, Eva-Maria and Schonborn, Vinzenz and Koziel, Agnieszka and Lambrou, George N. and Hiestand, Peter and Weissert, Robert and Foster, Carolyn-Ann (2007) FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis. Brain Research Bulletin, 74 (5). pp. 307-316. ISSN 0361-9230

Barclay, Jane and Clark, Anna and Ganju, Pam and Gentry, Clive and Patel, Sadhana and Wotherspoon, Glen and Buxton, Francis and Song, Chuanzheng and Ullah, Jakir and Winter, Janet and Fox, Alyson and Bevan, Stuart and Malcangio, Marzia (2007) Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain, 130 (3). pp. 225-234. ISSN 1872-6623

Baumruker, Thomas and Billich, Andreas and Brinkmann, Volker (2007) FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis. Expert Opinion on Investigational Drugs, 16 (3). pp. 283-289. ISSN 1744-7658

Beckmann, Nicolau (2007) Magnetic Resonance Imaging in Drug Discovery: Opportunities and Challenges. American Pharmaceutical Review, 10 (1). pp. 104-111. ISSN 1099-8012

Beckmann, Nicolau and Cannet, Catherine and Karmouty Quintana, Harry and Tigani, Bruno and Zurbruegg, Stefan and Ble, Francois-Xavier and Cremillieux, Yannick and Trifilieff, Alexandre (2007) Lung MRI for experimental drug research. European Journal of Radiology, 64 (3). pp. 381-396. ISSN 0720-048X

Bender, Andreas and Young, Daniel and Jenkins, Jeremy and Serrano, Martin and Mikhailov, Dmitri and Clemons, Paul and Davies, John (2007) Chemogenomic data analysis: prediction of small-molecule targets and the advent of biological fingerprint. Combinatorial Chemistry & High Throughput Screening, 10 (8). pp. 719-731. ISSN 1386-2073

Berger, Cedric and Gremlich, Hans-Ulrich and Schmidt, Philipp and Cannet, Catherine and Kneuer, Rainer and Hiestand, Peter and Rausch, Martin and Rudin, Markus (2007) In vivo monitoring the fate of Cy5.5-Tat labeled T lymphocytes by quantitative near-infrared fluorescence imaging during acute brain inflammation in a rat model of experimental autoimmune encephalomyelitis. Journal of Immunological Methods, 323 (1). pp. 65-77. ISSN 0022-1759

Beuvink, Iwan and Kolb, Fabrice and Budach, Wolfgang Ernst and Garnier, Arlette and Lange, Joerg and Natt, Francois and Dengler, Uwe and Hall, Jonathan and Filipowicz, Witold and Weiler, Jan (2007) A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs. Nucleic Acids Research, 35 (7). e52. ISSN 1362-4962

Billich, Andreas (2007) Drug evaluation: apilimod, an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency. IDrugs : the investigational drugs journal, 10 (1). pp. 53-59. ISSN 1369-7056

Bordone, Laura and Guarente, Leng (2007) Sirtuins and beta-cell function. Diabetes, Obesity & Metabolism, 9 (Suppl 2). pp. 23-27. ISSN 1462-8902

Brogdon, Jennifer and Xu, Yongyao and Szabo, Susanne and An, Shaojian and Buxton, Francis and Cohen, Dalia and Huang, Qian (2007) Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function. Blood, 109 (3). pp. 1123-1130. ISSN 0006-4971

Budde, Klemens and Tedesco-Silva, Helio and Pestana, Jose Medina and Glander, Petra and Neumayer, Hans-H and Felipe, Claudia Rosso and Machado, Paula and Sechaud, Romain and Schmouder, Robert (2007) Enteric-coated mycophenolate sodium provides higher mycophenolic acid predose levels compared with mycophenolate mofetil: implications for therapeutic drug monitoring. Therapeutic drug monitoring, 29 (3). pp. 381-384. ISSN 0163-4356

Budde, Klemens and Tedesco-Silva, Helio and Pestana, Jose Medina and Glander, Petra and Neumayer, Hans-H and Felipe, Claudia Rosso and Machado, Paula Pinheiro and Sechaud, Romain and Schmouder, Robert (2007) Enteric-coated mycophenolate sodium provides higher mycophenolic acid predose levels compared with mycophenolate mofetil: implications for therapeutic drug monitoring. Therapeutic drug monitoring, 29 (3). pp. 381-384. ISSN 0163-4356

C

Caldwell, Jeremy (2007) Cancer cell-based genomic and small molecule screens. Advances in Cancer Research, 96. pp. 145-173. ISSN 0065-230X

Carter, Clare and Leighton-Davies, Juliet and Charlton, Steven (2007) Miniaturized receptor binding assays: complications arising from ligand depletion. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 12 (2). pp. 255-266. ISSN 1087-0571

Chalmel, Frédéric and Léveillard, Thierry and Jaillard, Céline and Lardenois, Aurélie and Berdugo, Naomi and Morel, Emmanuelle and Koehl, Patrice and Lambrou, George N. and Holmgren, Arne and Sahel, José and Poch, Olivier (2007) Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential. BMC Molecular Biology, 8 (1). p. 74. ISSN 1471-2199

Chamberlain, Philip and Qian, Xun and Stiles, Amanda and Cho, Jaiesoon and Jones, David and Lesley, Scott and Grabau, Elizabeth and Shears, Stephen and Spraggon, Glen (2007) Integration of inositol phosphate signaling pathways via human ITPK1. The Journal of Biological Chemistry, 282 (38). pp. 28117-28125. ISSN 0021-9258

Chatterjee, Arnab and Liu, Hong and Tully, David and Guo, Jianhua and Epple, Robert and Russo, Ross and Williams, Jennifer and Roberts, Michael and Tuntland, Tove and Chang, Jonathan and Gordon, P. and Hollenbeck, Thomas and Tumanut, Christine and Li, Jun and Harris, Jennifer (2007) Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorganic & Medicinal Chemistry Letters, 17 (10). pp. 2899-2903. ISSN 0960-894X

Chen, Taiping and Hevi, Sarah and Gay, Frédérique and Tsujimoto, Naomi and He, Timothy and Zhang, Bailin and Ueda, Yoshihide and Li, En (2007) Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nature Genetics, 39 (3). pp. 391-396. ISSN 1061-4036

Chuchalin, Alexander G and Tsoi, Alla N and Richter, Kai and Krug, Norbert and Dahl, Ronald and Luursema, P B and Cameron, Ray and Bao, Weibin and Higgins, Mark and Woessner, Ralph and van As, Andre (2007) Safety and tolerability of indacaterol in asthma: a randomized, placebo-controlled 28-day study. Respiratory Medicine, 101 (10). pp. 2065-2075. ISSN 0954-6111

