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Balatoni, Balazs, Storch, Maria, Swoboda, Eva-Maria, Schonborn, Vinzenz, Koziel, Agnieszka, Lambrou, George N., Hiestand, Peter, Weissert, Robert and Foster, Carolyn-Ann (2007) FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis. Brain Research Bulletin, 74 (5). pp. 307-316. ISSN 0361-9230

Barclay, Jane, Clark, Anna, Ganju, Pam, Gentry, Clive, Patel, Sadhana, Wotherspoon, Glen, Buxton, Francis, Song, Chuanzheng, Ullah, Jakir, Winter, Janet, Fox, Alyson, Bevan, Stuart and Malcangio, Marzia (2007) Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain, 130 (3). pp. 225-234. ISSN 1872-6623

Baumruker, Thomas, Billich, Andreas and Brinkmann, Volker (2007) FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis. Expert Opinion on Investigational Drugs, 16 (3). pp. 283-289. ISSN 1744-7658

Beckmann, Nicolau (2007) Magnetic Resonance Imaging in Drug Discovery: Opportunities and Challenges. American Pharmaceutical Review, 10 (1). pp. 104-111. ISSN 1099-8012

Beckmann, Nicolau, Cannet, Catherine, Karmouty Quintana, Harry, Tigani, Bruno, Zurbruegg, Stefan, Ble, Francois-Xavier, Cremillieux, Yannick and Trifilieff, Alexandre (2007) Lung MRI for experimental drug research. European Journal of Radiology, 64 (3). pp. 381-396. ISSN 0720-048X

Bender, Andreas, Young, Daniel, Jenkins, Jeremy, Serrano, Martin, Mikhailov, Dmitri, Clemons, Paul and Davies, John (2007) Chemogenomic data analysis: prediction of small-molecule targets and the advent of biological fingerprint. Combinatorial Chemistry & High Throughput Screening, 10 (8). pp. 719-731. ISSN 1386-2073

Berger, Cedric, Gremlich, Hans-Ulrich, Schmidt, Philipp, Cannet, Catherine, Kneuer, Rainer, Hiestand, Peter, Rausch, Martin and Rudin, Markus (2007) In vivo monitoring the fate of Cy5.5-Tat labeled T lymphocytes by quantitative near-infrared fluorescence imaging during acute brain inflammation in a rat model of experimental autoimmune encephalomyelitis. Journal of Immunological Methods, 323 (1). pp. 65-77. ISSN 0022-1759

Beuvink, Iwan, Kolb, Fabrice, Budach, Wolfgang Ernst, Garnier, Arlette, Lange, Joerg, Natt, Francois, Dengler, Uwe, Hall, Jonathan, Filipowicz, Witold and Weiler, Jan (2007) A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs. Nucleic Acids Research, 35 (7). e52. ISSN 1362-4962

Billich, Andreas (2007) Drug evaluation: apilimod, an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency. IDrugs : the investigational drugs journal, 10 (1). pp. 53-59. ISSN 1369-7056

Bordone, Laura and Guarente, Leng (2007) Sirtuins and beta-cell function. Diabetes, Obesity & Metabolism, 9 (Suppl 2). pp. 23-27. ISSN 1462-8902

Brogdon, Jennifer, Xu, Yongyao, Szabo, Susanne, An, Shaojian, Buxton, Francis, Cohen, Dalia and Huang, Qian (2007) Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function. Blood, 109 (3). pp. 1123-1130. ISSN 0006-4971

Budde, Klemens, Tedesco-Silva, Helio, Pestana, Jose Medina, Glander, Petra, Neumayer, Hans-H, Felipe, Claudia Rosso, Machado, Paula, Sechaud, Romain and Schmouder, Robert (2007) Enteric-coated mycophenolate sodium provides higher mycophenolic acid predose levels compared with mycophenolate mofetil: implications for therapeutic drug monitoring. Therapeutic drug monitoring, 29 (3). pp. 381-384. ISSN 0163-4356

Budde, Klemens, Tedesco-Silva, Helio, Pestana, Jose Medina, Glander, Petra, Neumayer, Hans-H, Felipe, Claudia Rosso, Machado, Paula Pinheiro, Sechaud, Romain and Schmouder, Robert (2007) Enteric-coated mycophenolate sodium provides higher mycophenolic acid predose levels compared with mycophenolate mofetil: implications for therapeutic drug monitoring. Therapeutic drug monitoring, 29 (3). pp. 381-384. ISSN 0163-4356

