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Optimization of halopemide for phospholipase D2 inhibition.

Monovich, Lauren, Mugrage, Benjamin, Quadros, Elizabeth, Toscano, Karen, Tommasi, Ruben, Lavoie, Stacey, Liu, Eugene, Du, Zhengming, Lasala, Daniel, Boyar, William and Steed, Paul (2007) Optimization of halopemide for phospholipase D2 inhibition. Bioorganic & Medicinal Chemistry Letters, 17 (8). pp. 2310-2311. ISSN 0960-894X


Halopemide, which was identified by HTS to inhibit phospholipase D2 (PLD2), provided the basis for an exploratory effort to identify potent inhibitors of PLD2 for use as inflammatory mediators. Parallel synthesis and purification were utilized to rapidly identify orally available amide analogs derived from indole 2-carboxylic acids with superior potency versus PLD2.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Halopemide; Phospholipase D; Inhibitor
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Date Deposited: 14 Dec 2009 13:58
Last Modified: 31 Jan 2013 01:14