Clarke, Brian and Drujan Mayer, Doreen and Willis, Monte S and Murphy, Leon and Corpina, Richard A and Burova, Elena and Rakhilin, Sergey and Stitt, Trevor N and Patterson, Cam and Latres, Esther and Glass, David (2007) The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle. Cell Metabolism, 6 (5). pp. 376-385. ISSN 1550-4131

Commerford, Susan and Vargas, Leonardo and Dorfman, Suzanne and Mitro, Nico and Rocheford, Erik and Mak, Pui Ying and Li, Xue and Kennedy, Patrick and Mullarkey, Tara and Saez, Enrique (2007) Dissection of the insulin-sensitizing effect of liver X receptor ligands. Molecular Endocrinology (Baltimore, Md.), 21 (12). pp. 3002-3012. ISSN 0888-8809

Crisman, Thomas and Jenkins, Jeremy and Parker, Christian and Hill, William and Bender, Andreas and Deng, Zhan and Nettles Jr., James and Davies, John and Glick, Meir (2007) "Plate cherry picking": a novel semi-sequential screening paradigm for cheaper, faster, information-rich compound selection. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 12 (3). pp. 320-327. ISSN 1087-0571

Cummings, Jeffrey and Lefevre, Gilbert and Small, Gary and Appel Dingemanse, Silke (2007) Pharmacokinetic rationale for the rivastigmine patch. Neurology, 69 (4 Suppl 1). S10-3. ISSN 1526-632X

D

Dean, Charles and Narayan, Shubha and Richards, Joel and Daigle, Denis and Esterow, Stacey and Leeds, Jennifer and Kamp, Heather and Puyang, Xiaoling and Wiedmann, Brigitte and Mueller, Dieter and Voshol, Johannes and Van Oostrum, Jan and Wall, Daniel and Koehn, James and Dzink-Fox, Joann and Ryder, Neil (2007) Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number. Antimicrobial agents and chemotherapy, 51 (3). pp. 1004-1010. ISSN 0066-4804

Dev, Kumlesh K. (2007) PDZ domain protein-protein interactions: a case study with PICK1. Current Topics in Medicinal Chemistry, 7 (1). pp. 3-20. ISSN 1873-4294

Dierks, Christine and Grbic, Jovana and Zirlik, Katja and Beigi, Ronak and Englund, Nathan and Guo, Gui-Rong and Veelken, Hendrik and Engelhardt, Monika and Mertelsmann, Roland and Kelleher, Joseph F and Schultz, Peter and Warmuth, Markus (2007) Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nature Medicine, 13 (8). pp. 944-951. ISSN 1078-8956

Dirnberger, Dietmar and Seuwen, Klaus (2007) Signaling of human frizzled receptors to the mating pathway in yeast. PLoS ONE, 2 (9). e954. ISSN 1932-6203

Dubaele, Sandy and Chene, Patrick (2007) Cellular studies of MrDb (DDX18). Oncology Research, 16 (12). pp. 549-556. ISSN 0965-0407

Dubaele, Sandy and Martin, Christophe and Bohn, Jacqueline and Chene, Patrick (2007) Biochemical study of recombinant PcrA from Staphylococcus aureus for the development of screening assays. Journal of Biochemistry and Molecular Biology, 40 (1). pp. 7-14. ISSN 1225-8687

E

Eder, Joerg and Hommel, Ulrich and Cumin, Frederic and Martoglio, Bruno and Gerhartz, Bernd (2007) Aspartic proteases in drug discovery. Current Pharmaceutical Design, 13 (3). pp. 271-285. ISSN 1873-4286

Epple, Robert and Urbina, Hugo and Russo, Ross and Liu, Hong and Mason, Daniel and Bursulaya, Badry and Tumanut, Christine and Li, Jun and Harris, Jennifer (2007) Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. Bioorganic & Medicinal Chemistry Letters, 17 (5). pp. 1254-1259. ISSN 0960-894X

Ertl, Peter and Jelfs, Stephen (2007) Designing drugs on the internet? Free web tools and services supporting medicinal chemistry. Current Topics in Medicinal Chemistry, 7 (15). pp. 1491-1501. ISSN 1873-4294

Ertl, Peter (2007) In silico identification of bioisosteric functional groups. Current Opinion in Drug Discovery & Development, 10 (3). pp. 281-288. ISSN 1367-6733

F

Faller, Bernard and Ertl, Peter (2007) Computational approaches to determine drug solubility☆. Advanced Drug Delivery Reviews, 59 (7). pp. 533-545. ISSN 0169-409X

Faupel, Michel Daniel and Bonenfant, Debora and Schindler, Patrick and Bertrand, Eric and Mueller, Dieter and Stoeckli, Markus and Bitsch, Francis and Rohner, Tatiana and Staab, Dieter and Van Oostrum, Jan (2007) Biophotonics applied to proteomics. In: Biophotonics applied to Proteomics. Subcellular Proteomics, 43 . Springer, pp. 323-338. ISBN 978-1-4020-5942-1 (Print); 978-1-4020-5943-8 (Online)

Feuerbach, Dominik and Nozulak, Joachim and Lingenhoehl, Kurt and Mcallister, Kevin and Hoyer, Daniel (2007) JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist. Neuroscience Letters, 416 (1). pp. 61-65. ISSN 0304-3940

Fink, Joshua and Gu, Feng and Ling, Ling and Tolfvenstam, Thomas and Olfat, Farzad and Chin, Keh Chuang and Aw, Pauline and George, Joshy and Kuznetsov, Vladimir A and Schreiber, Mark and Vasudevan, Subhash and Hibberd, Martin L (2007) Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Neglected Tropical Diseases, 1 (2). e86. ISSN 1935-2735

G

Gadhachanda, Venkat and Wu, Baogen and Wang, Zhiwei and Kuhen, Kelli and Caldwell, Jeremy and Zondler, Helmut and Walter, Harald and Havenhand, Mark and He, Yun (2007) 4-Aminopyrimidines as novel HIV-1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 17 (1). pp. 260-265. ISSN 0960-894X

Gaither, Alex and Iourgenko, Vadim (2007) RNA interference technologies and their use in cancer research. Current Opinion in Oncology, 19 (1). pp. 50-54. ISSN 1040-8746

Gaither, Alex and Porter, Dale and Yao, Yao and Borawski, Jason and Yang, Guang and Donovan, Jerry and Sage, David and Slisz, Joanna and Tran, Mary and Straub, Christopher and Ramsey, Timothy and Iourgenko, Vadim and Huang, Alan and Chen, Yan and Schlegel, Robert and Labow, Mark and Fawell, Stephen and Sellers, William and Zawel, Leigh (2007) A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. Cancer Research, 67 (24). pp. 11493-11498. ISSN 1538-7445