C

Caldwell, Jeremy (2007) Cancer cell-based genomic and small molecule screens. Advances in Cancer Research, 96. pp. 145-173. ISSN 0065-230X

Carter, Clare, Leighton-Davies, Juliet and Charlton, Steven (2007) Miniaturized receptor binding assays: complications arising from ligand depletion. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 12 (2). pp. 255-266. ISSN 1087-0571

Chalmel, Frédéric, Léveillard, Thierry, Jaillard, Céline, Lardenois, Aurélie, Berdugo, Naomi, Morel, Emmanuelle, Koehl, Patrice, Lambrou, George N., Holmgren, Arne, Sahel, José and Poch, Olivier (2007) Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential. BMC Molecular Biology, 8 (1). p. 74. ISSN 1471-2199

Chamberlain, Philip, Qian, Xun, Stiles, Amanda, Cho, Jaiesoon, Jones, David, Lesley, Scott, Grabau, Elizabeth, Shears, Stephen and Spraggon, Glen (2007) Integration of inositol phosphate signaling pathways via human ITPK1. The Journal of Biological Chemistry, 282 (38). pp. 28117-28125. ISSN 0021-9258

Chatterjee, Arnab, Liu, Hong, Tully, David, Guo, Jianhua, Epple, Robert, Russo, Ross, Williams, Jennifer, Roberts, Michael, Tuntland, Tove, Chang, Jonathan, Gordon, P., Hollenbeck, Thomas, Tumanut, Christine, Li, Jun and Harris, Jennifer (2007) Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorganic & Medicinal Chemistry Letters, 17 (10). pp. 2899-2903. ISSN 0960-894X

Chen, Taiping, Hevi, Sarah, Gay, Frédérique, Tsujimoto, Naomi, He, Timothy, Zhang, Bailin, Ueda, Yoshihide and Li, En (2007) Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nature Genetics, 39 (3). pp. 391-396. ISSN 1061-4036

Chuchalin, Alexander G, Tsoi, Alla N, Richter, Kai, Krug, Norbert, Dahl, Ronald, Luursema, P B, Cameron, Ray, Bao, Weibin, Higgins, Mark, Woessner, Ralph and van As, Andre (2007) Safety and tolerability of indacaterol in asthma: a randomized, placebo-controlled 28-day study. Respiratory Medicine, 101 (10). pp. 2065-2075. ISSN 0954-6111

Clarke, Brian, Drujan Mayer, Doreen, Willis, Monte S, Murphy, Leon, Corpina, Richard A, Burova, Elena, Rakhilin, Sergey, Stitt, Trevor N, Patterson, Cam, Latres, Esther and Glass, David (2007) The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle. Cell Metabolism, 6 (5). pp. 376-385. ISSN 1550-4131

Commerford, Susan, Vargas, Leonardo, Dorfman, Suzanne, Mitro, Nico, Rocheford, Erik, Mak, Pui Ying, Li, Xue, Kennedy, Patrick, Mullarkey, Tara and Saez, Enrique (2007) Dissection of the insulin-sensitizing effect of liver X receptor ligands. Molecular Endocrinology (Baltimore, Md.), 21 (12). pp. 3002-3012. ISSN 0888-8809

Crisman, Thomas, Jenkins, Jeremy, Parker, Christian, Hill, William, Bender, Andreas, Deng, Zhan, Nettles Jr., James, Davies, John and Glick, Meir (2007) "Plate cherry picking": a novel semi-sequential screening paradigm for cheaper, faster, information-rich compound selection. Journal of Biomolecular Screening : the official journal of the Society for Biomolecular Screening, 12 (3). pp. 320-327. ISSN 1087-0571

Cummings, Jeffrey, Lefevre, Gilbert, Small, Gary and Appel Dingemanse, Silke (2007) Pharmacokinetic rationale for the rivastigmine patch. Neurology, 69 (4 Suppl 1). S10-3. ISSN 1526-632X

