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Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry.

Stoeckli, Markus and Staab, Dieter and Schweitzer, Alain and Gardiner, James and Seebach, Dieter (2007) Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry. Journal of the American Society for Mass Spectrometry, 18 (11). pp. 1921-1924. ISSN 1044-0305

Abstract

Mass spectrometric imaging was applied to assess compound distributions on whole-body sections of mice after i.v. dosing of a beta-peptide and an alpha-peptide control. Animals were sacrificed at different time points (5 min, 1 h, 24 h) post-dose, providing simultaneous spatial as well as kinetic information. As a result of this study, no detection of the alpha-peptide control was observed at 1 h post-dose, while retention of the beta-peptide was observed for longer than 24 h post-dose.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
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Date Deposited: 14 Dec 2009 14:00
Last Modified: 31 Jan 2013 01:18
URI: https://oak.novartis.com/id/eprint/377

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