Galkin, Anna and Melnick, Jonathan S and Kim, Sungjoon and Hood, Tami and Li, Nanxin and Li, Lintong and Xia, Gang and Steensma, Ruo and Chopiuk, Gregory and Jiang, Jiqing and Wan, Yongqin and Ding, Peter and Liu, Yi and Sun, Fangxian and Schultz, Peter and Gray, Nathanael and Warmuth, Markus (2007) Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proceedings of the National Academy of Sciences of the United States of America, 104 (1). pp. 270-275. ISSN 0027-8424

Graf, Christine and Rovina, Philipp and Tauzin, Loic and Schanzer, Andrea and Bornancin, Frederic (2007) Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells. Biochemical and Biophysical Research Communications, 354 (1). pp. 309-314. ISSN 0006-291X

Gromada, Jesper and Franklin, Isobel and Wollheim, Claes B. (2007) Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocrine Reviews, 28 (1). pp. 84-116. ISSN 0163-769X

Guery, Sebastien and Floersheim, Philipp and Kaupmann, Klemens and Froestl, Wolfgang (2007) Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors. Bioorganic & Medicinal Chemistry Letters, 17 (22). pp. 6206-6211. ISSN 0960-894X

H

Halder, Jyotsnabaran and Lin, Yvonne G and Merritt, William M and Spannuth, Whitney A and Nick, Alpa M and Honda, Toshiyuki and Kamat, Aparna A and Han, Liz Y and Kim, Tae Jin and Lu, Chunhua and Tari, Ana M and Bornmann, William and Fernandez, Ariel and Lopez-Berestein, Gabriel and Sood, Anil K (2007) Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. Cancer Research, 67 (22). pp. 10976-10983. ISSN 1538-7445

Hampton, Eric and Knuth, Mark and Li, Jun and Harris, Jennifer and Lesley, Scott and Spraggon, Glen (2007) The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain. Proceedings of the National Academy of Sciences of the United States of America, 104 (37). pp. 14604-14609. ISSN 0027-8424

Harant, Hanna and Wolff-Winiski, Barbara and Schreiner, Erwin and Oberhauser, Berndt and Hofer, Lotte and Lettner, Nicole and Maier, Sabine and De Vries, Jan Egbert and Lindley, Ivan-J.D. (2007) Inhibition of vascular endothelial growth factor cotranslational translocation by the cyclopeptolide CAM741. Molecular Pharmacology, 71 (6). pp. 1657-1665. ISSN 0026-895X

Hassiepen, Ulrich and Eidhoff, Ulf and Meder, Gabriele and Bulber, Jean-Francois and Hein, Andreas and Bodendorf, Ursula and Lorthiois, Edwige and Martoglio, Bruno (2007) A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate. Analytical Biochemistry, 371 (2). pp. 201-207. ISSN 0003-2697

Hintermann, Samuel and Chiesi, Michele and Von Krosigk, Ulrike and Mathe, Daniele and Felber, Richard and Hengerer, Bastian (2007) Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorganic & Medicinal Chemistry Letters, 17 (1). pp. 193-196. ISSN 0960-894X

Hintermann, Samuel and Vranesic, Ivan-Toma and Allgeier, Hans and Bruelisauer, Armin and Hoyer, Daniel and Lemaire, Michel and Moenius, Thomas and Urwyler, Stephan and Whitebread, Steven and Gasparini, Fabrizio and Auberson, Yves (2007) ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorganic & Medicinal Chemistry, 15 (2). pp. 903-914. ISSN 0968-0896

Hoyer, Daniel (2007) RNA interference for studying the molecular basis of neuropsychiatric disorders. Current Opinion in Drug Discovery & Development, 10 (2). pp. 122-129. ISSN 1367-6733

Hummel, Manfred and Yonan, Nizar and Ross, Heather and Miller, Leslie W and Sechaud, Romain and Balez, Sebastien and Koelle, Ernst Ulrich and Gerosa, Gino (2007) Pharmacokinetics and variability of mycophenolic acid from enteric-coated mycophenolate sodium compared with mycophenolate mofetil in de novo heart transplant recipients. Clinical transplantation, 21 (1). pp. 18-23. ISSN 0902-0063

I

Imbach, Patricia and Lang, Marc and Garcia-Echeverria, Carlos and Guagnano, Vito and Noorani, Maria and Roesel, Johannes and Bitsch, Francis and Rihs, Grety and Furet, Pascal (2007) Novel beta-lactam derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome. Bioorganic & Medicinal Chemistry Letters, 17 (2). pp. 358-362. ISSN 0960-894X

Irelan, Jeffrey and Murphy, Thomas and DeJesus, Paul and Teo, Hsiangling and Xu, Dingyue and Gomez--Ferreria, Maria and Zhou, Yingyao and Miraglia, Loren and Rines, Daniel and Verma, Inder and Sharp, David and Tergaonkar, Vinay and Chanda, Sumit (2007) A role for IkappaB kinase 2 in bipolar spindle assembly. Proceedings of the National Academy of Sciences of the United States of America, 104 (43). pp. 16940-16945. ISSN 0027-8424

J

Jacob, Sandra and Fendrich, Gabriele and Floersheimer, Andreas and Furet, Pascal and Liebetanz, Janis and Rummel, Gabriele and Rheinberger, Paul and Centeleghe, Mario and Fabbro, Doriano and Manley, Paul W. (2007) Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. Acta Crystallographica. Section D, Biological crystallography, 63 (Pt 1). pp. 80-93. ISSN 0907-4449

Jacobson, Laura and Bettler, Bernhard and Kaupmann, Klemens and Cryan, John F. (2007) Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety. Psychopharmacology, 190 (4). pp. 541-553. ISSN 0033-3158

Jacobson, Laura and Cryan, John F. (2007) Feeling strained? Influence of genetic background on depression-related behavior in mice: a review. Behavior Genetics, 37 (1). pp. 171-213. ISSN 0001-8244

Jagle, Ulrike and Gasser, Juerg Andreas and Muller, Matthias and Kinzel, Bernd (2007) Conditional transgene expression mediated by the mouse beta-actin locus. Genesis (New York, N.Y. : 2000), 45 (11). pp. 659-666. ISSN 1526-954X

Jansma, Ariane and Zhang, Qiong and Li, Bing and Ding, Qiang and Uno, Tetsuo and Bursulaya, Badry and Liu, Yi and Furet, Pascal and Gray, Nathanael and Geierstanger, Bernhard (2007) Verification of a designed intramolecular hydrogen bond in a drug scaffold by nuclear magnetic resonance spectroscopy. Journal of Medicinal Chemistry, 50 (24). pp. 5875-5877. ISSN 0022-2623