D

Dean, Charles, Narayan, Shubha, Richards, Joel, Daigle, Denis, Esterow, Stacey, Leeds, Jennifer, Kamp, Heather, Puyang, Xiaoling, Wiedmann, Brigitte, Mueller, Dieter, Voshol, Johannes, Van Oostrum, Jan, Wall, Daniel, Koehn, James, Dzink-Fox, Joann and Ryder, Neil (2007) Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number. Antimicrobial agents and chemotherapy, 51 (3). pp. 1004-1010. ISSN 0066-4804

Dev, Kumlesh K. (2007) PDZ domain protein-protein interactions: a case study with PICK1. Current Topics in Medicinal Chemistry, 7 (1). pp. 3-20. ISSN 1873-4294

Dierks, Christine, Grbic, Jovana, Zirlik, Katja, Beigi, Ronak, Englund, Nathan, Guo, Gui-Rong, Veelken, Hendrik, Engelhardt, Monika, Mertelsmann, Roland, Kelleher, Joseph F, Schultz, Peter and Warmuth, Markus (2007) Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nature Medicine, 13 (8). pp. 944-951. ISSN 1078-8956

Dirnberger, Dietmar and Seuwen, Klaus (2007) Signaling of human frizzled receptors to the mating pathway in yeast. PLoS ONE, 2 (9). e954. ISSN 1932-6203

Dubaele, Sandy and Chene, Patrick (2007) Cellular studies of MrDb (DDX18). Oncology Research, 16 (12). pp. 549-556. ISSN 0965-0407

Dubaele, Sandy, Martin, Christophe, Bohn, Jacqueline and Chene, Patrick (2007) Biochemical study of recombinant PcrA from Staphylococcus aureus for the development of screening assays. Journal of Biochemistry and Molecular Biology, 40 (1). pp. 7-14. ISSN 1225-8687

E

Eder, Joerg, Hommel, Ulrich, Cumin, Frederic, Martoglio, Bruno and Gerhartz, Bernd (2007) Aspartic proteases in drug discovery. Current Pharmaceutical Design, 13 (3). pp. 271-285. ISSN 1873-4286

Epple, Robert, Urbina, Hugo, Russo, Ross, Liu, Hong, Mason, Daniel, Bursulaya, Badry, Tumanut, Christine, Li, Jun and Harris, Jennifer (2007) Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. Bioorganic & Medicinal Chemistry Letters, 17 (5). pp. 1254-1259. ISSN 0960-894X

Ertl, Peter and Jelfs, Stephen (2007) Designing drugs on the internet? Free web tools and services supporting medicinal chemistry. Current Topics in Medicinal Chemistry, 7 (15). pp. 1491-1501. ISSN 1873-4294

Ertl, Peter (2007) In silico identification of bioisosteric functional groups. Current Opinion in Drug Discovery & Development, 10 (3). pp. 281-288. ISSN 1367-6733

F

Faller, Bernard and Ertl, Peter (2007) Computational approaches to determine drug solubility☆. Advanced Drug Delivery Reviews, 59 (7). pp. 533-545. ISSN 0169-409X

Faupel, Michel Daniel, Bonenfant, Debora, Schindler, Patrick, Bertrand, Eric, Mueller, Dieter, Stoeckli, Markus, Bitsch, Francis, Rohner, Tatiana, Staab, Dieter and Van Oostrum, Jan (2007) Biophotonics applied to proteomics. In: Biophotonics applied to Proteomics. Subcellular Proteomics, 43 . Springer, pp. 323-338. ISBN 978-1-4020-5942-1 (Print); 978-1-4020-5943-8 (Online)

Feuerbach, Dominik, Nozulak, Joachim, Lingenhoehl, Kurt, Mcallister, Kevin and Hoyer, Daniel (2007) JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist. Neuroscience Letters, 416 (1). pp. 61-65. ISSN 0304-3940

Fink, Joshua, Gu, Feng, Ling, Ling, Tolfvenstam, Thomas, Olfat, Farzad, Chin, Keh Chuang, Aw, Pauline, George, Joshy, Kuznetsov, Vladimir A, Schreiber, Mark, Vasudevan, Subhash and Hibberd, Martin L (2007) Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Neglected Tropical Diseases, 1 (2). e86. ISSN 1935-2735

G

Gadhachanda, Venkat, Wu, Baogen, Wang, Zhiwei, Kuhen, Kelli, Caldwell, Jeremy, Zondler, Helmut, Walter, Harald, Havenhand, Mark and He, Yun (2007) 4-Aminopyrimidines as novel HIV-1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 17 (1). pp. 260-265. ISSN 0960-894X

Gaither, Alex and Iourgenko, Vadim (2007) RNA interference technologies and their use in cancer research. Current Opinion in Oncology, 19 (1). pp. 50-54. ISSN 1040-8746

Gaither, Alex, Porter, Dale, Yao, Yao, Borawski, Jason, Yang, Guang, Donovan, Jerry, Sage, David, Slisz, Joanna, Tran, Mary, Straub, Christopher, Ramsey, Timothy, Iourgenko, Vadim, Huang, Alan, Chen, Yan, Schlegel, Robert, Labow, Mark, Fawell, Stephen, Sellers, William and Zawel, Leigh (2007) A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. Cancer Research, 67 (24). pp. 11493-11498. ISSN 1538-7445

Galkin, Anna, Melnick, Jonathan S, Kim, Sungjoon, Hood, Tami, Li, Nanxin, Li, Lintong, Xia, Gang, Steensma, Ruo, Chopiuk, Gregory, Jiang, Jiqing, Wan, Yongqin, Ding, Peter, Liu, Yi, Sun, Fangxian, Schultz, Peter, Gray, Nathanael and Warmuth, Markus (2007) Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proceedings of the National Academy of Sciences of the United States of America, 104 (1). pp. 270-275. ISSN 0027-8424

Graf, Christine, Rovina, Philipp, Tauzin, Loic, Schanzer, Andrea and Bornancin, Frederic (2007) Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells. Biochemical and Biophysical Research Communications, 354 (1). pp. 309-314. ISSN 0006-291X

Gromada, Jesper, Franklin, Isobel and Wollheim, Claes B. (2007) Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocrine Reviews, 28 (1). pp. 84-116. ISSN 0163-769X

Guery, Sebastien, Floersheim, Philipp, Kaupmann, Klemens and Froestl, Wolfgang (2007) Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors. Bioorganic & Medicinal Chemistry Letters, 17 (22). pp. 6206-6211. ISSN 0960-894X

H

Halder, Jyotsnabaran, Lin, Yvonne G, Merritt, William M, Spannuth, Whitney A, Nick, Alpa M, Honda, Toshiyuki, Kamat, Aparna A, Han, Liz Y, Kim, Tae Jin, Lu, Chunhua, Tari, Ana M, Bornmann, William, Fernandez, Ariel, Lopez-Berestein, Gabriel and Sood, Anil K (2007) Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. Cancer Research, 67 (22). pp. 10976-10983. ISSN 1538-7445

Hampton, Eric, Knuth, Mark, Li, Jun, Harris, Jennifer, Lesley, Scott and Spraggon, Glen (2007) The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain. Proceedings of the National Academy of Sciences of the United States of America, 104 (37). pp. 14604-14609. ISSN 0027-8424

Harant, Hanna, Wolff-Winiski, Barbara, Schreiner, Erwin, Oberhauser, Berndt, Hofer, Lotte, Lettner, Nicole, Maier, Sabine, De Vries, Jan Egbert and Lindley, Ivan-J.D. (2007) Inhibition of vascular endothelial growth factor cotranslational translocation by the cyclopeptolide CAM741. Molecular Pharmacology, 71 (6). pp. 1657-1665. ISSN 0026-895X

Hassiepen, Ulrich, Eidhoff, Ulf, Meder, Gabriele, Bulber, Jean-Francois, Hein, Andreas, Bodendorf, Ursula, Lorthiois, Edwige and Martoglio, Bruno (2007) A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate. Analytical Biochemistry, 371 (2). pp. 201-207. ISSN 0003-2697

Hintermann, Samuel, Chiesi, Michele, Von Krosigk, Ulrike, Mathe, Daniele, Felber, Richard and Hengerer, Bastian (2007) Identification of a series of highly potent activators of the Nurr1 signaling pathway. Bioorganic & Medicinal Chemistry Letters, 17 (1). pp. 193-196. ISSN 0960-894X