Jelfs, Stephen and Ertl, Peter and Selzer, Paul (2007) Estimation of pKa for druglike compounds using semiempirical and information-based descriptors. Journal of Chemical Information and Modeling, 47 (2). pp. 450-459. ISSN 1549-9596

K

Kalthoff, Frank and Winiski, Anthony and Fichtinger, Petra and Schwendinger, Brigitte and Wang, Shirley and Weishaeupl, Cordula and Stuetz, Anton (2007) Differential inhibition of primary versus preactivated T cells by pimecrolimus but not by tacrolimus in vitro. International Archives of Allergy and Immunology, 142 (3). pp. 255-264. ISSN 1018-2438

Karmouty Quintana, Harry and Cannet, Catherine and Sugar, Rosemary and Fozard, John R. and Page, Christopher and Beckmann, Nicolau (2007) Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging. British Journal of Pharmacology, 150 (8). pp. 1022-1030. ISSN 0007-1188

Karmouty Quintana, Harry and Cannet, Catherine and Zurbruegg, Stefan and Ble, Francois-Xavier and Fozard, John R. and Page, Clive and Beckmann, Nicolau (2007) Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI. Journal of Magnetic Resonance Imaging: JMRI, 26 (4). pp. 941-949. ISSN 1053-1807

Kemp, Daniel and Nirmala, Nanguneri and Szustakowski, Joseph (2007) Extending the pathway analysis framework with a test for transcriptional variance implicates novel pathway modulation during myogenic differentiation. Bioinformatics, 23 (11). pp. 1356-1362. ISSN 1460-2059

Kiffe, Michael and Graf, Daniel and Trunzer, Markus (2007) Two-dimensional liquid chromatography/mass spectrometry set-up for structural elucidation of metabolites in complex biological matrices. Rapid Communications in Mass Spectrometry: RCM, 21 (6). pp. 961-970. ISSN 0951-4198

Kim, Mijung and Park, Sang Ho and Opella, Stanley and Marsilje, Thomas and Michellys, Pierre and Seidel, Martin and Tian, Shin-Shay (2007) NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains. The Journal of Biological Chemistry, 282 (19). pp. 14253-14261. ISSN 0021-9258

Kirkham, Paul (2007) Oxidative stress and macrophage function: a failure to resolve the inflammatory response. Biochemical Society Transactions, 35 (Pt 2). pp. 284-287. ISSN 0300-5127

Koehn, Jadranka and Huesken, Dieter and Jaritz, Markus and Rot, Antal and Zurini, Mauro and Dwertmann, Anne and Beutler, Bruce and Korthauer, Ulf (2007) Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response. Human Immunology, 68 (11). pp. 871-878. ISSN 0198-8859

Konig, Renate and Chiang, Chih-Yuan and Tu, Buu and Yan, Frank and DeJesus, Paul and Romero, Angelica and Bergauer, Tobias and Orth, Anthony and Krueger, Ute and Zhou, Yingyao and Chanda, Sumit (2007) A probability-based approach for the analysis of large-scale RNAi screens. Nature Methods, 4 (10). pp. 847-849. ISSN 1548-7091

Koziczak-Holbro, Magdalena and Joyce, Claire and Gluck-Gade, Aurelie and Kinzel, Bernd and Muller, Michel and Gram, Hermann (2007) Solving the IRAK-4 enigma: application of kinase-dead knock-in mice. Ernst Schering Foundation Symposium Proceedings (3). pp. 63-82.

Koziczak-Holbro, Magdalena and Joyce, Claire and Glueck, Anton and Kinzel, Bernd and Mueller, Matthias and Tschopp, Claude and Mathison, John and Davis, Christopher and Gram, Hermann (2007) IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression. The Journal of Biological Chemistry, 282 (18). pp. 13552-13560. ISSN 0021-9258

L

Leder, Lukas and Freuler, Felix and Forstner, Michael and Mayr, Lorenz (2007) New methods for efficient protein production in drug discovery. Current Opinion in Drug Discovery & Development, 10 (2). pp. 193-202. ISSN 1367-6733

Lefevre, Gilbert and Sedek, Greg and Huang, Hsun-Lun and Saltzman, Marc and Rosenberg, Mitchell and Kiese, Beate and Fordham, Peter (2007) Pharmacokinetics of a rivastigmine transdermal patch formulation in healthy volunteers: relative effects of body site application. Journal of clinical pharmacology, 47 (4). pp. 471-478. ISSN 0091-2700

Lefterov, Iliya and Bookout, Angie and Wang, Zhu and Staufenbiel, Matthias and Mangelsdorf, David and Koldamova, Radosveta (2007) Expression profiling in APP23 mouse brain: inhibition of Aß amyloidosis and inflammation in response to LXR agonist treatment. Molecular Neurodegeneration, 2 (1). p. 20. ISSN 1750-1326

Lewis, C A and Ambrose, Carly and Banner, Kathy and Battram, Cliff and Butler, Keith and Giddings, June and Mok, Joanie and Nasra, Julie and Winney, Cerys and Poll, Chris (2007) Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig. Pulmonary Pharmacology & Therapeutics, 20 (4). pp. 325-333. ISSN 1094-5539

Lewis, C A and Ambrose, Carly and Banner, Kathy and Battram, Cliff and Butler, Keith and Giddings, June and Mok, Joanie and Nasra, Julie and Winny, C and Poll, Chris (2007) Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig. Pulmonary Pharmacology & Therapeutics, 20 (4). pp. 325-333. ISSN 1094-5539

Lhuillier, Loic and Mombereau, Cedric and Cryan, John F. and Kaupmann, Klemens (2007) GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32 (2). pp. 388-398. ISSN 0893-133X

Li, Jun and Tumanut, Christine and Gavigan, Julie-Ann and Huang, Waan and Hampton, Eric and Tuman, Rachelle and Suen, Ka Fai and Trauger, John and Spraggon, Glen and Lesley, Scott and Liau, Gene and Yowe, David and Harris, Jennifer (2007) Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity. The Biochemical Journal, 406 (2). pp. 203-207. ISSN 1470-8728

Li, Guochun and Vega, Raquel and Nelms, Keats and Gekakis, Nicholas and Goodnow, Christopher and McNamara, Peter and Wu, Hua and Hong, Nancy A and Glynne, Richard (2007) A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence. PLoS Genetics, 3 (1). e8. ISSN 1553-7404

Li, Nanxin and Batt, David and Warmuth, Markus (2007) B-Raf kinase inhibitors for cancer treatment. Current opinion in investigational drugs (London, England : 2000), 8 (6). pp. 452-456. ISSN 1472-4472

Liu, Ta-Jen and LaFortune, Tiffany and Honda, Toshiyuki and Ohmori, Osamu and Hatakeyama, Shinji and Meyer, Thomas and Jackson, Daniel and de Groot, John and Yung, W K Alfred (2007) Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Molecular Cancer Therapeutics, 6 (4). pp. 1357-1367. ISSN 1535-7163