Hintermann, Samuel, Vranesic, Ivan-Toma, Allgeier, Hans, Bruelisauer, Armin, Hoyer, Daniel, Lemaire, Michel, Moenius, Thomas, Urwyler, Stephan, Whitebread, Steven, Gasparini, Fabrizio and Auberson, Yves (2007) ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorganic & Medicinal Chemistry, 15 (2). pp. 903-914. ISSN 0968-0896

Hoyer, Daniel (2007) RNA interference for studying the molecular basis of neuropsychiatric disorders. Current Opinion in Drug Discovery & Development, 10 (2). pp. 122-129. ISSN 1367-6733

Hummel, Manfred, Yonan, Nizar, Ross, Heather, Miller, Leslie W, Sechaud, Romain, Balez, Sebastien, Koelle, Ernst Ulrich and Gerosa, Gino (2007) Pharmacokinetics and variability of mycophenolic acid from enteric-coated mycophenolate sodium compared with mycophenolate mofetil in de novo heart transplant recipients. Clinical transplantation, 21 (1). pp. 18-23. ISSN 0902-0063

I

Imbach, Patricia, Lang, Marc, Garcia-Echeverria, Carlos, Guagnano, Vito, Noorani, Maria, Roesel, Johannes, Bitsch, Francis, Rihs, Grety and Furet, Pascal (2007) Novel beta-lactam derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome. Bioorganic & Medicinal Chemistry Letters, 17 (2). pp. 358-362. ISSN 0960-894X

Irelan, Jeffrey, Murphy, Thomas, DeJesus, Paul, Teo, Hsiangling, Xu, Dingyue, Gomez--Ferreria, Maria, Zhou, Yingyao, Miraglia, Loren, Rines, Daniel, Verma, Inder, Sharp, David, Tergaonkar, Vinay and Chanda, Sumit (2007) A role for IkappaB kinase 2 in bipolar spindle assembly. Proceedings of the National Academy of Sciences of the United States of America, 104 (43). pp. 16940-16945. ISSN 0027-8424

J

Jacob, Sandra, Fendrich, Gabriele, Floersheimer, Andreas, Furet, Pascal, Liebetanz, Janis, Rummel, Gabriele, Rheinberger, Paul, Centeleghe, Mario, Fabbro, Doriano and Manley, Paul W. (2007) Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. Acta Crystallographica. Section D, Biological crystallography, 63 (Pt 1). pp. 80-93. ISSN 0907-4449

Jacobson, Laura, Bettler, Bernhard, Kaupmann, Klemens and Cryan, John F. (2007) Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety. Psychopharmacology, 190 (4). pp. 541-553. ISSN 0033-3158

Jacobson, Laura and Cryan, John F. (2007) Feeling strained? Influence of genetic background on depression-related behavior in mice: a review. Behavior Genetics, 37 (1). pp. 171-213. ISSN 0001-8244

Jagle, Ulrike, Gasser, Juerg Andreas, Muller, Matthias and Kinzel, Bernd (2007) Conditional transgene expression mediated by the mouse beta-actin locus. Genesis (New York, N.Y. : 2000), 45 (11). pp. 659-666. ISSN 1526-954X

Jansma, Ariane, Zhang, Qiong, Li, Bing, Ding, Qiang, Uno, Tetsuo, Bursulaya, Badry, Liu, Yi, Furet, Pascal, Gray, Nathanael and Geierstanger, Bernhard (2007) Verification of a designed intramolecular hydrogen bond in a drug scaffold by nuclear magnetic resonance spectroscopy. Journal of Medicinal Chemistry, 50 (24). pp. 5875-5877. ISSN 0022-2623

Jelfs, Stephen, Ertl, Peter and Selzer, Paul (2007) Estimation of pKa for druglike compounds using semiempirical and information-based descriptors. Journal of Chemical Information and Modeling, 47 (2). pp. 450-459. ISSN 1549-9596

K

Kalthoff, Frank, Winiski, Anthony, Fichtinger, Petra, Schwendinger, Brigitte, Wang, Shirley, Weishaeupl, Cordula and Stuetz, Anton (2007) Differential inhibition of primary versus preactivated T cells by pimecrolimus but not by tacrolimus in vitro. International Archives of Allergy and Immunology, 142 (3). pp. 255-264. ISSN 1018-2438