Loehr, Kristina and Knox, John and Phong, Wai Yee and Ma, Ngai Ling and Yin, Zheng and Sampath, Aruna and Patel, Sejal and Wang, Wei and Chan, Wai Ling and Rao, Ranga and Wang, Gang and Vasudevan, Subhash and Keller, Thomas and Lim, Siew Pheng (2007) Yellow fever virus NS3 protease: peptide-inhibition studies. The Journal of General Virology, 88 (Pt 8). pp. 2223-2227. ISSN 0022-1317

Loferer, Markus and Kolossváry, István and Aszódi, András (2007) Analyzing the performance of conformational search programs on compound databases. Journal of Molecular Graphics & Modelling, 25 (5). pp. 700-710. ISSN 1093-3263

M

Maclaurin, Sarah and Krucker, Thomas and Fish, Kenneth (2007) Hippocampal dendritic arbor growth in vitro: regulation by Reelin-Disabled-1 signaling. Brain Research, 1172. pp. 1-9. ISSN 0006-8993

Maibaum, Jurgen and Stutz, Stefan and Goschke, Richard and Rigollier, Pascal and Yamaguchi, Yasuchika and Cumin, Frederic and Rahuel, Joseph and Baum, Hans-Peter and Cohen, Nissim-Claude and Schnell, Christian and Fuhrer, Walter and Gruetter, Markus and Schilling, Walter and Wood, Jeanette (2007) Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets. Journal of Medicinal Chemistry, 50 (20). pp. 4832-4844. ISSN 0022-2623

Marwick, John and Ito, Kazuhiro and Adcock, Ian and Kirkham, Paul (2007) Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy. Expert Opinion on Therapeutic Targets, 11 (6). pp. 745-755. ISSN 1472-8222

Mccleverty, Clare and Hornsby, Michael and Spraggon, Glen and Kreusch, Andreas (2007) Crystal structure of human Pus10, a novel pseudouridine synthase. Journal of Molecular Biology, 373 (5). pp. 1243-1254. ISSN 0022-2836

Mcclurg, Phillip and Janes, Jeff and Wu, Chunlei and Delano, David and Walker, John and Batalov, Sergei and Takahashi, Joseph and Shimomura, Kazuhiro and Kohsaka, Akira and Bass, Joseph and Wiltshire, Timothy and Su, Andrew (2007) Genomewide association analysis in diverse inbred mice: power and population structure. Genetics, 176 (1). pp. 675-683. ISSN 0016-6731

Mechtcheriakova, Diana and Wlachos, Alexander and Sobanov, Jury and Kopp, Tamara and Reuschel, Roland and Bornancin, Frederic and Cai, Richard and Zemann, Barbara and Urtz, Nicole and Stingl, Georg and Zlabinger, Gerhard and Woisetschlaeger, Maximilian and Baumruker, Thomas and Billich, Andreas (2007) Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. Cellular Signalling, 19 (4). pp. 748-760. ISSN 0898-6568

Mercier, Francois and Lefevre, Gilbert and Huang, Hsun-Lun Aaron and Schmidli, Heinz and Amzal, Billy and Appel Dingemanse, Silke (2007) Rivastigmine exposure provided by a transdermal patch versus capsules. Current medical research and opinion, 23 (12). pp. 3199-3204. ISSN 1473-4877

Miller, Andrew and Sandberg, Mark and Huang, Yina and Young, Michael and Sutton, Susan and Sauer, Karsten and Cooke, Michael (2007) Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation. Nature Immunology, 8 (5). pp. 514-521. ISSN 1529-2908

Mirkina, Irina and Schweighoffer, Tamas and Kricek, Franz (2007) Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15/1 versus anti-IgE Omalizumab. Immunology Letters, 109 (2). pp. 120-128. ISSN 0165-2478

Mitro, Nico and Mak, Puiying and Vargas, Leonardo and Godio, Cristina and Hampton, Eric and Molteni, Valentina and Kreusch, Andreas and Saez, Enrique (2007) The nuclear receptor LXR is a glucose sensor. Nature, 445 (7124). pp. 219-223. ISSN 0028-0836

Mitro, Nico and Vargas, Leonardo and Romeo, Russell and Koder, Alan and Saez, Enrique (2007) T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. FEBS Letters, 581 (9). pp. 1721-1726. ISSN 0014-5793

Molteni, Valentina and Li, Xiaolin and Nabakka, Juliet and Liang, Fang and Wityak, John and Koder, Alan and Vargas, Leonardo and Romeo, Russell and Mitro, Nico and Mak, Pui Ying and Seidel, Martin and Haslam, Jennifer and Chow, Donald and Tuntland, Tove and Spalding, Tracy and Brock, Ansgar and Bradley, Michelle and Castrillo, Antonio and Tontonoz, Peter and Saez, Enrique (2007) N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta. Journal of Medicinal Chemistry, 50 (17). pp. 4255-4259. ISSN 0022-2623

Mombereau, Cedric and Lhuillier, Loic and Kaupmann, Klemens and Cryan, John F. (2007) GABAB receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens DeltaFosB accumulation. The Journal of Pharmacology and Experimental Therapeutics, 321 (1). pp. 172-177. ISSN 0022-3565

Monovich, Lauren and Mugrage, Benjamin and Quadros, Elizabeth and Toscano, Karen and Tommasi, Ruben and Lavoie, Stacey and Liu, Eugene and Du, Zhengming and Lasala, Daniel and Boyar, William and Steed, Paul (2007) Optimization of halopemide for phospholipase D2 inhibition. Bioorganic & Medicinal Chemistry Letters, 17 (8). pp. 2310-2311. ISSN 0960-894X

Morrison, Dennis and Roy, Sandip and Rayner, Craig and Amer, Ahmed and Howard, Danny and Smith, James R and Evans, Thomasg (2007) A randomized, crossover study to evaluate the pharmacokinetics of amantadine and oseltamivir administered alone and in combination. PLoS ONE, 2 (12). e1305. ISSN 1932-6203

Mueller, Dieter and Voshol, Hans and Waldt, Annick and Wiedmann, Brigitte and Van Oostrum, Jan (2007) LC-MALDI MS and MS/MS--an efficient tool in proteome analysis. In: LC-MALDI MS and MS/MS — An Efficient Tool in Proteome Analysis. Subcellular Biochemistry, 43 . Springer, pp. 355-380. ISBN 0306-0225

N

Nettles Jr., James and Jenkins, Jeremy and Williams, Christopher and Clark, Adam and Bender, Andreas and Deng, Zhan and Davies, John and Glick, Meir (2007) Flexible 3D pharmacophores as descriptors of dynamic biological space. Journal of Molecular Graphics & Modelling, 26 (3). pp. 622-633. ISSN 1093-3263

Ng, Chuan Young and Gu, Feng and Phong, Wai Yee and Chen, Yen Liang and Lim, Siew Pheng and Davidson, Andrew and Vasudevan, Subhash (2007) Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing. Antiviral Research, 76 (3). pp. 222-231. ISSN 0166-3542

Nguyen, Deborah and Yin, Hong and Zhou, Yingyao and Wolff, Karen and Kuhen, Kelli and Caldwell, Jeremy (2007) Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening. Virology, 362 (1). pp. 16-25. ISSN 0042-6822

Novak, Hermann and Mueller, Anke and Harrer, Nathalie and Guenther, Claudia and Carballido, Jose and Woisetschlaeger, Maximilian (2007) CCL23 expression is induced by IL-4 in a STAT6-dependent fashion. Journal of Immunology (Baltimore, Md. : 1950), 178 (7). pp. 4335-4341. ISSN 0022-1767

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O'Reilly, Terence and Ostergaard, C and Vaxelaire, Juliane and Zak, O (2007) Systemic inflammation alters the inflammatory response in experimental lipopolysaccharide-induced meningitis. Clinical and Experimental Immunology, 147 (1). pp. 112-119. ISSN 0009-9104

Obrist, Brigit and Iteba, Nelly and Lengeler, Christian and Makemba, Ahmed and Mshana, Christopher and Nathan, Rose and Alba, Sandra and Dillip, Angel and Hetzel, Manuel W and Mayumana, Iddy and Schulze, Alexander and Mshinda, Hassan (2007) Access to health care in contexts of livelihood insecurity: a framework for analysis and action. PLoS Medicine, 4 (10). pp. 1584-1588. ISSN 1549-1676

Osinde, Maribel and Muellershausen, Florian and Dev, Kumlesh K. (2007) Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors. Neuropharmacology, 52 (5). pp. 1210-1218. ISSN 0028-3908

Owen, Charles (2007) Immunoglobulin E: role in asthma and allergic disease: lessons from the clinic. Pharmacology & Therapeutics, 113 (1). pp. 121-133. ISSN 0163-7258

P

Palmer, Helen and Diagana, Thierry (2007) Re-starting malaria research at the Novartis Institute for Tropical Diseases (NITD). Biotechnology Journal, 2 (11). pp. 1337-1338. ISSN 1860-7314

Peters, Carsten and Bacher, Markus and Buenemann, Christoph and Kricek, Franz and Rondeau, Jean-Jacques and Weigand, Klaus (2007) Conformationally constrained mimics of the membrane-proximal domain of Fc epsilonRIalpha. Chembiochem : a European journal of Chemical Biology, 8 (15). pp. 1785-1789. ISSN 1439-4227

Peters, Carsten and Billich, Andreas and Ghobrial, Micha and Hoegenauer, Klemens and Ullrich, Thomas and Nussbaumer, Peter (2007) Synthesis of borondipyrromethene (BODIPY)-labeled sphingosine derivatives by cross-metathesis reaction. The Journal of Organic Chemistry, 72 (5). pp. 1842-1845. ISSN 0022-3263

Peters, Eric and Gray, Nathanael (2007) Chemical proteomics identifies unanticipated targets of clinical kinase inhibitors. ACS Chemical Biology, 2 (10). pp. 661-664. ISSN 1554-8937

Petkov, Petko and Graber, Joel H and Churchill, Gary A and Dipetrillo, Keith and King, Benjamin L and Paigen, Kenneth (2007) Evidence of a large-scale functional organization of Mammalian chromosomes. PLoS Biology, 5 (5). e127; author reply e128. ISSN 1545-7885

Picha, Kristen and Patel, Smita and Mandiyan, Sreekala and Koehn, James and Wennogle, Lawrence (2007) The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding. The Journal of Biological Chemistry, 282 (5). pp. 2911-2917. ISSN 0021-9258

Pirard, Bernard (2007) Insight into the structural determinants for selective inhibition of matrix metalloproteinases. Drug Discovery Today, 12 (15-16). pp. 640-646. ISSN 1359-6446

Plikat, Uwe and Voshol, Johannes and Dangendorf, Yvonne and Wiedmann, Brigitte and Devay, Piroska and Mueller, Dieter and Wirth, Urs and Szustakowski, Joseph and Chirn, Gung-Wei and Inverardi, Bruno and Puyang, Xiaoling and Brown, Karen and Kamp, Heather and Hoving, Sjouke and Ruchti, Alexandra and Brendlen, Nathalie and Peterson, Ron and Buco, Jennifer and Van Oostrum, Jan and Peitsch, Manuel (2007) From proteomics to systems biology of bacterial pathogens: approaches, tools, and applications. Proteomics, 7 (6). pp. 992-1003. ISSN 1615-9853

Prut, Laetitia and Abramowski, Dorothee and Krucker, Thomas and Levy, C.L. and Roberts, Andrew and Staufenbiel, Matthias and Wiessner, Christoph (2007) Aged APP23 mice show a delay in switching to the use of a strategy in the Barnes maze. Behavioural Brain Research, 179 (1). pp. 107-110. ISSN 0166-4328

R

Roddy, Thomas and Horvath, Christopher and Stout, Steven and Kenny, Kristin and Ho, Pei-I and Zhang, Ji and Vickers, Chad and Kaushik, Virendar and Hubbard, Brian and Wang, Y Karen (2007) Mass spectrometric techniques for label-free high-throughput screening in drug discovery. Analytical Chemistry, 79 (21). pp. 8207-8213. ISSN 0003-2700

Rooks, Daniel and Gautam, Shiva and Romeling, Matthew and Cross, Martha and Stratigakis, Diana and Evans, Brittany and Goldenberg, Don and Iversen, Maura and Katz, Jeffrey (2007) Group exercise, education, and combination self-management in women with fibromyalgia: a randomized trial. Archives of Internal Medicine, 167 (20). pp. 2192-2200. ISSN 0003-9926

Ryder, Neil (2007) Discontinued drugs in 2006: anti-infectives. Expert Opinion on Investigational Drugs, 16 (12). pp. 1867-1878. ISSN 1744-7658

S

Sakaki, Junichi and Kishida, Masashi and Konishi, Kazuhide and Gunji, Hiroki and Toyao, Atsushi and Matsumoto, Yuki and Kanazawa, Takanori and Uchiyama, Hidefumi and Fukaya, Hiroaki and Mitani, Hironobu and Arai, Yoshie and Kimura, Masaaki (2007) Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents. Bioorganic & Medicinal Chemistry Letters, 17 (17). pp. 4804-4807. ISSN 0960-894X