Karmouty Quintana, Harry, Cannet, Catherine, Sugar, Rosemary, Fozard, John R., Page, Christopher and Beckmann, Nicolau (2007) Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging. British Journal of Pharmacology, 150 (8). pp. 1022-1030. ISSN 0007-1188

Karmouty Quintana, Harry, Cannet, Catherine, Zurbruegg, Stefan, Ble, Francois-Xavier, Fozard, John R., Page, Clive and Beckmann, Nicolau (2007) Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI. Journal of Magnetic Resonance Imaging: JMRI, 26 (4). pp. 941-949. ISSN 1053-1807

Kemp, Daniel, Nirmala, Nanguneri and Szustakowski, Joseph (2007) Extending the pathway analysis framework with a test for transcriptional variance implicates novel pathway modulation during myogenic differentiation. Bioinformatics, 23 (11). pp. 1356-1362. ISSN 1460-2059

Kiffe, Michael, Graf, Daniel and Trunzer, Markus (2007) Two-dimensional liquid chromatography/mass spectrometry set-up for structural elucidation of metabolites in complex biological matrices. Rapid Communications in Mass Spectrometry: RCM, 21 (6). pp. 961-970. ISSN 0951-4198

Kim, Mijung, Park, Sang Ho, Opella, Stanley, Marsilje, Thomas, Michellys, Pierre, Seidel, Martin and Tian, Shin-Shay (2007) NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains. The Journal of Biological Chemistry, 282 (19). pp. 14253-14261. ISSN 0021-9258

Kirkham, Paul (2007) Oxidative stress and macrophage function: a failure to resolve the inflammatory response. Biochemical Society Transactions, 35 (Pt 2). pp. 284-287. ISSN 0300-5127

Koehn, Jadranka, Huesken, Dieter, Jaritz, Markus, Rot, Antal, Zurini, Mauro, Dwertmann, Anne, Beutler, Bruce and Korthauer, Ulf (2007) Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response. Human Immunology, 68 (11). pp. 871-878. ISSN 0198-8859

Konig, Renate, Chiang, Chih-Yuan, Tu, Buu, Yan, Frank, DeJesus, Paul, Romero, Angelica, Bergauer, Tobias, Orth, Anthony, Krueger, Ute, Zhou, Yingyao and Chanda, Sumit (2007) A probability-based approach for the analysis of large-scale RNAi screens. Nature Methods, 4 (10). pp. 847-849. ISSN 1548-7091

Koziczak-Holbro, Magdalena, Joyce, Claire, Gluck-Gade, Aurelie, Kinzel, Bernd, Muller, Michel and Gram, Hermann (2007) Solving the IRAK-4 enigma: application of kinase-dead knock-in mice. Ernst Schering Foundation Symposium Proceedings (3). pp. 63-82.

Koziczak-Holbro, Magdalena, Joyce, Claire, Glueck, Anton, Kinzel, Bernd, Mueller, Matthias, Tschopp, Claude, Mathison, John, Davis, Christopher and Gram, Hermann (2007) IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression. The Journal of Biological Chemistry, 282 (18). pp. 13552-13560. ISSN 0021-9258

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Leder, Lukas, Freuler, Felix, Forstner, Michael and Mayr, Lorenz (2007) New methods for efficient protein production in drug discovery. Current Opinion in Drug Discovery & Development, 10 (2). pp. 193-202. ISSN 1367-6733

Lefevre, Gilbert, Sedek, Greg, Huang, Hsun-Lun, Saltzman, Marc, Rosenberg, Mitchell, Kiese, Beate and Fordham, Peter (2007) Pharmacokinetics of a rivastigmine transdermal patch formulation in healthy volunteers: relative effects of body site application. Journal of clinical pharmacology, 47 (4). pp. 471-478. ISSN 0091-2700

Lefterov, Iliya, Bookout, Angie, Wang, Zhu, Staufenbiel, Matthias, Mangelsdorf, David and Koldamova, Radosveta (2007) Expression profiling in APP23 mouse brain: inhibition of Aß amyloidosis and inflammation in response to LXR agonist treatment. Molecular Neurodegeneration, 2 (1). p. 20. ISSN 1750-1326

Lewis, C A, Ambrose, Carly, Banner, Kathy, Battram, Cliff, Butler, Keith, Giddings, June, Mok, Joanie, Nasra, Julie, Winney, Cerys and Poll, Chris (2007) Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig. Pulmonary Pharmacology & Therapeutics, 20 (4). pp. 325-333. ISSN 1094-5539

Lewis, C A, Ambrose, Carly, Banner, Kathy, Battram, Cliff, Butler, Keith, Giddings, June, Mok, Joanie, Nasra, Julie, Winny, C and Poll, Chris (2007) Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig. Pulmonary Pharmacology & Therapeutics, 20 (4). pp. 325-333. ISSN 1094-5539

Lhuillier, Loic, Mombereau, Cedric, Cryan, John F. and Kaupmann, Klemens (2007) GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32 (2). pp. 388-398. ISSN 0893-133X

Li, Jun, Tumanut, Christine, Gavigan, Julie-Ann, Huang, Waan, Hampton, Eric, Tuman, Rachelle, Suen, Ka Fai, Trauger, John, Spraggon, Glen, Lesley, Scott, Liau, Gene, Yowe, David and Harris, Jennifer (2007) Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity. The Biochemical Journal, 406 (2). pp. 203-207. ISSN 1470-8728

Li, Guochun, Vega, Raquel, Nelms, Keats, Gekakis, Nicholas, Goodnow, Christopher, McNamara, Peter, Wu, Hua, Hong, Nancy A and Glynne, Richard (2007) A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence. PLoS Genetics, 3 (1). e8. ISSN 1553-7404

Li, Nanxin, Batt, David and Warmuth, Markus (2007) B-Raf kinase inhibitors for cancer treatment. Current opinion in investigational drugs (London, England : 2000), 8 (6). pp. 452-456. ISSN 1472-4472

Liu, Ta-Jen, LaFortune, Tiffany, Honda, Toshiyuki, Ohmori, Osamu, Hatakeyama, Shinji, Meyer, Thomas, Jackson, Daniel, de Groot, John and Yung, W K Alfred (2007) Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Molecular Cancer Therapeutics, 6 (4). pp. 1357-1367. ISSN 1535-7163

Loehr, Kristina, Knox, John, Phong, Wai Yee, Ma, Ngai Ling, Yin, Zheng, Sampath, Aruna, Patel, Sejal, Wang, Wei, Chan, Wai Ling, Rao, Ranga, Wang, Gang, Vasudevan, Subhash, Keller, Thomas and Lim, Siew Pheng (2007) Yellow fever virus NS3 protease: peptide-inhibition studies. The Journal of General Virology, 88 (Pt 8). pp. 2223-2227. ISSN 0022-1317

Loferer, Markus, Kolossváry, István and Aszódi, András (2007) Analyzing the performance of conformational search programs on compound databases. Journal of Molecular Graphics & Modelling, 25 (5). pp. 700-710. ISSN 1093-3263

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Maclaurin, Sarah, Krucker, Thomas and Fish, Kenneth (2007) Hippocampal dendritic arbor growth in vitro: regulation by Reelin-Disabled-1 signaling. Brain Research, 1172. pp. 1-9. ISSN 0006-8993

Maibaum, Jurgen, Stutz, Stefan, Goschke, Richard, Rigollier, Pascal, Yamaguchi, Yasuchika, Cumin, Frederic, Rahuel, Joseph, Baum, Hans-Peter, Cohen, Nissim-Claude, Schnell, Christian, Fuhrer, Walter, Gruetter, Markus, Schilling, Walter and Wood, Jeanette (2007) Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets. Journal of Medicinal Chemistry, 50 (20). pp. 4832-4844. ISSN 0022-2623

Marwick, John, Ito, Kazuhiro, Adcock, Ian and Kirkham, Paul (2007) Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy. Expert Opinion on Therapeutic Targets, 11 (6). pp. 745-755. ISSN 1472-8222

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Nguyen, Deborah, Yin, Hong, Zhou, Yingyao, Wolff, Karen, Kuhen, Kelli and Caldwell, Jeremy (2007) Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening. Virology, 362 (1). pp. 16-25. ISSN 0042-6822

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Zehender, Hartmut and Mayr, Lorenz (2007) Application of mass spectrometry technologies for the discovery of low-molecular weight modulators of enzymes and protein-protein interactions. Current Opinion in Chemical Biology, 11 (5). pp. 511-517. ISSN 1367-5931

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