Sakata, Tomoyo and Winzeler, Elizabeth (2007) Genomics, systems biology and drug development for infectious diseases. Molecular BioSystems, 3 (12). pp. 841-848. ISSN 1742-206X

Schneider, Martin and Meingassner, Josef and Lipp, Martin and Moore, Henrietta D. and Rot, Antal (2007) CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells. The Journal of Experimental Medicine, 204 (4). pp. 735-745. ISSN 0022-1007

Schofield, Darren and Pope, Anthony and Clementel, Veronica and Buckell, Jenny and Chapple, Susan and Clarke, Kay and Conquer, Jennie and Crofts, Anna and Crowther, Sandra and Dyson, Michael and Flack, Gillian and Griffin, Gareth and Hooks, Yvette and Howat, William and Kolb-Kokocinski, Anja and Kunze, Susan and Martin, Cecile and Maslen, Gareth and Mitchell, Joanne and O'Sullivan, Maureen and Perera, Rajika and Roake, Wendy and Shadbolt, Paul and Vincent, Karen and Warford, Anthony and Wilson, Wendy and Xie, Jane and Young, Joyce and McCafferty, John (2007) Application of phage display to high throughput antibody generation and characterization. Genome Biology, 8 (11). R254. ISSN 1465-6906

Schreiber, Mark and Ong, Swee Hoe and Holland, Richard C G and Hibberd, Martin L and Vasudevan, Subhash and Mitchell, Wayne P and Holmes, Edward C (2007) DengueInfo: A web portal to dengue information resources. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and evolutionary genetics in infectious diseases, 7 (4). pp. 540-541. ISSN 1567-1348

Schuffenhauer, Ansgar and Brown, Nathan and Ertl, Peter and Jenkins, Jeremy and Selzer, Paul and Hamon, Jacques (2007) Clustering and rule-based classifications of chemical structures evaluated in the biological activity space. Journal of Chemical Information and Modeling, 47 (2). pp. 325-336. ISSN 1549-9596

Schuffenhauer, Ansgar and Ertl, Peter and Roggo, Silvio and Wetzel, Stefan and Koch, Marcus A and Waldmann, Herbert (2007) The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification. Journal of Chemical Information and Modeling, 47 (1). pp. 47-58. ISSN 1549-9596

Schul, Wouter and Liu, Wei and Xu, Hao Ying and Flamand, Marie and Vasudevan, Subhash (2007) A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. The Journal of Infectious Diseases, 195 (5). pp. 665-674. ISSN 0022-1899

Schutte, Daniela and Um-Boock, Alphonse and Mensah-Quainoo, Ernestina and Itin, Peter and Schmid, Peter and Pluschke, Gerd (2007) Development of highly organized lymphoid structures in buruli ulcer lesions after treatment with rifampicin and streptomycin. PLoS Neglected Tropical Diseases, 1 (1). e2. ISSN 1935-2735

Shi, Qing and Hjelmeland, Anita B and Keir, Stephen T and Song, Linhua and Wickman, Sarah and Jackson, Dowdy and Ohmori, Osamu and Bigner, Darell D and Friedman, Henry S and Rich, Jeremy N (2007) A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Molecular Carcinogenesis, 46 (6). pp. 488-496. ISSN 0899-1987

Slattery, David Anthony and Markou, Athina and Cryan, John F. (2007) Evaluation of reward processes in an animal model of depression. Psychopharmacology, 190 (4). pp. 555-568. ISSN 0033-3158

Staub, Eike and Groene, Joern and Heinze, Maya and Mennerich, Detlev and Roepcke, Stefan and Klaman, Irina and Hinzmann, Bernd and Castanos-Velez, Esmeralda and Pilarsky, Christian and Mann, Benno and Brummendorf, Thomas and Weber, Birgit and Buhr, Heinz-Johannes and Rosenthal, André (2007) Genome-wide expression patterns of invasion front, inner tumor mass and surrounding normal epithelium of colorectal tumors. Molecular Cancer, 6 (1). p. 79. ISSN 1476-4598

Stoeckli, Markus and Staab, Dieter and Schweitzer, Alain and Gardiner, James and Seebach, Dieter (2007) Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry. Journal of the American Society for Mass Spectrometry, 18 (11). pp. 1921-1924. ISSN 1044-0305

Stoeckli, Markus and Staab, Dieter and Schweitzer, Alain and Gardiner, James and Seebach, Dieter (2007) Imaging of a β-Peptide Distribution in Whole-Body Mice Sections by MALDI Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 18 (11). pp. 1921-1924. ISSN 1044-0305

Stroup, Bryan and Szklennik, Paul and Forster, Cornelia and Serrano-Wu, Michael (2007) Chemoselective amination of 5-bromo-2-chloro-3-fluoropyridine. Organic Letters, 9 (10). pp. 2039-2042. ISSN 1523-7060

Szustakowski, Joseph and Kosinski, Penelope and Marrese, Christine and Lee, Jee and Elliman, Stephen and Nirmala, Nanguneri and Kemp, Daniel (2007) Dynamic resolution of functionally related gene sets in response to acute heat stress. BMC Molecular Biology, 8 (1). p. 46. ISSN 1471-2199

T

Tauzin, Loic and Graf, Christine and Sun, Mei and Rovina, Philipp and Bouveyron, Nicolas and Jaritz, Markus and Winiski, Anthony and Hartmann, Nicole and Staedtler, Frank and Billich, Andreas and Baumruker, Thomas and Zhang, Mei and Bornancin, Frederic (2007) Effects of ceramide-1-phosphate on cultured cells: dependence on dodecane in the vehicle. Journal of Lipid Research, 48 (1). pp. 66-76. ISSN 0022-2275

Teno, Naoki and Miyake, Takahiro and Ehara, Takeru and Irie, Osamu and Sakaki, Junichi and Ohmori, Osamu and Gunji, Hiroki and Matsuura, Naoko and Masuya, Keiichi and Hitomi, Yuko and Nonomura, Kazuhiko and Horiuchi, Miyuki and Gohda, Keigo and Iwasaki, Atsuko and Umemura, Ichiro and Tada, Sachiyo and Kometani, Motohiko and Iwasaki, Genji and Cowan-Jacob, Sandra and Missbach, Martin and Lattmann, Rene and Betschart, Claudia (2007) Novel scaffold for cathepsin K inhibitors. Bioorganic & Medicinal Chemistry Letters, 17 (22). pp. 6096-6100. ISSN 0960-894X

U

Umareddy, Indira and Pluquet, Olivier and Wang, Qing Yin and Vasudevan, Subhash and Chevet, Eric and Gu, Feng (2007) Dengue virus serotype infection specifies the activation of the unfolded protein response. Virology Journal, 4. p. 91. ISSN 1743-422X

V

Vaidyanathan, Sujata and Warren, Vance and Yeh, Chingming and Bizot, Marie-Noelle and Dieterich, Hans Armin and Dole, William P (2007) Pharmacokinetics, safety, and tolerability of the oral Renin inhibitor aliskiren in patients with hepatic impairment. Journal of Clinical Pharmacology, 47 (2). pp. 192-200. ISSN 0091-2700

W

Waldmeier, Felix and Glaenzel, Ulrike and Wirz, Bernard and Oberer, Lukas and Schmid, Dietmar and Seiberling, Michael and Valencia, Jessica and Riviere, Gilles-Jacques and End, Peter and Vaidyanathan, Sujata (2007) Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers. Drug metabolism and disposition: the biological fate of chemicals, 35 (8). pp. 1418-1428. ISSN 0090-9556

Wang, Jianling and Urban, Laszlo and Bojanic, Dejan (2007) Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety. Expert Opinion on Drug Metabolism & Toxicology, 3 (5). pp. 641-665. ISSN 1742-5255

Warmuth, Markus and Kim, Sungjoon and Gu, Xiang-Ju and Xia, Gang and Adrian, Francisco (2007) Ba/F3 cells and their use in kinase drug discovery. Current Opinion in Oncology, 19 (1). pp. 55-60. ISSN 1040-8746

Weckbecker, Gisbert and Bruns, Christian and Fischer, Klaus-Dieter and Heusser, Christoph and Li, Jianping and Metzler, Barbara and Morris, Randall and Nuesslein-Hildesheim, Barbara and Raulf, Friedrich and Wieczorek, Grazyna and Zenke, Gerhard (2007) Strongly reduced alloreactivity and long-term survival times of cardiac allografts in Vav1- and Vav1/Vav2-knockout mice. Transplant international: official journal of the European Society for Organ Transplantation, 20 (4). pp. 353-364. ISSN 0934-0874

Weidemann, Thomas and Hoefinger, Siegfried and Mueller, Kurt and Auer, Manfred (2007) Beyond dimerization: a membrane-dependent activation model for interleukin-4 receptor-mediated signalling. Journal of Molecular Biology, 366 (5). pp. 1365-1373. ISSN 0022-2836

Weiss, Markus and Wirz, Bernard and Schweitzer, Alain and Amstutz, Rene and Rodriguez Perez, Maria I and Andres, Hendrik and Metz, Yves and Gardiner, James and Seebach, Dieter (2007) ADME investigations of unnatural peptides: distribution of a 14C-labeled beta 3-octaarginine in rats. Chemistry & biodiversity, 4 (7). pp. 1413-1437. ISSN 1612-1880

Werner, Nicola Susann and Weber, Wilfried and Fussenegger, Martin and Geisse, Sabine (2007) A gas-inducible expression system in HEK.EBNA cells applied to controlled proliferation studies by expression of p27(Kip1). Biotechnology and Bioengineering, 96 (6). pp. 1155-1166. ISSN 0006-3592

Wiederschain, Dmitri and Chen, Lin and Johnson, Brett and Bettano, Kimberly and Jackson, Dowdy and Taraszka, John and Wang, Y Karen and Jones, Michael and Morrissey, Michael and Deeds, James and Mosher, Rebecca and Fordjour, Paul and Lengauer, Christoph and Benson, John (2007) Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. Molecular and Cellular Biology, 27 (13). pp. 4968-4979. ISSN 0270-7306

Wilson, Leanne and Yang, Qing and Szustakowski, Joseph and Gullicksen, P. Scott and Halse, Reza (2007) Pyruvate induces mitochondrial biogenesis by a PGC-1 alpha-independent mechanism. American Journal of Physiology. Cell physiology, 292 (5). C1599-C1605. ISSN 0363-6143

Wu, Zhidan and Boss, Olivier (2007) Targeting PGC-1 alpha to control energy homeostasis. Expert Opinion on Therapeutic Targets, 11 (10). pp. 1329-1338. ISSN 1744-7631

Wyss, Daniel and Bonneau, Olivier and Trifilieff, Alexandre (2007) Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation. British journal of pharmacology, 152 (1). pp. 83-90. ISSN 0007-1188

Y

Yap, Thai Leong and Chen, Yen Liang and Xu, Ting and Wen, Daying and Vasudevan, Subhash and Lescar, Julien (2007) A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 63 (Pt 2). pp. 78-83. ISSN 1744-3091

Yap, Thai Leong and Xu, Ting and Chen, Yen Liang and Malet, Helene and Egloff, Marie-Pierre and Canard, Bruno and Vasudevan, Subhash and Lescar, Julien (2007) Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. Journal of Virology, 81 (9). pp. 4753-4765. ISSN 0022-538X

Yu, Fuqu and Harada, Josephine and Brown, Helen J and Deng, Hongyu and Song, Moon Jung and Wu, Ting-Ting and Kato-Stankiewicz, Juran and Nelson, Christian G and Vieira, Jeffrey and Tamanoi, Fuyuhiko and Chanda, Sumit and Sun, Ren (2007) Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus. PLoS Pathogens, 3 (3). e44. ISSN 1553-7374

Z

Zehender, Hartmut and Mayr, Lorenz (2007) Application of mass spectrometry technologies for the discovery of low-molecular weight modulators of enzymes and protein-protein interactions. Current Opinion in Chemical Biology, 11 (5). pp. 511-517. ISSN 1367-5931

Zemann, Barbara and Urtz, Nicole and Reuschel, Roland and Mechtcheriakova, Diana and Bornancin, Frederic and Badegruber, Rudolf and Baumruker, Thomas and Billich, Andreas (2007) Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice. Immunology Letters, 109 (1). pp. 56-63. ISSN 0165-2478

Zhang, Jia and Wu, Y and Xiao, Li and Li, Kai and Chen, L and Sirois, P (2007) Therapeutic potential of RNA interference against cellular targets of HIV infection. Molecular Biotechnology, 37 (3). pp. 225-236. ISSN 1073-6085

Zhou, Yingyao and Zhou, Bin and Chen, Kaisheng and Yan, Frank and King, Frederick and Jiang, Shumei and Winzeler, Elizabeth (2007) Large-scale annotation of small-molecule libraries using public databases. Journal of Chemical Information and Modeling, 47 (4). pp. 1386-1394. ISSN 1549-9596

Zhou, Liping and Yang, Linhong and Skolnik, Suzanne and Wang, Jianling (2007) Development of a High Throughput Equilibrium Solubility Assay Using Miniaturized Shake-Flask Method in Early Drug Discovery. Development of a High Throughput Equilibrium Solubility Assay Using Miniaturized Shake-Flask Method in Early Drug Discovery, 96 (11). pp. 3052-3071. ISSN 0022-3549

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